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山田 亮
学長直属
教授

研究者情報

■ 学位
  • 医学博士, 九州大学
■ 研究分野
  • ライフサイエンス, 免疫学
■ 研究テーマ
  • がんペプチドワクチンの開発
  • がん免疫の分子機構の解明
  • 次世代シークエンサーを用いたがん免疫療法の新規標的分子(ネオアンチゲン)の探索研究
  • がん細胞由来ダメージ関連モチーフ分子の免疫に及ぼす作用の解析

経歴

■ 学歴
  • 1986年, 九州大学, Graduate School, Division of Medicine
  • 1980年, 北里大学, Faculty of Pharmaceutical Science
  • 北里大学薬学部薬学科, School of Pharmaceutical Sciences
  • 九州大学, 医学, 医学

研究活動情報

■ 論文
  • Evaluation of the Immunological Response of Childhood Cancer Patients Treated with a Personalized Peptide Vaccine for Refractory Soft Tissue Tumor: A Four-Case Series.
    Keiko Oda; Yasuhiko Ito; Akira Yamada; Shigeru Yutani; Kyogo Itoh; Shuichi Ozono
    The Kurume medical journal, 2023年07月03日
  • Suppression of high mobility group box 1 in B16F10 tumor does not inhibit the induction of neoantigen-specific T cells.               
    Waki K, Ozawa M, Yamada A.
    Cancer Sci, 2022年12月
  • Knockout of high-mobility group box 1 in B16F10 melanoma cells induced host immunity-mediated suppression of in vivo tumor growth.               
    Yokomizo K, Waki K, Ozawa M, Yamamoto K, Ogasawara S, Yano H, and Yamada A.
    Med Oncol, 2022年02月
  • Diversity and shared T-cell receptor repertoire analysis in esophageal squamous cell carcinoma.               
    Sudo T, Kawahara A, Ishi K, Mizoguchi A, Nagasu S, Nakagawa M, Fujisaki M, Hino H, Saisho K, Kaku H, Matono S, Mori N, Akiba J, Yamada A, Akagi Y.
    Oncol Lett., 2021年08月
  • Investigation of factors associated with reduced clinical benefits of personalized peptide vaccination for pancreatic cancer.               
    Uchino Y, Muroya D, Yoshitomi M, Shichijo S, Yamada A, Sasada T, Yamada T, Okuda K, Itoh K, Yutani S.
    Mol Clin Oncol, 2021年02月
  • Integrity of circulating cell-free DNA as a biomarker for vaccine therapy in patients with non-small cell lung cancer.               
    Waki K, Yokomizo K, Yoshiyama K, Takamori S, Komatsu N, Yamada A.
    Immunopharmacol Immunotoxicol., 2021年02月
  • Integrity of plasma cell-free DNA as a prognostic factor for vaccine therapy in patients with endometrial cancer.               
    Waki K, Yokomizo K, Kawano K, Tsuda N, Komatsu N, Yamada A.
    Mol Clin Oncol., 2021年02月
  • Plasma level of prostate-related antigen peptide-reactive IgG is a prognostic factor of patients with breast cancer treated with personalized peptide vaccines.               
    Saku S, Toh U, Takao Y, Sakurai S, Yamada A, Shichijo S, Itoh K, Akagi Y.
    Exp Ther Med, 2021年
  • Early phase II study of mixed 19-peptide vaccine monotherapy for refractory triple-negative breast cancers. 2020 Aug;111(8):2760-2769.               
    Toh U, Sakurai S, Saku S, Takao Y, Okabe M, Iwakuma N, Shichijo S, Yamada A, Itoh K, Akagi Y.
    Cancer Sci., 2020年08月
  • Identification of biomarkers for personalized peptide vaccination in 2,588 cancer patients.               
    Suekane S, Yutani S, Yamada A, Sasada T, Matsueda S, Takamori S, Toh U, Kawano K, Yoshiyama K, Sakamoto S, Sugawara S, Komatsu N, Yamada T, Naito M, Terasaki M, Mine T, Itoh K, Shichijo S, Noguchi M.
