SEARCH
Search DetailsYamada Rikuhiro
Department of System Biology Institute of Life Science
Associate Professor
Career
■ Career
- Apr. 2024 - Present
Kurume University, Institute of Life Science - Apr. 2023 - Present
RIKEN, Center for Biosystems Dynamics Research, Visiting scientist - Aug. 2020 - Present
The University of Tokyo, The University of Tokyo Graduate School of Medicine, Visiting researcher - Oct. 2019 - Present
CUBICStars, Inc., Senior scientist - Apr. 2023 - Mar. 2024
Osaka University, Graduate School of Medicine, Specially Appointed Researcher/Fellow (Full time) - Apr. 2021 - Mar. 2024
ACCELStars, Inc., Senior scientist - Apr. 2021 - Mar. 2023
Osaka University, Graduate School of Medicine, Guest Associate Professor - Oct. 2014 - Mar. 2023
RIKEN, Center for Biosystems Dynamics Research, Senior scientist - Apr. 2011 - Sep. 2014
RIKEN, Center for Developmental Biology, Laboratory for Systems Biology, Researcher - Apr. 2008 - Mar. 2011
RIKEN, Center for Developmental Biology, Special Postdoctoral Researchers Program - Apr. 2007 - Mar. 2008
RIKEN, Center for Developmental Biology, Research associate
Research activity information
■ Award
- 2011
RIKEN, RIKEN Research and Technology Incentive Awards 2010
Elucidation of a design principle in the circadian transcriptional network
- A whole-brain single-cell atlas of circadian neural activity in mice
Katsunari Yamashita; Fukuaki L. Kinoshita; Shota Y. Yoshida; Katsuhiko Matsumoto; Tomoki T. Mitani; Hiroshi Fujishima; Yoichi Minami; Eiichi Morii; Rikuhiro G. Yamada; Seiji Okada; Hiroki R. Ueda
Science, 13 Nov. 2025 - A unified framework to model synaptic dynamics during the sleep–wake cycle
Fukuaki L. Kinoshita; Rikuhiro G. Yamada; Koji L. Ode; Hiroki R. Ueda
PLOS Biology, 12 Jun. 2025 - Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice
Hiroyuki J. Kanaya; Ken Kuwajima; Yuko Ito; Yuta Shinohara; Yohei Okubo; Shinnosuke Shiono; Fumiya Tatsuki; Rei-ichiro Ohno; Hideki Ukai; Maki Ukai-Tadenuma; Kenta Sumiyama; Hiroshi Fujishima; Rikuhiro G. Yamada; Daisuke Tone; Hiroshi Kiyonari; Masaki Kikuchi; Takashi Umehara; Takashi Murayama; Kazunori Kanemaru; Masamitsu Iino; Koji L. Ode; Takatsugu Hirokawa; Hiroki R. Ueda
PLOS Biology, 03 Jun. 2025 - Whole‐brain Cellome‐Wide Association Study (CWAS) Unveils Ultra‐Early Neurodegeneration Phenomena in a 3D Spatial Cell Atlas
Tomoki T Mitani; Kosei Yamaura; Katsuhiko Matsumoto; Rikuhiro Yamada; Etsuo A Susaki; Hiroki R Ueda
Alzheimer's & Dementia, Dec. 2024 - Postsynaptic competition between calcineurin and PKA regulates mammalian sleep–wake cycles
Yimeng Wang; Siyu Cao; Daisuke Tone; Hiroshi Fujishima; Rikuhiro G. Yamada; Rei-ichiro Ohno; Shoi Shi; Kyoko Matsuzawa; Saori Yada; Mari Kaneko; Hirokazu Sakamoto; Taichi Onishi; Maki Ukai-Tadenuma; Hideki Ukai; Carina Hanashima; Kenzo Hirose; Hiroshi Kiyonari; Kenta Sumiyama; Koji L. Ode; Hiroki R. Ueda
Nature, 06 Nov. 2024 - An automated sleep staging tool based on simple statistical features of mice electroencephalography (EEG) and electromyography (EMG) data
Rikuhiro G. Yamada; Kyoko Matsuzawa; Koji L. Ode; Hiroki R. Ueda
European Journal of Neuroscience, 28 Jul. 2024 - Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation
Kazuhiro Kon; Koji L. Ode; Tomoyuki Mano; Hiroshi Fujishima; Riina R. Takahashi; Daisuke Tone; Chika Shimizu; Shinnosuke Shiono; Saori Yada; Kyoko Matsuzawa; Shota Y. Yoshida; Junko Yoshida Garçon; Mari Kaneko; Yuta Shinohara; Rikuhiro G. Yamada; Shoi Shi; Kazunari Miyamichi; Kenta Sumiyama; Hiroshi Kiyonari; Etsuo A. Susaki; Hiroki R. Ueda
