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王 麗香
医化学講座
助教

研究者情報

■ 研究分野
  • ライフサイエンス, 細胞生物学, ミトコンドリアダイナミクス
  • ライフサイエンス, 実験動物学
  • ライフサイエンス, 代謝、内分泌学
■ 専門分野
  • 内科学
  • 生体防御と免疫系一般
  • 代謝異常,栄養性疾患
  • 内分泌系の医学
■ 研究テーマ
  • ミトコンドリア分裂に着眼した新たなエネルギー代謝・自然免疫連関の解明

研究活動情報

■ 論文
  • Mitochondrial fission is required for thermogenesis in brown adipose tissue.
    Yuta Ibayashi; Nao Hasuzawa; Seiji Nomura; Masaharu Kabashima; Ayako Nagayama; Shimpei Iwata; Miyuki Kitamura; Kenji Ashida; Yoshinori Moriyama; Ken Yamamoto; Masatoshi Nomura; Lixiang Wang
    PloS one, 2024年
  • Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS               
    Wang L, Zhang Y, Kiprowska M, Guo Y, Yamamoto K, Li X.
    Metabolites., 2021年12月
  • Quinacrine is not a vital fluorescent probe for vesicular ATP storage               
    Hasuzawa N, Moriyama S, Wang L, Nagayama A, Ashida K, Moriyama Y, Nomura M.
    Purinergic Signal., 2021年12月
  • An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing's Syndrome and Autonomous Cortisol Secretion               
    Oda S, Ashida K, Uchiyama M, Sakamoto S, Hasuzawa N, Nagayama A, Wang L, Nagata H, Sakamoto R, Kishimoto J, Todaka K, Ogawa Y, Nakanishi Y, Nomura M.
    J Clin Endocrinol Metab., 2021年09月
  • Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor               
    Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y.
    Diabetologia., 2021年09月
  • Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion               
    Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E.
    Cardiovasc Res., 2021年09月
  • Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice               
    Wang L, Li X, Hanada Y, Hasuzawa N, Moriyama Y, Nomura M, Yamamoto K.
    Commun Biol., 2021年07月
  • Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury               
    Hasuzawa N, Tatsushima K, Wang L, Kabashima M, Tokubuchi R, Nagayama A, Ashida K, Ogawa Y, Moriyama Y, Nomura M.
    Sci Rep., 2021年04月
  • Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis               
    Tatsushima K, Hasuzawa N, Wang L, Hiasa M, Sakamoto S, Ashida K, Sudo N, Moriyama Y, Nomura M.
    Biochim Biophys Acta Mol Basis Dis., 2021年03月
  • MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity               
    Hanada Y, Ishihara N, Wang L, Otera H, Ishihara T, Koshiba T, Mihara K, Ogawa Y, Nomura M.
    Nat Commun., 2020年11月
  • Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury               
    Umezu R, Koga JI, Matoba T, Katsuki S, Wang L, Hasuzawa N, Nomura M, Tsutsui H, Egashira K.
    Arterioscler Thromb Vasc Biol., 2020年07月
  • Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma               
    Yano S, Ashida K, Nagata H, Ohe K, Wada N, Takeichi Y, Hanada Y, Ibayashi Y, Wang L, Sakamoto S, Sakamoto R, Uchi H, Shiratsuchi M, Furue M, Nomura M, Ogawa Y.
    BMC Endocr Disord., 2018年06月
  • Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids               
    Baba T, Otake H, Inoue M, Sato T, Ishihara Y, Moon JY, Tsuchiya M, Miyabayashi K, Ogawa H, Shima Y, Wang L, Sato R, Yamazaki T, Suyama M, Nomura M, Choi MH, Ohkawa Y, Morohashi KI.
    Commun Biol., 2018年03月
  • SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes               
    Inoue C, Zhao C, Tsuduki Y, Udono M, Wang L, Nomura M, Katakura Y.
    NPJ Aging Mech Dis., 2017年08月
  • Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration               
    Wang L, Ishihara T, Ibayashi Y, Tatsushima K, Setoyama D, Hanada Y, Takeichi Y, Sakamoto S, Yokota S, Mihara K, Kang D, Ishihara N, Takayanagi R, Nomura M.
    Diabetologia., 2015年10月
  • Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system               
    Wang L, Nomura M.
    Genom Data., 2015年07月
  • Dietary vitamin D3 improves postprandial hyperglycemia in aged mice               
    Enciso PL, Wang L, Kawahara Y, Sakamoto S, Shimada S, Takeichi Y, Takayanagi R, Nomura M.
    Biochem Biophys Res Commun., 2015年05月
  • Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity               
    Nomura M, Morinaga H, Zhu HL, Wang L, Hasuzawa N, Takayanagi R, Teramoto N.
    Biochem Biophys Res Commun., 2014年07月
  • SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity               
    Nomura M, Zhu HL, Wang L, Morinaga H, Takayanagi R, Teramoto N.
    Diabetologia., 2014年01月
  • Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice               
    Sakamoto R, Matsubara E, Nomura M, Wang L, Kawahara Y, Yanase T, Nawata H, Takayanagi R.
    Metabolism., 2013年12月
  • Activin stimulates CYP19A gene expression in human ovarian granulosa cell-like KGN cells via the Smad2 signaling pathway               
    Nomura M, Sakamoto R, Morinaga H, Wang L, Mukasa C, Takayanagi R.
    Biochem Biophys Res Commun., 2013年07月
  • Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model               
    Nomura M, Tanaka K, Wang L, Goto Y, Mukasa C, Ashida K, Takayanagi R.
    Biochem Biophys Res Commun., 2013年01月
  • Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia               
    Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y.
    Am J Med Genet B Neuropsychiatr Genet., 2011年12月
  • Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice               
    Wang L, Nomura M, Goto Y, Tanaka K, Sakamoto R, Abe I, Sakamoto S, Shibata A, Enciso PL, Adachi M, Ohnaka K, Kawate H, Takayanagi R.
    J Biol Chem., 2011年05月
  • Generation and characterization of T1R2-LacZ knock-in mouse               
    Iwatsuki K, Nomura M, Shibata A, Ichikawa R, Enciso PL, Wang L, Takayanagi R, Torii K, Uneyama H.
    Biochem Biophys Res Commun, 2010年11月
  • A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H)               
    Furuya H, Ikezoe K, Wang L, Ohyagi Y, Motomura K, Fujii N, Kira J, Fukumaki Y.
    Am J Med Genet A, 2008年02月
■ MISC
■ 共同研究・競争的資金等の研究課題