    Int J Oncol., 2020年06月
  • Integrity of plasma DNA is inversely correlated with vaccine-induced anti-tumor immunity in ovarian cancer patients.               
    Waki K, Yokomizo K, Kawano K, Tsuda N, Komatsu N, Yamada A.
    Cancer Immunol Immunother., 2020年05月
  • Mixed 20-peptide cancer vaccine in combination with docetaxel and dexamethasone for castration-resistant prostate cancer: a randomized phase II trial.               
    Noguchi M, Arai G, Egawa S, Ohyama C, Naito S, Matsumoto K, Uemura H, Nakagawa M, Nasu Y, Eto M, Suekane S, Sasada T, Shichijo S, Yamada A, Kakuma T, Itoh K.
    Cancer Immunol Immunother, 2020年02月
  • The CD4/CD8 ratio is a prognostic factor in IgG non-responders among peptide vaccine treated ovarian cancer patients.               
    Waki K, Kawano K, Tsuda N, Komatsu N, Yamada A.
    Cancer Sci,, 2020年01月
  • Identification of dominant T-cell epitopes in the major Japanese cypress pollen allergen Cha o 3.               
    Osada T, Yamada A, Sasaki E, Utsugi T.
    Allergol Int., 2019年08月
  • A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma.               
    Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y, Ichikawa T, Kobayashi H, Fujimaki T, Goto H, Takeshima H, Ueba T, Abe H, Tamiya T, Sonoda Y, Natsume A, Kakuma T, Sugita Y, Komatsu N, Yamada A, Sasada T, Matsueda S, Shichijo S, Itoh K, Terasaki M.
    Neuro Oncol., 2019年02月
  • Identification of Cha o 3 homolog Cry j 4 from Cryptomeria japonica (Japanese cedar) pollen: Limitation of the present Japanese cedar-specific ASIT.               
    Osada T, Tanaka Y, Yamada A, Sasaki E, Utsugi T.
    Allergol Int., 2018年10月
  • Survival analysis of multiple peptide vaccination for the selection of correlated peptides in urological cancers.               
    Noguchi M, Koga N, Moriya F, Suekane S, Yutani S, Yamada A, Shichijo S, Kakuma T, Itoh K.
    Cancer Sci., 2018年09月
  • Immunological efficacy of herbal medicines in prostate cancer patients treated by personalized peptide vaccine.               
    Koga N, Moriya F, Waki K, Yamada A, Itoh K, Noguchi M.
    Cancer Sci., 2017年12月
  • Feasibility Study of Personalized Peptide Vaccination for Advanced Small Cell Lung Cancer.               
    Sakamoto S, Yamada T, Terazaki Y, Yoshiyama K, Sugawara S, Takamori S, Matsueda S, Shichijo S, Yamada A, Noguchi M, Itoh K, Hattori N, Kohno N, Sasada T.
    Clin Lung Cancer, 2017年11月
  • Clinical Impact of Tumor-Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma.               
    Sudo T, Nishida R, Kawahara A, Saisho K, Mimori K, Yamada A, Mizoguchi A, Kadoya K, Matono S, Mori N, Tanaka T, Akagi Y.
    Ann Surg Oncol., 2017年11月
  • Feasibility study of personalized peptide vaccination for hepatocellular carcinoma patients refractory to locoregional therapies.               
    Yutani S, Shirahama T, Muroya D, Matsueda S, Yamaguchi R, Morita M, Shichijo S, Yamada A, Sasada T, Itoh K.
    Cancer Sci., 2017年09月
  • A randomized phase II trial of personalized peptide vaccine with low dose cyclophosphamide in biliary tract cancer.               
    Shirahama T, Muroya D, Matsueda S, Yamada A, Shichijo S, Naito M, Yamashita T, Sakamoto S, Okuda K, Itoh K, Sasada T, Yutani S.
