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Mizoguchi Emiko
Department of Immunology
Professor
Career
■ Career
- Jan. 2022 - Present
 Kurume University School of Medicine, Department of Immunology, Professor
- Oct. 2019 - Present
 Brown University (USA) Warren Alpert Medical School, Department of Molecular Microbiology and Immunology (MMI), Visiting Professor
- Apr. 2016 - Dec. 2021
 Kurume University School of Medicine, Department of Immunology, Associate Professor
- Mar. 2006 - Mar. 2016
 Harvard Medical School, Department of Medicine, Gastrointestinal Division, Assistant Professor
- Mar. 2003 - Feb. 2006
 Harvard Medical School, Department of Medicine, Gastrointestinal Division, Instractor
- Jul. 1997 - Feb. 2003
 Harvard Medical School, Department of Pathology, Immunopathology Unit, Instractor
- Jul. 1992 - Jun. 1997, Postodoctoral Fellow, Harvard Medical School, Immunopathology Unit
- Apr. 1990 - Mar. 1994, Kurume University, Graduate School of Medicine, Department of Immunology
- Apr. 1984 - Mar. 1990, Kurume University, School of Medicine, Faculty of Medicine
- Jul. 2024 - Present
 Invited Ad hoc Grant Reviewer, National Research Foundation Prime Minister’s Office Singapore
- Apr. 2024 - Present
 がん助成金審査委員, 公益財団法人ふくおか公衆衛生推進機構
- Mar. 2023 - Present
 Frontiers in Immunology, Academic Editor
- Jan. 2011 - Present
 PLOS ONE Academic Editor
- Apr. 2020 - Mar. 2022
 Career Development Award, Immunology Field, JSPS
- Jan. 2011 - Mar. 2016
 Tumor Microenvironment Study Section, Ad hoc Grant Reviewer, National Institutes of Health
- Jan. 2003 - Mar. 2016
 Grant reviewer in the field of Inflammatory Bowel Disease, The Eli and Edythe L. Broad Foundation, Los Angeles, CA
- May 2014 - Feb. 2015
 Gastrointesinal Mucosal Pathobiology (GMPB) Study Section, Ad hoc Grant Reviewer, National Institutes of Health
Research activity information
■ Award
■ Media Coverage
■ 共同研究希望
■ 関心を持って取組んでいる活動
- May 2024
 久留米大学医学部, ”Michael ”Citation Immunology Award
 Emiko Mizoguchi
- Mar. 2024
 国際ソロプチミスト久留米アウラ, Female Research Award
 Emiko Mizoguchi
- Jan. 2023
 Public Library of Science, Long Service Award by the PLOS ONE Editorial Board
 Emiko Mizoguchi
- Apr. 2019
 医療・介護・教育研究財団, The 13th ”Clinical Medical Research Award” in Fukuoka
 口腔内慢性炎症からの口腔癌発症におけるキチナーゼとサイトカインの役割
 Emiko Mizoguchi
- Apr. 2017
 女性健康科学研究所, The 8th The Women’s Health Science Reserach Award
 Emiko Mizoguchi
- May 2012
 The American Association of Immunologists (AAI), Faculty Travel Award
 Emiko Mizoguchi
- Apr. 2009
 National Institutes of Health, Administrative Supplemental Award
 Emiko Mizoguchi
- May 2008
 The American Gastroenterological Association (AGA), Bridging Award
 Emiko Mizoguchi
- Apr. 2003
 National Institutes of Health, Mentored Clinical Scientist Developmental Award(KO8)
 Emiko Mizoguchi
- Brown-Kurume Exchange Programs Have Developed Through Many Unexpected Encounters and Relationships.
 Emiko Mizoguchi
 The Kurume medical journal, 14 May 2024
- Recently Updated Role of Chitinase 3-like 1 on Various Cell Types as a Major Influencer of Chronic Inflammation.
 Emiko Mizoguchi; Takayuki Sadanaga; Linda Nanni; Siyuan Wang; Atsushi Mizoguchi
 Cells, 14 Apr. 2024
- Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?
