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野村 政壽
内科学講座（内分泌代謝内科部門）
教授
経歴
■ 経歴
- 1997年 - 1999年
ハーバード医科大研究員 - 1997年 - 1999年
Post doctral fellow at Hanuard Medical School - 1996年 - 1999年
日本学術振興会特別研究員 - 1999年
- 九州大学 - 1999年
- Assistant Prof, Department of Medicine, Kyushu - University
- 1995年, 九州大学, 医学系研究科, 分子生命
- 1995年, 九州大学, Graduate School, Division of Medical Sciences
- 1988年, 九州大学, 医学部, 医学科
- 1988年, 九州大学, Faculty of Medicine
研究活動情報
■ 受賞
■ 論文
■ 共同研究・競争的資金等の研究課題
■ 共同研究希望
■ 研究者からの一言アピール
■ 関心を持って取組んでいる活動
■ 論文
- Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice
Lixiang Wang; Xin Li; Yuki Hanada; Nao Hasuzawa; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
Communications Biology, 2021年12月 - An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing’s Syndrome and Autonomous Cortisol Secretion
Satoko Oda; Kenji Ashida; Makiko Uchiyama; Shohei Sakamoto; Nao Hasuzawa; Ayako Nagayama; Lixiang Wang; Hiromi Nagata; Ryuichi Sakamoto; Junji Kishimoto; Koji Todaka; Yoshihiro Ogawa; Yoichi Nakanishi; Masatoshi Nomura
The Journal of Clinical Endocrinology & Metabolism, 2021年09月27日 - Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor.
Yukina Takeichi; Takashi Miyazawa; Shohei Sakamoto; Yuki Hanada; Lixiang Wang; Kazuhito Gotoh; Keiichiro Uchida; Shunsuke Katsuhara; Ryuichi Sakamoto; Takaya Ishihara; Keiji Masuda; Naotada Ishihara; Masatoshi Nomura; Yoshihiro Ogawa
Diabetologia, 2021年05月29日 - Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Nao Hasuzawa; Keita Tatsushima; Lixiang Wang; Masaharu Kabashima; Rie Tokubuchi; Ayako Nagayama; Kenji Ashida; Yoshihiro Ogawa; Yoshinori Moriyama; Masatoshi Nomura
Scientific reports, 2021年03月04日 - MAVS is energized by Mff which senses mitochondrial metabolism via AMPK for acute antiviral immunity.
Yuki Hanada; Naotada Ishihara; Lixiang Wang; Hidenori Otera; Takaya Ishihara; Takumi Koshiba; Katsuyoshi Mihara; Yoshihiro Ogawa; Masatoshi Nomura
Nature communications, 2020年11月11日 - Human leucocyte antigen DR15, a possible predictive marker for immune checkpoint inhibitor-induced secondary adrenal insufficiency.
Seiichi Yano; Kenji Ashida; Ryuichi Sakamoto; Chihiro Sakaguchi; Masatoshi Ogata; Kengo Maruyama; Shohei Sakamoto; Munehiko Ikeda; Kenji Ohe; Shoko Akasu; Shimpei Iwata; Nobuhiko Wada; Yayoi Matsuda; Yoichi Nakanishi; Masatoshi Nomura; Yoshihiro Ogawa
European journal of cancer (Oxford, England : 1990), 2020年05月, ［査読有り］ - A Case of Acute Exacerbation of Chronic Adrenal Insufficiency Due to Ipilimumab Treatment for Advanced Melanoma.
