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青木 浩樹
循環器病研究所
教授
経歴
■ 経歴
- 2011年07月
久留米大学 循環器病研究所, 教授 - 2008年
久留米大学循環器病研究所，准教授, The Cardiovascular Research Institute - 2007年
山口大学医学部分子脈管病態学講座，准教授（改組による）, School of Medicine - 1997年 - 2000年
Research Fellow in Medicine, Harvard Medical - 1997年 - 2000年
Postdoctoral Fellow, Cardiovascular Division, - 1999年
山口大学医学部分子脈管病態学講座，助教授, School of Medicine - 1999年
Beth lsrael Deaconess Medical Center and - 1999年
- Associate Professor of Medicine, Department of - 1995年 - 1997年
Postdoctoral Fellow, Department of - 1997年
Beth lsrael Deaconess Medical Center and - 1995年
University of Michigan School of Medicine, - 1992年
九州大学医学部心臓血管研究施設臨床細胞科学部門医員 - 1992年
- Ph.D.Kyushu University, Japan - Harvard Medical School, Visiting Scientist
- Harvard Medical School, Postdoctoral Fellow
- Fellow
- Cardiovascular Research Center, Postdoctoral
- Ube, Japan
- Uamaguchi University School of Medicine,
- Molecular Cardiovascular Biology,
- School, Boston, MA
- MA
- Beth Israel Deaconess Medical Center, Boston,
- University of Michigan, Ann Arbor, MI.
- Research Center,
- Internal Medicine-Cardiology, Cardiovascular
- (mplecular Biology), Research Fellow
研究活動情報
■ 受賞
■ 共同研究・競争的資金等の研究課題
■ 産業財産権
■ 共同研究希望
■ 共同研究実績
■ 関心を持って取組んでいる活動
- 1998年
American Heart Association Massachusetts Affiliate Research Fellowship - 1998年
New England Cardiovascular Research Competition Awards Program, first prize - 1998年
American Heart Association Massachusetts Affiliate Research Fellowship - 1998年
New England Cardiovascular Research Competition Awards Program, first prize - 1996年
American Heart Association Michigan Affiliate Research Fellowship - 1996年
American Heart Association Michigan Affiliate Research Fellowship
- The polyol pathway is an evolutionarily conserved system for sensing glucose uptake
Hiroko Sano; Akira Nakamura; Mariko Yamane; Hitoshi Niwa; Takashi Nishimura; Kimi Araki; Kazumasa Takemoto; Kei-ichiro Ishiguro; Hiroki Aoki; Yuzuru Kato; Masayasu Kojima
PLOS Biology, 2022年06月10日, ［査読有り］ - Multidisciplinary Team-Based Palliative Care for Heart Failure and Food Intake at the End of Life.
Tatsuhiro Shibata; Kazutoshi Mawatari; Naoko Nakashima; Koutatsu Shimozono; Kouko Ushijima; Yumiko Yamaji; Kumi Tetsuka; Miki Murakami; Kouta Okabe; Toshiyuki Yanai; Shoichiro Nohara; Jinya Takahashi; Hiroki Aoki; Hideo Yasukawa; Yoshihiro Fukumoto
Nutrients, 2021年07月13日, ［査読有り］ - Ying and Yang of Stat3 in pathogenesis of aortic dissection.
Hiroki Aoki; Ryohei Majima; Yohei Hashimoto; Saki Hirakata; Satoko Ohno-Urabe
Journal of cardiology, 2021年05月, ［査読有り］
筆頭著者, 責任著者 - Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
Satoshi Kikusaki; Kazuyoshi Takagi; Takahiro Shojima; Kosuke Saku; Tomofumi Fukuda; Atsunobu Oryoji; Tomoyuki Anegawa; Yoshihiro Fukumoto; Hiroki Aoki; Hiroyuki Tanaka
General Thoracic and Cardiovascular Surgery, 2021年01月08日, ［査読有り］
責任著者 - A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms.
Koichi Yoshimura; Hiroki Aoki; Chie Teruyama; Masumi Iijima; Hiromori Tsutsumi; Shun'ichi Kuroda; Kimikazu Hamano
International journal of molecular sciences, 2020年08月02日, ［査読有り］ - Therapeutic Effect of Rapamycin on Aortic Dissection in Mice.
Makiko Hayashi-Hori; Hiroki Aoki; Miho Matsukuma; Ryohei Majima; Yohei Hashimoto; Sohei Ito; Saki Hirakata; Norifumi Nishida; Aya Furusho; Satoko Ohno-Urabe; Yoshihiro Fukumoto
International journal of molecular sciences, 2020年05月08日, ［査読有り］
責任著者 - Interleukin-22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription-3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury.
Jinya Takahashi; Mai Yamamoto; Hideo Yasukawa; Shoichiro Nohara; Takanobu Nagata; Koutatsu Shimozono; Toshiyuki Yanai; Tomoko Sasaki; Kota Okabe; Tatsuhiro Shibata; Kazutoshi Mawatari; Tatsuyuki Kakuma; Hiroki Aoki; Yoshihiro Fukumoto
Journal of the American Heart Association, 2020年04月21日 - MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice
Sohei Ito; Yohei Hashimoto; Ryohei Majima; Eichi Nakao; Hiroki Aoki; Michihide Nishihara; Satoko Ohno-Urabe; Aya Furusho; Saki Hirakata; Norifumi Nishida; Makiko Hayashi; Koichiro Kuwahara; Yoshihiro Fukumoto
PLOS ONE, 2020年03月
責任著者 - Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice.
Saki Hirakata; Hiroki Aoki; Satoko Ohno-Urabe; Michihide Nishihara; Aya Furusho; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Hideo Yasukawa; Tsutomu Imaizumi; Sinichi Hiromatsu; Hiroyuki Tanaka; Yoshihiro Fukumoto
JACC. Basic to translational science, 2020年02月
責任著者 - High Salt Intake Worsens Aortic Dissection in Mice: Involvement of IL (Interleukin)-17A-Dependent ECM (Extracellular Matrix) Metabolism.
Norifumi Nishida; Hiroki Aoki; Satoko Ohno-Urabe; Michihide Nishihara; Aya Furusho; Saki Hirakata; Makiko Hayashi; Sohei Ito; Hiroshi Yamada; Yuichiro Hirata; Hideo Yasukawa; Tsutomu Imaizumi; Hiroyuki Tanaka; Yoshihiro Fukumoto
Arteriosclerosis, thrombosis, and vascular biology, 2020年01月
責任著者 - Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model.
Shota Tomida; Kenichi Aizawa; Norifumi Nishida; Hiroki Aoki; Yasushi Imai; Ryozo Nagai; Toru Suzuki
Scientific reports, 2019年07月24日, ［査読有り］ - STAT3 Activation Correlates with Adventitial Neutrophil Infiltration in Human Aortic Dissection.
Shohei Yoshida; Mai Yamamoto; Hiroki Aoki; Hayato Fukuda; Koji Akasu; Kazuyoshi Takagi; Takahiro Shojima; Yoshihiro Fukumoto; Hidetoshi Akashi; Hiroyuki Tanaka
Annals of vascular diseases, 2019年06月25日 - Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice: From individual elastic lamella to 3D analysis
Gerlinde Logghe; Bram Trachet; Lydia Aslanidou; Pablo Villaneuva-Perez; Julie De Backer; Nikolaos Stergiopulos; Marco Stampanoni; Hiroki Aoki; Patrick Segers
Scientific Reports, 2018年12月01日, ［査読有り］ - 大動脈解離の分子病態におけるmTORの役割
堀 真貴子; 青木 浩樹; 大野 聡子; 西原 通秀; 古荘 文; 平方 佐季; 西田 憲史; 伊東 壮平; 橋本 洋平; 眞島 涼平; 福本 義弘
脈管学, 2018年09月 - Activation of the AKT Pathway in the Ascending Aorta With Bicuspid Aortic Valve.
Hirata Y; Aoki H; Shojima T; Takagi K; Takaseya T; Akasu K; Tobinaga S; Fukumoto Y; Tanaka H
Circulation journal : official journal of the Japanese Circulation Society, 2018年09月, ［査読有り］
責任著者 - Smooth muscle-specific biomarker for abdominal aortic aneurysm: a beacon for the silent killer.