 Emiko Mizoguchi; Takayuki Sadanaga; Toshiyuki Okada; Takanori Minagawa; Jun Akiba
 Intestinal research, Jul. 2023
- Chitinase 3-like 1, Carcinoembryonic Antigen-related Cell Adhesion Molecule 6, and Ectopic Claudin-2 in the Carcinogenic Processes of Ulcerative Colitis.
 Tetsushi Kinugasa; Toshiyuki Tsunoda; Emiko Mizoguchi; Toshiyuki Okada; Tomoya Sudo; Akihiko Kawahara; Jun Akiba; Yoshito Akagi
 Anticancer research, Aug. 2022
- Landscape of inflammatory bowel disease in Singapore.
 Daren Low; Nidhi Swarup; Toshiyuki Okada; Emiko Mizoguchi
 Intestinal research, Jul. 2022
- Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19.
 Suchitra Kamle; Bing Ma; Chuan Hua He; Bedia Akosman; Yang Zhou; Chang-Min Lee; Wafik S El-Deiry; Kelsey Huntington; Olin Liang; Jason T Machan; Min-Jong Kang; Hyeon Jun Shin; Emiko Mizoguchi; Chun Geun Lee; Jack A Elias
 JCI insight, 08 Nov. 2021
- Chitinase 3-like-1 is a Therapeutic Target That Mediates the Effects of Aging in COVID-19.
 Suchitra Kamle; Bing Ma; Chuan Hua He; Bedia Akosman; Yang Zhou; Chang-Min Lee; Wafik S El-Deiry; Kelsey Huntington; Olin Liang; Jason T Machan; Min-Jong Kang; Hyeon Jun Shin; Emiko Mizoguchi; Chun Geun Lee; Jack A Elias
 bioRxiv : the preprint server for biology, 16 Feb. 2021
- A Review of Selected IBD Biomarkers: From Animal Models to Bedside.
 Emiko Mizoguchi; Renuka Subramaniam; Toshiyuki Okada; Atsushi Mizoguchi
 Diagnostics (Basel, Switzerland), 30 Jan. 2021
- Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models.
 Emiko Mizoguchi; Daren Low; Yui Ezaki; Toshiyuki Okada
 Intestinal research, Apr. 2020
- Clinical importance of IL-22 cascade in IBD.
 Atsushi Mizoguchi; Arisa Yano; Hidetomo Himuro; Yui Ezaki; Takayuki Sadanaga; Emiko Mizoguchi
 Journal of gastroenterology, Apr. 2018
- CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN.
 Diana Legarda; Scott J Justus; Rosalind L Ang; Nimisha Rikhi; Wenjing Li; Thomas M Moran; Jianke Zhang; Emiko Mizoguchi; Matija Zelic; Michelle A Kelliher; J Magarian Blander; Adrian T Ting
 Cell reports, 14 Jun. 2016
- Current Understanding of Dysbiosis in Disease in Human and Animal Models.
 Arianna K DeGruttola; Daren Low; Atsushi Mizoguchi; Emiko Mizoguchi
 Inflammatory bowel diseases, May 2016
- Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer.
 Renuka Subramaniam; Atsushi Mizoguchi; Emiko Mizoguchi
 Cancer research frontiers, Feb. 2016
- Genetically engineered mouse models for studying inflammatory bowel disease.
 Atsushi Mizoguchi; Takahito Takeuchi; Hidetomo Himuro; Toshiyuki Okada; Emiko Mizoguchi
 The Journal of pathology, Jan. 2016
- Chitinase 3-like 1 induces survival and proliferation of intestinal epithelial cells during chronic inflammation and colitis-associated cancer by regulating S100A9.
 Daren Low; Renuka Subramaniam; Li Lin; Tomoki Aomatsu; Atsushi Mizoguchi; Aylwin Ng; Arianna K DeGruttola; Chun Geun Lee; Jack A Elias; Akira Andoh; Mari Mino-Kenudson; Emiko Mizoguchi
 Oncotarget, 03 Nov. 2015
- High Endogenous Expression of Chitinase 3-Like 1 and Excessive Epithelial Proliferation with Colonic Tumor Formation in MOLF/EiJ Mice.
