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Nakashima Noriyuki
Division of Brain Science Department of Physiology
Professor
Researcher information
Career
■ Career
- Apr. 2021 - Present
Kurume University School of Medicine, Department of Physiology, Associate professor - Mar. 2020 - Mar. 2021
Kurume University, School of Medicine, 講師 - Dec. 2015 - Feb. 2020
Kurume University, 医学部生理学講座, 助教 - Jan. 2013 - Nov. 2015
Kyoto Univ., Department of Physiology and Neurobiology, Assistant Prof. - Apr. 2011 - Dec. 2012
Kyoto Univ, GCOE Research Fellow - Apr. 2008 - Mar. 2011
JSPS, research fellow - DC1
Research activity information
■ Paper
■ Research Themes
■ 研究者からの一言アピール
- Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export.
Noriyuki Nakashima; Akiko Nakashima; Kie Nakashima; Makoto Takano
Molecular brain, 04 Nov. 2022 - Olfactory marker protein is unlikely to be cleaved by calpain 5.
Noriyuki Nakashima; Kie Nakashima; Akiko Nakashima; Makoto Takano
Molecular brain, 29 Oct. 2022 - Olfactory receptor 78 is expressed in hypothalamic vasopressin/oxytocin neurons, parenchymal microglia and choroidal macrophages in mice.
Akiko Nakashima; Noriyuki Nakashima; Kie Nakashima; Makoto Takano
Molecular brain, 04 Apr. 2022 - PDGFRα+ subepithelial interstitial cells act as a pacemaker to drive smooth muscle of the guinea pig seminal vesicle.
Mitsue Takeya; Ryuhei Higashi; Hikaru Hashitani; Kei-Ichiro Nakamura; Tokumasa Hayashi; Noriyuki Nakashima; Makoto Takano
The Journal of physiology, Apr. 2022 - 人間ドックにおけるロコモ健診の意義について
手嶋 義高; 宮本 祐一; 川口 達大; 山川 公子; 大坪 義彦; 小柳 徳明; 山田 安代; 重光 貴弘; 石田 千尋; 中島 則行
人間ドック, Jun. 2021 - Olfactory marker protein interacts with adenosine nucleotide derivatives.
Noriyuki Nakashima; Kie Nakashima; Akiko Nakashima; Makoto Takano
Biochemistry and biophysics reports, Mar. 2021 - Olfactory marker protein contributes to the evaluation of odour values by olfactory glomerular processing.
Akiko Nakashima; Taku Nakagawa; Makoto Takano; Noriyuki Nakashima
Neuroscience letters, 20 Nov. 2020 - Expression of the pacemaker channel HCN4 in excitatory interneurons in the dorsal horn of the murine spinal cord.
Taku Nakagawa; Toshiharu Yasaka; Noriyuki Nakashima; Mitsue Takeya; Kensuke Oshita; Makoto Tsuda; Ken Yamaura; Makoto Takano
Molecular brain, 18 Sep. 2020 - Olfactory marker protein elevates basal cAMP concentration.
Noriyuki Nakashima; Kie Nakashima; Akiko Nakashima; Makoto Takano
Biochemical and biophysical research communications, 10 Aug. 2020, [Reviewed] - 統合失調症患者の血清に存在する抗PDHA1抗体と抗体陽性者の脳画像的特徴
中神 由香子; 杉原 玄一; 中島 則行; 挾間 雅章; 孫 樹洛; 馬 舒荷; 松本 理器; 村井 俊哉; 池田 昭夫; 村上 孝作
日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集, Aug. 2020 - Olfactory marker protein captures cAMP produced via Gαs-protein-coupled receptor activation
Noriyuki Nakashima; Kie Nakashima; Akiko Nakashima; Makoto Takano
Biochemical and Biophysical Research Communications, Aug. 2020, [Reviewed] - Anti-PDHA1 antibody is detected in a subset of patients with schizophrenia.
Yukako Nakagami; Genichi Sugihara; Noriyuki Nakashima; Masaaki Hazama; Shuraku Son; Shuhe Ma; Riki Matsumoto; Toshiya Murai; Akio Ikeda; Kosaku Murakami
Scientific reports, 13 May 2020, [Reviewed] - Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons.
Noriyuki Nakashima; Kie Nakashima; Akiko Taura; Akiko Takaku-Nakashima; Harunori Ohmori; Makoto Takano
Nature communications, 04 May 2020, [Reviewed] - Virus database annotations assist in tracing information on patients infected with emerging pathogens.
Akiko Nakashima; Mitsue Takeya; Keiji Kuba; Makoto Takano; Noriyuki Nakashima
Informatics in medicine unlocked, 2020 - Surgical outcomes and unique histological features of tonsils after tonsillectomy in adults with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis syndrome.
Kohei Yamahara; Kana Lee; Yuki Egawa; Noriyuki Nakashima; Satoshi Ikegami
Auris, nasus, larynx, 05 Sep. 2019, [Reviewed] - Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia.
Kensuke Oshita; Yuko Kozasa; Yasuaki Nakagawa; Yoshihiro Kuwabara; Koichiro Kuwahara; Taku Nakagawa; Noriyuki Nakashima; Teruyuki Hiraki; Makoto Takano
The journal of physiological sciences : JPS, Jul. 2019, [Reviewed] - Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus.
