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LIXIANG WANG
Department of Medical Biochemistry
Assistant Professor
Research activity information
■ Paper
- Vesicular nucleotide transporter (VNUT)-dependent ATP secretion by hepatic stellate cells promotes liver fibrosis
Masaharu Kabashima; Nao Hasuzawa; Lixiang Wang; Junjiro Rikitake; Seiji Nomura; Tomohiro Niimoto; Rie Tokubuchi; Sawako Moriyama; Mizuki Gobaru; Yukihiro Inoguchi; Ayako Nagayama; Kenji Ashida; Keisuke Ohta; Yoshinori Moriyama; Masatoshi Nomura
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Apr. 2026 - Drp1-mediated mitochondrial fission protects macrophages from mtDNA/ZBP1-mediated inflammation and inhibits post-infarct cardiac remodelling
Yuki Kondo; Jun-ichiro Koga; Nasanbadrakh Orkhonselenge; Lixiang Wang; Nao Hasuzawa; Shunsuke Katsuki; Tetsuya Matoba; Yosuke Nishimura; Masatoshi Nomura; Masaharu Kataoka
Cardiovascular Research, 16 Jan. 2026 - Development of a questionnaire-based Dietary Inflammatory Index assessment for clinical implementation
Mamiko Yano; Nao Hasuzawa; Natsumi Maruyama; Lixiang Wang; Mizuki Gobaru; Ayako Nagayama; Kenji Ashida; Hitoshi Obara; Kenta Murotani; Yoshinori Moriyama; Masatoshi Nomura
Journal of Clinical Biochemistry and Nutrition, 2026 - Sodium-glucose cotransporter 2 inhibitors—but not insulin—enhance renal branched-chain amino acid catabolism
Moeko Sakamoto; Nao Hasuzawa; Lixiang Wang; Kyoko Tashiro; Miyuki Kitamura; Shimpei Iwata; Nobuhiko Wada; Seiji Nomura; Sawako Moriyama; Mizuki Gobaru; Yukihiro Inoguchi; Ayako Nagayama; Kenji Ashida; Yoshinori Moriyama; Masatoshi Nomura
Frontiers in Endocrinology, 07 Nov. 2025 - Imeglimin attenuates liver fibrosis by inhibiting vesicular
ATP release from hepatic stellate cells
Seiji Nomura; Lixiang Wang; Nao Hasuzawa; Ayako Nagayama; Sawako Moriyama; Kenji Ashida; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
FEBS Letters, 15 Sep. 2025 - Impact of Drp1 Loss on Organelle Interaction, Metabolism, and Inflammation in Mouse Liver
Lixiang Wang; Seiji Nomura; Nao Hasuzawa; Sadaki Yokota; Ayako Nagayama; Kenji Ashida; Junjiro Rikitake; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
Cells, 08 May 2025 - Mitochondrial fission is required for thermogenesis in brown adipose tissue.
Yuta Ibayashi; Nao Hasuzawa; Seiji Nomura; Masaharu Kabashima; Ayako Nagayama; Shimpei Iwata; Miyuki Kitamura; Kenji Ashida; Yoshinori Moriyama; Ken Yamamoto; Masatoshi Nomura; Lixiang Wang
PloS one, 2024 - Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS
Lixiang Wang; Yanli Zhang; Magdalena Kiprowska; Yuqi Guo; Ken Yamamoto; Xin Li
Metabolites, 08 Dec. 2021 - Quinacrine is not a vital fluorescent probe for vesicular ATP storage.
Hasuzawa N; Moriyama S; Wang L; Nagayama A; Ashida K; Moriyama Y; Nomura M
Purinergic signalling, 28 Oct. 2021 - Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion
Maximillian A Rogers; Joshua D Hutcheson; Takehito Okui; Claudia Goettsch; Sasha A Singh; Arda Halu; Florian Schlotter; Hideyuki Higashi; Lixiang Wang; Mary C Whelan; Andrew K Mlynarchik; Alan Daugherty; Masatoshi Nomura; Masanori Aikawa; Elena Aikawa
Cardiovascular Research, 28 Sep. 2021 - An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing's Syndrome and Autonomous Cortisol Secretion.
Oda S; Ashida K; Uchiyama M; Sakamoto S; Hasuzawa N; Nagayama A; Wang L; Nagata H; Sakamoto R; Kishimoto J; Todaka K; Ogawa Y; Nakanishi Y; Nomura M
The Journal of clinical endocrinology and metabolism, 01 Sep. 2021 - Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice
Lixiang Wang; Xin Li; Yuki Hanada; Nao Hasuzawa; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
Communications Biology, 21 Jul. 2021 - Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor.
Takeichi Y; Miyazawa T; Sakamoto S; Hanada Y; Wang L; Gotoh K; Uchida K; Katsuhara S; Sakamoto R; Ishihara T; Masuda K; Ishihara N; Nomura M; Ogawa Y
Diabetologia, 29 May 2021 - Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Hasuzawa N; Tatsushima K; Wang L; Kabashima M; Tokubuchi R; Nagayama A; Ashida K; Ogawa Y; Moriyama Y; Nomura M
Scientific reports, 04 Mar. 2021 - Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis.
