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王 麗香
医化学講座
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- Vesicular nucleotide transporter (VNUT)-dependent ATP secretion by hepatic stellate cells promotes liver fibrosis
Masaharu Kabashima; Nao Hasuzawa; Lixiang Wang; Junjiro Rikitake; Seiji Nomura; Tomohiro Niimoto; Rie Tokubuchi; Sawako Moriyama; Mizuki Gobaru; Yukihiro Inoguchi; Ayako Nagayama; Kenji Ashida; Keisuke Ohta; Yoshinori Moriyama; Masatoshi Nomura
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2026年04月 - Drp1-mediated mitochondrial fission protects macrophages from mtDNA/ZBP1-mediated inflammation and inhibits post-infarct cardiac remodelling
Yuki Kondo; Jun-ichiro Koga; Nasanbadrakh Orkhonselenge; Lixiang Wang; Nao Hasuzawa; Shunsuke Katsuki; Tetsuya Matoba; Yosuke Nishimura; Masatoshi Nomura; Masaharu Kataoka
Cardiovascular Research, 2026年01月16日 - Development of a questionnaire-based Dietary Inflammatory Index assessment for clinical implementation
Mamiko Yano; Nao Hasuzawa; Natsumi Maruyama; Lixiang Wang; Mizuki Gobaru; Ayako Nagayama; Kenji Ashida; Hitoshi Obara; Kenta Murotani; Yoshinori Moriyama; Masatoshi Nomura
Journal of Clinical Biochemistry and Nutrition, 2026年 - Sodium-glucose cotransporter 2 inhibitors—but not insulin—enhance renal branched-chain amino acid catabolism
Moeko Sakamoto; Nao Hasuzawa; Lixiang Wang; Kyoko Tashiro; Miyuki Kitamura; Shimpei Iwata; Nobuhiko Wada; Seiji Nomura; Sawako Moriyama; Mizuki Gobaru; Yukihiro Inoguchi; Ayako Nagayama; Kenji Ashida; Yoshinori Moriyama; Masatoshi Nomura
Frontiers in Endocrinology, 2025年11月07日 - Imeglimin attenuates liver fibrosis by inhibiting vesicular
ATP release from hepatic stellate cells
Seiji Nomura; Lixiang Wang; Nao Hasuzawa; Ayako Nagayama; Sawako Moriyama; Kenji Ashida; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
FEBS Letters, 2025年09月15日 - Impact of Drp1 Loss on Organelle Interaction, Metabolism, and Inflammation in Mouse Liver
Lixiang Wang; Seiji Nomura; Nao Hasuzawa; Sadaki Yokota; Ayako Nagayama; Kenji Ashida; Junjiro Rikitake; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
Cells, 2025年05月08日 - Mitochondrial fission is required for thermogenesis in brown adipose tissue.
Yuta Ibayashi; Nao Hasuzawa; Seiji Nomura; Masaharu Kabashima; Ayako Nagayama; Shimpei Iwata; Miyuki Kitamura; Kenji Ashida; Yoshinori Moriyama; Ken Yamamoto; Masatoshi Nomura; Lixiang Wang
PloS one, 2024年 - Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS
Lixiang Wang; Yanli Zhang; Magdalena Kiprowska; Yuqi Guo; Ken Yamamoto; Xin Li
Metabolites, 2021年12月08日 - Quinacrine is not a vital fluorescent probe for vesicular ATP storage.
Hasuzawa N; Moriyama S; Wang L; Nagayama A; Ashida K; Moriyama Y; Nomura M
Purinergic signalling, 2021年10月28日 - Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion
Maximillian A Rogers; Joshua D Hutcheson; Takehito Okui; Claudia Goettsch; Sasha A Singh; Arda Halu; Florian Schlotter; Hideyuki Higashi; Lixiang Wang; Mary C Whelan; Andrew K Mlynarchik; Alan Daugherty; Masatoshi Nomura; Masanori Aikawa; Elena Aikawa
Cardiovascular Research, 2021年09月28日 - An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing's Syndrome and Autonomous Cortisol Secretion
Oda S, Ashida K, Uchiyama M, Sakamoto S, Hasuzawa N, Nagayama A, Wang L, Nagata H, Sakamoto R, Kishimoto J, Todaka K, Ogawa Y, Nakanishi Y, Nomura M.
J Clin Endocrinol Metab., 2021年09月01日 - Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice
Lixiang Wang; Xin Li; Yuki Hanada; Nao Hasuzawa; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
Communications Biology, 2021年07月21日 - Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor.
Takeichi Y; Miyazawa T; Sakamoto S; Hanada Y; Wang L; Gotoh K; Uchida K; Katsuhara S; Sakamoto R; Ishihara T; Masuda K; Ishihara N; Nomura M; Ogawa Y
Diabetologia, 2021年05月29日 - Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Hasuzawa N; Tatsushima K; Wang L; Kabashima M; Tokubuchi R; Nagayama A; Ashida K; Ogawa Y; Moriyama Y; Nomura M
Scientific reports, 2021年03月04日 - Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis.
