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Aoki Hiroki
Cardiovascular Research Institute
Professor
Career
■ Career
- Jul. 2011
Cardiovascular Research Institute, Kurume University, Professor - 2008
Kurume University, The Cardiovascular Research Institute - 2007
Yamaguchi University, School of Medicine - 1997 - 2000
Research Fellow in Medicine, Harvard Medical - 1997 - 2000
Postdoctoral Fellow, Cardiovascular Division, - 1999
Yamaguchi University, School of Medicine - 1999
Beth lsrael Deaconess Medical Center and - 1999
- Associate Professor of Medicine, Department of - 1995 - 1997
Postdoctoral Fellow, Department of - 1997
Beth lsrael Deaconess Medical Center and - 1995
University of Michigan School of Medicine, - 1992
九州大学医学部心臓血管研究施設臨床細胞科学部門医員 - 1992
- Ph.D.Kyushu University, Japan - Harvard Medical School, Visiting Scientist
- Harvard Medical School, Postdoctoral Fellow
- Fellow
- Cardiovascular Research Center, Postdoctoral
- Ube, Japan
- Uamaguchi University School of Medicine,
- Molecular Cardiovascular Biology,
- School, Boston, MA
- MA
- Beth Israel Deaconess Medical Center, Boston,
- University of Michigan, Ann Arbor, MI.
- Research Center,
- Internal Medicine-Cardiology, Cardiovascular
- (mplecular Biology), Research Fellow
Research activity information
■ Award
■ Research Themes
■ 共同研究希望
■ 共同研究実績
■ 関心を持って取組んでいる活動
- 1998
American Heart Association Massachusetts Affiliate Research Fellowship - 1998
New England Cardiovascular Research Competition Awards Program, first prize - 1998
American Heart Association Massachusetts Affiliate Research Fellowship - 1998
New England Cardiovascular Research Competition Awards Program, first prize - 1996
American Heart Association Michigan Affiliate Research Fellowship - 1996
American Heart Association Michigan Affiliate Research Fellowship
- The polyol pathway is an evolutionarily conserved system for sensing glucose uptake
Hiroko Sano; Akira Nakamura; Mariko Yamane; Hitoshi Niwa; Takashi Nishimura; Kimi Araki; Kazumasa Takemoto; Kei-ichiro Ishiguro; Hiroki Aoki; Yuzuru Kato; Masayasu Kojima
PLOS Biology, 10 Jun. 2022, [Reviewed] - Multidisciplinary Team-Based Palliative Care for Heart Failure and Food Intake at the End of Life.
Tatsuhiro Shibata; Kazutoshi Mawatari; Naoko Nakashima; Koutatsu Shimozono; Kouko Ushijima; Yumiko Yamaji; Kumi Tetsuka; Miki Murakami; Kouta Okabe; Toshiyuki Yanai; Shoichiro Nohara; Jinya Takahashi; Hiroki Aoki; Hideo Yasukawa; Yoshihiro Fukumoto
Nutrients, 13 Jul. 2021, [Reviewed] - Ying and Yang of Stat3 in pathogenesis of aortic dissection.
Hiroki Aoki; Ryohei Majima; Yohei Hashimoto; Saki Hirakata; Satoko Ohno-Urabe
Journal of cardiology, May 2021, [Reviewed]
Lead, Corresponding - Prevention of postoperative intrapericardial adhesion by dextrin hydrogel
Satoshi Kikusaki; Kazuyoshi Takagi; Takahiro Shojima; Kosuke Saku; Tomofumi Fukuda; Atsunobu Oryoji; Tomoyuki Anegawa; Yoshihiro Fukumoto; Hiroki Aoki; Hiroyuki Tanaka
General Thoracic and Cardiovascular Surgery, 08 Jan. 2021, [Reviewed]
Corresponding - A Novel Hybrid Drug Delivery System for Treatment of Aortic Aneurysms.
Koichi Yoshimura; Hiroki Aoki; Chie Teruyama; Masumi Iijima; Hiromori Tsutsumi; Shun'ichi Kuroda; Kimikazu Hamano
International journal of molecular sciences, 02 Aug. 2020, [Reviewed] - Therapeutic Effect of Rapamycin on Aortic Dissection in Mice.
Makiko Hayashi-Hori; Hiroki Aoki; Miho Matsukuma; Ryohei Majima; Yohei Hashimoto; Sohei Ito; Saki Hirakata; Norifumi Nishida; Aya Furusho; Satoko Ohno-Urabe; Yoshihiro Fukumoto
International journal of molecular sciences, 08 May 2020, [Reviewed]
Corresponding - Interleukin-22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription-3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury.
Jinya Takahashi; Mai Yamamoto; Hideo Yasukawa; Shoichiro Nohara; Takanobu Nagata; Koutatsu Shimozono; Toshiyuki Yanai; Tomoko Sasaki; Kota Okabe; Tatsuhiro Shibata; Kazutoshi Mawatari; Tatsuyuki Kakuma; Hiroki Aoki; Yoshihiro Fukumoto
Journal of the American Heart Association, 21 Apr. 2020 - MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice
Sohei Ito; Yohei Hashimoto; Ryohei Majima; Eichi Nakao; Hiroki Aoki; Michihide Nishihara; Satoko Ohno-Urabe; Aya Furusho; Saki Hirakata; Norifumi Nishida; Makiko Hayashi; Koichiro Kuwahara; Yoshihiro Fukumoto
PLOS ONE, Mar. 2020
Corresponding - Genetic Deletion of Socs3 in Smooth Muscle Cells Ameliorates Aortic Dissection in Mice.
Saki Hirakata; Hiroki Aoki; Satoko Ohno-Urabe; Michihide Nishihara; Aya Furusho; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Hideo Yasukawa; Tsutomu Imaizumi; Sinichi Hiromatsu; Hiroyuki Tanaka; Yoshihiro Fukumoto
JACC. Basic to translational science, Feb. 2020
Corresponding - High Salt Intake Worsens Aortic Dissection in Mice: Involvement of IL (Interleukin)-17A-Dependent ECM (Extracellular Matrix) Metabolism.
Norifumi Nishida; Hiroki Aoki; Satoko Ohno-Urabe; Michihide Nishihara; Aya Furusho; Saki Hirakata; Makiko Hayashi; Sohei Ito; Hiroshi Yamada; Yuichiro Hirata; Hideo Yasukawa; Tsutomu Imaizumi; Hiroyuki Tanaka; Yoshihiro Fukumoto
Arteriosclerosis, thrombosis, and vascular biology, Jan. 2020
Corresponding - Indomethacin reduces rates of aortic dissection and rupture of the abdominal aorta by inhibiting monocyte/macrophage accumulation in a murine model.
Shota Tomida; Kenichi Aizawa; Norifumi Nishida; Hiroki Aoki; Yasushi Imai; Ryozo Nagai; Toru Suzuki
Scientific reports, 24 Jul. 2019, [Reviewed] - STAT3 Activation Correlates with Adventitial Neutrophil Infiltration in Human Aortic Dissection.
Shohei Yoshida; Mai Yamamoto; Hiroki Aoki; Hayato Fukuda; Koji Akasu; Kazuyoshi Takagi; Takahiro Shojima; Yoshihiro Fukumoto; Hidetoshi Akashi; Hiroyuki Tanaka
Annals of vascular diseases, 25 Jun. 2019 - Propagation-based phase-contrast synchrotron imaging of aortic dissection in mice: From individual elastic lamella to 3D analysis
Gerlinde Logghe; Bram Trachet; Lydia Aslanidou; Pablo Villaneuva-Perez; Julie De Backer; Nikolaos Stergiopulos; Marco Stampanoni; Hiroki Aoki; Patrick Segers
Scientific Reports, 01 Dec. 2018, [Reviewed] - 大動脈解離の分子病態におけるmTORの役割
堀 真貴子; 青木 浩樹; 大野 聡子; 西原 通秀; 古荘 文; 平方 佐季; 西田 憲史; 伊東 壮平; 橋本 洋平; 眞島 涼平; 福本 義弘
脈管学, Sep. 2018 - Activation of the AKT Pathway in the Ascending Aorta With Bicuspid Aortic Valve.
Hirata Y; Aoki H; Shojima T; Takagi K; Takaseya T; Akasu K; Tobinaga S; Fukumoto Y; Tanaka H
Circulation journal : official journal of the Japanese Circulation Society, Sep. 2018, [Reviewed]
Corresponding - Smooth muscle-specific biomarker for abdominal aortic aneurysm: a beacon for the silent killer.
Aoki H
American journal of physiology. Heart and circulatory physiology, Sep. 2018, [Reviewed] - Involvement of B cells, immunoglobulins, and syk in the pathogenesis of abdominal aortic aneurysm
Aya Furusho; Hiroki Aoki; Satoko Ohno-Urabe; Michihide Nishihara; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Tsutomu Imaizumi; Shinichi Hiromatsu; Hidetoshi Akashi; Hiroyuki Tanaka; Yoshihiro Fukumoto
Journal of the American Heart Association, 20 Mar. 2018, [Reviewed]
Corresponding - Cytokine Profile of Human Abdominal Aortic Aneurysm: Involvement of JAK/STAT Pathway.
Ohno T; Aoki H; Ohno S; Nishihara M; Furusho A; Hiromatsu S; Akashi H; Fukumoto Y; Tanaka H
Annals of vascular diseases, Mar. 2018, [Reviewed]
Corresponding - Characterization of SMAD2 Activation in Human Thoracic Aortic Aneurysm.