Aoki H
American journal of physiology. Heart and circulatory physiology, 2018年09月, ［査読有り］ - Involvement of B cells, immunoglobulins, and syk in the pathogenesis of abdominal aortic aneurysm
Aya Furusho; Hiroki Aoki; Satoko Ohno-Urabe; Michihide Nishihara; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Tsutomu Imaizumi; Shinichi Hiromatsu; Hidetoshi Akashi; Hiroyuki Tanaka; Yoshihiro Fukumoto
Journal of the American Heart Association, 2018年03月20日, ［査読有り］
責任著者 - Cytokine Profile of Human Abdominal Aortic Aneurysm: Involvement of JAK/STAT Pathway.
Ohno T; Aoki H; Ohno S; Nishihara M; Furusho A; Hiromatsu S; Akashi H; Fukumoto Y; Tanaka H
Annals of vascular diseases, 2018年03月, ［査読有り］
責任著者 - Characterization of SMAD2 Activation in Human Thoracic Aortic Aneurysm.
Fukuda H; Aoki H; Yoshida S; Tobinaga S; Otsuka H; Shojima T; Takagi K; Fukumoto Y; Akashi H; Kato S; Tanaka H
Annals of vascular diseases, 2018年03月, ［査読有り］
責任著者 - Role of macrophage Socs3 in the pathogenesis of aortic dissection
Satoko Ohno-Urabe; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Hideo Yasukawa; Tsutomu Imaizumi; Hidetoshi Akashi; Hiroyuki Tanaka; Yoshihiro Fukumoto
Journal of the American Heart Association, 2018年01月01日, ［査読有り］
責任著者 - The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice
Michihide Nishihara; Hiroki Aoki; Satoko Ohno; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Tsutomu Imaizumi; Yoshihiro Fukumoto
PLOS ONE, 2017年10月, ［査読有り］
責任著者 - Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm
Kotaro Miyagawa; Takehiro Ogata; Tomomi Ueyama; Takeru Kasahara; Naohiko Nakanishi; Daisuke Naito; Takuya Taniguchi; Tetsuro Hamaoka; Naoki Maruyama; Masahiro Nishi; Taizo Kimura; Hiroyuki Yamada; Hiroki Aoki; Satoaki Matoba
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017年06月, ［査読有り］ - Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways
Tetsushi Nakao; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tomohiro Nishino; Masayasu Izuhara; Yasuhide Kuwabara; Hitoo Nishi; Shunsuke Usami; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Naoya Sowa; Satoko Ohno; Hiroki Aoki; Koji Hasegawa; Kazuhisa Sakamoto; Kenji Minatoya; Takeshi Kimura; Koh Ono
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2017年, ［査読有り］ - Taking Control of the Time Bomb in Abdominal Aortic Aneurysm
Hiroki Aoki
CIRCULATION JOURNAL, 2016年02月, ［査読有り］
筆頭著者, 責任著者 - Mouse model of abdominal aortic aneurysm induced by CaCl2
Hiroki Aoki; Satoko Ohno; Aya Furusho; Michihide Nishihara; Norifumi Nishida; Saki Hirakata; Koichi Yoshimura
Mouse Models of Vascular Diseases, 2016年01月01日, ［査読有り］
筆頭著者, 責任著者 - Tissue remodeling in vascular wall in Kawasaki disease-related vasculitis model mice
Yukako Yoshikane; Mitsuhisa Koga; Tamaki Cho; Kyoko Imanaka-Yoshida; Yumi Yamamoto; Junichi Hashimoto; Hiroki Aoki; Koichi Yoshimura; Shinichi Hirose
Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology, 2016年01月01日, ［査読有り］ - Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms
Batmunkh Bumdelger; Hiroki Kokubo; Ryo Kamata; Masayuki Fujii; Koichi Yoshimura; Hiroki Aoki; Yuichi Orita; Takafumi Ishida; Megu Ohtaki; Masataka Nagao; Mari Ishida; Masao Yoshizumi
PLOS ONE, 2016年01月, ［査読有り］ - Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning
Toyoharu Oba; Hideo Yasukawa; Takanobu Nagata; Sachiko Kyogoku; Tomoko Minami; Michihide Nishihara; Hideki Ohshima; Kazutoshi Mawatari; Shoichiro Nohara; Jinya Takahashi; Yusuke Sugi; Sachiyo Igata; Yoshiko Iwamoto; Hisashi Kai; Hidehiro Matsuoka; Makoto Takano; Hiroki Aoki; Yoshihiro Fukumoto; Tsutomu Imaizumi
CIRCULATION JOURNAL, 2015年07月, ［査読有り］ - Inhibitory Effect of Statins on Inflammation-Related Pathways in Human Abdominal Aortic Aneurysm Tissue
Koichi Yoshimura; Ayako Nagasawa; Junichi Kudo; Masahiko Onoda; Noriyasu Morikage; Akira Furutani; Hiroki Aoki; Kimikazu Hamano
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2015年05月, ［査読有り］ - Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules
Takanobu Nagata; Hideo Yasukawa; Sachiko Kyogoku; Toyoharu Oba; Jinya Takahashi; Shoichiro Nohara; Tomoko Minami; Kazutoshi Mawatari; Yusuke Sugi; Koutatsu Shimozono; Sylvain Pradervand; Masahiko Hoshijima; Hiroki Aoki; Yoshihiro Fukumoto; Tsutomu Imaizumi
PLOS ONE, 2015年05月, ［査読有り］ - Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma
Bo-Kyung Son; Daigo Sawaki; Shota Tomida; Daishi Fujita; Kenichi Aizawa; Hiroki Aoki; Masahiro Akishita; Ichiro Manabe; Issei Komuro; Scott L. Friedman; Ryozo Nagai; Toru Suzuki
NATURE COMMUNICATIONS, 2015年04月, ［査読有り］ - BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Suguru Yasuoka; Takahiro Anegawa; Yuji Mishina; Akira Suzuki; Yoshihiro Fukumoto; Tsutomu Imaizumi
KIDNEY INTERNATIONAL, 2015年01月, ［査読有り］ - Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Takaya Ishihara; Reiko Ban-Ishihara; Maki Maeda; Yui Matsunaga; Ayaka Ichimura; Sachiko Kyogoku; Hiroki Aoki; Shun Katada; Kazuto Nakada; Masatoshi Nomura; Noboru Mizushima; Katsuyoshi Mihara; Naotada Ishihara
Molecular and cellular biology, 2015年01月, ［査読有り］ - Inflammasome Activation by Mitochondrial Oxidative Stress in Macrophages Leads to the Development of Angiotensin II-Induced Aortic Aneurysm
Fumitake Usui; Koumei Shirasuna; Hiroaki Kimura; Kazuki Tatsumi; Akira Kawashima; Tadayoshi Karasawa; Koichi Yoshimura; Hiroki Aoki; Hiroko Tsutsui; Tetsuo Noda; Junji Sagara; Shun'ichiro Taniguchi; Masafumi Takahashi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2015年01月, ［査読有り］ - Tenascin C protects aorta from acute dissection in mice
Taizo Kimura; Kozoh Shiraishi; Aya Furusho; Sohei Ito; Saki Hirakata; Norifumi Nishida; Koichi Yoshimura; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; Yasuhiro Ikeda; Takanobu Miyamoto; Takafumi Ueno; Kimikazu Hamano; Michiaki Hiroe; Kazutaka Aonuma; Masunori Matsuzaki; Tsutomu Imaizumi; Hiroki Aoki
SCIENTIFIC REPORTS, 2014年02月, ［査読有り］
責任著者 - Prostaglandin E-2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling
Utako Yokoyama; Susumu Minamisawa; Aki Shioda; Ryo Ishiwata; Mei-Hua Jin; Munetaka Masuda; Toshihide Asou; Yukihiko Sugimoto; Hiroki Aoki; Tomoyuki Nakamura; Yoshihiro Ishikawa
CIRCULATION, 2014年01月, ［査読有り］ - Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system
Kyoko Imanaka-Yoshida; Hiroki Aoki
Frontiers in Physiology, 2014年, ［査読有り］ - JNK阻害薬による動脈瘤形成の抑制 川崎病類似汎血管炎モデルマウスを用いた検討
吉兼 由佳子; 吉村 耕一; 今中 恭子; 長 環; 古賀 允久; 山本 由美子; 青木 浩樹; 橋本 淳一; 上田 誠; 廣瀬 伸一
日本小児循環器学会雑誌, 2013年06月 - Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice
Haruya Ohmura; Hideo Yasukawa; Tomoko Minami; Yusuke Sugi; Toyoharu Oba; Takanobu Nagata; Sachiko Kyogoku; Hideki Ohshima; Hiroki Aoki; Tsutomu Imaizumi
HYPERTENSION RESEARCH, 2012年11月, ［査読有り］ - Modern Angiogenic Thermal Therapy From the Country of Traditional Thermal Therapy
Hiroki Aoki
CIRCULATION JOURNAL, 2012年07月, ［査読有り］
筆頭著者, 責任著者 - Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm
Hirokazu Tazume; Keishi Miyata; Zhe Tian; Motoyoshi Endo; Haruki Horiguchi; Otowa Takahashi; Eiji Horio; Hiroto Tsukano; Tsuyoshi Kadomatsu; Yukiko Nakashima; Ryuji Kunitomo; Yasushi Kaneko; Shuji Moriyama; Hisashi Sakaguchi; Ken Okamoto; Masahiko Hara; Takashi Yoshinaga; Koichi Yoshimura; Hiroki Aoki; Kimi Araki; Hiroyuki Hao; Michio Kawasuji; Yuichi Oike
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2012年06月, ［査読有り］ - Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation
Utako Yokoyama; Ryo Ishiwata; Mei-Hua Jin; Yuko Kato; Orie Suzuki; Huiling Jin; Yasuhiro Ichikawa; Syun Kumagaya; Yuzo Katayama; Takayuki Fujita; Satoshi Okumura; Motohiko Sato; Yukihiko Sugimoto; Hiroki Aoki; Shinichi Suzuki; Munetaka Masuda; Susumu Minamisawa; Yoshihiro Ishikawa
PLOS ONE, 2012年05月, ［査読有り］ - Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Suguru Yasuoka; Takahiro Anegawa; Yuji Aoki; Seiji Ueda; Seiya Okuda; Tsutomu Imaizumi
KIDNEY INTERNATIONAL, 2012年04月, ［査読有り］ - Heart Failure-Inducible Gene Therapy Targeting Protein Phosphatase 1 Prevents Progressive Left Ventricular Remodeling
Yosuke Miyazaki; Yasuhiro Ikeda; Kozo Shiraishi; Shizuka N. Fujimoto; Hidekazu Aoyama; Koichi Yoshimura; Makoto Inui; Masahiko Hoshijima; Hideko Kasahara; Hiroki Aoki; Masunori Matsuzaki
PLOS ONE, 2012年04月, ［査読有り］ - Prostaglandin E-2-EP4 Signaling Inhibits Vascular Elastic Fiber Formation in the Rodent Ductus Arteriosus.
Minamisawa S; Yokoyama U; Ishiwata R; Sugimoto Y; Aoki H; Nakamura T; Ishikawa Y
2012年, ［査読有り］ - Recent advances in pharmacotherapy development for abdominal aortic aneurysm
Koichi Yoshimura; Hiroki Aoki
International Journal of Vascular Medicine, 2012年, ［査読有り］ - Innocent bystander? Intraluminal thrombus in abdominal aortic aneurysm
Koichi Yoshimura; Yasuhiro Ikeda; Hiroki Aoki
ATHEROSCLEROSIS, 2011年10月, ［査読有り］ - Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process
Taizo Kimura; Koichi Yoshimura; Hiroki Aoki; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; Yasuhiro Ikeda; Noriyasu Morikage; Hisako Endo; Kimikazu Hamano; Tsutomu Imaizumi; Michiaki Hiroe; Kazutaka Aonuma; Masunori Matsuzaki
PATHOLOGY INTERNATIONAL, 2011年10月, ［査読有り］
責任著者 - Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization
Hidehiro Kaneko; Toshihisa Anzai; Maho Morisawa; Takashi Kohno; Toshiyuki Nagai; Atsushi Anzai; Toshiyuki Takahashi; Masayuki Shimoda; Aya Sasaki; Yuichiro Maekawa; Koichi Yoshimura; Hiroki Aoki; Kazuo Tsubota; Tsutomu Yoshikawa; Yasunori Okada; Satoshi Ogawa; Keiichi Fukuda
ATHEROSCLEROSIS, 2011年08月, ［査読有り］ - Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm
Hidehiro Kaneko; Toshihisa Anzai; Toshiyuki Takahashi; Takashi Kohno; Masayuki Shimoda; Aya Sasaki; Hideyuki Shimizu; Toshiyuki Nagai; Yuichiro Maekawa; Koichi Yoshimura; Hiroki Aoki; Tsutomu Yoshikawa; Yasunori Okada; Ryohei Yozu; Satoshi Ogawa; Keiichi Fukuda
CARDIOVASCULAR RESEARCH, 2011年07月, ［査読有り］ - Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue
Yusuke Shintani; Hiroki Aoki; Michihide Nishihara; Satoko Ohno; Aya Furusho; Shin-ichi Hiromatsu; Hidetoshi Akashi; Tsutomu Imaizumi; Shigeaki Aoyagi
ATHEROSCLEROSIS, 2011年06月, ［査読有り］
責任著者 - Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling
Hidekazu Aoyama; Yasuhiro Ikeda; Yosuke Miyazaki; Koichi Yoshimura; Shizuka Nishino; Takeshi Yamamoto; Masafumi Yano; Makoto Inui; Hiroki Aoki; Masunori Matsuzaki
CARDIOVASCULAR RESEARCH, 2011年01月, ［査読有り］ - Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly in the Ductus Arteriosus
Yokoyama Utako; Shioda Aki; Kato Yuko; Asou Toshihide; Aoki Hiroki; Nakamura Tomoyuki; Minamisawa Susumu; Ishikawa Yoshihiro
CIRCULATION, 2010年11月23日, ［査読有り］ - 大動脈ステントグラフトの未来 再充填可能な薬剤徐放性ステントグラフトの開発と将来展望
吉村 耕一; 青木 浩樹; 黒田 俊一; 堤 宏守; 濱野 公一
人工臓器, 2010年11月 - IT技術と21世紀の外科 日本発の新しい医療機器、システム 大動脈瘤低侵襲治療のための革新的システムの開発と展望
吉村 耕一; 青木 浩樹; 黒田 俊一; 堤 宏守; 古谷 彰; 濱野 公一
日本外科学会雑誌, 2010年03月 - Tenascin-c Has a Protective Role During the Development of Abdominal Aortic Aneurysm
Kimura, Taizo; Yoshimura, Koichi; Aoki, Hiroki; Ikeda, Yasuhiro; Imanaka-Yoshida, Kyoko; Yoshida, Toshimichi; Hamano, Kimikazu; Hiroe, Michiaki; Aonuma, Kazutaka; Matsuzaki, Masunori
CIRCULATION, 2009年11月, ［査読有り］ - 人工臓器としてのステントグラフト 素材とデザインの問題点 再充填可能な薬剤徐放性ステントグラフトの開発
吉村 耕一; 青木 浩樹; 黒田 俊一; 堤 宏守; 古谷 彰; 濱野 公一; 松崎 益徳
人工臓器, 2009年10月 - 大動脈瘤壁においてACE阻害薬は組織保護サイトカインHGFの分泌を促進する
新谷 悠介; 青木 浩樹; 奈田 慎一; 金谷 蔵人; 坂下 英樹; 鬼塚 誠二; 岡崎 悌之; 福永 周司; 廣松 伸一; 明石 英俊; 今泉 勉; 青柳 成明
脈管学, 2009年09月 - Angiotensin II Induces Cardiac Systolic and Diastolic Dysfunction via Toll-Like Receptor 4 Mediated Upregulation of Oxidative Stress in Murine Heart
Susumu Matsuda; Seiji Umemoto; Hiroko Yoshino; Shinichi Itoh; Hiroki Aoki; Koichi Yoshimura; Murata Tomoaki; Masunori Matsuzaki
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009年03月, ［査読有り］ - PJ-789 Angiotensin II Induces Cardiac Systolic and Diastolic Dysfunction via Toll-like Receptor 4 Mediated Up-regulation of Oxidative Stress in Murine Heart(PJ132,Heart Failure, Basic (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