    Cancer Sci., 2017年05月
  • Immunological evaluation of peptide vaccination for cancer patients with the HLA-A11+ or -A33+ allele.               
    Sakamoto S, Matsueda S, Takamori S, Toh U, Noguchi M, Yutani S, Yamada A, Shichijo S, Yamada T, Suekane S, Kawano K, Naitou M, Sasada T, Hattori N, Kohno N, Itoh K.
    Cancer Sci., 2017年04月
  • Plasma Levels of High-Mobility Group Box 1 during Peptide Vaccination in Patients with Recurrent Ovarian Cancer.               
    Waki K, Kawano K, Tsuda N, Ushijima K, Itoh K, Yamada A.
    J Immunol Res., 2017年
  • Single nucleotide polymorphisms of the Haptoglobin gene in non-small cell lung cancer treated with personalized peptide vaccination.               
    Waki K, Yamada T, Yoshiyama K, Terazaki Y, Sakamoto S, Sugawara S, Takamori S, Itoh K, Yamada A.
    Oncol Letter, 2017年
  • Immunological evaluation of personalized peptide vaccination for patients with histologically unfavorable carcinoma of unknown primary site.               
    Sakamoto S, Yutani S, Shichijo S, Morita M, Yamada A, Itoh K, Noguchi M.
    Cancer Immunol Immunother., 2016年10月
  • Identification and gene of new major allergen Cha o 3 from Chamaecyparis obtusa (Japanes Cypress) pollen.               
    Osada T, Harada T, Asaka N, Kino K, Sasaki E, Okano M, Yamada A, Utsugi T.
    J Allergy Clin Immunol., 2016年09月
  • A Phase 2 Randomized Controlled Trial of Personalized Peptide Vaccine Immunotherapy with Low-dose Dexamethasone Versus Dexamethasone Alone in Chemotherapy-naive Castration-resistant Prostate Cancer.               
    Yoshimura K, Minami T, Nozawa M, Kimura T, Egawa S, Fujimoto H, Yamada A, Itoh K, Uemura H.
    Eur Urol., 2016年07月
  • Randomized phase II study of docetaxel plus personalized peptide vaccination versus docetaxel plus placebo for patients with previously treated advanced wild type EGFR non-small-cell lung cancer.               
    Takayama K, Sugawara S, Saijo Y, Maemondo M, Sato A, Takamori S, Harada T, Sasada T, Kakuma T, Kishimoto J, Yamada A, Noguchi M, Itoh K, Nakanishi Y.
    J Immunol Res., 2016年05月
  • Phase I study of a new cancer vaccine of ten mixed peptides for advanced cancer patients.               
    Iwasa S, Yamada Y, Heike Y, Shoji H, Honma Y, Komatsu N, Matsueda S, Yamada A, Morita M, Yamaguchi R, Tanaka N, Kawahara A, Kage M, Shichijo S, Sasada T, Itoh K.
    Cancer Science, 2016年05月
  • A randomized phase II clinical trial of personalized peptide vaccination with metronomic low-dose cyclophosphamide in patients with metastatic castration-resistant prostate cancer.               
    Noguchi M, Moriya F, Koga N, Matsueda S, Sasada T, Yamada A, Kakuma T, Itoh K.
    Cancer Immunol Immunother., 2016年02月
  • Blockade of High Mobility Group Box 1 (HMGB1) augments anti-tumor T-cell response induced by peptide vaccination as a co-adjuvant.               
    Waki K, Yamada A.
    Cancer Sci., 2016年
  • Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer.               
    Muroya D, Yutani S, Shichijo S, Yamada A, Sakamoto S, Naito M, Okuda K, Morita M, Yamaguchi R, Itoh K.
    Evid Based Complement Alternat Med., 2016年
  • An Open-Label, Randomized Phase II Trial of Personalized Peptide Vaccination in Patients with Bladder Cancer that Progressed after Platinum-Based Chemotherapy.               