Fukuda H; Aoki H; Yoshida S; Tobinaga S; Otsuka H; Shojima T; Takagi K; Fukumoto Y; Akashi H; Kato S; Tanaka H
Annals of vascular diseases, Mar. 2018, [Reviewed]
Corresponding - Role of macrophage Socs3 in the pathogenesis of aortic dissection
Satoko Ohno-Urabe; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Hideo Yasukawa; Tsutomu Imaizumi; Hidetoshi Akashi; Hiroyuki Tanaka; Yoshihiro Fukumoto
Journal of the American Heart Association, 01 Jan. 2018, [Reviewed]
Corresponding - The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice
Michihide Nishihara; Hiroki Aoki; Satoko Ohno; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Tsutomu Imaizumi; Yoshihiro Fukumoto
PLOS ONE, Oct. 2017, [Reviewed]
Corresponding - Loss of MURC/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm
Kotaro Miyagawa; Takehiro Ogata; Tomomi Ueyama; Takeru Kasahara; Naohiko Nakanishi; Daisuke Naito; Takuya Taniguchi; Tetsuro Hamaoka; Naoki Maruyama; Masahiro Nishi; Taizo Kimura; Hiroyuki Yamada; Hiroki Aoki; Satoaki Matoba
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2017, [Reviewed] - Genetic Ablation of MicroRNA-33 Attenuates Inflammation and Abdominal Aortic Aneurysm Formation via Several Anti-Inflammatory Pathways
Tetsushi Nakao; Takahiro Horie; Osamu Baba; Masataka Nishiga; Tomohiro Nishino; Masayasu Izuhara; Yasuhide Kuwabara; Hitoo Nishi; Shunsuke Usami; Fumiko Nakazeki; Yuya Ide; Satoshi Koyama; Masahiro Kimura; Naoya Sowa; Satoko Ohno; Hiroki Aoki; Koji Hasegawa; Kazuhisa Sakamoto; Kenji Minatoya; Takeshi Kimura; Koh Ono
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2017, [Reviewed] - Taking Control of the Time Bomb in Abdominal Aortic Aneurysm
Hiroki Aoki
CIRCULATION JOURNAL, Feb. 2016, [Reviewed]
Lead, Corresponding - Mouse model of abdominal aortic aneurysm induced by CaCl2
Hiroki Aoki; Satoko Ohno; Aya Furusho; Michihide Nishihara; Norifumi Nishida; Saki Hirakata; Koichi Yoshimura
Mouse Models of Vascular Diseases, 01 Jan. 2016, [Reviewed]
Lead, Corresponding - Tissue remodeling in vascular wall in Kawasaki disease-related vasculitis model mice
Yukako Yoshikane; Mitsuhisa Koga; Tamaki Cho; Kyoko Imanaka-Yoshida; Yumi Yamamoto; Junichi Hashimoto; Hiroki Aoki; Koichi Yoshimura; Shinichi Hirose
Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology, 01 Jan. 2016, [Reviewed] - Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms
Batmunkh Bumdelger; Hiroki Kokubo; Ryo Kamata; Masayuki Fujii; Koichi Yoshimura; Hiroki Aoki; Yuichi Orita; Takafumi Ishida; Megu Ohtaki; Masataka Nagao; Mari Ishida; Masao Yoshizumi
PLOS ONE, Jan. 2016, [Reviewed] - Renal Nerve-Mediated Erythropoietin Release Confers Cardioprotection During Remote Ischemic Preconditioning
Toyoharu Oba; Hideo Yasukawa; Takanobu Nagata; Sachiko Kyogoku; Tomoko Minami; Michihide Nishihara; Hideki Ohshima; Kazutoshi Mawatari; Shoichiro Nohara; Jinya Takahashi; Yusuke Sugi; Sachiyo Igata; Yoshiko Iwamoto; Hisashi Kai; Hidehiro Matsuoka; Makoto Takano; Hiroki Aoki; Yoshihiro Fukumoto; Tsutomu Imaizumi
CIRCULATION JOURNAL, Jul. 2015, [Reviewed] - Fountain of Youth in the Aorta
Hiroki Aoki
CIRCULATION JOURNAL, Jul. 2015, [Reviewed]
Lead, Corresponding - Inhibitory Effect of Statins on Inflammation-Related Pathways in Human Abdominal Aortic Aneurysm Tissue
Koichi Yoshimura; Ayako Nagasawa; Junichi Kudo; Masahiko Onoda; Noriyasu Morikage; Akira Furutani; Hiroki Aoki; Kimikazu Hamano
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, May 2015, [Reviewed] - Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules
Takanobu Nagata; Hideo Yasukawa; Sachiko Kyogoku; Toyoharu Oba; Jinya Takahashi; Shoichiro Nohara; Tomoko Minami; Kazutoshi Mawatari; Yusuke Sugi; Koutatsu Shimozono; Sylvain Pradervand; Masahiko Hoshijima; Hiroki Aoki; Yoshihiro Fukumoto; Tsutomu Imaizumi
PLOS ONE, May 2015, [Reviewed] - Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma
Bo-Kyung Son; Daigo Sawaki; Shota Tomida; Daishi Fujita; Kenichi Aizawa; Hiroki Aoki; Masahiro Akishita; Ichiro Manabe; Issei Komuro; Scott L. Friedman; Ryozo Nagai; Toru Suzuki
NATURE COMMUNICATIONS, Apr. 2015, [Reviewed] - BMP type I receptor inhibition attenuates endothelial dysfunction in mice with chronic kidney disease
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Suguru Yasuoka; Takahiro Anegawa; Yuji Mishina; Akira Suzuki; Yoshihiro Fukumoto; Tsutomu Imaizumi
KIDNEY INTERNATIONAL, Jan. 2015, [Reviewed] - Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Takaya Ishihara; Reiko Ban-Ishihara; Maki Maeda; Yui Matsunaga; Ayaka Ichimura; Sachiko Kyogoku; Hiroki Aoki; Shun Katada; Kazuto Nakada; Masatoshi Nomura; Noboru Mizushima; Katsuyoshi Mihara; Naotada Ishihara
Molecular and cellular biology, Jan. 2015, [Reviewed] - Inflammasome Activation by Mitochondrial Oxidative Stress in Macrophages Leads to the Development of Angiotensin II-Induced Aortic Aneurysm
Fumitake Usui; Koumei Shirasuna; Hiroaki Kimura; Kazuki Tatsumi; Akira Kawashima; Tadayoshi Karasawa; Koichi Yoshimura; Hiroki Aoki; Hiroko Tsutsui; Tetsuo Noda; Junji Sagara; Shun'ichiro Taniguchi; Masafumi Takahashi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jan. 2015, [Reviewed] - Tenascin C protects aorta from acute dissection in mice
Taizo Kimura; Kozoh Shiraishi; Aya Furusho; Sohei Ito; Saki Hirakata; Norifumi Nishida; Koichi Yoshimura; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; Yasuhiro Ikeda; Takanobu Miyamoto; Takafumi Ueno; Kimikazu Hamano; Michiaki Hiroe; Kazutaka Aonuma; Masunori Matsuzaki; Tsutomu Imaizumi; Hiroki Aoki
SCIENTIFIC REPORTS, Feb. 2014, [Reviewed]
Corresponding - Prostaglandin E-2 Inhibits Elastogenesis in the Ductus Arteriosus via EP4 Signaling
Utako Yokoyama; Susumu Minamisawa; Aki Shioda; Ryo Ishiwata; Mei-Hua Jin; Munetaka Masuda; Toshihide Asou; Yukihiko Sugimoto; Hiroki Aoki; Tomoyuki Nakamura; Yoshihiro Ishikawa
CIRCULATION, Jan. 2014, [Reviewed] - Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system
Kyoko Imanaka-Yoshida; Hiroki Aoki
Frontiers in Physiology, 2014, [Reviewed] - JNK阻害薬による動脈瘤形成の抑制 川崎病類似汎血管炎モデルマウスを用いた検討
吉兼 由佳子; 吉村 耕一; 今中 恭子; 長 環; 古賀 允久; 山本 由美子; 青木 浩樹; 橋本 淳一; 上田 誠; 廣瀬 伸一
日本小児循環器学会雑誌, Jun. 2013 - Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice
Haruya Ohmura; Hideo Yasukawa; Tomoko Minami; Yusuke Sugi; Toyoharu Oba; Takanobu Nagata; Sachiko Kyogoku; Hideki Ohshima; Hiroki Aoki; Tsutomu Imaizumi
HYPERTENSION RESEARCH, Nov. 2012, [Reviewed] - Modern Angiogenic Thermal Therapy From the Country of Traditional Thermal Therapy
Hiroki Aoki
CIRCULATION JOURNAL, Jul. 2012, [Reviewed]
Lead, Corresponding - Macrophage-Derived Angiopoietin-Like Protein 2 Accelerates Development of Abdominal Aortic Aneurysm
Hirokazu Tazume; Keishi Miyata; Zhe Tian; Motoyoshi Endo; Haruki Horiguchi; Otowa Takahashi; Eiji Horio; Hiroto Tsukano; Tsuyoshi Kadomatsu; Yukiko Nakashima; Ryuji Kunitomo; Yasushi Kaneko; Shuji Moriyama; Hisashi Sakaguchi; Ken Okamoto; Masahiko Hara; Takashi Yoshinaga; Koichi Yoshimura; Hiroki Aoki; Kimi Araki; Hiroyuki Hao; Michio Kawasuji; Yuichi Oike
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Jun. 2012, [Reviewed] - Inhibition of EP4 Signaling Attenuates Aortic Aneurysm Formation
Utako Yokoyama; Ryo Ishiwata; Mei-Hua Jin; Yuko Kato; Orie Suzuki; Huiling Jin; Yasuhiro Ichikawa; Syun Kumagaya; Yuzo Katayama; Takayuki Fujita; Satoshi Okumura; Motohiko Sato; Yukihiko Sugimoto; Hiroki Aoki; Shinichi Suzuki; Munetaka Masuda; Susumu Minamisawa; Yoshihiro Ishikawa
PLOS ONE, May 2012, [Reviewed] - Inhibition of eNOS phosphorylation mediates endothelial dysfunction in renal failure: new effect of asymmetric dimethylarginine
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Suguru Yasuoka; Takahiro Anegawa; Yuji Aoki; Seiji Ueda; Seiya Okuda; Tsutomu Imaizumi
KIDNEY INTERNATIONAL, Apr. 2012, [Reviewed] - Heart Failure-Inducible Gene Therapy Targeting Protein Phosphatase 1 Prevents Progressive Left Ventricular Remodeling
Yosuke Miyazaki; Yasuhiro Ikeda; Kozo Shiraishi; Shizuka N. Fujimoto; Hidekazu Aoyama; Koichi Yoshimura; Makoto Inui; Masahiko Hoshijima; Hideko Kasahara; Hiroki Aoki; Masunori Matsuzaki
PLOS ONE, Apr. 2012, [Reviewed] - Prostaglandin E-2-EP4 Signaling Inhibits Vascular Elastic Fiber Formation in the Rodent Ductus Arteriosus.