 Daren Low; Arianna K DeGruttola; Alexander Poltrak; Atsushi Mizoguchi; Mari Mino-Kenudson; Emiko Mizoguchi
 PloS one, 2015
- Recent advancement in understanding colitis-associated tumorigenesis.
 Daren Low; Mari Mino-Kenudson; Emiko Mizoguchi
 Inflammatory bowel diseases, Nov. 2014
- Oral caffeine administration ameliorates acute colitis by suppressing chitinase 3-like 1 expression in intestinal epithelial cells.
 In-Ah Lee; Daren Low; Alan Kamba; Victoria Llado; Emiko Mizoguchi
 Journal of gastroenterology, Aug. 2014
- Chitinase 3-like 1 synergistically activates IL6-mediated STAT3 phosphorylation in intestinal epithelial cells in murine models of infectious colitis.
 Hoa T Tran; In-Ah Lee; Daren Low; Alan Kamba; Atsushi Mizoguchi; Hai N Shi; Chun G Lee; Jack A Elias; Emiko Mizoguchi
 Inflammatory bowel diseases, May 2014
- Novel methylxanthine derivative-mediated anti-inflammatory effects in inflammatory bowel disease.
 In-Ah Lee; Alan Kamba; Daren Low; Emiko Mizoguchi
 World journal of gastroenterology, 07 Feb. 2014
- Glucocorticoid-induced TNF receptor family-related protein ligand regulates the migration of monocytes to the inflamed intestine.
 Gongxian Liao; Boaz van Driel; Erica Magelky; Michael S O'Keeffe; Rene de Waal Malefyt; Pablo Engel; Roland W Herzog; Emiko Mizoguchi; Atul K Bhan; Cox Terhorst
 FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jan. 2014
- Regulatory B cells in mouse models of intestinal inflammation.
 Atsushi Nishida; Cindy W Lau; Emiko Mizoguchi; Atsushi Mizoguchi
 Methods in molecular biology (Clifton, N.J.), 2014
- Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection.
 Kara L Conway; Petric Kuballa; Joo-Hye Song; Khushbu K Patel; Adam B Castoreno; Omer H Yilmaz; Humberto B Jijon; Mei Zhang; Leslie N Aldrich; Eduardo J Villablanca; Joanna M Peloquin; Gautam Goel; In-Ah Lee; Emiko Mizoguchi; Hai Ning Shi; Atul K Bhan; Stanley Y Shaw; Stuart L Schreiber; Herbert W Virgin; Alykhan F Shamji; Thaddeus S Stappenbeck; Hans-Christian Reinecker; Ramnik J Xavier
 Gastroenterology, Dec. 2013
- Chitin-binding domains of Escherichia coli ChiA mediate interactions with intestinal epithelial cells in mice with colitis.
 Daren Low; Hoa T Tran; In-Ah Lee; Nicolas Dreux; Alan Kamba; Hans-Christian Reinecker; Arlette Darfeuille-Michaud; Nicolas Barnich; Emiko Mizoguchi
 Gastroenterology, Sep. 2013
- DNA methylation in inflammatory bowel disease and beyond.
 Daren Low; Atsushi Mizoguchi; Emiko Mizoguchi
 World journal of gastroenterology, 28 Aug. 2013
- Heparan sulfate on intestinal epithelial cells plays a critical role in intestinal crypt homeostasis via Wnt/β-catenin signaling.
 Shuji Yamamoto; Hiroshi Nakase; Minoru Matsuura; Yusuke Honzawa; Kayoko Matsumura; Norimitsu Uza; Yu Yamaguchi; Emiko Mizoguchi; Tsutomu Chiba
 American journal of physiology. Gastrointestinal and liver physiology, 01 Aug. 2013
- Animal models of ulcerative colitis and their application in drug research.
 Daren Low; Deanna D Nguyen; Emiko Mizoguchi
 Drug design, development and therapy, 2013
- Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells.