Matsuda Susumu; Umemoto Seiji; Yoshino Hiroko; Itoh Shinichi; Aoki Hiroki; Yoshimura Koichi; Murata Tomoaki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2009年03月01日 - PJ-306 Toll-like Receptor 4 Upregulates Oxidative Stress by Inhibiting Extracellular Superoxide Dismutase in Angiotensin II-induced Hypertension(PJ052,Hypertension, Basic (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Cir
Yoshino Hiroko; Umemoto Seiji; Matsuda Susumu; Itoh Shinichi; Aoki Hiroki; Yoshimura Koichi; Murata Tomoaki; Fukai Tohru; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2009年03月01日 - OJ-249 Tenascin-C is Tissue Protective during the Development of Abdominal Aortic Aneurysm in Mice(OJ42,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
Kimura, Taizo; Yoshimura, Koichi; Aoki, Hiroki; Ikeda, Yasuhiro; Imanaka-yoshida, Kyoko; Hiroe, Michiaki; Aonuma, Kazutaka; Matsuzaki, Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2009年03月, ［査読有り］
責任著者 - Regression of Abdominal Aortic Aneurysms through Pharmacologic Therapy
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
ADVANCES IN UNDERSTANDING AORTIC DISEASES, 2009年, ［査読有り］ - TOLL-LIKE RECEPTOR 4 INCREASES OXIDATIVE STRESS BY INHIBITING EXTRACELLULAR SUPEROXIDE DISMUTASE IN ANGIOTENSIN II-INDUCED HYPERTENSION
Hiroko Yoshino; Seiji Umemoto; Susumu Matsuda; Tadaaki Nakashima; Shinichi Itoh; Hiroki Aoki; Koichi Yoshimura; Tomoaki Murata; Tohru Fukai; Masunori Matsuzaki
JOURNAL OF VASCULAR RESEARCH, 2009年, ［査読有り］ - Toll-Like Receptor 4 Upregulates Oxidative Stress by Inhibiting the Upregulation of Extracellular Superoxide Dismutase in Angiotensin II-Induced Hypertension
Hiroko Yoshino; Seiji Umemoto; Shinichi Ito; Susumu Matsuda; Hiroki Aoki; Koichi Yoshimura; Tomoaki Murata; Masunori Matsuzaki
CIRCULATION, 2008年10月, ［査読有り］ - PJ-326 Effect of Toll-like Receptor 4 on Cardiac Hypertrophy and Function in Angiotensin II-induced Hypertension(Hypertension, basic(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Yoshino Hiroko; Umemoto Seiji; Itoh Shinichi; Matsuda Susumu; Aoki Hiroki; Yoshimura Koichi; Murata Tomoaki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2008年03月01日 - 適応の破綻と修復 心不全での脱リン酸化制御とカルシウムハンドリング
池田 安宏; 青木 浩樹; 青山 英和; 吉村 耕一; 山本 健; 矢野 雅文; 松崎 益徳
適応医学, 2007年05月 - Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY AND MOLECULAR BIOLOGY, 2006年, ［査読有り］ - Characterization of Homo- and Heterodimerization of Cardiac Csx/Nkx2.5 Homeoprotein
Hideko Kasahara; Anny Usheva; Tomomi Ueyama; Hiroki Aoki; Nobuo Horikoshi; Seigo Izumo
Journal of Biological Chemistry, 2001年02月16日, ［査読有り］ - Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation
PM Kang; A Haunstetter; H Aoki; A Usheva; S Izumo
CIRCULATION RESEARCH, 2000年07月, ［査読有り］ - Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes
J Sadoshima; H Aoki; S Izumo
CIRCULATION RESEARCH, 1997年02月, ［査読有り］
- STAT3 in Vascular Smooth Muscle Cells Protects Aorta From Dissection by Reinforcing Aortic Wall
Saki Hirakata; Hiroki Aoki; Michihide Nishihara; Satoko Ohno; Aya Furusho; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Yoshihiro Fukumoto
CIRCULATION, 2015年11月 - Excessive NaCl Intake Aggravates Aortic Dissection Through IL-17 Pathway
Norifumi Nishida; Hiroki Aoki; Satoko Ohno; Michihide Nishihara; Aya Furusho; Saki Hirakata; Makiko Hayashi; Sohei Ito; Hideo Yasukawa; Yoshihiro Fukumoto
CIRCULATION, 2015年11月 - The Role of Macrophage STAT3 Signaling in Pathogenesis of Aortic Dissection
Satoko Ohno; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Yoshihiro Fukumoto
CIRCULATION, 2015年11月 - A Common Gene Network Governs the Cellular Phenotypes in Acute Aortic Dissection
Satoko Ohno; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Hideo Yasukawa; Yoshihiro Fukumoto
CIRCULATION, 2014年11月 - Protective Role of Stat3 in Vascular Smooth Muscle Cells During the Development of Acute Aortic Dissection
Saki Hirakata; Hiroki Aoki; Michihide Nishihara; Satoko Ohno; Aya Furusho; Norifumi Nishida; Sohei Ito; Yoshihiro Fukumoto
CIRCULATION, 2014年11月 - Involvement of IL-6 in Pathogenesis of Abdominal Aortic Aneurysm
Michihide Nishihara; Hiroki Aoki; Satoko Ohno; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Tsutomu Imaizumi
CIRCULATION, 2013年11月 - C.-jun N-terminal Kinase is a Novel Therapeutic Target for Controlling the Development of Kawasaki Disease-related Arterial Aneurysm
Yukako Yoshikane; Mitsuhisa Koga; Tamaki Cho; Kyoko Imanaka-Yoshida; Junichi Hashimoto; Hiroki Aoki; Koichi Yoshimura; Shinichi Hirose
CIRCULATION, 2013年11月 - Deciphering the Sequential Molecular Events During Onset of Acute Aortic Dissection
Satoko Ohno; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Souhei Itou; Tsutomu Imaizumi
CIRCULATION, 2013年11月 - BMP Type I Receptor Inhibition Reduces Endothelial Dysfunction and Vascular Osteogenic Differentiation in Mice With Chronic Kidney Disease
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Yoshiko Iwamoto; Takahiro Anegawa; Kenji Fukuda; Tsutomu Imaizumi
CIRCULATION, 2013年11月 - Increased Phosphatase and Tensin Homolog Plays a Crucial Role in Endothelial Dysfunction in Mice with Renal Failure
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Takahro Anegawa; Tsutomu Imaizumi
CIRCULATION, 2012年11月 - Cardiac-Specific Deletion of Suppressor of Cytokine Signaling-3 Prevents Doxorubicin-Induced Cardiomyopathy in Mice
Sachiko Kyogoku; Hideo Yasukawa; Takanobu Nagata; Toyoharu Oha; Hideki Ohshima; Tomoko Minami; Toshitaka Yajima; Masahiko Hoshijima; Hiroki Aoki; Kirk U. Knowlton; Tsutomu Imaizumi
CIRCULATION, 2012年11月 - Inhibition of CaMKII/ERK-Mediated eNOS Phosphorylation Impairs Endothelial Function in Renal Failure Mice: New Effect of AsymmetricDimethylarginine
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Tsutomu Imaizumi
JOURNAL OF CARDIAC FAILURE, 2012年10月 - 新たな技術で探る血管構築から機能獲得へのメカニズム 血管の弾性機能制御の分子メカニズム
横山 詩子; 塩田 亜樹; 石渡 遼; 鈴木 伸一; 益田 宗孝; 麻生 俊英; 青木 浩樹; 杉本 幸彦; 中邨 智之; 南沢 享; 石川 義弘
日本生理学雑誌, 2012年09月 - Tenascin C protects aorta from acute dissection in mice.