    Noguchi M, Matsumoto K, Uemura H, Arai G, Eto M, Naito S, Ohyama C, Nasu Y, Tanaka M, Moriya F, Suekane S, Matsueda S, Komatsu N, Sasada T, Yamada A, Kakuma T, Itoh K.
    Clin Cancer Res., 2016年01月
  • Immunological evaluation of peptide vaccination for cancer patients with the HLA-A26 allele.               
    Sakamoto S, Matsueda S, Takamori S, Toh U, Noguchi M, Yutani S, Yamada A, Shichijo S, Yamada T, Suekane S, Kawano K, Sasada T, Hattori N, Kohno N, Itoh K.
    Cancer Sci., 2015年10月
  • Phase II study of personalized peptide vaccination with both a hepatitis C virus (HCV)-derived peptide and peptides from tumor-associated antigens for the treatment of HCV-positive advanced hepatocellular carcinoma patients.               
    Yutani S, Ueshima K, Abe K, Ishiguro A, Eguchi J, Matsueda S, Komatsu N, Shichijo S, Yamada A, Itoh K, Sasada T, Kudo M, Noguchi M.
    J Immunol Res., 2015年10月
  • Evaluation of prognostic significance of granulocyte-related factors in cancer patients undergoing personalized peptide vaccination.               
    Sakamoto S, Yoshitomi M, Yutani S, Terazaki Y, Yoshiyama K, Ioji T, Matsueda S, Yamada A, Takamori S, Itoh K, Hattori N, Kohno N, Sasada T.
    Hum Vaccin Immunother, 2015年09月
  • Personalized peptide vaccination for cervical cancer patients who have received prior platinum-based chemotherapy.               
    Kawano K, Tsuda N, Waki K, Matsueda S, Hata Y, Ushijima K, Itoh K, Yamada A, Kamura T.
    Cancer Sci., 2015年09月
  • Identification of Novel Lck-derived T Helper Epitope Long Peptides Applicable for HLA-A2+ Cancer Patients as Cancer Vaccine.               
    Matsueda S, Shichijo S, Nagata S, Seki C, Yamada A, Noguchi M, Itoh K.
    Cancer Sci., 2015年08月
  • Phase I trial of a cancer vaccine consisting of 20 mixed peptides in patients with castration-resistant prostate cancer: dose-related immune boosting and suppression.               
    Noguchi M, Arai G, Matsumoto K, Naito S, Moriya F, Suekane S, Komatsu N, Matsueda S, Sasada T, Yamada A, Kakuma T, Itoh K.
    Cancer Immunol Immunother, 2015年04月
  • Feasibility study of personalized peptide vaccination for advanced non-small cell lung cancer patients who failed two or more treatment regimens.               
    Yamada T, Terazaki Y, Sakamoto S, Yoshiyama K, Matsueda S, Komatsu N, Waki K, Yamada A, Kawahara A, Kage M, Sugawara S, Yamashita Y, Sasada T, Takamori S, Itoh K.
    Int J Oncol., 2015年01月
  • Phase II Study of Personalized Peptide Vaccination for Previously Treated Advanced Colorectal Cancer.               
    Kibe S, Yutani S, Motoyama S, Nomura T, Tanaka N, Kawahara A, Yamaguchi T, Matsueda S, Komatsu N, Miura M, Hinai Y, Hattori S, Yamada A, Kage M, Itoh K, Akagi Y, Sasada T.
    Cancer Immunol Res., 2014年12月
  • PD-1 expression on peripheral blood T-cell subsets correlates with prognosis in non-small cell lung cancer.               
    Waki K, Yamada T, Yoshiyama K, Terazaki Y, Sakamoto S, Matsueda S, Komatsu N, Sugawara S, Takamori S, Itoh K, Yamada A.
    Cancer Sci., 2014年10月
  • Feasibility study of personalized peptide vaccination for recurrent ovarian cancer patients.               
    Kawano K, Tsuda N, Matsueda S, Sasada T, Watanabe N, Ushijima K, Yamaguchi T, Yokomine M, Itoh K, Yamada A, Kamura T.