Chihiro Sakaguchi; Seiichi Yano; Kenji Ashida; Naoko Wada; Kenji Ohe; Hiromi Nagata; Yayoi Matsuda; Shohei Sakamoto; Ryuichi Sakamoto; Keizo Ohnaka; Hiroshi Uchi; Masutaka Furue; Masatoshi Nomura; Yoshihiro Ogawa
The American journal of case reports, 2019年01月25日 - Nivolumab-induced thyroid dysfunction lacking antithyroid antibody is frequently evoked in Japanese patients with malignant melanoma
Seiichi Yano; Kenji Ashida; Hiromi Nagata; Kenji Ohe; Naoko Wada; Yukina Takeichi; Yuki Hanada; Yuta Ibayashi; Lixiang Wang; Shohei Sakamoto; Ryuichi Sakamoto; Hiroshi Uchi; Motoaki Shiratsuchi; Masutaka Furue; Masatoshi Nomura; Yoshihiro Ogawa
BMC Endocrine Disorders, 2018年06月08日, ［査読有り］ - Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
Takashi Baba; Hiroyuki Otake; Miki Inoue; Tetsuya Sato; Yasuhiro Ishihara; Ju-Yeon Moon; Megumi Tsuchiya; Kanako Miyabayashi; Hidesato Ogawa; Yuichi Shima; Lixiang Wang; Ryuichiro Sato; Takeshi Yamazaki; Mikita Suyama; Masatoshi Nomura; Man Ho Choi; Yasuyuki Ohkawa; Ken-Ichirou Morohashi
Communications biology, 2018年 - SMARCD1 regulates senescence-associated lipid accumulation in hepatocytes.
Chisato Inoue; Chong Zhao; Yumi Tsuduki; Miyako Udono; Lixiang Wang; Masatoshi Nomura; Yoshinori Katakura
NPJ aging and mechanisms of disease, 2017年, ［査読有り］ - Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration
Lixiang Wang; Takaya Ishihara; Yuta Ibayashi; Keita Tatsushima; Daiki Setoyama; Yuki Hanada; Yukina Takeichi; Shohei Sakamoto; Sadaki Yokota; Katsuyoshi Mihara; Dongchon Kang; Naotada Ishihara; Ryoichi Takayanagi; Masatoshi Nomura
Diabetologia, 2015年10月24日, ［査読有り］ - Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Takaya Ishihara; Reiko Ban-Ishihara; Maki Maeda; Yui Matsunaga; Ayaka Ichimura; Sachiko Kyogoku; Hiroki Aoki; Shun Katada; Kazuto Nakada; Masatoshi Nomura; Noboru Mizushima; Katsuyoshi Mihara; Naotada Ishihara
Molecular and cellular biology, 2015年01月, ［査読有り］ - Mitochondrial fission factor Drp1 maintains oocyte quality via dynamic rearrangement of multiple organelles.
Osamu Udagawa; Takaya Ishihara; Maki Maeda; Yui Matsunaga; Satoshi Tsukamoto; Natsuko Kawano; Kenji Miyado; Hiroshi Shitara; Sadaki Yokota; Masatoshi Nomura; Katsuyoshi Mihara; Noboru Mizushima; Naotada Ishihara
Current biology : CB, 2014年10月20日, ［査読有り］ - Activin stimulates CYP19A gene expression in human ovarian granulosa cell-like KGN cells via the Smad2 signaling pathway.
Masatoshi Nomura; Ryuichi Sakamoto; Hidetaka Morinaga; Lixiang Wang; Chizu Mukasa; Ryoichi Takayanagi
Biochemical and biophysical research communications, 2013年07月05日, ［査読有り］ - Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model
Masatoshi Nomura; Kimitaka Tanaka; Lixiang Wang; Yutaka Goto; Chizu Mukasa; Kenji Ashida; Ryoichi Takayanagi
Biochemical and Biophysical Research Communications, 2013年01月04日, ［査読有り］ - Smad2 and Smad3 are redundantly essential for the suppression of iNOS synthesis in macrophages by regulating IRF3 and STAT1 pathways
Yuki Sugiyama; Kyosuke Kakoi; Akihiro Kimura; Ichiro Takada; Ikko Kashiwagi; Yu Wakabayashi; Rimpei Morita; Masatoshi Nomura; Akihiko Yoshimura
INTERNATIONAL IMMUNOLOGY, 2012年04月, ［査読有り］ - Smad2 Protein Disruption in the Central Nervous System Leads to Aberrant Cerebellar Development and Early Postnatal Ataxia in Mice