 Atsushi Nishida; Kiyotaka Nagahama; Hirotsugu Imaeda; Atsuhiro Ogawa; Cindy W Lau; Taku Kobayashi; Tadakazu Hisamatsu; Frederic I Preffer; Emiko Mizoguchi; Hiroki Ikeuchi; Toshifumi Hibi; Minoru Fukuda; Akira Andoh; Richard S Blumberg; Atsushi Mizoguchi
 The Journal of experimental medicine, 17 Dec. 2012
- Signaling lymphocyte activation molecule regulates development of colitis in mice.
 Boaz van Driel; Gongxian Liao; Xavier Romero; Michael S O'Keeffe; Guoxing Wang; William A Faubion; Scott B Berger; Erica M Magelky; Monika Manocha; Veronica Azcutia; Matthew Grisham; Francis W Luscinskas; Emiko Mizoguchi; Rene de Waal Malefyt; Hans-Christian Reinecker; Atul K Bhan; Ninghai Wang; Cox Terhorst
 Gastroenterology, Dec. 2012
- p40phox expression regulates neutrophil recruitment and function during the resolution phase of intestinal inflammation.
 Kara L Conway; Gautam Goel; Harry Sokol; Monika Manocha; Emiko Mizoguchi; Cox Terhorst; Atul K Bhan; Agnès Gardet; Ramnik J Xavier
 Journal of immunology (Baltimore, Md. : 1950), 01 Oct. 2012
- Chitin microparticles for the control of intestinal inflammation.
 Katsuya Nagatani; Sen Wang; Victoria Llado; Cindy W Lau; Zongxi Li; Atsushi Mizoguchi; Cathryn R Nagler; Yoshimi Shibata; Hans-Christian Reinecker; J Rodrigo Mora; Emiko Mizoguchi
 Inflammatory bowel diseases, Sep. 2012
- The membrane-bound mucin Muc1 regulates T helper 17-cell responses and colitis in mice.
 Atsushi Nishida; Cindy W Lau; Mei Zhang; Akira Andoh; Hai Ning Shi; Emiko Mizoguchi; Atsushi Mizoguchi
 Gastroenterology, Apr. 2012
- Role of chitotriosidase (chitinase 1) under normal and disease conditions.
 Manasa Kanneganti; Alan Kamba; Emiko Mizoguchi
 Journal of epithelial biology & pharmacology, 2012
- Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells.
 Chun-Chuan Chen; Victoria Llado; Katrin Eurich; Hoa T Tran; Emiko Mizoguchi
 Clinical immunology (Orlando, Fla.), Sep. 2011
- Chitinase 3-like-1 expression in colonic epithelial cells as a potentially novel marker for colitis-associated neoplasia.
 Chun-Chuan Chen; Joel Pekow; Victoria Llado; Manasa Kanneganti; Cindy W Lau; Atsushi Mizoguchi; Mari Mino-Kenudson; Marc Bissonnette; Emiko Mizoguchi
 The American journal of pathology, Sep. 2011
- Chitin particles induce size-dependent but carbohydrate-independent innate eosinophilia.
 Mari Kogiso; Akihito Nishiyama; Tsutomu Shinohara; Masataka Nakamura; Emiko Mizoguchi; Yoshinori Misawa; Elisabeth Guinet; Mahyar Nouri-Shirazi; C Kathleen Dorey; Ruth Ann Henriksen; Yoshimi Shibata
 Journal of leukocyte biology, Jul. 2011
- MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties.
 Sen Wang; Eduardo J Villablanca; Jaime De Calisto; Daniel C O Gomes; Deanna D Nguyen; Emiko Mizoguchi; Jonathan C Kagan; Hans-Christian Reinecker; Nir Hacohen; Cathryn Nagler; Ramnik J Xavier; Bartira Rossi-Bergmann; Yi-Bin Chen; Rune Blomhoff; Scott B Snapper; J Rodrigo Mora
 Journal of immunology (Baltimore, Md. : 1950), 01 Jul. 2011
- Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes.