Minamisawa S; Yokoyama U; Ishiwata R; Sugimoto Y; Aoki H; Nakamura T; Ishikawa Y
2012, [Reviewed] - Recent advances in pharmacotherapy development for abdominal aortic aneurysm
Koichi Yoshimura; Hiroki Aoki
International Journal of Vascular Medicine, 2012, [Reviewed] - Innocent bystander? Intraluminal thrombus in abdominal aortic aneurysm
Koichi Yoshimura; Yasuhiro Ikeda; Hiroki Aoki
ATHEROSCLEROSIS, Oct. 2011, [Reviewed] - Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process
Taizo Kimura; Koichi Yoshimura; Hiroki Aoki; Kyoko Imanaka-Yoshida; Toshimichi Yoshida; Yasuhiro Ikeda; Noriyasu Morikage; Hisako Endo; Kimikazu Hamano; Tsutomu Imaizumi; Michiaki Hiroe; Kazutaka Aonuma; Masunori Matsuzaki
PATHOLOGY INTERNATIONAL, Oct. 2011, [Reviewed]
Corresponding - Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization
Hidehiro Kaneko; Toshihisa Anzai; Maho Morisawa; Takashi Kohno; Toshiyuki Nagai; Atsushi Anzai; Toshiyuki Takahashi; Masayuki Shimoda; Aya Sasaki; Yuichiro Maekawa; Koichi Yoshimura; Hiroki Aoki; Kazuo Tsubota; Tsutomu Yoshikawa; Yasunori Okada; Satoshi Ogawa; Keiichi Fukuda
ATHEROSCLEROSIS, Aug. 2011, [Reviewed] - Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm
Hidehiro Kaneko; Toshihisa Anzai; Toshiyuki Takahashi; Takashi Kohno; Masayuki Shimoda; Aya Sasaki; Hideyuki Shimizu; Toshiyuki Nagai; Yuichiro Maekawa; Koichi Yoshimura; Hiroki Aoki; Tsutomu Yoshikawa; Yasunori Okada; Ryohei Yozu; Satoshi Ogawa; Keiichi Fukuda
CARDIOVASCULAR RESEARCH, Jul. 2011, [Reviewed] - Hepatocyte growth factor promotes an anti-inflammatory cytokine profile in human abdominal aortic aneurysm tissue
Yusuke Shintani; Hiroki Aoki; Michihide Nishihara; Satoko Ohno; Aya Furusho; Shin-ichi Hiromatsu; Hidetoshi Akashi; Tsutomu Imaizumi; Shigeaki Aoyagi
ATHEROSCLEROSIS, Jun. 2011, [Reviewed]
Corresponding - Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling
Hidekazu Aoyama; Yasuhiro Ikeda; Yosuke Miyazaki; Koichi Yoshimura; Shizuka Nishino; Takeshi Yamamoto; Masafumi Yano; Makoto Inui; Hiroki Aoki; Masunori Matsuzaki
CARDIOVASCULAR RESEARCH, Jan. 2011, [Reviewed] - Prostaglandin EP4 Signaling Negatively Regulates Vascular Elastic Fiber Assembly in the Ductus Arteriosus
Yokoyama Utako; Shioda Aki; Kato Yuko; Asou Toshihide; Aoki Hiroki; Nakamura Tomoyuki; Minamisawa Susumu; Ishikawa Yoshihiro
CIRCULATION, 23 Nov. 2010, [Reviewed] - 大動脈ステントグラフトの未来 再充填可能な薬剤徐放性ステントグラフトの開発と将来展望
吉村 耕一; 青木 浩樹; 黒田 俊一; 堤 宏守; 濱野 公一
人工臓器, Nov. 2010 - IT技術と21世紀の外科 日本発の新しい医療機器、システム 大動脈瘤低侵襲治療のための革新的システムの開発と展望
吉村 耕一; 青木 浩樹; 黒田 俊一; 堤 宏守; 古谷 彰; 濱野 公一
日本外科学会雑誌, Mar. 2010 - Tenascin-c Has a Protective Role During the Development of Abdominal Aortic Aneurysm
Kimura, Taizo; Yoshimura, Koichi; Aoki, Hiroki; Ikeda, Yasuhiro; Imanaka-Yoshida, Kyoko; Yoshida, Toshimichi; Hamano, Kimikazu; Hiroe, Michiaki; Aonuma, Kazutaka; Matsuzaki, Masunori
CIRCULATION, Nov. 2009, [Reviewed] - 人工臓器としてのステントグラフト 素材とデザインの問題点 再充填可能な薬剤徐放性ステントグラフトの開発
吉村 耕一; 青木 浩樹; 黒田 俊一; 堤 宏守; 古谷 彰; 濱野 公一; 松崎 益徳
人工臓器, Oct. 2009 - 大動脈瘤壁においてACE阻害薬は組織保護サイトカインHGFの分泌を促進する
新谷 悠介; 青木 浩樹; 奈田 慎一; 金谷 蔵人; 坂下 英樹; 鬼塚 誠二; 岡崎 悌之; 福永 周司; 廣松 伸一; 明石 英俊; 今泉 勉; 青柳 成明
脈管学, Sep. 2009 - Angiotensin II Induces Cardiac Systolic and Diastolic Dysfunction via Toll-Like Receptor 4 Mediated Upregulation of Oxidative Stress in Murine Heart
Susumu Matsuda; Seiji Umemoto; Hiroko Yoshino; Shinichi Itoh; Hiroki Aoki; Koichi Yoshimura; Murata Tomoaki; Masunori Matsuzaki
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2009, [Reviewed] - PJ-789 Angiotensin II Induces Cardiac Systolic and Diastolic Dysfunction via Toll-like Receptor 4 Mediated Up-regulation of Oxidative Stress in Murine Heart(PJ132,Heart Failure, Basic (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The
Matsuda Susumu; Umemoto Seiji; Yoshino Hiroko; Itoh Shinichi; Aoki Hiroki; Yoshimura Koichi; Murata Tomoaki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009 - PJ-306 Toll-like Receptor 4 Upregulates Oxidative Stress by Inhibiting Extracellular Superoxide Dismutase in Angiotensin II-induced Hypertension(PJ052,Hypertension, Basic (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Cir
Yoshino Hiroko; Umemoto Seiji; Matsuda Susumu; Itoh Shinichi; Aoki Hiroki; Yoshimura Koichi; Murata Tomoaki; Fukai Tohru; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009 - OJ-249 Tenascin-C is Tissue Protective during the Development of Abdominal Aortic Aneurysm in Mice(OJ42,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Ci
Kimura, Taizo; Yoshimura, Koichi; Aoki, Hiroki; Ikeda, Yasuhiro; Imanaka-yoshida, Kyoko; Hiroe, Michiaki; Aonuma, Kazutaka; Matsuzaki, Masunori
Circulation journal : official journal of the Japanese Circulation Society, Mar. 2009, [Reviewed]
Corresponding - Regression of Abdominal Aortic Aneurysms through Pharmacologic Therapy
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
ADVANCES IN UNDERSTANDING AORTIC DISEASES, 2009, [Reviewed] - TOLL-LIKE RECEPTOR 4 INCREASES OXIDATIVE STRESS BY INHIBITING EXTRACELLULAR SUPEROXIDE DISMUTASE IN ANGIOTENSIN II-INDUCED HYPERTENSION
Hiroko Yoshino; Seiji Umemoto; Susumu Matsuda; Tadaaki Nakashima; Shinichi Itoh; Hiroki Aoki; Koichi Yoshimura; Tomoaki Murata; Tohru Fukai; Masunori Matsuzaki
JOURNAL OF VASCULAR RESEARCH, 2009, [Reviewed] - Toll-Like Receptor 4 Upregulates Oxidative Stress by Inhibiting the Upregulation of Extracellular Superoxide Dismutase in Angiotensin II-Induced Hypertension
Hiroko Yoshino; Seiji Umemoto; Shinichi Ito; Susumu Matsuda; Hiroki Aoki; Koichi Yoshimura; Tomoaki Murata; Masunori Matsuzaki
CIRCULATION, Oct. 2008, [Reviewed] - PJ-326 Effect of Toll-like Receptor 4 on Cardiac Hypertrophy and Function in Angiotensin II-induced Hypertension(Hypertension, basic(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Yoshino Hiroko; Umemoto Seiji; Itoh Shinichi; Matsuda Susumu; Aoki Hiroki; Yoshimura Koichi; Murata Tomoaki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008 - 適応の破綻と修復 心不全での脱リン酸化制御とカルシウムハンドリング
池田 安宏; 青木 浩樹; 青山 英和; 吉村 耕一; 山本 健; 矢野 雅文; 松崎 益徳