Lixiang Wang; Masatoshi Nomura; Yutaka Goto; Kimitaka Tanaka; Ryuichi Sakamoto; Ichiro Abe; Shohei Sakamoto; Atsushi Shibata; Patricio L. M. Enciso; Masahiro Adachi; Keizo Ohnaka; Hisaya Kawate; Ryoichi Takayanagi
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011年05月, ［査読有り］ - Generation and characterization of T1R2-LacZ knock-in mouse
Ken Iwatsuki; Masatoshi Nomura; Atsushi Shibata; Reiko Ichikawa; Patricio L. M. Enciso; Lixiang Wang; Ryoichi Takayanagi; Kunio Torii; Hisayuki Uneyama
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010年11月, ［査読有り］ - A Novel Synthetic Androgen Receptor Ligand, S42, Works as a Selective Androgen Receptor Modulator and Possesses Metabolic Effects with Little Impact on the Prostate
Liu Min; Toshihiko Yanase; Tomoko Tanaka; WuQiang Fan; Masatoshi Nomura; Hisaya Kawate; Taijiro Okabe; Ryoichi Takayanagi; Hajime Nawata
ENDOCRINOLOGY, 2009年12月, ［査読有り］ - Adipose tissue-derived and bone marrow-derived mesenchymal cells develop into different lineage of steroidogenic cells by forced expression of steroidogenic factor 1.
Shigeki Gondo; Taijiro Okabe; Tomoko Tanaka; Hidetaka Morinaga; Masatoshi Nomura; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Endocrinology, 2008年09月, ［査読有り］ - Methylation of a conserved intronic CpG island of mouse SF-1 is associated with cell-specific expression of SF-1 in a culture system but not with tissue-specific expression
Hisao Shirohzu; Taijiro Okabe; Shigeki Gondo; Tomoko Tanaka; Kenji Ohe; Hidetaka Morinaga; Hisaya Kawate; Masatoshi Nomura; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008年05月, ［査読有り］ - Steroidogenic factor 1/adrenal 4 binding protein transforms human bone marrow mesenchymal cells into steroidogenic cells.
Tomoko Tanaka; Shigeki Gondo; Taijiro Okabe; Kenji Ohe; Hisao Shirohzu; Hidetaka Morinaga; Masatoshi Nomura; Kenzaburo Tani; Ryoichi Takayanagi; Hajime Nawata; Toshihiko Yanase
Journal of molecular endocrinology, 2007年11月, ［査読有り］ - Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets.
Yutaka Goto; Masatoshi Nomura; Kimitaka Tanaka; Akiyo Kondo; Hidetaka Morinaga; Taijirou Okabe; Toshihiko Yanase; Hajime Nawata; Ryoichi Takayanagi; En Li
Developmental dynamics : an official publication of the American Association of Anatomists, 2007年10月 - Atrazine-induced aromatase expression is SF-1 dependent: Implications for endocrine disruption in wildlife and reproductive cancers in humans
Fan WuQiang; Yanase Toshihiko; Morinaga Hidetaka; Ondo Shigeki; Okabe Taijiro; Nomura Masatoshi; Komatsu Tomoko; Morohashi Ken-Ichirou; Hayes Tyrone B; Takayanagi Ryoichi; Nawata Hajime
ENVIRONMENTAL HEALTH PERSPECTIVES, 2007年05月, ［査読有り］ - Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II.
Wuqiang Fan; Toshihiko Yanase; Hidetaka Morinaga; Shigeki Gondo; Taijiro Okabe; Masatoshi Nomura; Tyrone B Hayes; Ryoichi Takayanagi; Hajime Nawata
Biochemical and biophysical research communications, 2007年04月20日 - Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor.
WuQiang Fan; Toshihiko Yanase; Hidetaka Morinaga; Taijiro Okabe; Masatoshi Nomura; Hiroaki Daitoku; Akiyoshi Fukamizu; Shigeaki Kato; Ryoichi Takayanagi; Hajime Nawata
The Journal of biological chemistry, 2007年03月09日 - Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor.