 Biju Parekkadan; Rabi Upadhyay; Joshua Dunham; Yoshiko Iwamoto; Emiko Mizoguchi; Atsushi Mizoguchi; Ralph Weissleder; Martin L Yarmush
 Gastroenterology, Mar. 2011
- Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis.
 Sundaram Ramasamy; Deanna D Nguyen; Michelle A Eston; Sayeda Nasrin Alam; Angela K Moss; Farzad Ebrahimi; Brishti Biswas; Golam Mostafa; Kathryn T Chen; Kanakaraju Kaliannan; Halim Yammine; Sonoko Narisawa; José Luis Millán; H Shaw Warren; Elizabeth L Hohmann; Emiko Mizoguchi; Hans-Christian Reinecker; Atul K Bhan; Scott B Snapper; Madhu S Malo; Richard A Hodin
 Inflammatory bowel diseases, Feb. 2011
- Animal models of colitis-associated carcinogenesis.
 Manasa Kanneganti; Mari Mino-Kenudson; Emiko Mizoguchi
 Journal of biomedicine & biotechnology, 2011
- Animal models of IBD: linkage to human disease.
 Atsushi Mizoguchi; Emiko Mizoguchi
 Current opinion in pharmacology, Oct. 2010
- Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells.
 Katrin Eurich; Mayuko Segawa; Satoko Toei-Shimizu; Emiko Mizoguchi
 World journal of gastroenterology, 14 Nov. 2009
- Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice.
 Kabir S Matharu; Emiko Mizoguchi; Carmen Alonso Cotoner; Deanna D Nguyen; Bethany Mingle; Onyinye I Iweala; Megan E McBee; Andrew T Stefka; Guenolee Prioult; Kevin M Haigis; Atul K Bhan; Scott B Snapper; Hidehiro Murakami; David B Schauer; Hans-Christian Reinecker; Atsushi Mizoguchi; Cathryn R Nagler
 Gastroenterology, Oct. 2009
- Roles of galectins in inflammatory bowel disease.
 Akira Hokama; Emiko Mizoguchi; Atsushi Mizoguchi
 World journal of gastroenterology, 07 Sep. 2008
- Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein.
 Mayumi Kawada; Chun-Chuan Chen; Atsuko Arihiro; Katsuya Nagatani; Takeshi Watanabe; Emiko Mizoguchi
 Laboratory investigation; a journal of technical methods and pathology, Aug. 2008
- A unique B2 B cell subset in the intestine.
 Yasuyo Shimomura; Atsuhiro Ogawa; Mayumi Kawada; Ken Sugimoto; Emiko Mizoguchi; Hai-Ning Shi; Shiv Pillai; Atul K Bhan; Atsushi Mizoguchi
 The Journal of experimental medicine, 09 Jun. 2008
- Regulatory role of B-1 B cells in chronic colitis.
 Yasuyo Shimomura; Emiko Mizoguchi; Ken Sugimoto; Ryoko Kibe; Yoshimi Benno; Atsushi Mizoguchi; Atul K Bhan
 International immunology, Jun. 2008
- IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis.
 Ken Sugimoto; Atsuhiro Ogawa; Emiko Mizoguchi; Yasuyo Shimomura; Akira Andoh; Atul K Bhan; Richard S Blumberg; Ramnik J Xavier; Atsushi Mizoguchi
 The Journal of clinical investigation, Feb. 2008
- TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality.
 Emiko Mizoguchi; Yuriko Hachiya; Mayumi Kawada; Katsuya Nagatani; Atsuhiro Ogawa; Ken Sugimoto; Atsushi Mizoguchi; Daniel K Podolsky
 Gastroenterology, Feb. 2008
- Inflammatory bowel disease, past, present and future: lessons from animal models.
 Atsushi Mizoguchi; Emiko Mizoguchi
 Journal of gastroenterology, 2008
- Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease.
 Mayumi Kawada; Atsuko Arihiro; Emiko Mizoguchi
 World journal of gastroenterology, 14 Nov. 2007
- Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein.