Tatsushima K; Hasuzawa N; Wang L; Hiasa M; Sakamoto S; Ashida K; Sudo N; Moriyama Y; Nomura M
Biochimica et biophysica acta. Molecular basis of disease, 2020年11月17日 - MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity
Yuki Hanada; Naotada Ishihara; Lixiang Wang; Hidenori Otera; Takaya Ishihara; Takumi Koshiba; Katsuyoshi Mihara; Yoshihiro Ogawa; Masatoshi Nomura
Nature Communications, 2020年11月11日 - Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury.
Umezu R; Koga JI; Matoba T; Katsuki S; Wang L; Hasuzawa N; Nomura M; Tsutsui H; Egashira K
Arteriosclerosis, thrombosis, and vascular biology, 2020年06月04日 - Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma.
Yano S; Ashida K; Nagata H; Ohe K; Wada N; Takeichi Y; Hanada Y; Ibayashi Y; Wang L; Sakamoto S; Sakamoto R; Uchi H; Shiratsuchi M; Furue M; Nomura M; Ogawa Y
BMC endocrine disorders, 2018年06月08日 - Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
Baba T; Otake H; Inoue M; Sato T; Ishihara Y; Moon JY; Tsuchiya M; Miyabayashi K; Ogawa H; Shima Y; Wang L; Sato R; Yamazaki T; Suyama M; Nomura M; Choi MH; Ohkawa Y; Morohashi KI
Communications biology, 2018年03月22日 - SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes.
Inoue C; Zhao C; Tsuduki Y; Udono M; Wang L; Nomura M; Katakura Y
NPJ aging and mechanisms of disease, 2017年08月30日 - Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.
Wang L; Ishihara T; Ibayashi Y; Tatsushima K; Setoyama D; Hanada Y; Takeichi Y; Sakamoto S; Yokota S; Mihara K; Kang D; Ishihara N; Takayanagi R; Nomura M
Diabetologia, 2015年08月02日 - Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system.
Wang L; Nomura M
Genomics data, 2015年07月29日 - Dietary vitamin D3 improves postprandial hyperglycemia in aged mice.
Enciso PL; Wang L; Kawahara Y; Sakamoto S; Shimada S; Takeichi Y; Takayanagi R; Nomura M
Biochemical and biophysical research communications, 2015年04月11日 - Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity
Nomura M, Morinaga H, Zhu HL, Wang L, Hasuzawa N, Takayanagi R, Teramoto N.
Biochem Biophys Res Commun., 2014年06月10日 - SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity.
Nomura M; Zhu HL; Wang L; Morinaga H; Takayanagi R; Teramoto N
Diabetologia, 2013年09月26日 - Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice.
Sakamoto R; Matsubara E; Nomura M; Wang L; Kawahara Y; Yanase T; Nawata H; Takayanagi R
Metabolism: clinical and experimental, 2013年09月17日 - Activin stimulates CYP19A gene expression in human ovarian granulosa cell-like KGN cells via the Smad2 signaling pathway.
Nomura M; Sakamoto R; Morinaga H; Wang L; Mukasa C; Takayanagi R
Biochemical and biophysical research communications, 2013年06月06日 - Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model.
Nomura M; Tanaka K; Wang L; Goto Y; Mukasa C; Ashida K; Takayanagi R
Biochemical and biophysical research communications, 2012年11月15日 - Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.
Deng X; Takaki H; Wang L; Kuroki T; Nakahara T; Hashimoto K; Ninomiya H; Arinami T; Inada T; Ujike H; Itokawa M; Tochigi M; Watanabe Y; Someya T; Kunugi H; Iwata N; Ozaki N; Shibata H; Fukumaki Y
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2011年08月23日 - Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice.
Wang L; Nomura M; Goto Y; Tanaka K; Sakamoto R; Abe I; Sakamoto S; Shibata A; Enciso PL; Adachi M; Ohnaka K; Kawate H; Takayanagi R
The Journal of biological chemistry, 2011年04月04日 - Generation and characterization of T1R2-LacZ knock-in mouse.
Iwatsuki K; Nomura M; Shibata A; Ichikawa R; Enciso PL; Wang L; Takayanagi R; Torii K; Uneyama H
Biochemical and biophysical research communications, 2010年10月20日 - A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H).
Furuya H; Ikezoe K; Wang L; Ohyagi Y; Motomura K; Fujii N; Kira J; Fukumaki Y
American journal of medical genetics. Part A, 2008年02月01日
- Cutting-Edge肥満症学 肥満症治療とミトコンドリア品質管理
野村 政壽; 王 麗香; 井林 雄太; 蓮澤 奈央
肥満研究, 2022年11月 - 動脈硬化症とメタボリックシンドローム VNUTを介した細胞外ATP分泌と動脈硬化
蓮澤 奈央; 徳渕 里恵; 椛島 正治; 王 麗香; 森山 芳則; 野村 政壽
日本動脈硬化学会総会プログラム・抄録集, 2022年07月 - 糖尿病治療標的としてのミトコンドリア
野村 政壽; 王 麗香; 蓮澤 奈央; 蘆田 健二
糖尿病, 2022年04月 - ミトコンドリアと疾患・老化 糖尿病の病態形成におけるミトコンドリアダイナミクスの役割
蓮澤 奈央; 王 麗香; 大塚 由絵; 坂本 萌子; 喜多村 美幸; 野村 政壽
日本内分泌学会雑誌, 2021年04月
