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LIXIANG WANG
Department of Medical Biochemistry
Assistant Professor

Researcher information

■ Field Of Study
  • Life sciences, Cell biology, ミトコンドリアダイナミクス
  • Life sciences, Laboratory animal science
  • Life sciences, Metabolism and endocrinology
■ Research Keyword
  • 内科学
  • 生体防御と免疫系一般
  • 代謝異常，栄養性疾患
  • 内分泌系の医学
■ Research Theme
  • ミトコンドリア分裂に着眼した新たなエネルギー代謝・自然免疫連関の解明

Research activity information

■ Paper
  • Mitochondrial fission is required for thermogenesis in brown adipose tissue.
    Yuta Ibayashi; Nao Hasuzawa; Seiji Nomura; Masaharu Kabashima; Ayako Nagayama; Shimpei Iwata; Miyuki Kitamura; Kenji Ashida; Yoshinori Moriyama; Ken Yamamoto; Masatoshi Nomura; Lixiang Wang
    PloS one, 2024
  • Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS　　　　　　　　　　　　　　　
    Wang L, Zhang Y, Kiprowska M, Guo Y, Yamamoto K, Li X.
    Metabolites., Dec. 2021
  • Quinacrine is not a vital fluorescent probe for vesicular ATP storage　　　　　　　　　　　　　　　
    Hasuzawa N, Moriyama S, Wang L, Nagayama A, Ashida K, Moriyama Y, Nomura M.
    Purinergic Signal., Dec. 2021
  • An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing's Syndrome and Autonomous Cortisol Secretion　　　　　　　　　　　　　　　
    Oda S, Ashida K, Uchiyama M, Sakamoto S, Hasuzawa N, Nagayama A, Wang L, Nagata H, Sakamoto R, Kishimoto J, Todaka K, Ogawa Y, Nakanishi Y, Nomura M.
    J Clin Endocrinol Metab., Sep. 2021
  • Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor　　　　　　　　　　　　　　　
    Takeichi Y, Miyazawa T, Sakamoto S, Hanada Y, Wang L, Gotoh K, Uchida K, Katsuhara S, Sakamoto R, Ishihara T, Masuda K, Ishihara N, Nomura M, Ogawa Y.
    Diabetologia., Sep. 2021
  • Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion　　　　　　　　　　　　　　　
    Rogers MA, Hutcheson JD, Okui T, Goettsch C, Singh SA, Halu A, Schlotter F, Higashi H, Wang L, Whelan MC, Mlynarchik AK, Daugherty A, Nomura M, Aikawa M, Aikawa E.
    Cardiovasc Res., Sep. 2021
  • Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice　　　　　　　　　　　　　　　
    Wang L, Li X, Hanada Y, Hasuzawa N, Moriyama Y, Nomura M, Yamamoto K.
    Commun Biol., Jul. 2021
  • Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury　　　　　　　　　　　　　　　
    Hasuzawa N, Tatsushima K, Wang L, Kabashima M, Tokubuchi R, Nagayama A, Ashida K, Ogawa Y, Moriyama Y, Nomura M.
    Sci Rep., Apr. 2021
  • Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis　　　　　　　　　　　　　　　
    Tatsushima K, Hasuzawa N, Wang L, Hiasa M, Sakamoto S, Ashida K, Sudo N, Moriyama Y, Nomura M.
    Biochim Biophys Acta Mol Basis Dis., Mar. 2021
  • MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity　　　　　　　　　　　　　　　
    Hanada Y, Ishihara N, Wang L, Otera H, Ishihara T, Koshiba T, Mihara K, Ogawa Y, Nomura M.
    Nat Commun., Nov. 2020
  • Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury　　　　　　　　　　　　　　　
    Umezu R, Koga JI, Matoba T, Katsuki S, Wang L, Hasuzawa N, Nomura M, Tsutsui H, Egashira K.
    Arterioscler Thromb Vasc Biol., Jul. 2020
  • Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma　　　　　　　　　　　　　　　
    Yano S, Ashida K, Nagata H, Ohe K, Wada N, Takeichi Y, Hanada Y, Ibayashi Y, Wang L, Sakamoto S, Sakamoto R, Uchi H, Shiratsuchi M, Furue M, Nomura M, Ogawa Y.
    BMC Endocr Disord., Jun. 2018
  • Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids　　　　　　　　　　　　　　　
    Baba T, Otake H, Inoue M, Sato T, Ishihara Y, Moon JY, Tsuchiya M, Miyabayashi K, Ogawa H, Shima Y, Wang L, Sato R, Yamazaki T, Suyama M, Nomura M, Choi MH, Ohkawa Y, Morohashi KI.
    Commun Biol., Mar. 2018
  • SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes　　　　　　　　　　　　　　　
    Inoue C, Zhao C, Tsuduki Y, Udono M, Wang L, Nomura M, Katakura Y.
    NPJ Aging Mech Dis., Aug. 2017
  • Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration　　　　　　　　　　　　　　　
    Wang L, Ishihara T, Ibayashi Y, Tatsushima K, Setoyama D, Hanada Y, Takeichi Y, Sakamoto S, Yokota S, Mihara K, Kang D, Ishihara N, Takayanagi R, Nomura M.
    Diabetologia., Oct. 2015
  • Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system　　　　　　　　　　　　　　　
    Wang L, Nomura M.
    Genom Data., Jul. 2015
  • Dietary vitamin D3 improves postprandial hyperglycemia in aged mice　　　　　　　　　　　　　　　
    Enciso PL, Wang L, Kawahara Y, Sakamoto S, Shimada S, Takeichi Y, Takayanagi R, Nomura M.
    Biochem Biophys Res Commun., May 2015
  • Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity　　　　　　　　　　　　　　　
    Nomura M, Morinaga H, Zhu HL, Wang L, Hasuzawa N, Takayanagi R, Teramoto N.
    Biochem Biophys Res Commun., Jul. 2014
  • SMAD2 disruption in mouse pancreatic beta cells leads to islet hyperplasia and impaired insulin secretion due to the attenuation of ATP-sensitive K+ channel activity　　　　　　　　　　　　　　　
    Nomura M, Zhu HL, Wang L, Morinaga H, Takayanagi R, Teramoto N.
    Diabetologia., Jan. 2014
  • Roles for corticotropin-releasing factor receptor type 1 in energy homeostasis in mice　　　　　　　　　　　　　　　
    Sakamoto R, Matsubara E, Nomura M, Wang L, Kawahara Y, Yanase T, Nawata H, Takayanagi R.
    Metabolism., Dec. 2013
  • Activin stimulates CYP19A gene expression in human ovarian granulosa cell-like KGN cells via the Smad2 signaling pathway　　　　　　　　　　　　　　　
    Nomura M, Sakamoto R, Morinaga H, Wang L, Mukasa C, Takayanagi R.
    Biochem Biophys Res Commun., Jul. 2013
  • Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model　　　　　　　　　　　　　　　
    Nomura M, Tanaka K, Wang L, Goto Y, Mukasa C, Ashida K, Takayanagi R.
    Biochem Biophys Res Commun., Jan. 2013
  • Positive association of phencyclidine-responsive genes, PDE4A and PLAT, with schizophrenia　　　　　　　　　　　　　　　
    Deng X, Takaki H, Wang L, Kuroki T, Nakahara T, Hashimoto K, Ninomiya H, Arinami T, Inada T, Ujike H, Itokawa M, Tochigi M, Watanabe Y, Someya T, Kunugi H, Iwata N, Ozaki N, Shibata H, Fukumaki Y.
    Am J Med Genet B Neuropsychiatr Genet., Dec. 2011
  • Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice　　　　　　　　　　　　　　　
    Wang L, Nomura M, Goto Y, Tanaka K, Sakamoto R, Abe I, Sakamoto S, Shibata A, Enciso PL, Adachi M, Ohnaka K, Kawate H, Takayanagi R.
    J Biol Chem., May 2011
  • Generation and characterization of T1R2-LacZ knock-in mouse　　　　　　　　　　　　　　　
    Iwatsuki K, Nomura M, Shibata A, Ichikawa R, Enciso PL, Wang L, Takayanagi R, Torii K, Uneyama H.
    Biochem Biophys Res Commun, Nov. 2010
  • A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H)　　　　　　　　　　　　　　　
    Furuya H, Ikezoe K, Wang L, Ohyagi Y, Motomura K, Fujii N, Kira J, Fukumaki Y.
    Am J Med Genet A, Feb. 2008
■ MISC
■ Research Themes