H. Aoki; T. Kimura; K. Yoshimura; K. Shiraishi; K. Imanaka-Yoshida; T. Yoshida; Y. Ikeda; T. Miyamoto; M. Hiroe; K. Hamano; K. Aonuma; M. Matsuzaki; T. Imaizumi
MOLECULAR BIOLOGY OF THE CELL, 2012年 - Activation of Hypoxia Inducible Factor-Erythropoietin Pathway May Prevent Acute Myocardial Injury During Remote Ischemic Preconditioning
Toyoharu Oba; Hideo Yaskawa; Takanobu Nagata; Sachiko Kyougoku; Nobuyoshi Futamata; Kazutoshi Mawatari; Tomoko Minami; Yusuke Sugi; Daisuke Fukui; Hiroki Aoki; Tsutomu Imaizumi
CIRCULATION, 2011年11月 - Inhibition of CaMKII- and ERK-Mediated eNOS Phosphorylation Impairs Endothelial Function in Renal Failure Mice: New Effect of Asymmetric Dimethylarginine
Hidemi Kajimoto; Hisashi Kai; Suguru Yasuoka; Takahiro Anegawa; Hiroki Aoki; Tsutomu Imaizumi
CIRCULATION, 2011年11月 - Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling
Hidekazu Aoyama; Yasuhiro Ikeda; Yosuke Miyazaki; Koichi Yoshimura; Shizuka Nishino; Takeshi Yamamoto; Masafumi Yano; Makoto Inui; Hiroki Aoki; Masunori Matsuzaki
CARDIOVASCULAR RESEARCH, 2011年01月 - プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御
塩田 亜樹; 横山 詩子; 加藤 優子; 麻生 俊英; 青木 浩樹; 中邨 智之; 南沢 亨; 石川 義弘
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2010年12月 - Increased Circulating Asymmetric Dimethylarginine in Chronic Kidney Disease Mice Induces Endothelial Dysfunction by Inhibiting Ca/Calmodulin-Dependent Protein Kinase II-eNOS Signaling
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Suguru Yasuoka; Takahiro Anegawa; Tsutomu Imaizumi
CIRCULATION, 2010年11月 - Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells
Junko K. Akada; Hiroki Aoki; Yuji Torigoe; Takao Kitagawa; Hisao Kurazono; Hisashi Hoshida; Jun Nishikawa; Shuji Terai; Masunori Matsuzaki; Toshiya Hirayama; Teruko Nakazawa; Rinji Akada; Kazuyuki Nakamura
DISEASE MODELS & MECHANISMS, 2010年09月 - Protein Phosphatase 1 beta is Critical to Determine Cardiac Systolic and Diastolic Function in Cardiomyopathic Mice
Yosuke Miyazaki; Yasuhiro Ikeda; Hidekazu Aoyama; Kouzou Shiraishi; Koichi Yoshimura; Masafumi Yano; Hiroki Aoki; Masunori Matsuzaki
JOURNAL OF CARDIAC FAILURE, 2010年09月 - Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm
Masahiko Onoda; Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Noriyasu Morikage; Akira Furutani; Masunori Matsuzaki; Kimikazu Hamano
ATHEROSCLEROSIS, 2010年02月 - Role of Vascular Endothelial Growth Factor-A in the Development of Mice CaCl2 Induced Abdominal Aortic Aneurysm
Hidehiro Kaneko; Toshihisa Anzai; Toshiyuki Takahashi; Yuichiro Maekawa; Masayuki Shimoda; Koichi Yoshimura; Hiroki Aoki; Hideyuki Shimizu; Yasunori Okada; Ryohei Yozu; Tsutomu Yoshikawa; Satoshi Ogawa
CIRCULATION, 2009年11月 - Asymmetric Dimethylarginine Triggers Vasculo-Renal Interaction in CKD Mice
Hidemi Kajimoto; Hisashi Kai; Suguru Yasuoka; Takahiro Anegawa; Hiroki Aoki; Tsutomu Imaizumi
CIRCULATION, 2009年11月 - Asymmetric Dimethylarginine is a Paracrine Regulator of Vascular Function in CKD
Hidemi Kajimoto; Hisashi Kai; Suguru Yasuoka; Hiroki Aoki; Takahiro Anegawa; Tsutomu Imaizumi
JOURNAL OF CARDIAC FAILURE, 2009年09月 - PE-190 Involvement of JNK2 in Mechanosensing and Proinflammatory Signaling during Development of Aortic Aneurysm(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Kimura Taizo; Ikeda Yasuhiro; Aoyama Hidekazu; Miyazaki Yosuke; Morikage Noriyasu; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2009年03月01日 - PJ-071 In Vivo Knockdown of Protein Phosphatase 1β Augments Cardiac Contracitility in Mice(PJ012,Calcium Handling, Cardiac Function (Basic) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Miyazaki Yousuke; Ikeda Yasuhiro; Aoyama Hidekazu; Yoshimura Koichi; Yano Masafumi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2009年03月01日 - PJ-073 Protein Phosphatase 1 Beta is Most Significant Subunit in the Longitudinal Sarcoplasmic Reticulum and Controles Phospholamban Phosphorylation in Cardiomyocytes(PJ012,Calcium Handling, Cardiac Function (Basic) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Aoyama Hidekazu; Ikeda Yasuhiro; Miyazaki Yousuke; Ono Makoto; Yamamoto Ken; Yano Masafumi; Yoshimura Koichi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2009年03月01日 - 1 Stage-Specific Molecular Therapy for Abdominal Aortic Aneurysm(Recent Progress in Diagnosis and Treatment of Aortic Diseases,Symposium 5 (SY-05) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Aoki Hiroki; Yoshimura Koichi; Shigematsu Hiroshi; Imaizumi Tsutomu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2009年03月01日 - RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
Hiroyo Oda; Manabu Fujimoto; Michael S Patrick; Dai Chida; Yoshinori Sato; Yoshinao Azuma; Hiroki Aoki; Takaya Abe; Harumi Suzuki; Mutsunori Shirai
Journal of immunology (Baltimore, Md. : 1950), 2009年01月15日 - RhoH Plays Critical Roles in Fc epsilon RI-Dependent Signal Transduction in Mast Cells
Hiroyo Oda; Manabu Fujimoto; Michael S. Patrick; Dai Chida; Yoshinori Sato; Yoshinao Azuma; Hiroki Aoki; Takaya Abe; Harumi Suzuki; Mutsunori Shirai
JOURNAL OF IMMUNOLOGY, 2009年01月 - 191) Angiotensin II負荷高血圧マウスにおけるToll-Like Receptor 4の血管リモデリングに対する役割(第92回日本循環器学会中国・四国合同地方会)
吉野 敬子; 梅本 誠治; 伊藤 真一; 松田 晋; 青木 浩樹; 吉村 耕一; 村田 智昭; 松暗 益徳
Circulation journal : official journal of the Japanese Circulation Society, 2008年10月20日 - 198) 蛋白ホスファターゼ1βは,心筋培養細胞系においてホスホランバン脱リン酸化の主要なホスファターゼである(第92回日本循環器学会中国・四国合同地方会)
青山 英和; 池田 安宏; 吉村 耕一; 矢野 雅文; 青木 浩樹; 松崎 益徳
Circulation journal : official journal of the Japanese Circulation Society, 2008年10月20日 - The Vascular Smooth Muscle Cell-Autonomous Role of Id2 in Phenotypic Modulation In Vitro And Atherogenesis In Vivo
Hiroki Aoki; Koichi Yoshimura; Yasuhiro Ikeda; Masunori Matsuzaki
CIRCULATION, 2008年10月 - Protein Phosphatase 1 Beta is Most Abundant Isoform in the Longitudinal Sarcoplasmic Reticulum and Regulates Phospholamban Phosphorylation in Cardiomyocytes
Hidekazu Aoyama; Yasuhiro Ikeda; Yosuke Miyazaki; Makoto Ono; Koichi Yoshimura; Takeshi Yamamoto; Masafumi Yano; Hiroki Aoki; Makoto Inui; Masunori Matsuzaki
CIRCULATION, 2008年10月 - Role of NonO-histone interaction in TNF alpha-suppressed prolyl-4-hydroxylase alpha 1
Cheng Zhang; Ming-Xiang Zhang; Ying H. Shen; Jared K. Burks; Xiao-Nan Li; Scott A. LeMaire; Koichi Yoshimura; Hiroki Aoki; Masunori Matsuzaki; Feng-Shuang An; David A. Engler; Rise K. Matsunami; Joseph S. Coselli; Yun Zhang; Xing Li Wang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008年08月 - Role of Protein Phosphatase 1 Isoforms on Calcium Regulation in the Sarcoplasmic Reticulum
Yasuhiro Ikeda; Hidekazu Aoyama; Hiroki Aoki; Koichi Yoshmura; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
CIRCULATION RESEARCH, 2008年08月 - 97) 高血圧性心肥大形成過程におけるToll-Like Receptor 4の役割(第91回日本循環器学会中国地方会)
吉野 敬子; 梅本 誠治; 伊藤 真一; 松田 晋; 青木 浩樹; 吉村 耕一; 村田 智昭; 松崎 益徳
Circulation journal : official journal of the Japanese Circulation Society, 2008年04月20日 - Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation
Shinichi Itoh; Ha Won Kim; Osamu Nakagawa; Kiyoshi Ozumi; Susan M. Lessner; Hiroki Aoki; Kamran Akram; Ronald D. McKinney; Masuko Ushio-Fukai; Tohru Fukai
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008年04月 - Identification of cardiac-specific myosin light chain kinase
Jason Y. Chan; Morihiko Takeda; Laura E. Briggs; Megan L. Graham; Jonathan T. Lu; Nobuo Horikoshi; Ellen O. Weinberg; Hiroki Aoki; Naruki Sato; Kenneth R. Chien; Hideko Kasahara
CIRCULATION RESEARCH, 2008年03月 - 2 Critical Role of JNK in Chronic Inflammation of Abdominal Aortic Aneurysms(Chronic Inflammation and Cardiovascular Diseases,Roundtable Discussion 7 (RT-07) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2008年03月01日 - 4 Phospho-regulation of Sarcoplasmic Reticulum Microdomain in Heart Failure(Symposium 7 (SY-07) (M) Molecular Mechanism and Novel Therapeutic Target in Heart Failure,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Ikeda Yasuhiro; Aoki Hiroki; Aoyama Hidekazu; Yamamoto Takeshi; Yoshimura Koichi; Yano Masafumi; matsuzaki masunori
Circulation journal : official journal of the Japanese Circulation Society, 2008年03月01日 - PE-179 JNK Activation Causes Endoplasmic Reticulum Stress Response in Adipocytes to Suppress The Adiponectin Secretion In Vivo(Diabetes/Obesity/Metabolic syndrome(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Aoki Hiroki; Yoshimura Koichi; Ikeda Yasuhiro; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2008年03月01日 - PE-115 Critical Role of JNK2 for Development of Abdominal Aortic Aneurysm in Mice(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Aoyama Hidekazu; Morikage Noriyasu; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2008年03月01日 - OJ-092 Protein Phosphatase 1 β is the Major Phospholamban Phosphatase that Negatively Regulates Cardiac Contraction and Relaxation.(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Aoyama Hidekazu; Ikeda Yasuhiro; Yoshimura Koichi; Yano Masafumi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2008年03月01日 - 大動脈瘤に対する薬物療法開発の最前線
吉村耕一; 青木浩樹; 松﨑益徳
医学のあゆみ, 2008年 - 大動脈瘤の分子病態と研究の可能性
青木浩樹; 吉村耕一; 松﨑益德
実験医学, 2008年 - 大動脈瘤に対する薬物療法のup-to-date.