Shuli Fan; Kiminobu Goto; Guangchun Chen; Hidetaka Morinaga; Masatoshi Nomura; Taijiro Okabe; Hajime Nawata; Toshihiko Yanase
Biochemical and biophysical research communications, 2006年03月03日, ［査読有り］ - Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.
Guangchun Chen; Masatoshi Nomura; Hidetaka Morinaga; Eri Matsubara; Taijiro Okabe; Kiminobu Goto; Toshihiko Yanase; Hong Zheng; Jian Lu; Hajime Nawata
The Journal of biological chemistry, 2005年10月28日 - Activation of peroxisome proliferator-activated receptor-gamma and retinoid X receptor inhibits aromatase transcription via nuclear factor-kappaB.
WuQiang Fan; Toshihiko Yanase; Hidetaka Morinaga; Yi-Ming Mu; Masatoshi Nomura; Taijiro Okabe; Kiminobu Goto; Nobuhiro Harada; Hajime Nawata
Endocrinology, 2005年01月 - SF-1/Ad4BP transforms primary long-term cultured bone marrow cells into ACTH-responsive steroidogenic cells.
Shigeki Gondo; Toshihiko Yanase; Taijiro Okabe; Tomoko Tanaka; Hidetaka Morinaga; Masatoshi Nomura; Kiminobu Goto; Hajime Nawata
Genes to cells : devoted to molecular & cellular mechanisms, 2004年12月, ［査読有り］ - A benzimidazole fungicide, benomyl, and its metabolite, carbendazim, induce aromatase activity in a human ovarian granulose-like tumor cell line (KGN).
Hidetaka Morinaga; Toshihiko Yanase; Masatoshi Nomura; Taijiro Okabe; Kiminobu Goto; Nobuhiro Harada; Hajime Nawata
Endocrinology, 2004年04月 - Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments.
Kiminobu Goto; Yue Zhao; Masayuki Saito; Arihiro Tomura; Hidetaka Morinaga; Masatoshi Nomura; Taijiro Okabe; Toshihiko Yanase; Ryoichi Takayanagi; Hajime Nawata
The Journal of steroid biochemistry and molecular biology, 2003年06月, ［査読有り］ - Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues
Ken Ichirou Morohashi; Hiroshi Iida; Masatoshi Nomura; Osamu Hatano; Shin Ichiro Honda; Toshio Tsukiyama; Ohtsura Niwa; Takayuki Hara; Akira Takakusu; Yosaburo Shibata; Tsuneo Omura
Molecular Endocrinology, 1994年05月 - EXPRESSION AND FUNCTION OF AD4BP, A STEROIDOGENIC CELL-SPECIFIC TRANSCRIPTION FACTOR
KI MOROHASHI; SI HONDA; M NOMURA; K TAKAYAMA; M HARA; T OMURA
CYTOCHROME P450, 1994年, ［査読有り］
- Functional Potentiation of Leptin-Signal Transducer and Activator of Transcription 3 Signaling by the Androgen Receptor
WuQiang Fan; Toshihiko Yanase; Yoshihiro Nishi; Seiichi Chiba; Taijiro Okabe; Masatoshi Nomura; Hironobu Yoshimatsu; Shigeaki Kato; Ryoichi Takayanagi; Hajime Nawata
ENDOCRINOLOGY, 2008年12月 - The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development
CA Ferguson; AS Tucker; K Heikinheimo; M Nomura; P Oh; E Li; PT Sharpe
DEVELOPMENT, 2001年11月 - 副腎におけるAd4BP遺伝子の発現に及ぼす下垂体ACTHの影響
柳瀬 敏彦; 野村 政壽; 大庭 功一; 市野 功; 高柳 涼一; 居石 克夫; 諸橋 憲一郎; 名和田 新
ホルモンと臨牀, 2000年11月15日 - Identification of novel first exons in Ad4BP/SF-1 (NR5A1) gene and their tissue- and species-specific usage
R Kimura; H Yoshii; M Nomura; N Kotomura; T Mukai; S Ishihara; K Ohba; T Yanase; O Gotoh; H Nawata; K Morohashi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000年11月 - Smad2 role in mesoderm formation, left-right patterning and craniofacial development
M Nomura; E Li