適応医学, May 2007 - Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY AND MOLECULAR BIOLOGY, 2006, [Reviewed] - Characterization of Homo- and Heterodimerization of Cardiac Csx/Nkx2.5 Homeoprotein
Hideko Kasahara; Anny Usheva; Tomomi Ueyama; Hiroki Aoki; Nobuo Horikoshi; Seigo Izumo
Journal of Biological Chemistry, 16 Feb. 2001, [Reviewed] - Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation
PM Kang; A Haunstetter; H Aoki; A Usheva; S Izumo
CIRCULATION RESEARCH, Jul. 2000, [Reviewed] - Angiotensin II and serum differentially regulate expression of cyclins, activity of cyclin-dependent kinases, and phosphorylation of retinoblastoma gene product in neonatal cardiac myocytes
J Sadoshima; H Aoki; S Izumo
CIRCULATION RESEARCH, Feb. 1997, [Reviewed]
- STAT3 in Vascular Smooth Muscle Cells Protects Aorta From Dissection by Reinforcing Aortic Wall
Saki Hirakata; Hiroki Aoki; Michihide Nishihara; Satoko Ohno; Aya Furusho; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Yoshihiro Fukumoto
CIRCULATION, Nov. 2015 - Excessive NaCl Intake Aggravates Aortic Dissection Through IL-17 Pathway
Norifumi Nishida; Hiroki Aoki; Satoko Ohno; Michihide Nishihara; Aya Furusho; Saki Hirakata; Makiko Hayashi; Sohei Ito; Hideo Yasukawa; Yoshihiro Fukumoto
CIRCULATION, Nov. 2015 - The Role of Macrophage STAT3 Signaling in Pathogenesis of Aortic Dissection
Satoko Ohno; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Makiko Hayashi; Yoshihiro Fukumoto
CIRCULATION, Nov. 2015 - A Common Gene Network Governs the Cellular Phenotypes in Acute Aortic Dissection
Satoko Ohno; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Hideo Yasukawa; Yoshihiro Fukumoto
CIRCULATION, Nov. 2014 - Protective Role of Stat3 in Vascular Smooth Muscle Cells During the Development of Acute Aortic Dissection
Saki Hirakata; Hiroki Aoki; Michihide Nishihara; Satoko Ohno; Aya Furusho; Norifumi Nishida; Sohei Ito; Yoshihiro Fukumoto
CIRCULATION, Nov. 2014 - Involvement of IL-6 in Pathogenesis of Abdominal Aortic Aneurysm
Michihide Nishihara; Hiroki Aoki; Satoko Ohno; Aya Furusho; Saki Hirakata; Norifumi Nishida; Sohei Ito; Tsutomu Imaizumi
CIRCULATION, Nov. 2013 - C.-jun N-terminal Kinase is a Novel Therapeutic Target for Controlling the Development of Kawasaki Disease-related Arterial Aneurysm
Yukako Yoshikane; Mitsuhisa Koga; Tamaki Cho; Kyoko Imanaka-Yoshida; Junichi Hashimoto; Hiroki Aoki; Koichi Yoshimura; Shinichi Hirose
CIRCULATION, Nov. 2013 - Deciphering the Sequential Molecular Events During Onset of Acute Aortic Dissection
Satoko Ohno; Hiroki Aoki; Michihide Nishihara; Aya Furusho; Saki Hirakata; Norifumi Nishida; Souhei Itou; Tsutomu Imaizumi
CIRCULATION, Nov. 2013 - BMP Type I Receptor Inhibition Reduces Endothelial Dysfunction and Vascular Osteogenic Differentiation in Mice With Chronic Kidney Disease
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Yoshiko Iwamoto; Takahiro Anegawa; Kenji Fukuda; Tsutomu Imaizumi
CIRCULATION, Nov. 2013 - Increased Phosphatase and Tensin Homolog Plays a Crucial Role in Endothelial Dysfunction in Mice with Renal Failure
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Takahro Anegawa; Tsutomu Imaizumi
CIRCULATION, Nov. 2012 - Cardiac-Specific Deletion of Suppressor of Cytokine Signaling-3 Prevents Doxorubicin-Induced Cardiomyopathy in Mice
Sachiko Kyogoku; Hideo Yasukawa; Takanobu Nagata; Toyoharu Oha; Hideki Ohshima; Tomoko Minami; Toshitaka Yajima; Masahiko Hoshijima; Hiroki Aoki; Kirk U. Knowlton; Tsutomu Imaizumi
CIRCULATION, Nov. 2012 - Inhibition of CaMKII/ERK-Mediated eNOS Phosphorylation Impairs Endothelial Function in Renal Failure Mice: New Effect of AsymmetricDimethylarginine
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Hiroki Uchiwa; Yuji Aoki; Tsutomu Imaizumi
JOURNAL OF CARDIAC FAILURE, Oct. 2012 - 新たな技術で探る血管構築から機能獲得へのメカニズム 血管の弾性機能制御の分子メカニズム
横山 詩子; 塩田 亜樹; 石渡 遼; 鈴木 伸一; 益田 宗孝; 麻生 俊英; 青木 浩樹; 杉本 幸彦; 中邨 智之; 南沢 享; 石川 義弘
日本生理学雑誌, Sep. 2012 - Tenascin C protects aorta from acute dissection in mice.
H. Aoki; T. Kimura; K. Yoshimura; K. Shiraishi; K. Imanaka-Yoshida; T. Yoshida; Y. Ikeda; T. Miyamoto; M. Hiroe; K. Hamano; K. Aonuma; M. Matsuzaki; T. Imaizumi
MOLECULAR BIOLOGY OF THE CELL, 2012 - Activation of Hypoxia Inducible Factor-Erythropoietin Pathway May Prevent Acute Myocardial Injury During Remote Ischemic Preconditioning
Toyoharu Oba; Hideo Yaskawa; Takanobu Nagata; Sachiko Kyougoku; Nobuyoshi Futamata; Kazutoshi Mawatari; Tomoko Minami; Yusuke Sugi; Daisuke Fukui; Hiroki Aoki; Tsutomu Imaizumi
CIRCULATION, Nov. 2011 - Inhibition of CaMKII- and ERK-Mediated eNOS Phosphorylation Impairs Endothelial Function in Renal Failure Mice: New Effect of Asymmetric Dimethylarginine
Hidemi Kajimoto; Hisashi Kai; Suguru Yasuoka; Takahiro Anegawa; Hiroki Aoki; Tsutomu Imaizumi
CIRCULATION, Nov. 2011 - Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca2+ cycling
Hidekazu Aoyama; Yasuhiro Ikeda; Yosuke Miyazaki; Koichi Yoshimura; Shizuka Nishino; Takeshi Yamamoto; Masafumi Yano; Makoto Inui; Hiroki Aoki; Masunori Matsuzaki
CARDIOVASCULAR RESEARCH, Jan. 2011 - プロスタグランディンE受容体EP4シグナルによる弾性線維形成の制御
塩田 亜樹; 横山 詩子; 加藤 優子; 麻生 俊英; 青木 浩樹; 中邨 智之; 南沢 亨; 石川 義弘
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010 - Increased Circulating Asymmetric Dimethylarginine in Chronic Kidney Disease Mice Induces Endothelial Dysfunction by Inhibiting Ca/Calmodulin-Dependent Protein Kinase II-eNOS Signaling
Hidemi Kajimoto; Hisashi Kai; Hiroki Aoki; Suguru Yasuoka; Takahiro Anegawa; Tsutomu Imaizumi
CIRCULATION, Nov. 2010 - Helicobacter pylori CagA inhibits endocytosis of cytotoxin VacA in host cells
Junko K. Akada; Hiroki Aoki; Yuji Torigoe; Takao Kitagawa; Hisao Kurazono; Hisashi Hoshida; Jun Nishikawa; Shuji Terai; Masunori Matsuzaki; Toshiya Hirayama; Teruko Nakazawa; Rinji Akada; Kazuyuki Nakamura
DISEASE MODELS & MECHANISMS, Sep. 2010 - Protein Phosphatase 1 beta is Critical to Determine Cardiac Systolic and Diastolic Function in Cardiomyopathic Mice
Yosuke Miyazaki; Yasuhiro Ikeda; Hidekazu Aoyama; Kouzou Shiraishi; Koichi Yoshimura; Masafumi Yano; Hiroki Aoki; Masunori Matsuzaki
JOURNAL OF CARDIAC FAILURE, Sep. 2010 - 1) Activation of JNK and Aortic Diseases.