Nature Communications, 18 Jul. 2024 - Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep
Arthur Millius; Rikuhiro G. Yamada; Hiroshi Fujishima; Kazuhiko Maeda; Daron M. Standley; Kenta Sumiyama; Dimitri Perrin; Hiroki R. Ueda
Proceedings of the National Academy of Sciences, 28 Sep. 2023 - Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep
Daisuke Tone; Koji L. Ode; Qianhui Zhang; Hiroshi Fujishima; Rikuhiro G. Yamada; Yoshiki Nagashima; Katsuhiko Matsumoto; Zhiqing Wen; Shota Y. Yoshida; Tomoki T. Mitani; Yuki Arisato; Rei-ichiro Ohno; Maki Ukai-Tadenuma; Junko Yoshida Garçon; Mari Kaneko; Shoi Shi; Hideki Ukai; Kazunari Miyamichi; Takashi Okada; Kenta Sumiyama; Hiroshi Kiyonari; Hiroki R. Ueda
PLOS Biology, 04 Oct. 2022 - The circadian clock ticks in organoids
Rikuhiro G Yamada; Hiroki R Ueda
The EMBO Journal, 17 Jan. 2022 - CUBIC-Cloud provides an integrative computational framework toward community-driven whole-mouse-brain mapping
Tomoyuki Mano; Ken Murata; Kazuhiro Kon; Chika Shimizu; Hiroaki Ono; Shoi Shi; Rikuhiro G. Yamada; Kazunari Miyamichi; Etsuo A. Susaki; Kazushige Touhara; Hiroki R. Ueda
Cell Reports Methods, Jun. 2021 - A Microfluidic Platform Based on Robust Gas and Liquid Exchange for Long-term Culturing of Explanted Tissues
Nobutoshi Ota; Genki N. Kanda; Hiroyuki Moriguchi; Yusufu Aishan; Yigang Shen; Rikuhiro G. Yamada; Hiroki R. Ueda; Yo Tanaka
ANALYTICAL SCIENCES, Oct. 2019, [Reviewed] - Molecular Mechanisms of REM Sleep.
Rikuhiro G Yamada; Hiroki R Ueda
Frontiers in neuroscience, 2019, [Reviewed] - Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Yasutaka Niwa; Genki N Kanda; Rikuhiro G Yamada; Shoi Shi; Genshiro A Sunagawa; Maki Ukai-Tadenuma; Hiroshi Fujishima; Naomi Matsumoto; Koh-Hei Masumoto; Mamoru Nagano; Takeya Kasukawa; James Galloway; Dimitri Perrin; Yasufumi Shigeyoshi; Hideki Ukai; Hiroshi Kiyonari; Kenta Sumiyama; Hiroki R Ueda
Cell reports, 28 Aug. 2018, [Reviewed] - Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.
Yuta Shinohara; Yohei M Koyama; Maki Ukai-Tadenuma; Takatsugu Hirokawa; Masaki Kikuchi; Rikuhiro G Yamada; Hideki Ukai; Hiroshi Fujishima; Takashi Umehara; Kazuki Tainaka; Hiroki R Ueda
Molecular cell, 07 Sep. 2017, [Reviewed] - Compass in the data ocean: Toward chronotherapy.
Rikuhiro G Yamada; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 16 May 2017, [Invited] - Metabolites as clock hands: Estimation of internal body time using blood metabolomics
Hitoshi Iuchi; Rikuhiro G. Yamada; Hiroki R. Ueda
Neuromethods, 2016, [Reviewed] - A MICROFLUIDIC PLATFORM TO GENERATE A ROBUST GAS-LIQUID INTERFACE FOR ORGANOTYPIC SLICE CULTURE OVER A LONG PERIOD
G.N. Kanda; H. Moriguchi; R.G. Yamada; Y. Tanaka; H.R. Ueda
MicroTAS 2013, Oct. 2013 - Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light-dark conditions
Kiyomasa K. Honda; Takeshi Kawamoto; Hiroki R. Ueda; Ayumu Nakashima; Taichi Ueshima; Rikuhiro G. Yamada; Masahiro Nishimura; Ryo Oda; Shigeo Nakamura; Tomoko Kojima; Mitsuhide Noshiro; Katsumi Fujimoto; Seiichi Hashimoto; Yukio Kato
JOURNAL OF BIOCHEMISTRY, Oct. 2013, [Reviewed] - A simple process for long-term culture of adherent mammalian cells in micro-flow chamber based on PDMS and polystyrene
Rikuhiro G. Yamada
Proceedings of 2011 International Conference on Microtechnologies in Medicine and Biology, May 2011, [Reviewed] - Delay in feedback repression by cryptochrome 1 is required for circadian clock function.