    Immunopharmacol Immunotoxicol., 2014年06月
  • Personalized Peptide Vaccine for Treatment of Advanced Cancer.               
    Sasada T, Yamada A, Noguchi M, Itoh K.
    Curr Med Chem., 2014年02月
  • The influence of Chlorella and its hot water extract supplementation on quality of life in patients with breast cancer.               
    Noguchi N, Maruyama I, Yamada A.
    Evid Based Complement Alternat Med., 2014年
  • A phase II trial of personalized peptide vaccination in castration-resistant prostate cancer patients: prolongation of prostate-specific antigen doubling time.               
    Noguchi M, Moriya F, Suekane S, Ohnishi R, Matsueda S, Sasada T, Yamada A, Itoh K.
    BMC Cancer., 2013年12月
  • A phase II study of a personalized peptide vaccination for chemotherapy-resistant advanced pancreatic cancer patients.               
    Yutani S, Komatsu N, Yoshitomi M, Matsueda S, Yonemoto K, Mine T, Noguchi M, Ishihara Y, Yamada A, Itoh K, Sasada T.
    Oncol Rep., 2013年09月
  • Humoral immune responses to CTL epitope peptides from tumor-associated antigens are widely detectable in humans: a new biomarker for overall survival of patients with malignant diseases.
    Matsueda S; Komatsu N; Kusumoto K; Koga S; Yamada A; Kuromatsu R; Yamada S; Seki R; Yutani S; Shichijo S; Mine T; Fukuda T; Okamura T; Okuda S; Sata M; Honda J; Kaji M; Itoh K; Sasada T
    Developmental and comparative immunology, 2013年09月, [査読有り]
  • Juzentaihoto Failed to Augment Antigen-Specific Immunity but Prevented Deterioration of Patients' Conditions in Advanced Pancreatic Cancer under Personalized Peptide Vaccine.               
    Yutani S, Komatsu N, Matsueda S, Yoshitomi M, Shirahama T, Yamada A, Itoh K, Sasada T.
    Evid Based Complement Alternat Med., 2013年06月
  • Current status of immunotherapy for the treatment of biliary tract cancer.               
    Takahashi R, Yoshitomi M, Yutani S, Shirahama T, Noguchi M, Yamada A, Itoh K, Sasada T.
    Hum Vaccin Immunother., 2013年05月
  • The next generation of peptide vaccines for advanced cancer.               
    Yamada A, Sasada T, Noguchi M, Itoh K.
    Cancer Sci, 2013年01月
  • Controversies in Clinical Trials of Cancer Vaccines for Glioblastoma.               
    Terasaki1 M, Murotani K, Narita Y, Nishikawa R, Sasada T, Yamada A, Itoh K, Morioka M.
    J Vaccines Vaccin., 2013年
  • In vitro induction of specific CD8+ T lymphocytes by tumor-associated antigenic peptides in patients with oral squamous cell carcinoma.
    Toyoshima T, Kumamaru W, Hayashida J, Moriyama M, Kitamura R, Tanaka H, Yamada A, Itoh K, Nakamura S.
    Cancer Lett, 2012年09月, [査読有り]
  • Gene expression profiles in peripheral blood as a biomarker in cancer patients receiving peptide vaccination.
    Komatsu N, Matsueda S, Tashiro K, Ioji T, Shichijo S, Noguchi M, Yamada A, Doi A, Suekane S, Moriya F, Matsuoka K, Kuhara S, Itoh K, Sasada T.
    Cancer, 2012年06月15日, [査読有り]
  • Phase II study of personalized peptide vaccination for castration-resistant prostate cancer patients who failed in docetaxel-based chemotherapy.
    Noguchi M, Moriya F, Suekane S, Matsuoka K, Arai G, Matsueda S, Sasada T, Yamada A, Itoh K.
    Prostate, 2012年06月01日, [査読有り]
  • Personalized peptide vaccination in patients with refractory non-small cell lung cancer.