Yoshimura Koichi; Aoki Hiroki; Hamano Kimikazu; Matsuzaki Masunori
Nihon Naika Gakkai Zasshi, 10 Feb. 2010 - Lysyl oxidase resolves inflammation by reducing monocyte chemoattractant protein-1 in abdominal aortic aneurysm
Masahiko Onoda; Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Noriyasu Morikage; Akira Furutani; Masunori Matsuzaki; Kimikazu Hamano
ATHEROSCLEROSIS, Feb. 2010 - Role of Vascular Endothelial Growth Factor-A in the Development of Mice CaCl2 Induced Abdominal Aortic Aneurysm
Hidehiro Kaneko; Toshihisa Anzai; Toshiyuki Takahashi; Yuichiro Maekawa; Masayuki Shimoda; Koichi Yoshimura; Hiroki Aoki; Hideyuki Shimizu; Yasunori Okada; Ryohei Yozu; Tsutomu Yoshikawa; Satoshi Ogawa
CIRCULATION, Nov. 2009 - Asymmetric Dimethylarginine Triggers Vasculo-Renal Interaction in CKD Mice
Hidemi Kajimoto; Hisashi Kai; Suguru Yasuoka; Takahiro Anegawa; Hiroki Aoki; Tsutomu Imaizumi
CIRCULATION, Nov. 2009 - Asymmetric Dimethylarginine is a Paracrine Regulator of Vascular Function in CKD
Hidemi Kajimoto; Hisashi Kai; Suguru Yasuoka; Hiroki Aoki; Takahiro Anegawa; Tsutomu Imaizumi
JOURNAL OF CARDIAC FAILURE, Sep. 2009 - PE-190 Involvement of JNK2 in Mechanosensing and Proinflammatory Signaling during Development of Aortic Aneurysm(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Kimura Taizo; Ikeda Yasuhiro; Aoyama Hidekazu; Miyazaki Yosuke; Morikage Noriyasu; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009 - PJ-071 In Vivo Knockdown of Protein Phosphatase 1β Augments Cardiac Contracitility in Mice(PJ012,Calcium Handling, Cardiac Function (Basic) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Miyazaki Yousuke; Ikeda Yasuhiro; Aoyama Hidekazu; Yoshimura Koichi; Yano Masafumi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009 - PJ-073 Protein Phosphatase 1 Beta is Most Significant Subunit in the Longitudinal Sarcoplasmic Reticulum and Controles Phospholamban Phosphorylation in Cardiomyocytes(PJ012,Calcium Handling, Cardiac Function (Basic) (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Aoyama Hidekazu; Ikeda Yasuhiro; Miyazaki Yousuke; Ono Makoto; Yamamoto Ken; Yano Masafumi; Yoshimura Koichi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009 - 1 Stage-Specific Molecular Therapy for Abdominal Aortic Aneurysm(Recent Progress in Diagnosis and Treatment of Aortic Diseases,Symposium 5 (SY-05) (A),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
Aoki Hiroki; Yoshimura Koichi; Shigematsu Hiroshi; Imaizumi Tsutomu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2009 - RhoH plays critical roles in Fc epsilon RI-dependent signal transduction in mast cells.
Hiroyo Oda; Manabu Fujimoto; Michael S Patrick; Dai Chida; Yoshinori Sato; Yoshinao Azuma; Hiroki Aoki; Takaya Abe; Harumi Suzuki; Mutsunori Shirai
Journal of immunology (Baltimore, Md. : 1950), 15 Jan. 2009 - RhoH Plays Critical Roles in Fc epsilon RI-Dependent Signal Transduction in Mast Cells
Hiroyo Oda; Manabu Fujimoto; Michael S. Patrick; Dai Chida; Yoshinori Sato; Yoshinao Azuma; Hiroki Aoki; Takaya Abe; Harumi Suzuki; Mutsunori Shirai
JOURNAL OF IMMUNOLOGY, Jan. 2009 - 191) Angiotensin II負荷高血圧マウスにおけるToll-Like Receptor 4の血管リモデリングに対する役割(第92回日本循環器学会中国・四国合同地方会)
吉野 敬子; 梅本 誠治; 伊藤 真一; 松田 晋; 青木 浩樹; 吉村 耕一; 村田 智昭; 松暗 益徳
Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2008 - 198) 蛋白ホスファターゼ1βは,心筋培養細胞系においてホスホランバン脱リン酸化の主要なホスファターゼである(第92回日本循環器学会中国・四国合同地方会)
青山 英和; 池田 安宏; 吉村 耕一; 矢野 雅文; 青木 浩樹; 松崎 益徳
Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2008 - The Vascular Smooth Muscle Cell-Autonomous Role of Id2 in Phenotypic Modulation In Vitro And Atherogenesis In Vivo
Hiroki Aoki; Koichi Yoshimura; Yasuhiro Ikeda; Masunori Matsuzaki
CIRCULATION, Oct. 2008 - Protein Phosphatase 1 Beta is Most Abundant Isoform in the Longitudinal Sarcoplasmic Reticulum and Regulates Phospholamban Phosphorylation in Cardiomyocytes
Hidekazu Aoyama; Yasuhiro Ikeda; Yosuke Miyazaki; Makoto Ono; Koichi Yoshimura; Takeshi Yamamoto; Masafumi Yano; Hiroki Aoki; Makoto Inui; Masunori Matsuzaki
CIRCULATION, Oct. 2008 - Role of NonO-histone interaction in TNF alpha-suppressed prolyl-4-hydroxylase alpha 1
Cheng Zhang; Ming-Xiang Zhang; Ying H. Shen; Jared K. Burks; Xiao-Nan Li; Scott A. LeMaire; Koichi Yoshimura; Hiroki Aoki; Masunori Matsuzaki; Feng-Shuang An; David A. Engler; Rise K. Matsunami; Joseph S. Coselli; Yun Zhang; Xing Li Wang
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Aug. 2008 - Role of Protein Phosphatase 1 Isoforms on Calcium Regulation in the Sarcoplasmic Reticulum
Yasuhiro Ikeda; Hidekazu Aoyama; Hiroki Aoki; Koichi Yoshmura; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
CIRCULATION RESEARCH, Aug. 2008 - 97) 高血圧性心肥大形成過程におけるToll-Like Receptor 4の役割(第91回日本循環器学会中国地方会)
吉野 敬子; 梅本 誠治; 伊藤 真一; 松田 晋; 青木 浩樹; 吉村 耕一; 村田 智昭; 松崎 益徳
Circulation journal : official journal of the Japanese Circulation Society, 20 Apr. 2008 - Novel role of antioxidant-1 (Atox1) as a copper-dependent transcription factor involved in cell proliferation
Shinichi Itoh; Ha Won Kim; Osamu Nakagawa; Kiyoshi Ozumi; Susan M. Lessner; Hiroki Aoki; Kamran Akram; Ronald D. McKinney; Masuko Ushio-Fukai; Tohru Fukai
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2008 - Identification of cardiac-specific myosin light chain kinase
Jason Y. Chan; Morihiko Takeda; Laura E. Briggs; Megan L. Graham; Jonathan T. Lu; Nobuo Horikoshi; Ellen O. Weinberg; Hiroki Aoki; Naruki Sato; Kenneth R. Chien; Hideko Kasahara
CIRCULATION RESEARCH, Mar. 2008 - 2 Critical Role of JNK in Chronic Inflammation of Abdominal Aortic Aneurysms(Chronic Inflammation and Cardiovascular Diseases,Roundtable Discussion 7 (RT-07) (H),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008 - 4 Phospho-regulation of Sarcoplasmic Reticulum Microdomain in Heart Failure(Symposium 7 (SY-07) (M) Molecular Mechanism and Novel Therapeutic Target in Heart Failure,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Ikeda Yasuhiro; Aoki Hiroki; Aoyama Hidekazu; Yamamoto Takeshi; Yoshimura Koichi; Yano Masafumi; matsuzaki masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008 - PE-179 JNK Activation Causes Endoplasmic Reticulum Stress Response in Adipocytes to Suppress The Adiponectin Secretion In Vivo(Diabetes/Obesity/Metabolic syndrome(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Aoki Hiroki; Yoshimura Koichi; Ikeda Yasuhiro; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008 - PE-115 Critical Role of JNK2 for Development of Abdominal Aortic Aneurysm in Mice(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Aoyama Hidekazu; Morikage Noriyasu; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008 - OJ-092 Protein Phosphatase 1 β is the Major Phospholamban Phosphatase that Negatively Regulates Cardiac Contraction and Relaxation.(Heart failure, basic(02)(M),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Aoyama Hidekazu; Ikeda Yasuhiro; Yoshimura Koichi; Yano Masafumi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2008 - Research Opportunities in the Translational Research of Aortic Aneurysm
AOKI Hiroki; YOSHIMURA Koichi; MATSUZAKI Masunori
KAGAKU TO SEIBUTSU, 01 Mar. 2008 - 大動脈瘤に対する薬物療法開発の最前線
吉村耕一; 青木浩樹; 松﨑益徳
医学のあゆみ, 2008 - 大動脈瘤の分子病態と研究の可能性
青木浩樹; 吉村耕一; 松﨑益德
実験医学, 2008 - 大動脈瘤に対する薬物療法のup-to-date.