Maki Ukai-Tadenuma; Rikuhiro G Yamada; Haiyan Xu; Jürgen A Ripperger; Andrew C Liu; Hiroki R Ueda
Cell, 21 Jan. 2011, [Reviewed] - CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.
Yasushi Isojima; Masato Nakajima; Hideki Ukai; Hiroshi Fujishima; Rikuhiro G Yamada; Koh-hei Masumoto; Reiko Kiuchi; Mayumi Ishida; Maki Ukai-Tadenuma; Yoichi Minami; Ryotaku Kito; Kazuki Nakao; Wataru Kishimoto; Seung-Hee Yoo; Kazuhiro Shimomura; Toshifumi Takao; Atsuko Takano; Toshio Kojima; Katsuya Nagai; Yoshiyuki Sakaki; Joseph S Takahashi; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 15 Sep. 2009, [Reviewed] - Genetic and Molecular Analysis of Wild-Derived Arrhythmic Mice
Tsuyoshi Watanabe; Tohru Suzuki; Akira Ishikawa; Yuki Yokota; Hiroki R. Ueda; Rikuhiro G. Yamada; Hajime Tei; Saki Imai; Shigeru Tomida; Junya Kobayashi; Emiko Naito; Shinobu Yasuo; Nobuhiro Nakao; Takao Namikawa; Takashi Yoshimura; Shizufumi Ebihara
PLOS ONE, Jan. 2009, [Reviewed] - A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock.
Akira Matsumoto; Maki Ukai-Tadenuma; Rikuhiro G Yamada; Jerry Houl; Kenichiro D Uno; Takeya Kasukawa; Brigitte Dauwalder; Taichi Q Itoh; Kuniaki Takahashi; Ryu Ueda; Paul E Hardin; Teiichi Tanimura; Hiroki R Ueda
Genes & development, 01 Jul. 2007, [Reviewed] - Microarrays: Statistical methods for circadian rhythms
Rikuhiro Yamada; Hiroki R. Ueda
Methods in Molecular Biology, 11 Jan. 2007, [Reviewed] - Feedback repression is required for mammalian circadian clock function.
Trey K Sato; Rikuhiro G Yamada; Hideki Ukai; Julie E Baggs; Loren J Miraglia; Tetsuya J Kobayashi; David K Welsh; Steve A Kay; Hiroki R Ueda; John B Hogenesch
Nature genetics, Mar. 2006, [Reviewed] - An improved single-cell cDNA amplification method for efficient high-density oligonucleotide microarray analysis
Kazuki Kurimoto; Yukihiro Yabuta; Yasuhide Ohinata; Yukiko Ono; Kenichiro D. Uno; Rikuhiro G. Yamada; Hiroki R. Ueda; Mitinori Saitou
Nucleic Acids Research, 2006, [Reviewed]
- Study on the dephosphorylated-modulation of synaptic proteins engaged in sleep-wakefulness regulation
曹思ぎょく; 戸根大輔; 山田陸裕; 隅山健太; 上田泰己; 上田泰己
日本薬理学雑誌, 2023 - Investigating roles of pore-loop cation channels for cortical neuronal synchrony and sleep quality and time
バイエステロッチ マリアネウス; 史蕭逸; 戸根大輔; 大出晃士; 藤島博史; 山田陸裕; 隅山健太; 上田泰己
時間生物学, 2023 - アルツハイマー病関連因子による睡眠要求量制御機構の解析
山浦港生; 山浦港生; 戸根大輔; 山田陸裕; 山田陸裕; 山田陸裕; 木下福章; 木下福章; 上田泰己; 上田泰己; 上田泰己
時間生物学, 2023 - in vitro睡眠評価系を用いた神経伝達と睡眠制御の解析
山本敬太; 山本敬太; YILIN Jiang; 戸根大輔; 戸根大輔; 山田陸裕; 山田陸裕; 上田泰己; 上田泰己; 上田泰己
時間生物学, 2023 - Molecular mechanisms of REM sleep
Rikuhiro G. Yamada; Hiroki Ueda
The CELL, Sep. 2020
Lead - 【細胞の少数性と多様性に挑む-シングルセルアナリシス】次世代シーケンサーを用いた細胞多様性の解明 生体リズム・発生現象における1細胞シーケンスを用いた細胞多様性の解明
山田 陸裕; 洲崎 悦生; 上田 泰己
生体の科学, Apr. 2014 - 【細胞を創る・生命システムを創る 合成生物学が挑む生命機能の再構築と計算機シミュレーション、医療・社会との関わり】第4章 遺伝子ネットワークを創る 概日時計の転写ネットワークの再構成
鵜飼 磨貴[蓼沼]; 山田 陸裕
実験医学, May 2011 - 正しい知識が捏造を防ぐ データを正確に解釈するための6つのポイント 大規模データの解析における問題点 DNAマイクロアレイによる遺伝子発現量の測定を例として
山田 陸裕; 上田 泰己
蛋白質・核酸・酵素, Aug. 2009 - 哺乳類概日時計の周期決定因子の探索
礒島康史; 礒島康史; 鵜飼英樹; 藤島博史; 山田陸裕; 中嶋正人; 升本宏平; 木内玲子; 木内玲子; 南陽一; 木藤良沢; 小島俊男; 榊佳之; 上田泰己; 上田泰己