吉村耕一; 青木浩樹; 木村泰三; 古谷彰; 濱野公一; 松﨑益徳
Heart View, 2008年 - 大動脈瘤に対する薬物治療
吉村耕一; 青木浩樹; 古谷彰; 濱野公一; 松崎益徳
Heart View, 2008年 - 3. Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy
山田 倫生; 池田 安宏; 吉村 耕一; 西野 静香; 青山 英和; 青木 浩樹; Wang Lili; 矢野 雅文; 松崎 益徳
山口医学, 2007年12月31日 - Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy
Hiroki Aoki; Koichi Yoshimura; Masunori Matsuzaki
JOURNAL OF MOLECULAR MEDICINE-JMM, 2007年10月 - C-jun n-terminal kinase 2 is required for development of abdominal aortic aneurysm in mice
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Hidekazu Aoyama; Noriyasu Morikage; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
CIRCULATION, 2007年10月 - Protein phosphatase 1 beta is the major phospholamban phosphatase that regulates cardiomyocyte contractility
Hidekazu Aoyama; Yasuhiro Ikeda; Koichi Yoshimura; Masafumi Yano; Hiroki Aoki; Masunori Matsuzalki
CIRCULATION, 2007年10月 - Cardiaic-specific myosin light chain kinase (MLCK), a third member of MLCK family, potentiates sarcomere formation and cardiac contraction
Jason Y. Chan; Morihilko Takeda; Laura E. Briggs; Jonathan T. Lu; Nobuo Horikoshi; Ellen Weinberg; Hiroki Aoki; Kenneth R. Chien; Hideko Kasahara
CIRCULATION, 2007年10月 - TNF-alpha suppresses prolyl-4-hydroxylase alpha 1 expression via the ASK1-JNK-NonO pathway
Cheng Zhang; Ming-Xiang Zhang; Ying H. Shen; Jared K. Burks; Yun Zhang; Jian Wang; Scott A. LeMaire; Koichi Yoshimura; Hiroki Aoki; Joseph S. Coselli; Xing Li Wang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007年08月 - 110)瘤壁培養法を用いた腹部大動脈瘤治療薬の探索(第89回日本循環器学会中国地方会)
小野寺 雅彦; 吉村 耕一; 森景 則保; 古谷 彰; 池田 安宏; 青木 浩樹; 松崎 益徳; 濱野 公一
Circulation journal : official journal of the Japanese Circulation Society, 2007年04月20日 - 細胞外マトリックスの安定化は炎症シグナルを抑制し, 腹部大動脈瘤形成を阻止する
小野田 雅彦; 吉村 耕一; 森景 則保; 古谷 彰; 池田 安宏; 青木 浩樹; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 2007年03月10日 - OE-175 Stabilization of Extracellular Matrix Counteracts Proinflammatory Signaling and Prevents Progression of Abdominal Aortic Aneurysm(Molecular biology, vascular-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Onoda Masahiko; Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Morikage Noriyasu; Furutani Akira; Matsuzaki Masunori; Hamano Kimikazu
Circulation journal : official journal of the Japanese Circulation Society, 2007年03月01日 - 4 The Essential Role of c-Jun N-Terminal Kinase in Destructive Vascular Remodeling(New Insight and Therapeutic Strategy for Plaque Stabilization, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Aoki Hiroki; Yoshimura Koichi; Ikeda Yasuhiro; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2007年03月01日 - FRS-034 Statins Reduce NF-κ B Activation and Chemokine Secretion in Human Abdominal Aortic Aneurysm Wall(Pathophysiology of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Kudo Junichi; Aoki Hiroki; Onoda Masahiko; Ikeda Yasuhiro; Morikage Noriyasu; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2007年03月01日 - OE-315 Protein Phosphatase 1β is the Major Phospholamban Phosphatase in Adult Rat Cardiomyocytes(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Aoyama Hidekazu; Ikeda Yasuhiro; Yoshimura Koichi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2007年03月01日 - OE-310 Specific Inhibition of Sarcoplasmic Reticulum-associated Protein Phosphatase 1 by Inhibitor-2 Confers a Novel Approach for Treatment of Heart Failure(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Ikeda Yasuhiro; Aoki Hiroki; Aoyama Hidekazu; Yoshimura Koichi; Yamada Michio; Yano Masafumi; Yamamoto Ken; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2007年03月01日 - 大動脈瘤の薬物治療.