吉村耕一; 青木浩樹; 木村泰三; 古谷彰; 濱野公一; 松﨑益徳
Heart View, 2008 - 大動脈瘤に対する薬物治療
吉村耕一; 青木浩樹; 古谷彰; 濱野公一; 松崎益徳
Heart View, 2008 - 3. Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy
Wang Lili
Yamaguchi medical journal, 31 Dec. 2007 - Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy
Hiroki Aoki; Koichi Yoshimura; Masunori Matsuzaki
JOURNAL OF MOLECULAR MEDICINE-JMM, Oct. 2007 - C-jun n-terminal kinase 2 is required for development of abdominal aortic aneurysm in mice
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Hidekazu Aoyama; Noriyasu Morikage; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
CIRCULATION, Oct. 2007 - Protein phosphatase 1 beta is the major phospholamban phosphatase that regulates cardiomyocyte contractility
Hidekazu Aoyama; Yasuhiro Ikeda; Koichi Yoshimura; Masafumi Yano; Hiroki Aoki; Masunori Matsuzalki
CIRCULATION, Oct. 2007 - Cardiaic-specific myosin light chain kinase (MLCK), a third member of MLCK family, potentiates sarcomere formation and cardiac contraction
Jason Y. Chan; Morihilko Takeda; Laura E. Briggs; Jonathan T. Lu; Nobuo Horikoshi; Ellen Weinberg; Hiroki Aoki; Kenneth R. Chien; Hideko Kasahara
CIRCULATION, Oct. 2007 - TNF-alpha suppresses prolyl-4-hydroxylase alpha 1 expression via the ASK1-JNK-NonO pathway
Cheng Zhang; Ming-Xiang Zhang; Ying H. Shen; Jared K. Burks; Yun Zhang; Jian Wang; Scott A. LeMaire; Koichi Yoshimura; Hiroki Aoki; Joseph S. Coselli; Xing Li Wang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Aug. 2007 - 110)瘤壁培養法を用いた腹部大動脈瘤治療薬の探索(第89回日本循環器学会中国地方会)
小野寺 雅彦; 吉村 耕一; 森景 則保; 古谷 彰; 池田 安宏; 青木 浩樹; 松崎 益徳; 濱野 公一
Circulation journal : official journal of the Japanese Circulation Society, 20 Apr. 2007 - 細胞外マトリックスの安定化は炎症シグナルを抑制し, 腹部大動脈瘤形成を阻止する
小野田 雅彦; 吉村 耕一; 森景 則保; 古谷 彰; 池田 安宏; 青木 浩樹; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 10 Mar. 2007 - OE-175 Stabilization of Extracellular Matrix Counteracts Proinflammatory Signaling and Prevents Progression of Abdominal Aortic Aneurysm(Molecular biology, vascular-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Onoda Masahiko; Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Morikage Noriyasu; Furutani Akira; Matsuzaki Masunori; Hamano Kimikazu
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - 4 The Essential Role of c-Jun N-Terminal Kinase in Destructive Vascular Remodeling(New Insight and Therapeutic Strategy for Plaque Stabilization, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Aoki Hiroki; Yoshimura Koichi; Ikeda Yasuhiro; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - FRS-034 Statins Reduce NF-κ B Activation and Chemokine Secretion in Human Abdominal Aortic Aneurysm Wall(Pathophysiology of Cardiovascular Disease, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Kudo Junichi; Aoki Hiroki; Onoda Masahiko; Ikeda Yasuhiro; Morikage Noriyasu; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - OE-315 Protein Phosphatase 1β is the Major Phospholamban Phosphatase in Adult Rat Cardiomyocytes(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Aoyama Hidekazu; Ikeda Yasuhiro; Yoshimura Koichi; Aoki Hiroki; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - OE-310 Specific Inhibition of Sarcoplasmic Reticulum-associated Protein Phosphatase 1 by Inhibitor-2 Confers a Novel Approach for Treatment of Heart Failure(Heart failure, basic-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
Ikeda Yasuhiro; Aoki Hiroki; Aoyama Hidekazu; Yoshimura Koichi; Yamada Michio; Yano Masafumi; Yamamoto Ken; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2007 - 大動脈瘤の薬物治療.
青木浩樹; 吉村耕一; 松崎益徳
Angiology Frontier, 2007 - 大動脈瘤の分子標的治療：JNKによる細胞外マトリクス代謝制御
青木浩樹; 吉村耕一; 松崎益徳
Annual Review 循環器2007, 2007 - Regression of abdominal aortic aneurysms by pharmacological inhibition of c-Jun N-terminal kinase
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
The bulletin of the Yamaguchi Medical School, 2007 - Translocation of protein phosphatase 1 with inhibitor-2 from sarcoplasmic reticulum to cytosol augments Ca2+ cycling in cardiomyocytes
Yasuhiro Ikeda; Hiroki Aoki; Michio Yamada; Koichi Yoshimura; Hidekazu Aoyama; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Dec. 2006 - Pharmacological Regression of Established Abdominal Aortic Aneurysm by Inhibition of c-Jun N-terminal Kinase
YOSHIMURA Koichi; AOKI Hiroki; AKIYAMA Norio; FURUTANI Akira; HAMANO Kimikazu; MATSUZAKI Masunori
脈管学, 25 Oct. 2006 - Translocation of protein phosphatase 1 with inhibitor-2 from sarcoplasmic reticulum to cytosol augments Ca2+ cycling in cardiomyocytes
Yasuhiro Ikeda; Hiroki Aoki; Michio Yamada; Koichi Yoshimura; Hidekazu Aoyama; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
JOURNAL OF CARDIAC FAILURE, Oct. 2006 - Stabilization of extracellular matrix antagonizes proinflammatory signaling and prevents progression of aortic aneurysm in vivo
Koichi Yoshimura; Hiroki Aoki; Masahiko Onoda; Yasuhiro Ikeda; Hidekazu Aoyama; Noriyasu Morikage; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
CIRCULATION, Oct. 2006 - Knockdown of Nkx2.5 results in altered sarcomere organization and cell shape
Hideko Kasahara; Colleen S. Martinov; Melissa S. Marks; Jonathan T Lu; Hiroki Aoki; Kenneth R. Chien
CIRCULATION, Oct. 2006 - Translocation of protein phosphatase 1 with inhibitor-2 from sarcoplasmic reticulum to cytosol augments Ca2+ cycling in cardiomyocytes
Yasuhiro Ikeda; Hiroki Aoki; Michio Yamada; Koichi Yoshimura; Hidekazu Aoyama; Takeshi Yamamoto; Masafumi Yano; Masunori Matsuzaki
CIRCULATION, Oct. 2006 - Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy
Michio Yamada; Yasuhiro Ikeda; Masafumi Yano; Koichi Yoshimura; Shizuka Nishino; Hidekazu Aoyama; Lili Wang; Hiroki Aoki; Masunori Matsuzaki
FASEB JOURNAL, Jun. 2006 - OJ-004 HMG-CoA Reductase Inhibitors Reduce Matrix Metalloproteinase-9 Activity by Multiple Mechanisms in Human Varicose Veins(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Nomura Shinji; Akiyama Norio; Furutani Akira; Aoki Hiroki; Matsuzaki Masunori; Hamano Kimikazu
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006 - OE-134 Inhibition of c-Jun N-terminal Kinase Causes Regression of Abdominal Aortic Aneurysm in Murine Models(Peripheral circulation-1 (H) OE23,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Yoshimura Koichi; Aoki Hiroki; Ikeda Yasuhiro; Akiyama Norio; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006 - OJ-295 Effect of Tautomycin, a Chemical Inhibitor of Protein Phosphatase 1, on Cellular Contractility and Calcium Transient in Adult Rat Cardiomyocytes(Cardiac function, basic/clinical-2 (M) OJ50,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Ikeda Yasuhiro; Aoki Hiroki; Yamada Michio; Yoshimura Koichi; Yamamoto Takeshi; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2006 - 大動脈瘤の薬物治療：分子病態の多面的制御.
青木浩樹; 吉村耕一; 松崎益徳
分子心血管病, 2006 - シグナル伝達と血管疾患：治療標的分子同定のストラテジー.