日本人類遺伝学会大会プログラム・抄録集, 2008 - ショウジョウバエの新規時計遺伝子clockwork orangeの発見
松本 顕; 鵜飼 磨貴[蓼沼]; 山田 陸裕; 上田 泰己
細胞工学, Oct. 2007
- Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
Rikuhiro Yamada
ERATO UK-Japan Joint Symposium On Circadian rhythms and Sleep, 12 Mar. 2024, [Invited] - Identification of a novel sleep-regulating factor by in vivo screening of neurodegenerative disease-related factors
Yamaura Kosei; Tone Daisuke; Yamada Rikuhiro; Ueda Hiroki
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022, Japanese Pharmacological Society - Analysis of a novel gene involved in the maintenance of wakefulness in mammals
Yimeng Wang; Yamada Rikuhiro; Tone Daisuke; Ueda Hiroki
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022, Japanese Pharmacological Society - In vivo molecular analysis of a novel gene involved in the maintenance of wakefulness
Yimeng Wang; Tone Daisuke; Yamada Rikuhiro; Ueda R.Hiroki
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022, Japanese Pharmacological Society - Analysis of protein dephosphorylation underlying mammalian sleep-wake regulation
Cao Siyu; Tone Daisuke; Yamada Rikuhiro; Ueda Hiroki
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022, Japanese Pharmacological Society - Investigation of dephosphorylation of synaptic phosphoproteins engaged in mammalian sleep-wake regulation
Siyu Cao; Tone Daisuke; Yamada Rikuhiro; Sumiyama Kenta; Ueda Hiroki
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022, Japanese Pharmacological Society - 夢見る睡眠研究
山田陸裕
第75回理研イブニングセミナー, 06 Nov. 2019 - Sleep measurement 次世代遺伝学と表現型解析
山田陸裕
第4回バイオインフォマティクスアゴラ, 2018 - 生物試料組織透明化技術(CUBIC法)の開発と展開
メディカルジャパン2016, 2016 - A hypothetical mechanism for encoding environmental time information in mouse SCN
山田陸裕
第22回 日本時間生物学会学術大会, 2015 - In vitro SCN's responses to environmental timing cues
山田陸裕
Neuroscience, 2013 - Systems and Synthetic Biology of Mammalian Circadian Clocks
Rikuhiro G. Yamada; Hiroki R. Ueda
13th Biennial Meeting Society for Research on Biological Rhythms, 2012 - The transcriptional-level delayed-feedback loop in mammalian circadian clock and an approach for tissue-level analysis
山田陸裕
The 34th Annual Meeting of the Molecular Biology Society of Japan, 2011 - 哺乳類概日時計:遅れを持った負の転写フィードバック機構と組織レベル解析へ向けて
山田陸裕
生理学研究所研究会「超階層シグナル伝達研究の新展開」, 2011 - 環境時間情報処理システムの解明に向けたSCN培養観察系
山田陸裕
第19回 日本時間生物学会学術大会, 2010 - A Functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock
山田陸裕
Neuroscience, 2008 - TilingArray を用いた Drosophila 概日時計システムの解析", 第2回バイオメディカル研究会
第2回バイオメディカル研究会, 2006
- マウス睡眠EEG/EMGデータ自動ステージ判定アルゴリズムと周辺ソフトウェア開発
Grant-in-Aid for Scientific Research (C)
Institute of Physical and Chemical Research
Apr. 2021 - Mar. 2024 - Designing the mammalian biological oscillators
Grant-in-Aid for Scientific Research (S)
The University of Tokyo
11 Jun. 2018 - 31 Mar. 2023 - Toward understanding the detection mechanism of the gradually changing time-information
Grant-in-Aid for Challenging Exploratory Research
Institute of Physical and Chemical Research
01 Apr. 2014 - 31 Mar. 2017