NATURE, 1998年06月 - The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
ZY Gu; M Nomura; BB Simpson; H Lei; A Feijen; J van den Eijnden-van Raaij; PK Donahoe; E Li
GENES & DEVELOPMENT, 1998年03月 - Adrenocortical and gonadal expression of the mammalian Ftz-F1 gene encoding Ad4BP/SF-1 is independent of pituitary control
Masatoshi Nomura; Ken Kawabe; Sumie Matsushita; Sanae Oka; Osamu Hatano; Nobuhiro Harada; Hajime Nawata; Ken Ichirou Morohashi
Journal of Biochemistry, 1998年01月01日 - Expression of aldosterone synthase cytochrome P450 (P450aldo) mRNA in rat adrenal glomerulosa cells by angiotensin II type 1 receptor
M Kakiki; K Morohashi; M Nomura; T Omura; T Horie
ENDOCRINE RESEARCH, 1997年 - Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11β- hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists
Motoharu Kakiki; Ken Ichirou Morohashi; Masatoshi Nomura; Tsuneo Omura; Toru Horie
Biological and Pharmaceutical Bulletin, 1997年01月01日 - Structural characterization of human Ad4BP (SF-1) gene
K Oba; T Yanase; M Nomura; K Morohashi; R Takayanagi; H Nawata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996年09月 - Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF-1
O Hatano; A Takakusu; M Nomura; K Morohashi
GENES TO CELLS, 1996年07月 - Autoregulatory loop in the regulation of the mammalian ftz-f1 gene
M Nomura; H Nawata; K Morohashi
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996年04月 - DEVELOPMENTAL DEFECTS OF THE VENTROMEDIAL HYPOTHALAMIC NUCLEUS AND PITUITARY GONADOTROPH IN THE FTZ-F1 DISRUPTED MICE
K SHINODA; H LEI; H YOSHII; M NOMURA; M NAGANO; H SHIBA; H SASAKI; Y OSAWA; Y NINOMIYA; O NIWA; K MOROHASHI; E LI
DEVELOPMENTAL DYNAMICS, 1995年09月 - Nomura M, Bartsch S, Nawata H, Omura T, Morohashi K An E boc elemen is required for the expression of the Ad4BPgene,
J Biol Chem, 1995年 - Function and distribution of a steroidogenic cell-specific transcription factor, Ad4BP
K. Morohashi; O. Hatano; M. Nomura; K. Takayama; M. Hara; H. Yoshii; A. Takakusu; T. Omura
Journal of Steroid Biochemistry and Molecular Biology, 1995年 - An E box element is required for the expression of the ad4bp gene, a mammalian homologue of ftz-f1 gene, which is essential for adrenal and gonadal development
M. Nomura; S. Bartsch; H. Nawata; T. Omura; K. I. Morohashi
Journal of Biological Chemistry, 1995年 - Ad4BP regulating steroidogenic P-450 gene is a member of steroid hormone receptor superfamily
Shin Ichiro Honda; Ken Ichirou Morohashi; Masatoshi Nomura; Hiroyuki Takeya; Masato Kitajima; Tsuneo Omura
Journal of Biological Chemistry, 1993年04月05日 - Three forms of rat CYP11B genes: Llß-hydroxylase gene, aldosterone synthase gene, and a novel gene
Masatoshi Nomura; Ken Ichirou Morohashi; Sirou Kirita; Yasuki Nonaka; Mitsuhiro Okamoto; Hajime Nawata; Tuneo Omura
Journal of Biochemistry, 1993年 - A TRANSCRIPTION FACTOR, Ad4BP, REGULATING ALL the STEROIDOGENIC P-450 GENES
Ken Ichirou Morohashi; Shin Ichiroq Honda; Masatoshi Nomura; Koichi Takayama; Tsuneo Omura
Journal of Basic and Clinical Physiology and Pharmacology, 1992年01月01日
■ 共同研究・競争的資金等の研究課題
■ 共同研究希望
■ 研究者からの一言アピール
■ 関心を持って取組んでいる活動