青木浩樹; 吉村耕一; 松崎益徳
実験医学増刊号「分子メカニズムから解き明かす疾患のサイエンス」, 2006 - Identification of c-Jun N-terminal kinase as a therapeutic target for abdominal aortic aneurysm
Koichi Yoshimura; Hiroki Aoki; Yasuhiro Ikeda; Akira Furutani; Kimikazu Hamano; Masunori Matsuzaki
ABDOMINAL AORTIC ANEURYSM: GENETICS, PATHOPHYSIOLOGY AND MOLECULAR BIOLOGY, 2006 - Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
K Yoshimura; H Aoki; Y Ikeda; K Fujii; N Akiyama; A Furutani; Y Hoshii; N Tanaka; R Ricci; T Ishihara; K Esato; K Hamano; M Matsuzaki
NATURE MEDICINE, Dec. 2005 - Increased protein phosphatase 1 activity as a new therapeutic target of heart failure in genetic cardiomyopathy
Y Ikeda; M Yamada; K Yoshimura; H Aoki; M Yano; M Matsuzaki
JOURNAL OF CARDIAC FAILURE, Dec. 2005 - Identification of a molecular therapeutic target for abdominal aortic aneurysm
H Aoki; K Yoshimura; Y Ikeda; K Fujii; N Akiyama; A Furutani; Y Hoshii; N Tanaka; R Ricci; T Ishihara; K Esato; K Hamano; M Matsuzaki
JOURNAL OF CARDIAC FAILURE, Dec. 2005 - Protein Phosphatase 1 Inhibitor-2の心筋遺伝子導入は心筋症ハムスターの左室機能を改善する(第86回日本循環器学会中国地方会)
山田 倫生; 矢野 雅文; 松崎 益徳; 池田 安宏; 青木 浩樹; 吉村 耕一
Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2005 - Inhibition of c-Jun N-terminal kinase causes regression of experimental aortic aneurysms
K Yoshimura; H Aoki; Y Ikeda; N Akiyama; A Furutani; K Hamano; M Matsuzaki
CIRCULATION, Oct. 2005 - 慢性静脈不全症におけるHMG-CoA還元酵素阻害薬のマトリックスメタロプロテアーゼ-9抑制効果(第105回日本外科学会定期学術集会)
野村 真治; 吉村 耕一; 工藤 淳一; 斉藤 聰; 大楽 耕司; 美甘 章仁; 秋山 紀雄; 古谷 彰; 青木 浩樹; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 05 Apr. 2005 - HMG-CoA還元酵素阻害薬は腹部大動脈瘤における炎症性サイトカイン発現を抑制する(第105回日本外科学会定期学術集会)
工藤 淳一; 吉村 耕一; 野村 真治; 斉藤 聰; 大楽 耕司; 秋山 紀雄; 古谷 彰; 青木 浩樹; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 05 Apr. 2005 - Cardiac Gene Transfer of Protein Phosphatase 1 Inhibitor-2 Restores Left Ventricular Function in Progressive Hamster Cardiomyopathy(Heart Failure, Basic 2 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
Yamada Michio; Ikeda Yasuhiro; Aoki Hiroki; Yoshimura Koichi; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2005 - HMG-CoA reductase inhibitors reduce matrix metalloproteinase-9 activity in human varicose veins
S Nomura; K Yoshimura; N Akiyama; A Mikamo; A Furutani; H Aoki; M Matsuzaki; K Hamano
EUROPEAN SURGICAL RESEARCH, 2005 - Gene silencing using adenoviral RNAi vector in vascular smooth muscle cells and cardiomyocytes
Kasahara; H. Aoki, H
Methods Mol Med, 2005 - 114) 心筋症ハムスター(UM-X7.1)心不全モデルにおけるprotein phosphatase活性の変化の検討(第84回日本循環器学会中国地方会)
山田 倫生; 池田 安宏; 吉村 耕一; 青木 浩樹; 矢野 雅文; 松崎 益徳
Circulation journal : official journal of the Japanese Circulation Society, 20 Oct. 2004 - Inhibition of c-Jun N-terminal kinase prevents development of abdominal aortic aneurysm in a murine model
K Yoshimura; H Aoki; M Yamada; Y Ikeda; N Akiyama; A Funutani; K Hamano; M Matsuzaki
CIRCULATION, Oct. 2004 - Cardiac gene transfer of protein phosphatase 1 inhibitor-2 restores left ventricular function in progressive hamster cardiomyopathy
M Yamada; Y Ikeda; H Aoki; K Yoshimura; M Yano; M Matsuzaki
CIRCULATION, Oct. 2004 - C-Jun N-terminal kinase regulates pathological extracellular matrix metabolism in abdominal aortic aneurysm in vivo
K Yoshimura; H Aoki; N Akiyama; A Furutani; K Hamano; M Matsuzaki
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Jul. 2004 - SF-043-4 大動脈瘤に対するc-Jun N-terminal kinaseを分子標的とした次世代治療をめざして
吉村 耕一; 青木 浩樹; 斉藤 聰; 大楽 耕司; 秋山 紀雄; 古谷 彰; 松崎 益徳; 濱野 公一
日本外科学会雑誌, 15 Mar. 2004 - FRS-019 Role of Cytosolic Regulatory Subunits of Protein Phosphatase 1 on Cell Shortening and Ca2+ Homeostasis in Isolated Adult Rat Cardiomyocytes(Cardiac Hypertrophy (M) : FRS3)(Featured Research Session (English))
Ikeda Yasuhiro; Yamada Michio; Yoshimura Koichi; Aoki Hiroki; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - OE-302 Sphingomyelinase causes Endothelium-dependent Relaxation through Nitric Oxide Production and Hyperpolarization without Cytosolic Ca^<2+> Elevation in Endothelial Cells in situ(Endothelium/NO 4 (H) : OE38)(Oral Presentation (English))
Mogami Kimiko; Aoki Hiroki; Yoshimura Koichi; Kishi Hiroko; Kobayashi Sei
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - OE-096 c-Jun N-terminal Kinase Is Required for Development of Abdominal Aortic Aneurysm In Vivo(Molecular Biology, Vascular 1 (H) : OE12)(Oral Presentation (English))
Yoshimura Koichi; Aoki Hiroki; Fuji Kozo; Yamada Michio; Ikeda Yasuhiro; Saito Satoshi; Akiyama Norio; Furutani Akira; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - OE-116 Id2 Regulates Post-Developmental Phenotype of Vascular Smooth Muscle Cells in Atherosclerosis In Vivo(Atherosclerosis, Basic 1 (IHD) : OE14)(Oral Presentation (English))
Aoki Hiroki; Yoshimura Koichi; Ikeda Yasuhiro; Yamada Michio; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - PJ-228 Protein Phosphatase Dysregulation and Its Effect on Phosphorylation of Ca^<2+> Regulatory Proteins in Hamster Cardiomyopathy(Heart Failure, Basic 2 (M) : PJ38)(Poster Session (Japanese))
Yamada Michio; Ikeda Yasuhiro; Yoshimura Koichi; Aoki Hiroki; Yano Masafumi; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2004 - Proteasome-dependent decrease in Akt by growth factors in vascular smooth muscle cells
M Adachi; KR Katsumura; K Fujii; S Kobayashi; H Aoki; M Matsuzaki
FEBS LETTERS, Nov. 2003 - Id2 regulates post-developmental phenotype of vascular smooth muscle cells in atherosclerosis in vivo
H Aoki; K Yoshimura; KR Katsumura; K Fujii; M Yamada; Y Ikeda
CIRCULATION, Oct. 2003 - C-Jun N-terminal kinase governs pathological extracellular matrix metabolism in human abdominal aortic aneurysm
K Yoshimura; K Fuji; M Yamada; Y Ikeda; S Saito; N Akiyama; A Furutani; K Hamano; H Aoki
CIRCULATION, Oct. 2003 - Differential effect of protein phosphatase 1 inhibitor-1 and inhibitor-2 on cell shortening and Ca2+ homeostasis in isolated adult rat cardiomyocytes
Y Ikeda; M Yamada; K Yoshimura; H Aoki; T Ohkusa
CIRCULATION, Oct. 2003 - c-Jun N-Terminal Kinase Regulates Matrix Metalloproteinase (MMP)-9 Activity in Human Abdominal Aortic Aneurysm
Yoshimura Koichi; Aoki Hiroki; Furutani Akira; Takenaka Hiroaki; Hamano Kimikazu; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003 - Id2 Mediates Phenotypic Modulation of Vascular Smooth Muscle Cells by MAP Kinase Pathway
Aoki Hiroki; Yoshimura Koichi; Fujii Kozo; Kobayashi Sei; Matsuzaki Masunori
Circulation journal : official journal of the Japanese Circulation Society, 01 Mar. 2003 - Id2 mediates phenotypic modulation of vascular smooth muscle cells by MAP kinase pathway
H Aoki; K Fujii; K Yoshimura; M Matsuzaki
MOLECULAR BIOLOGY OF THE CELL, Nov. 2002 - Direct activation of mitochondrial death machinery by c-Jun N-terminal kinase
Yoshimura Koichi; Aoki Hiroki; Fujii Kouzo; Matsuzaki Masunori; Kang Peter; Izumo Seigo
Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002 - Activation of stress-activated protein kinases in human abdominal aortic aneurysm
Yoshimura Koichi; Aoki Hiroki; Matsuzaki Masunori; Furutani Akira; Seyama Atsushi; Takenaka Hiroaki; Zempo Nobuya
Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002 - Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes
H Aoki; PM Kang; J Hampe; K Yoshimura; T Noma; M Matsuzaki; S Izumo
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2002 - 心不全の基礎と臨床．心筋肥大におけるRhoファミリーと筋線維形成の分子機構
医学のあゆみ, 2002 - Pravastatin inhibits cytoskeletal translocation of Akt by platelet-derived growth factor in vascular smooth muscle cells
M Adachi; H Aoki; K Yoshimura; K Fujii; M Matsuzaki
JAPANESE JOURNAL OF PHARMACOLOGY, 2002 - Direct activation of mitochondrial death machinery by c-Jun N-terminal kinase
H Aoki; K Yoshimura; P Kang; S Izumo; M Matsuzaki
MOLECULAR BIOLOGY OF THE CELL, Nov. 2001 - Direct activation of mitochondrial death machinery by C-jun N-terminal kinase
H Aoki; K Yoshimura; PM Kang; S Izumo
CIRCULATION, Oct. 2001 - c-jun N-terminal kinase activates mitochondrial death machinery in oxidative stress-induced apoptosis of adult cardiac myocytes in vitro
H Aoki; PM Kang; M Matsuzaki; S Izumo
MOLECULAR BIOLOGY OF THE CELL, Dec. 2000 - Sek1-JNK pathway mediates oxidative stress-induced apoptosis in adult cardiac myocytes
H Aoki; PM Kang; S Izumo
CIRCULATION, Oct. 2000 - Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro
H Aoki; M Richmond; S Izumo; J Sadoshima
BIOCHEMICAL JOURNAL, Apr. 2000 - Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro
H Aoki; M Richmond; S Izumo; J Sadoshima