 Deanna D Nguyen; Michel H Maillard; Vinicius Cotta-de-Almeida; Emiko Mizoguchi; Christoph Klein; Ivan Fuss; Cathryn Nagler; Atsushi Mizoguchi; Atul K Bhan; Scott B Snapper
 Gastroenterology, Oct. 2007
- Dependence of intestinal granuloma formation on unique myeloid DC-like cells.
 Atsushi Mizoguchi; Atsushiro Ogawa; Hidetoshi Takedatsu; Ken Sugimoto; Yasuyo Shimomura; Katsunori Shirane; Kiyotaka Nagahama; Takashi Nagaishi; Emiko Mizoguchi; Richard S Blumberg; Atul K Bhan
 The Journal of clinical investigation, Mar. 2007
- Role of mammalian chitinases in inflammatory conditions.
 Mayumi Kawada; Yuriko Hachiya; Atsuko Arihiro; Emiko Mizoguchi
 The Keio journal of medicine, Mar. 2007
- Is the sugar always sweet in intestinal inflammation?
 Emiko Mizoguchi; Atsushi Mizoguchi
 Immunologic research, 2007
- Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.
 Masaru Yoshida; Kanna Kobayashi; Timothy T Kuo; Lynn Bry; Jonathan N Glickman; Steven M Claypool; Arthur Kaser; Takashi Nagaishi; Darren E Higgins; Emiko Mizoguchi; Yoshio Wakatsuki; Derry C Roopenian; Atsushi Mizoguchi; Wayne I Lencer; Richard S Blumberg
 The Journal of clinical investigation, Aug. 2006
- Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.
 Emiko Mizoguchi
 Gastroenterology, Feb. 2006
- Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes.
 Xavier Valencia; Jonathan M G Higgins; Hans P Kiener; David M Lee; Theresa A Podrebarac; Christopher C Dascher; Gerald F M Watts; Emiko Mizoguchi; Barry Simmons; Dhavalkumar D Patel; Atul K Bhan; Michael B Brenner
 The Journal of experimental medicine, 20 Dec. 2004
- Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery.
 William A Faubion; Ype P De Jong; Ana Abadia Molina; Hongbin Ji; Kareem Clarke; Baoping Wang; Emiko Mizoguchi; Stephen J Simpson; Atul K Bhan; Cox Terhorst
 Gastroenterology, Jun. 2004
- Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation.
 Akira Hokama; Emiko Mizoguchi; Ken Sugimoto; Yasuyo Shimomura; Yosuke Tanaka; Masaru Yoshida; Svend T Rietdijk; Ype P de Jong; Scott B Snapper; Cox Terhorst; Richard S Blumberg; Atsushi Mizoguchi
 Immunity, Jun. 2004
- Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.
 Masaru Yoshida; Steven M Claypool; Jessica S Wagner; Emiko Mizoguchi; Atsushi Mizoguchi; Derry C Roopenian; Wayne I Lencer; Richard S Blumberg
 Immunity, Jun. 2004
- Impaired IgA class switching in APRIL-deficient mice.
 Emanuela Castigli; Sumi Scott; Fatma Dedeoglu; Paul Bryce; Haifa Jabara; Atul K Bhan; Emiko Mizoguchi; Raif S Geha
 Proceedings of the National Academy of Sciences of the United States of America, 16 Mar. 2004
- Blocking inducible co-stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis.
 Ype P de Jong; Svend T Rietdijk; William A Faubion; Ana C Abadia-Molina; Kareem Clarke; Emiko Mizoguchi; Jane Tian; Tracy Delaney; Stephen Manning; Jose-Carlos Gutierrez-Ramos; Atul K Bhan; Anthony J Coyle; Cox Terhorst
 International immunology, Feb. 2004
- Epicutaneous sensitization with superantigen induces allergic skin inflammation.
 Dhafer Laouini; Seiji Kawamoto; Ali Yalcindag; Paul Bryce; Emiko Mizoguchi; Hans Oettgen; Raif S Geha
 The Journal of allergy and clinical immunology, Nov. 2003
- Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells.