青木浩樹; 吉村耕一; 松崎益徳
Angiology Frontier, 2007年 - 大動脈瘤の分子標的治療：JNKによる細胞外マトリクス代謝制御
青木浩樹; 吉村耕一; 松崎益徳
Annual Review 循環器2007, 2007年 - Regression of abdominal aortic aneurysms by pharmacological inhibition of c-Jun N-terminal kinase
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
The bulletin of the Yamaguchi Medical School, 2007年 - Translocation of protein phosphatase 1 with inhibitor-2 from sarcoplasmic reticulum to cytosol augments Ca2+ cycling in cardiomyocytes
Yasuhiro Ikeda; Hiroki Aoki; Michio Yamada; Koichi Yoshimura; Hidekazu Aoyama; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006年12月 - Translocation of protein phosphatase 1 with inhibitor-2 from sarcoplasmic reticulum to cytosol augments Ca2+ cycling in cardiomyocytes
Yasuhiro Ikeda; Hiroki Aoki; Michio Yamada; Koichi Yoshimura; Hidekazu Aoyama; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
JOURNAL OF CARDIAC FAILURE, 2006年10月 - Stabilization of extracellular matrix antagonizes proinflammatory signaling and prevents progression of aortic aneurysm in vivo
Koichi Yoshimura; Hiroki Aoki; Masahiko Onoda; Yasuhiro Ikeda; Hidekazu Aoyama; Noriyasu Morikage; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
CIRCULATION, 2006年10月 - Knockdown of Nkx2.5 results in altered sarcomere organization and cell shape
Hideko Kasahara; Colleen S. Martinov; Melissa S. Marks; Jonathan T Lu; Hiroki Aoki; Kenneth R. Chien
CIRCULATION, 2006年10月 - Translocation of protein phosphatase 1 with inhibitor-2 from sarcoplasmic reticulum to cytosol augments Ca2+ cycling in cardiomyocytes
Yasuhiro Ikeda; Hiroki Aoki; Michio Yamada; Koichi Yoshimura; Hidekazu Aoyama; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
CIRCULATION, 2006年10月 - Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy
Michio Yamada; Yasuhiro Ikeda; Masafumi Yano; Koichi Yoshimura; Shizuka Nishino; Hidekazu Aoyama; Lili Wang; Hiroki Aoki; Masunori Matsuzaki
FASEB JOURNAL, 2006年06月 - OJ-004 HMG-CoA Reductase Inhibitors Reduce Matrix Metalloproteinase-9 Activity by Multiple Mechanisms in Human Varicose Veins(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Nomura Shinji; Akiyama Norio; Furutani Akira; Aoki Hiroki; Matsuzaki Masunori; Hamano Kimikazu
Circulation journal : official journal of the Japanese Circulation Society, 2006年03月01日 - OE-134 Inhibition of c-Jun N-terminal Kinase Causes Regression of Abdominal Aortic Aneurysm in Murine Models(Peripheral circulation-1 (H) OE23,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Akiyama Norio; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2006年03月01日 - OJ-295 Effect of Tautomycin, a Chemical Inhibitor of Protein Phosphatase 1, on Cellular Contractility and Calcium Transient in Adult Rat Cardiomyocytes(Cardiac function, basic/clinical-2 (M) OJ50,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Ikeda Yasuhiro; Aoki Hiroki; Yamada Michio; Yoshimura Koichi; Yamamoto Takeshi; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2006年03月01日 - 大動脈瘤の薬物治療：分子病態の多面的制御.
青木浩樹; 吉村耕一; 松崎益徳
分子心血管病, 2006年 - シグナル伝達と血管疾患：治療標的分子同定のストラテジー.
青木浩樹; 吉村耕一; 松崎益徳
実験医学増刊号「分子メカニズムから解き明かす疾患のサイエンス」, 2006年 - Identification of c-Jun N-terminal kinase as a therapeutic target for abdominal aortic aneurysm
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY AND MOLECULAR BIOLOGY, 2006年 - Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
K Yoshimura; H Aoki; Y Ikeda; K Fujii; N Akiyama; A Furutani; Y Hoshii; N Tanaka; R Ricci; T Ishihara; K Esato; K Hamano; M Matsuzaki
NATURE MEDICINE, 2005年12月 - Increased protein phosphatase 1 activity as a new therapeutic target of heart failure in genetic cardiomyopathy
Y Ikeda; M Yamada; K Yoshimura; H Aoki; M Yano; M Matsuzaki
JOURNAL OF CARDIAC FAILURE, 2005年12月 - Identification of a molecular therapeutic target for abdominal aortic aneurysm
H Aoki; K Yoshimura; Y Ikeda; K Fujii; N Akiyama; A Furutani; Y Hoshii; N Tanaka; R Ricci; T Ishihara; K Esato; K Hamano; M Matsuzaki
JOURNAL OF CARDIAC FAILURE, 2005年12月 - Protein Phosphatase 1 Inhibitor-2の心筋遺伝子導入は心筋症ハムスターの左室機能を改善する(第86回日本循環器学会中国地方会)
山田 倫生; 矢野 雅文; 松崎 益徳; 池田 安宏; 青木 浩樹; 吉村 耕一
Circulation journal : official journal of the Japanese Circulation Society, 2005年10月20日 - Inhibition of c-Jun N-terminal kinase causes regression of experimental aortic aneurysms
K Yoshimura; H Aoki; Y Ikeda; N Akiyama; A Furutani; K Hamano; M Matsuzaki
CIRCULATION, 2005年10月 - 慢性静脈不全症におけるHMG-CoA還元酵素阻害薬のマトリックスメタロプロテアーゼ-9抑制効果(第105回日本外科学会定期学術集会)
野村 真治; 吉村 耕一; 工藤 淳一; 斉藤 聰; 大楽 耕司; 美甘 章仁; 秋山 紀雄; 古谷 彰; 青木 浩樹; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 2005年04月05日 - HMG-CoA還元酵素阻害薬は腹部大動脈瘤における炎症性サイトカイン発現を抑制する(第105回日本外科学会定期学術集会)
工藤 淳一; 吉村 耕一; 野村 真治; 斉藤 聰; 大楽 耕司; 秋山 紀雄; 古谷 彰; 青木 浩樹; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 2005年04月05日 - Cardiac Gene Transfer of Protein Phosphatase 1 Inhibitor-2 Restores Left Ventricular Function in Progressive Hamster Cardiomyopathy(Heart Failure, Basic 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Yamada Michio; Ikeda Yasuhiro; Aoki Hiroki; Yoshimura Koichi; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2005年03月01日 - HMG-CoA reductase inhibitors reduce matrix metalloproteinase-9 activity in human varicose veins
S Nomura; K Yoshimura; N Akiyama; A Mikamo; A Furutani; H Aoki; M Matsuzaki; K Hamano
EUROPEAN SURGICAL RESEARCH, 2005年 - Gene silencing using adenoviral RNAi vector in vascular smooth muscle cells and cardiomyocytes
Kasahara; H. Aoki, H
Methods Mol Med, 2005年 - 114) 心筋症ハムスター(UM-X7.1)心不全モデルにおけるprotein phosphatase活性の変化の検討(第84回日本循環器学会中国地方会)
山田 倫生; 池田 安宏; 吉村 耕一; 青木 浩樹; 矢野 雅文; 松崎 益徳
Circulation journal : official journal of the Japanese Circulation Society, 2004年10月20日 - Inhibition of c-Jun N-terminal kinase prevents development of abdominal aortic aneurysm in a murine model
K Yoshimura; H Aoki; M Yamada; Y Ikeda; N Akiyama; A Funutani; K Hamano; M Matsuzaki
CIRCULATION, 2004年10月 - Cardiac gene transfer of protein phosphatase 1 inhibitor-2 restores left ventricular function in progressive hamster cardiomyopathy
M Yamada; Y Ikeda; H Aoki; K Yoshimura; M Yano; M Matsuzaki
CIRCULATION, 2004年10月 - C-Jun N-terminal kinase regulates pathological extracellular matrix metabolism in abdominal aortic aneurysm in vivo
K Yoshimura; H Aoki; N Akiyama; A Furutani; K Hamano; M Matsuzaki
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004年07月 - SF-043-4 大動脈瘤に対するc-Jun N-terminal kinaseを分子標的とした次世代治療をめざして
吉村 耕一; 青木 浩樹; 斉藤 聰; 大楽 耕司; 秋山 紀雄; 古谷 彰; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 2004年03月15日 - FRS-019 Role of Cytosolic Regulatory Subunits of Protein Phosphatase 1 on Cell Shortening and Ca2+ Homeostasis in Isolated Adult Rat Cardiomyocytes(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))
Ikeda Yasuhiro; Yamada Michio; Yoshimura Koichi; Aoki Hiroki; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2004年03月01日 - OE-302 Sphingomyelinase causes Endothelium-dependent Relaxation through Nitric Oxide Production and Hyperpolarization without Cytosolic Ca^<2+> Elevation in Endothelial Cells in situ(Endothelium/NO 4 (H) : OE38)(Oral Presentation (English))
Mogami Kimiko; Aoki Hiroki; Yoshimura Koichi; Kishi Hiroko; Kobayashi Sei