Tatsushima K; Hasuzawa N; Wang L; Hiasa M; Sakamoto S; Ashida K; Sudo N; Moriyama Y; Nomura M
Biochimica et biophysica acta. Molecular basis of disease, 17 Nov. 2020 - MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity
Yuki Hanada; Naotada Ishihara; Lixiang Wang; Hidenori Otera; Takaya Ishihara; Takumi Koshiba; Katsuyoshi Mihara; Yoshihiro Ogawa; Masatoshi Nomura
Nature Communications, 11 Nov. 2020 - Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury.
Umezu R; Koga JI; Matoba T; Katsuki S; Wang L; Hasuzawa N; Nomura M; Tsutsui H; Egashira K
Arteriosclerosis, thrombosis, and vascular biology, 04 Jun. 2020 - Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma.
Yano S; Ashida K; Nagata H; Ohe K; Wada N; Takeichi Y; Hanada Y; Ibayashi Y; Wang L; Sakamoto S; Sakamoto R; Uchi H; Shiratsuchi M; Furue M; Nomura M; Ogawa Y
BMC endocrine disorders, 08 Jun. 2018 - Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
Baba T; Otake H; Inoue M; Sato T; Ishihara Y; Moon JY; Tsuchiya M; Miyabayashi K; Ogawa H; Shima Y; Wang L; Sato R; Yamazaki T; Suyama M; Nomura M; Choi MH; Ohkawa Y; Morohashi KI
Communications biology, 22 Mar. 2018 - SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes.
Inoue C; Zhao C; Tsuduki Y; Udono M; Wang L; Nomura M; Katakura Y
NPJ aging and mechanisms of disease, 30 Aug. 2017 - Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.
Wang L; Ishihara T; Ibayashi Y; Tatsushima K; Setoyama D; Hanada Y; Takeichi Y; Sakamoto S; Yokota S; Mihara K; Kang D; Ishihara N; Takayanagi R; Nomura M
Diabetologia, 02 Aug. 2015 - Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system.
Wang L; Nomura M
Genomics data, 29 Jul. 2015 - Dietary vitamin D3 improves postprandial hyperglycemia in aged mice.
Enciso PL; Wang L; Kawahara Y; Sakamoto S; Shimada S; Takeichi Y; Takayanagi R; Nomura M
Biochemical and biophysical research communications, 11 Apr. 2015 - Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity.
Nomura M; Morinaga H; Zhu HL; Wang L; Hasuzawa N; Takayanagi R; Teramoto N
Biochemical and biophysical research communications, 10 Jun. 2014 - SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity.
Nomura M; Zhu HL; Wang L; Morinaga H; Takayanagi R; Teramoto N
Diabetologia, 26 Sep. 2013 - Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice.
Sakamoto R; Matsubara E; Nomura M; Wang L; Kawahara Y; Yanase T; Nawata H; Takayanagi R
Metabolism: clinical and experimental, 17 Sep. 2013 - Activin stimulates CYP19A gene expression in human ovarian granulosa cell-like KGN cells via the Smad2 signaling pathway.
Nomura M; Sakamoto R; Morinaga H; Wang L; Mukasa C; Takayanagi R
Biochemical and biophysical research communications, 06 Jun. 2013 - Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model.
Nomura M; Tanaka K; Wang L; Goto Y; Mukasa C; Ashida K; Takayanagi R
Biochemical and biophysical research communications, 15 Nov. 2012 - Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia.
Deng X; Takaki H; Wang L; Kuroki T; Nakahara T; Hashimoto K; Ninomiya H; Arinami T; Inada T; Ujike H; Itokawa M; Tochigi M; Watanabe Y; Someya T; Kunugi H; Iwata N; Ozaki N; Shibata H; Fukumaki Y
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 23 Aug. 2011 - Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice.
Wang L; Nomura M; Goto Y; Tanaka K; Sakamoto R; Abe I; Sakamoto S; Shibata A; Enciso PL; Adachi M; Ohnaka K; Kawate H; Takayanagi R
The Journal of biological chemistry, 04 Apr. 2011 - Generation and characterization of T1R2-LacZ knock-in mouse.
Iwatsuki K; Nomura M; Shibata A; Ichikawa R; Enciso PL; Wang L; Takayanagi R; Torii K; Uneyama H
Biochemical and biophysical research communications, 20 Oct. 2010 - A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H).
Furuya H; Ikezoe K; Wang L; Ohyagi Y; Motomura K; Fujii N; Kira J; Fukumaki Y
American journal of medical genetics. Part A, 01 Feb. 2008
- Cutting-Edge肥満症学 肥満症治療とミトコンドリア品質管理
野村 政壽; 王 麗香; 井林 雄太; 蓮澤 奈央
肥満研究, Nov. 2022 - 動脈硬化症とメタボリックシンドローム VNUTを介した細胞外ATP分泌と動脈硬化
蓮澤 奈央; 徳渕 里恵; 椛島 正治; 王 麗香; 森山 芳則; 野村 政壽
日本動脈硬化学会総会プログラム・抄録集, Jul. 2022 - 糖尿病治療標的としてのミトコンドリア
野村 政壽; 王 麗香; 蓮澤 奈央; 蘆田 健二
糖尿病, Apr. 2022 - ミトコンドリアと疾患・老化 糖尿病の病態形成におけるミトコンドリアダイナミクスの役割
蓮澤 奈央; 王 麗香; 大塚 由絵; 坂本 萌子; 喜多村 美幸; 野村 政壽
日本内分泌学会雑誌, Apr. 2021
- Impact of mitochondrial dynamics on metabolic disease and inflammation
Grant-in-Aid for Young Scientists (B)
01 Apr. 2016 - 31 Mar. 2018