    Yoshiyama K, Terazaki Y, Matsueda S, Shichijo S, Noguchi M, Yamada A, Mine T, Ioji T, Itoh K, Shirouzu K, Sasada T, Takamori S.
    Int J Oncol, 2012年05月, [査読有り]
  • Immunological Evaluation of Personalized Peptide Vaccination in Refractory Small Cell Lung Cancer.               
    Terazaki Y, Yoshiyama K, Matsueda S, Watanabe N, Kawahara A, Naito Y, Suekane S, Komatsu N, Ioji T, Yamada A, Mine T, Terasaki M, Itoh K, Takamori S, Sasada T.
    Cancer Sci., 2012年04月
  • Personalized peptide vaccination for advanced biliary tract cancer: IL-6, nutritional status, and pre-existing antigen -specific immunity as possible biomarkers for patient prognosis.
    Yoshitomi M, Yutani S, Matsueda S, Ioji T, Komatsu N, Shichijo S, Yamada A, Itoh K, Sasada T, Kinoshita H.
    Experimental and Therapeutic Medicine, 2012年03月, [査読有り]
  • A phase I study of personalized peptide vaccination using 14 kinds of vaccine in combination with low-dose estramustine in HLA-A24-positive patients with castration-resistant prostate cancer.               
    Noguchi M, Uemura H, Naito S, Akaza H, Yamada A, Itoh K.
    Prostate., 2011年04月
  • Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination.               
    Noguchi M, Mine T, Komatsu N, Suekane S, Moriya F, Matsuoka K, Yutani S, Shichijo S, Yamada A, Toh U, Kawano K, Azuma K, Uemura H, Okuno K, Matsumoto K, Yanagimoto H, Yamanaka R, Oka M, Todo S, Sasada T, Itoh K.
    Cancer Biol Ther., 2011年01月
  • Phase I trial of a personalized Peptide vaccine for patients positive for human leukocyte antigen--A24 with recurrent or progressive glioblastoma multiforme.               
    Terasaki M, Shibui S, Narita Y, Fujimaki T, Aoki T, Kajiwara K, Sawamura Y, Kurisu K, Mineta T, Yamada A, Itoh K.
    J Clin Oncol., 2011年01月
  • Characteristics of severe adverse events after peptide vaccination for advanced cancer patients: analysis of 500 cases.               
    Yoshida K, Noguchi M, Mine T, Komatsu N, Yutani S, Ueno T, Yanagimoto H, Kawano K, Itoh K, Yamada A.
    Oncol Report., 2011年01月
  • Phase-I clinical study of a personalized peptide vaccination available for six different HLA (HLA-A2, -A3, -A11, -A24, -A31, and -A33)-positive patients with advanced cancer.
    Yamada A, Noguchi M, Komatsu N, Suekane S, Yutani S, Moriya F, Mine T, Momozono K, Kawano K, Itoh K.
    Exp Ther Med., 2011年01月, [査読有り]
  • A phase I study of personalized peptide vaccination for advanced urothelial carcinoma patients who failed treatment with methotrexate, vinblastine, adriamycin and cisplatin.               
    Matsumoto K, Noguchi M, Satoh T, Tabata KI, Fujita T, Iwamura M, Yamada A, Komatsu N, Baba S, Itoh K.
    BJU Int., 2010年12月
  • A phase II study of personalized peptide vaccination combined with gemcitabine for non-resectable pancreatic cancer patients.               
    Yanagimoto H, Shiomi H, Satoi S, Mine T, Toyokawa H, Yamamoto T, Tani T, Yamada A, Kwon A, Komatsu N, Itoh K, Noguchi M.
    Oncol Rep., 2010年09月
  • Overcoming the hurdles of randomised clinical trials of therapeutic cancer vaccines.               
    Sasada T, Komatsu N, Suekane S, Yamada A, Noguchi M, Itoh K.
    Eur J Cancer, 2010年07月
  • A randomized phase II trial of personalized peptide vaccine plus low dose estramustine (EMP) versus standard dose EMP in patients with hormone refractory prostate cancer.               