BIOCHEMICAL JOURNAL, Apr. 2000 - Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro
H Aoki; J Sadoshima; S Izumo
NATURE MEDICINE, Feb. 2000 - Myosin light chain kinase mediates sarcomere organization during cardiac hypertrophy in vitro
H Aoki; J Sadoshima; S Izumo
NATURE MEDICINE, Feb. 2000 - Morphological characterization and appearance of cytosolic cytochrome C during reoxygenation-induced adult cardiac myocyte apoptosis
PM Kang; A Haunstetter; H Aoki; A Usheva; S Izumo
CIRCULATION, Nov. 1999 - The critical role of myosin light chain phosphorylation in cardiac myofibrillogenesis in cardiac hypertrophy in vitro
H Aoki; J Sadoshima; S Izumo
CIRCULATION, Oct. 1998 - Angiotensin II activates RhoA in cardiac myocytes - A critical role of RhoA in angiotensin II-induced premyofibril formation
H Aoki; S Izumo; J Sadoshima
CIRCULATION RESEARCH, Apr. 1998 - Angiotensin II activates RhoA in cardiac myocytes - A critical role of RhoA in angiotensin II-induced premyofibril formation
H Aoki; S Izumo; J Sadoshima
CIRCULATION RESEARCH, Apr. 1998 - Angiotensin II and serum differentially activate CDK4 and phosphorylate retinoblastoma gene product (pRb) in neonatal rat cardiac myocytes in vitro
H Aoki; J Sadoshima; S Izumo
CIRCULATION, Oct. 1996 - The role of mitogen-activated protein kinases in angiotensin II-induced cardiac hypertrophic responses in neonatal rat cardiac myocytes in vitro
H Aoki; J Sadoshima; S Izumo
CIRCULATION, Oct. 1996 - Endothelin-1 inhibits and enhances contraction of porcine coronary arterial strips with an intact endothelium
Masuko Ushio-Fukai; Junji Nishimura; Hiroki Aoki; Sei Kobayashi; Hideo Kanaide
Biochemical and Biophysical Research Communications, 15 Apr. 1992 - Endothelin induces the Ca2+-transient in endothelial cells in situ
Hiroki Aoki; Sei Kobayashi; Junji Nishimura; Hiromichi Yamamoto; Hideo Kanaide
Biochemical and Biophysical Research Communications, 31 Dec. 1991
- Mouse Models of Vascular Diseases
AOKI Hiroki, Joint work, Mouse Model of Abdominal Aortic Aneurysm Induced by CaCl2
Springer Japan, 2016, Not reviewed - Molecular Cardiology. Vol 112
Humana Press, 2004, Not reviewed - Signal Transduction of Cardiac Myocyte Hypertrophy
Academic Press, 2000, Not reviewed - Signal Transduction of Cardiac Myocyte Hypertrophy
Academic Press, 2000, Not reviewed
■ Research Themes
- Role of perivascular adipose tissue in the pathogenesis of aortic dissection
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2024 - Mar. 2027 - The role of odorant receptors in pathogenesis of aortic dissection
Grant-in-Aid for Scientific Research (B)
Kurume University
Apr. 2023 - Mar. 2027 - Development of a comprehensive evaluation method for medical equalization policy
Grant-in-Aid for Scientific Research (B)
Kobe University
Apr. 2022 - Mar. 2025 - Development of a comprehensive evaluation method for medical equalization policy
Grant-in-Aid for Scientific Research (B)
Kobe University
Apr. 2022 - Mar. 2025 - The role of fibrin immune complex in pathogenesis of aortic dissection
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2021 - Mar. 2024 - Dysregulation of tissue homeostasis by cellular senescence in pathogenesis of aortic dissection
Grant-in-Aid for Scientific Research (B)
Kurume University
Apr. 2019 - Mar. 2022 - The role of salt-inducible kinase(SIK) in aortic dissection
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2018 - Mar. 2021 - The role of Syk in pathogenesis of arctic dissection
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2017 - Mar. 2020 - Potential novel treatment for aortic aneurysm with hydorogen sulfide
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2015 - Mar. 2018 - Macrophage differentiation in the pathogenesis of aortic dissection
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2015 - Mar. 2018 - 大動脈解離の革新的な治療法開発：mTOR経路を標的とした病態制御戦略
2016 - 2018 - Molecular mechanisms of ductus arteriosus closure
Grant-in-Aid for Scientific Research (B)
Jikei University School of Medicine
Apr. 2014 - Mar. 2017 - Search for a promoting factor of internal elastic lamina formation derived from endothelial cells
Grant-in-Aid for Challenging Exploratory Research
Jikei University School of Medicine
Apr. 2014 - Mar. 2015 - Role of extracellular matrix proteins in abdominal aortic aneurysm
Grant-in-Aid for Scientific Research (B)
Yamaguchi University
Apr. 2012 - Mar. 2015 - Deciphering molecular pathogenesis of aortic dissection: the role of stress sensor molecules
Grant-in-Aid for Challenging Exploratory Research
Kurume University
2014 - 2015 - Development of A Novel Hybrid Device for Treatment of Aortic Aneurysms
Grant-in-Aid for Challenging Exploratory Research
Yamaguchi University
Apr. 2013 - Mar. 2014 - Molecular mechanisms of ductus arteriosus closure
Grant-in-Aid for Scientific Research (B)
Apr. 2011 - Mar. 2014 - Molecular mechanism of aortic dissection : regulation of aortic wall tensile strength through cell-cell interactions
Grant-in-Aid for Scientific Research (B)
Kurume University
2012 - 2014 - The role of developmental program in pathogenesis of acute aortic dissection
挑戦的萌芽研究
久留米大学
2012 - 2013 - Pathogenesis of shaggy aorta syndrome
Grant-in-Aid for Challenging Exploratory Research
Yamaguchi University
2010 - 2012 - Novel therapy for aortic aneurysms by targeting a mechanical stress sensor
Grant-in-Aid for Scientific Research (B)
Yamaguchi University
2009 - 2011 - Novel therapeutic strategy for aortic aneurysm targeting master cytokine and cellular senescence
基盤研究(B)
久留米大学
2009 - 2011 - Functional analysis of H. pylorivirulence factors for gastric disease induction through its endocytosis inhibition
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
2008 - 2010 - NOVEL DIAGNOSTIC AND THERAPEUTIC STRATEGY FOR AORTIC ANEURYSM
Grant-in-Aid for Scientific Research (B)
Research Institute, International Medical Center of Japan
2008 - 2010 - Pharmacologic therapy for pulmonary emphysema by inhibiting JNK
Grant-in-Aid for Scientific Research (C)
Department of Clinical Research National Hospital Organization, National Sanyo Hospital
2007 - 2008 - Pharmacologic therapy for aortic aneurysm by inhibiting inflammasome
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
2007 - 2008 - Exploration into the Development of New Therapy for Heart Failure by Modifying Sarcoplasmic Reticulum Nanodomain Function
Grant-in-Aid for Scientific Research (A)
Yamaguchi University
2007 - 2008 - MAPキナーゼ制御の治療的応用
1999 - 2008 - Effect of Toll-like Receptor 4 on Cardiac Hypertrophy in Hypertension
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
2006 - 2007 - Screening of host facters affected by CagA, a virulence factor of Helicobacter pylori
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
2005 - 2007 - Identification of a novel therapeutic target for abdominal aortic aneurysm
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
2005 - 2006 - Exploration of abnormal dephosphorylation mechanism via Protein phosphatase 1β in heart failure
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
2005 - 2006 - Development of molecular therapy correcting abnormal intracellular Ca^<2+> regulation in chronic heart failure
Grant-in-Aid for Scientific Research (A)
Yamaguchi University
2004 - 2006 - Pharmacotherapy for abdominal aortic aneurysm by the inhibition of c=jun N-terminal kinase
基盤研究(B)
山口大学
2004 - 2006 - Importance of Tall-like receptor 4 on molecular mechanisms of the oxidative stress-induced smooth muscle cell phenotypic change
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
2004 - 2005 - Development of gene therapy for treatment of dilated cardiomyopathy and associated heart failure
Grant-in-Aid for Scientific Research (B)
Yamaguchi University
2002 - 2003 - Investigation on the molecular mechanism of JNK-mediated apoptosis in cardiac myocytes
基盤研究(B)
山口大学
2002 - 2003
- 特許第5843239号, 特願2012-553721, 画像診断における二次元の診断画像の理解を助ける方法及び装置
姉川 敬裕; 青木 浩樹; 甲斐 久史; 今泉 勉 - 特許第5471447号, 特願2009-547150, 薬物送達システム
青木 浩樹; 吉村 耕一; 堤 宏守; 照山 智恵; 松崎 益徳; 黒田 俊一 - WO2012-099087, JP2012050770, 画像診断における二次元の診断画像の理解を助ける方法及び装置
姉川 敬裕; 青木 浩樹; 甲斐 久史; 今泉 勉 - 特許第4686704号, 特開2006-089455, 特願2005-035769, 動脈瘤予防および/または治療剤
吉村 耕一; 青木 浩樹; 松崎 益徳 - WO2009-082014, JP2008073884, 薬物送達システム
青木 浩樹; 吉村 耕一; 堤 宏守; 照山 智恵; 松崎 益徳; 黒田 俊一 - 特開2007-051086, 特願2005-236585, コラーゲンまたはエラスチン代謝異常疾患の予防剤および治療剤
吉村 耕一; 青木 浩樹; 松崎 益徳 - 特開2006-089455, 特願2005-035769, 動脈瘤予防および/または治療剤
吉村 耕一; 青木 浩樹; 松崎 益徳
■ 共同研究希望
■ 共同研究実績
■ 関心を持って取組んでいる活動