 Sean P Colgan; Richard S Pitman; Takashi Nagaishi; Atsushi Mizoguchi; Emiko Mizoguchi; Lloyd F Mayer; Ling Shao; R Balfour Sartor; John R Subjeck; Richard S Blumberg
 The Journal of clinical investigation, Sep. 2003
- Colonic epithelial functional phenotype varies with type and phase of experimental colitis.
 Emiko Mizoguchi; Ramnik J Xavier; Hans-Christian Reinecker; Hirofumi Uchino; Atul K Bhan; Daniel K Podolsky; Atsushi Mizoguchi
 Gastroenterology, Jul. 2003
- Immune networks in animal models of inflammatory bowel disease.
 Atsushi Mizoguchi; Emiko Mizoguchi; Atul K Bhan
 Inflammatory bowel diseases, Jul. 2003
- C4b-binding protein (C4BP) activates B cells through the CD40 receptor.
 Scott R Brodeur; Federica Angelini; Leonard B Bacharier; Anna M Blom; Emiko Mizoguchi; Hiroshi Fujiwara; Alessandro Plebani; Luigi D Notarangelo; Bjorn Dahlback; Erdyni Tsitsikov; Raif S Geha
 Immunity, Jun. 2003
- Essential role for Vav1 in activation, but not development, of gammadelta T cells.
 Wojciech Swat; Ramnik Xavier; Atsushi Mizoguchi; Emiko Mizoguchi; Jessica Fredericks; Keiko Fujikawa; Atul K Bhan; Frederick W Alt
 International immunology, Feb. 2003
- Role of the CD5 molecule on TCR gammadelta T cell-mediated immune functions: development of germinal centers and chronic intestinal inflammation.
 Atsushi Mizoguchi; Emiko Mizoguchi; Ype P de Jong; Hiroko Takedatsu; Frederic I Preffer; Cox Terhorst; Atul K Bhan
 International immunology, Jan. 2003
- The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching.
 Haifa Jabara; Dhafer Laouini; Erdyni Tsitsikov; Emiko Mizoguchi; Atul Bhan; Emanuela Castigli; Fatma Dedeoglu; Vadim Pivniouk; Scott Brodeur; Raif Geha
 Immunity, Sep. 2002
- Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation.
 Atsushi Mizoguchi; Emiko Mizoguchi; Hidetoshi Takedatsu; Richard S Blumberg; Atul K Bhan
 Immunity, Feb. 2002
- Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.
 Emiko Mizoguchi; Atsushi Mizoguchi; Hidetoshi Takedatsu; Elke Cario; Ype P de Jong; Choon Jin Ooi; Ramnik J Xavier; Cox Terhorst; Daniel K Podolsky; Atul K Bhan
 Gastroenterology, Jan. 2002
- Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation.