Noriyuki Nakashima; Kie Nakashima; Akiko Takaku-Nakashima; Makoto Takano
Molecular brain, 04 Jun. 2019, [Reviewed] - 統合失調症に特異的な新規抗体探索へのアプローチ 予備的研究結果
中神 由香子; 中島 則行; 杉原 玄一; 挾間 雅章; 松本 理器; 村上 孝作; 池田 昭夫; 村井 俊哉
精神神経学雑誌, Jun. 2019 - A Case of Adult-Onset Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome Responsive to Tonsillectomy in Japan.
Kohei Yamahara; Yuki Egawa; Kana Lee; Noriyuki Nakashima; Satoshi Ikegami
Case reports in otolaryngology, 2019, [Reviewed] - HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node.
Yuko Kozasa; Noriyuki Nakashima; Masayuki Ito; Taisuke Ishikawa; Hiroki Kimoto; Kazuo Ushijima; Naomasa Makita; Makoto Takano
The Journal of physiology, 01 Mar. 2018, [Reviewed] - Dual expression of constitutively active Gαs-protein-coupled receptors differentially establishes the resting activity of the cAMP-gated HCN2 channel in a single compartment.
Noriyuki Nakashima; Kie Nakashima; Takeo Nakayama; Akiko Takaku; Ryosuke Kanamori
Biochemical and biophysical research communications, 09 Dec. 2017, [Reviewed] - Regenerative therapy for vestibular disorders using human induced pluripotent stem cells (iPSCs): neural differentiation of human iPSC-derived neural stem cells after in vitro transplantation into mouse vestibular epithelia.
Akiko Taura; Noriyuki Nakashima; Hiroe Ohnishi; Takayuki Nakagawa; Kazuo Funabiki; Juichi Ito; Koichi Omori
Acta oto-laryngologica, Oct. 2016, [Reviewed] - Regeneration of dermal patterns from the remaining pigments after surgery in Eublepharis macularius (a case report).
Noriyuki Nakashima
BMC veterinary research, 12 Jul. 2016, [Reviewed] - The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites.
Masayuki Itoh; Keiko Ishihara; Noriyuki Nakashima; Makoto Takano
The journal of physiological sciences : JPS, May 2016, [Reviewed] - Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice.
Noriyuki Nakashima; Takahiro M Ishii; Yasumasa Bessho; Ryoichiro Kageyama; Harunori Ohmori
The Journal of physiology, 01 Apr. 2013, [Reviewed] - Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.
Takahiro M Ishii; Noriyuki Nakashima; Kenji Takatsuka; Harunori Ohmori
Biochemical and biophysical research communications, 03 Aug. 2007, [Reviewed] - Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation.
Takahiro M Ishii; Noriyuki Nakashima; Harunori Ohmori
The Journal of physiology, 01 Mar. 2007, [Reviewed]
- HCN channels regulate spontaneous firing rate of olfactory receptor neurons for axonal targeting to the olfactory bulb
Noriyuki Nakashima; Takahiro Ishii; Harunori Ohmori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013 - HCN channels control spontaneous activity of olfactory receptor neurons through the basal activation of beta 2 adrenoreceptor
Noriyuki Nakashima; Takahiro Ishii; Harunori Ohmori
NEUROSCIENCE RESEARCH, 2011 - HCN channels contribute to spontaneous activity in mouse olfactory receptor neurons
Noriyuki Nakashima; Takahiro Ishii; Harunori Ohmori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010 - INTERACTION BETWEEN S1 AND S4 IN THE VOLTAGE SENSOR OF HCN CHANNELS
Takahiro Ishii; Noriyuki Nakashima; Harunori Ohmori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009 - Contribution of HCN channels to the spontaneous activity in the mouse olfactory receptor neurons
Noriyuki Nakashima; Takahiro Ishii; Harunori Ohmori
NEUROSCIENCE RESEARCH, 2009
■ Research Themes
- The distribution and anatomical characteristics of olfactory chemosensory cells in the male reproductive organs using mice.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Investigating the roles of Olfactory Marker Protein
Grant-in-Aid for Early-Career Scientists
Kurume University
01 Apr. 2018 - 31 Mar. 2021 - Investigating the role of a conventional marker protein in ORNs
Grant-in-Aid for Young Scientists (B)
01 Apr. 2015 - 31 Mar. 2018 - Development and maintenance of vestibular hair cell in microgravity environment
Grant-in-Aid for Scientific Research (C)
01 Apr. 2014 - 31 Mar. 2018 - Simultaneous recording of electrical activity and fluorescence signal from deep brain tissues by the photometric patch electrode
Grant-in-Aid for Challenging Exploratory Research
Kyoto University
01 Apr. 2014 - 31 Mar. 2016 - Identification of HCN4-expressing neurons using HCN4-luciferase knock-in mouse
Grant-in-Aid for Challenging Exploratory Research
Kurume University
01 Apr. 2014 - 31 Mar. 2016
■ 研究者からの一言アピール
- 研究を目指す人達へ:「自由な発言を最重要視します。」生理学では、生命現象を説明するための基礎的な理論を探索します。生命現象の多くは時間軸に沿って何らかのパラメータが変化するため、数学を用いた表現が便利ですよ。学部生もぜひ研究室に学びに来てください。