    Noguchi M, Kakuma T, Uemura H, Nasu Y, Kumon H, Moriya F, Suekane S, Komatsu N, Yamada A, Itoh K.
    Cancer Immunol. Immunother., 2010年07月
  • Prophylactic effect of peptide vaccination against hepatocellular carcinoma associated with hepatitis C virus
    Nobukazu Komatsu; Shigeru Yutani; Akira Yamada; Shigeki Shichijo; Kazumi Yoshida; Minoru Itou; Ryoko Kuromatsu; Tatsuya Ide; Masatoshi Tanaka; Michio Sata; Kyogo Itoh
    Experimental and Therapeutic Medicine, 2010年07月, [査読有り]
  • Overcoming the hurdles of randomised clinical trials of therapeutic cancer vaccines.               
    Sasada T, Komatsu N, Suekane S, Yamada A, Noguchi M, Itoh K.
    Eur J Cancer., 2010年06月
  • Evaluation of a new oil adjuvant for use in peptide-based cancer vaccination.
    Iseki K, Matsunaga H, Komatsu N, Suekane S, Noguchi M, Itoh K, Yamada A.
    Cancer Sci., 2010年, [査読有り]
  • Immunological evaluation of personalized peptide vaccination in combination with UFT and UZEL for metastatic colorectal carcinoma patients.               
    Hattori T, Mine T, Komatu N, Yamada A, Itoh K, Shiozaki H, Okuno K.
    Cancer Immunol. Immunother., 2009年11月
  • Phase I clinical study of a peptide vaccination for hepatitis C virus-infected patients with different HLA-class I-A alleles.
    Yutani S, Komatsu N, Shichijo S, Yoshida K, Takedatsu H, Itou M, Kuromatu R, Ide T, Tanaka M, Sata M, Yamada A, and Itoh K.
    Cancer Science., 2009年10月, [査読有り]
  • A peptide derived from hepatitis C virus (HCV) core protein inducing cellular responses in patients infected with HCV with various HLA class IA allele.               
    Niu Y, Komatsu N, Komohara Y, Matsueda S, Yutani S, Ishihara Y, Itou M, Yamada A, Itoh K, Shichijo S.
    J. Med. Virol., 2009年07月
  • Expression of ERCC1 and class III beta-tubulin in non-small cell lung cancer patients treated with carboplatin and paclitaxel.               
    Azuma K, Sasada T, Kawahara A, Takamori S, Hattori S, Ikeda J, Itoh K, Yamada A, Kage M, Kuwano M, Aizawa H.
    Lung Cancer., 2009年06月
  • Dexamethasone did not suppress immune boosting by personalized peptide vaccination for advanced prostate cancer patients.
    Naito M, Itoh K, Komatsu N, Yamashita Y, Shirakusa T, Yamada A, Moriya F, Ayatuka H, Mohamed ER, Matsuoka K, Noguchi M.
    Prostate, 2008年12月01日, [査読有り]
  • Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2(+) glioma patients
    Mingyue Jin; Yoshihiro Komohara; Shigeki Shichijo; Ryuya Yamanaka; Junichi Nikawa; Kyogo Itoh; Akira Yamada
    CANCER SCIENCE, 2008年08月, [査読有り]
  • A randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms.               
    Noguchi M, Kakuma T, Tomiyasu K, Yamada A, Itoh K, Konishi F, Kumamoto S, Shimizu K, Kondo R, Matsuoka K.
    Asian J. Androl., 2008年
  • EphB6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in HLA-A2+ glioma patients.               
    Jin M, Komohara Y, Shichijo S, Nikawa J, Yamanaka R, Itoh K, Yamada A.
    Cancer Sci., 2008年
  • Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients.               
    Jin M, Komohara Y, Shichijo S, Harada M, Yamanaka R, Miyamoto S, Nikawa J, Itoh K, Yamada A.
    Oncol. Report, 2008年
  • Immunological evaluation of personalized peptide vaccination with gemcitabine for pancreatic cancer.               