 Harri Alenius; Dhafer Laouini; Amy Woodward; Emiko Mizoguchi; Atul K Bhan; Emanuela Castigli; Hans C Oettgen; Raif S Geha
 The Journal of allergy and clinical immunology, Jan. 2002
- Limited CD4 T-cell diversity associated with colitis in T-cell receptor α mutant mice requires a T helper 2 environment
 Atsushi Mizoguchi; Emiko Mizoguchi; Lawrence J. Saubermann; Koichi Higaki; Richard S. Blumberg; Atul K. Bhan
 Gastroenterology, Oct. 2000
- Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1+ Lymphocyte-Associated Th2-Type Immune Response in the Intestine
 Pietro G. Andres; Paul L. Beck; Emiko Mizoguchi; Atsushi Mizoguchi; Atul K. Bhan; Tracey Dawson; William A. Kuziel; Nobuyo Maeda; Richard P. MacDermott; Daniel K. Podolsky; Hans-Christian Reinecker
 The Journal of Immunology, 15 Jun. 2000
- Regulatory role of mature B cells in a murine model of inflammatory bowel disease
 Emiko Mizoguchi; Atsushi Mizoguchi; Frederic I. Preffer; Atul K. Bhan
 International Immunology, May 2000
- The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor α mutant mice
 Atsushi Mizoguchi; Emiko Mizoguchi; Atul K. Bhan
 Gastroenterology, Feb. 1999
- Suppressive Role of B Cells in Chronic Colitis of T Cell Receptor α Mutant Mice
 Atsushi Mizoguchi; Emiko Mizoguchi; R. Neal Smith; Frederic I. Preffer; Atul K. Bhan
 The Journal of Experimental Medicine, 17 Nov. 1997
- Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRα mutant mice with inflammatory bowel disease
 Atsushi Mizoguchi; Emiko Mizoguchi; Susumu Tonegawa; Atul K. Bhan; M. Taniguchi
 International Immunology, 1996
- Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis
 Emiko Mizoguchi; Takayuki Sadanaga; Toshiyuki Okada
 International Journal of Translational Medicine, Dec. 2021
- Aug. 2024 - Present
 Japanese Association for Biothepaputics
- Jan. 2017 - Present
 Japan Society for Medical English Education (JASMEE)
- Jan. 2017 - Present
 Japanese Society for Gastroenterology (JSGE)
- Jan. 2016 - Present
 Japanese Society for Inflammatory Bowel Disease (JSIBD)
- Jan. 2011 - Present
 Japanese Society for Immunology (JSI)
- Jan. 2022 - Aug. 2024
 The Society for Japanese Women Scientists (SJWS)
- Jan. 2003 - Dec. 2020
 Society for Mucosal Immunology (SMI)
- Jan. 1998 - Dec. 2020
 American Association of Immunologists (AAI)
- Jan. 1998 - Dec. 2017
 American Gastroenterological Association (AGA)
- Mechanism and role of nuclear translocation of CHI3L1 in the process of colonic epithelial cell transformation from colonic inflammation to cancer
 Grant-in-Aid for Scientific Research (C)
 Kurume University
 Apr. 2024 - Mar. 2027
- Epidemiological study of the relationship between atherosclerosis and intestinal inflammation and food
 Grant-in-Aid for Scientific Research (C)
 Kurume University
 01 Apr. 2023 - 31 Mar. 2026
- Mechanisms of CHI3L1-mediated p53 suppression in the early stage of colon cancer
 Grant-in-Aid for Scientific Research (C)
 Kurume University
 Apr. 2021 - Mar. 2024
- Analysis of inflammation-induced colon cancer development mechanism by adhesive invasive Escherichia coli (AIEC) related molecule
 Grant-in-Aid for Scientific Research (C)
 International University of Health and Welfare
 01 Apr. 2020 - 31 Mar. 2023
- Ptotective effect of xanthine derivatives on colitis-associated dysplasia
 Grant-in-Aid for Scientific Research (C)
 Kurume University
 Apr. 2018 - Mar. 2021
■ Media Coverage
■ 共同研究希望
- Extensive international collaborations for advancing the therapeutic and diagnostic strategy in the field of mammalian chitinases
- 客員教授: Brown University Alpert Medical School, Dept. of Molecular Microbiology and Immunology (Providence, RI, USA)
- 共同研究: Mount Sinai Medical Center, Immunology Institute (New York, NY, USA)
- Massachusetts General Hospital and Harvard Medical School, Dept. of Medicine and Pathology (Boston, MA, USA)
- Brigham and Women's Hospital and Harvard Medical School, Dept. of Medicine
- Beth Israel Deaconess Medical Center and Harvard Medical School, Dept. of Medicine
- Dana-Farber Cancer Institute and Harvard Medical School, Dept. of Medicine
- Florida Atlantic University, Dept. of Biology (Boca Raton, FL, USA)
- University of Chicago, Dept. of Medicine, Pathology and Pediatrics (Chicago, IL, USA)
- University of Meryland, Dept. of Veterinary Medicine (College Park, MD, USA)
- 滋賀医科大学、消化器内科学講座; 京都大学医学部、消化器内科学講座
■ 関心を持って取組んでいる活動