Circulation journal : official journal of the Japanese Circulation Society, 2004年03月01日 - OE-096 c-Jun N-terminal Kinase Is Required for Development of Abdominal Aortic Aneurysm In Vivo(Molecular Biology, Vascular 1 (H) : OE12)(Oral Presentation (English))
Yoshimura Koichi; Aoki Hiroki; Fuji Kozo; Yamada Michio; Ikeda Yasuhiro; Saito Satoshi; Akiyama Norio; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2004年03月01日 - OE-116 Id2 Regulates Post-Developmental Phenotype of Vascular Smooth Muscle Cells in Atherosclerosis In Vivo(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
Aoki Hiroki; Yoshimura Koichi; Ikeda Yasuhiro; Yamada Michio; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2004年03月01日 - PJ-228 Protein Phosphatase Dysregulation and Its Effect on Phosphorylation of Ca^<2+> Regulatory Proteins in Hamster Cardiomyopathy(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
Yamada Michio; Ikeda Yasuhiro; Yoshimura Koichi; Aoki Hiroki; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2004年03月01日 - Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells
M Adachi; KR Katsumura; K Fujii; S Kobayashi; H Aoki; M Matsuzaki
FEBS LETTERS, 2003年11月 - Id2 regulates post-developmental phenotype of vascular smooth muscle cells in atherosclerosis in vivo
H Aoki; K Yoshimura; KR Katsumura; K Fujii; M Yamada; Y Ikeda
CIRCULATION, 2003年10月 - C-Jun N-terminal kinase governs pathological extracellular matrix metabolism in human abdominal aortic aneurysm
K Yoshimura; K Fuji; M Yamada; Y Ikeda; S Saito; N Akiyama; A Furutani; K Hamano; H Aoki
CIRCULATION, 2003年10月 - Differential effect of protein phosphatase 1 inhibitor-1 and inhibitor-2 on cell shortening and Ca2+ homeostasis in isolated adult rat cardiomyocytes
Y Ikeda; M Yamada; K Yoshimura; H Aoki; T Ohkusa
CIRCULATION, 2003年10月 - c-Jun N-Terminal Kinase Regulates Matrix Metalloproteinase (MMP)-9 Activity in Human Abdominal Aortic Aneurysm
Yoshimura Koichi; Aoki Hiroki; Furutani Akira; Takenaka Hiroaki; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2003年03月01日 - Id2 Mediates Phenotypic Modulation of Vascular Smooth Muscle Cells by MAP Kinase Pathway
Aoki Hiroki; Yoshimura Koichi; Fujii Kozo; Kobayashi Sei; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 2003年03月01日 - Id2 mediates phenotypic modulation of vascular smooth muscle cells by MAP kinase pathway
H Aoki; K Fujii; K Yoshimura; M Matsuzaki
MOLECULAR BIOLOGY OF THE CELL, 2002年11月 - Direct activation of mitochondrial death machinery by c-Jun N-terminal kinase
Yoshimura Koichi; Aoki Hiroki; Fujii Kouzo; Matsuzaki Masunori; Kang Peter; Izumo Seigo
Circulation journal : official journal of the Japanese Circulation Society, 2002年03月31日 - Activation of stress-activated protein kinases in human abdominal aortic aneurysm
Yoshimura Koichi; Aoki Hiroki; Matsuzaki Masunori; Furutani Akira; Seyama Atsushi; Takenaka Hiroaki; Zempo Nobuya
Circulation journal : official journal of the Japanese Circulation Society, 2002年03月31日 - Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
H Aoki; PM Kang; J Hampe; K Yoshimura; T Noma; M Matsuzaki; S Izumo
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002年03月 - 心不全の基礎と臨床．心筋肥大におけるRhoファミリーと筋線維形成の分子機構
医学のあゆみ, 2002年 - Pravastatin inhibits cytoskeletal translocation of Akt by platelet-derived growth factor in vascular smooth muscle cells
M Adachi; H Aoki; K Yoshimura; K Fujii; M Matsuzaki
JAPANESE JOURNAL OF PHARMACOLOGY, 2002年 - Direct activation of mitochondrial death machinery by c-Jun N-terminal kinase
H Aoki; K Yoshimura; P Kang; S Izumo; M Matsuzaki
MOLECULAR BIOLOGY OF THE CELL, 2001年11月 - Direct activation of mitochondrial death machinery by C-jun N-terminal kinase
H Aoki; K Yoshimura; PM Kang; S Izumo
CIRCULATION, 2001年10月 - c-jun N-terminal kinase activates mitochondrial death machinery in oxidative stress-induced apoptosis of adult cardiac myocytes in vitro
H Aoki; PM Kang; M Matsuzaki; S Izumo
MOLECULAR BIOLOGY OF THE CELL, 2000年12月 - Sek1-JNK pathway mediates oxidative stress-induced apoptosis in adult cardiac myocytes
H Aoki; PM Kang; S Izumo
CIRCULATION, 2000年10月 - Specific role of the extracellular signal-regulated kinase pathway in angiotensin Ⅱ-induced cardiac hypertrophy in vitro
AOKI H; RICHMOND M; IZUMO S; SADOSHIMA J
BiochemJ, 2000年04月 - Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro
H Aoki; M Richmond; S Izumo; J Sadoshima
BIOCHEMICAL JOURNAL, 2000年04月 - Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro
H Aoki; J Sadoshima; S Izumo
NATURE MEDICINE, 2000年02月 - Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro
H Aoki; J Sadoshima; S Izumo
NATURE MEDICINE, 2000年02月 - Morphological characterization and appearance of cytosolic cytochrome C during reoxygenation-induced adult cardiac myocyte apoptosis
PM Kang; A Haunstetter; H Aoki; A Usheva; S Izumo
CIRCULATION, 1999年11月 - The critical role of myosin light chain phosphorylation in cardiac myofibrillogenesis in cardiac hypertrophy in vitro
H Aoki; J Sadoshima; S Izumo
CIRCULATION, 1998年10月 - Angiotensin Ⅱactivates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin Ⅱ-induced premyofibril fomation
H Aoki; S Izumo; J Sadoshima
Circ Res, 1998年04月 - Angiotensin II activates RhoA in cardiac myocytes - A critical role of RhoA in angiotensin II-induced premyofibril formation
H Aoki; S Izumo; J Sadoshima
CIRCULATION RESEARCH, 1998年04月 - Angiotensin II and serum differentially activate CDK4 and phosphorylate retinoblastoma gene product (pRb) in neonatal rat cardiac myocytes in vitro
H Aoki; J Sadoshima; S Izumo
CIRCULATION, 1996年10月 - The role of mitogen-activated protein kinases in angiotensin II-induced cardiac hypertrophic responses in neonatal rat cardiac myocytes in vitro
H Aoki; J Sadoshima; S Izumo
CIRCULATION, 1996年10月 - Endothelin-1 inhibits and enhances contraction of porcine coronary arterial strips with an intact endothelium
Masuko Ushio-Fukai; Junji Nishimura; Hiroki Aoki; Sei Kobayashi; Hideo Kanaide
Biochemical and Biophysical Research Communications, 1992年04月15日 - Endothelin induces the Ca2+-transient in endothelial cells in situ
Hiroki Aoki; Sei Kobayashi; Junji Nishimura; Hiromichi Yamamoto; Hideo Kanaide
Biochemical and Biophysical Research Communications, 1991年12月31日
- Mouse Models of Vascular Diseases
青木 浩樹, 共著, Mouse Model of Abdominal Aortic Aneurysm Induced by CaCl2
Springer Japan, 2016年, 査読無し - Molecular Cardiology. Vol 112
Humana Press, 2004年, 査読無し - Signal Transduction of Cardiac Myocyte Hypertrophy
Academic Press, 2000年, 査読無し - Signal Transduction of Cardiac Myocyte Hypertrophy
Academic Press, 2000年, 査読無し
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- 特許第5843239号, 特願2012-553721, 画像診断における二次元の診断画像の理解を助ける方法及び装置
姉川 敬裕; 青木 浩樹; 甲斐 久史; 今泉 勉 - 特許第5471447号, 特願2009-547150, 薬物送達システム
青木 浩樹; 吉村 耕一; 堤 宏守; 照山 智恵; 松崎 益徳; 黒田 俊一 - WO2012-099087, JP2012050770, 画像診断における二次元の診断画像の理解を助ける方法及び装置
姉川 敬裕; 青木 浩樹; 甲斐 久史; 今泉 勉 - 特許第4686704号, 特開2006-089455, 特願2005-035769, 動脈瘤予防および/または治療剤
吉村 耕一; 青木 浩樹; 松崎 益徳 - WO2009-082014, JP2008073884, 薬物送達システム
青木 浩樹; 吉村 耕一; 堤 宏守; 照山 智恵; 松崎 益徳; 黒田 俊一 - 特開2007-051086, 特願2005-236585, コラーゲンまたはエラスチン代謝異常疾患の予防剤および治療剤
吉村 耕一; 青木 浩樹; 松崎 益徳 - 特開2006-089455, 特願2005-035769, 動脈瘤予防および/または治療剤
吉村 耕一; 青木 浩樹; 松崎 益徳
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