    Yanagimoto Y., Takai S., Yamamoto K., Mine T., Satoi S., Takahashi K., Terakawa N., Yamada A, Itoh K., Kamiyama S
    Caner Science, 2007年
  • Serum levels of IgG to the peptide of HCV-1b core at positions 35-44 correlated with persistent infection, while levels f IgG to the peptide of NS5A at position 2132-2140 correlated with better prognosis in HCV-infected patients.               
    Takao Y, Yutani S, Ono T, Takedatsu H, Hiraga S, Nagao Y, Ando E, Yamada A, Itoh K, Sata M.
    Medical Microbiol. Immunol., 2007年
  • HLA-G as a target molecule in specific immunotherapy against renal cell carcinoma.               
    Komohara Y, Harada M, Ishihara Y, Suekane S, Noguchi M, Yamada A, Matsuoka K, Itoh K.
    Oncol Report, 2007年
  • Identification of target antigens in specific immunotherapy for renal cell carcinoma.               
    Komohara Y, Harada M, Arima Y, Suekane S, Noguchi M, Yamada A, Itoh K, Matsuoka K.
    J Urol., 2007年
  • Phase 1 clinical study of a personalized peptide vaccination for patients infected with hepatitis C virus (HCV) 1b who failed to respond to interferon-based therapy.               
    Yutani S, Yamada A, Yoshida K, Takao Y, Tamura M, Komatsu N, Ide T, Tanaka M, Sata M, and Itoh K.
    Vaccine, 2007年
  • Excision Repair Cross-Complementation Group 1 Predicts Progression-Free and Overall Survival in Non-Small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy.               
    Azuma K, Komohara Y, Sasada T, TerazakiY, Ikeda J, Hoshino T, Itoh K, Yamada A, Aizawa H.
    Cancer Science, 2007年
  • Identification of Lck-derived peptides applicable to anti-cancer vaccine for patients with human leukocyte antigen-A3 supertype alleles.               
    Naito M, Komohara Y, Ishihara Y, Noguchi M, Yamashita Y, Shirakusa T, Yamada A, Itoh K,and Harada M.
    Br. J. Cancer, 2007年
  • Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil derivative (TS-1) for advanced gastric or colorectal carcinoma patients.               
    Sato Y, Fujiwara T, Mine T, Shomura H, Honma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S.
    Cancer Science, 2007年
  • Combination therapy of personalized peptide vaccination and low-dose estramustine phosphate for metastatic hormone refractory prostate cancer patients: An analysis of prognostic factors in the treatment.               
    Noguchi M, Mine T, Yamada A, Obata Y, Yoshida K, Mizoguchi J, Harada M, Suekane S, Itoh K, Matsuoka K.
    Oncology Research, 2007年
  • Expression of APOBEC3G in kidney cells.               
    Y Komohara, S Suekane, M Noguchi, K Matsuoka, A Yamada, K Itoh.
    Tissue Antigen, 2007年
  • Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b that can induce both cellular and humoral immunity in HCV1b+ HLA-A24+ patients.               
    Takao Y, Yamada A, Yutani S, Takedatsu H, Ono T, Etoh K, Ide T, Simotohno K, Sata M, Itoh K.
    Hepatol. Res, 2007年
  • Identification of new immunogenic peptides in conserved regions of hepatitis C virus (HCV) 1b that can induce both cellular and humoral immunity in HCV1b+ HLA-A24+ patients.               
    Takao Y, Yamada A, Yutani S, Takedatsu H, Ono T, Etoh K, Ide T, Simotohno K, Sata M, Itoh K.
    Hepatol. Res., 2007年
  • A new epitope peptide derived from hepatitis C virus (HCV) 1b possessing the capacity to induce cytotoxic T-lymphocytes in HCV1b-infected patients with HLA-A11, -A31 and -A33.               
    S Matsueda, A Yamada, Y Takao, M Tamura, N Komatsu , S Yutani, T Ide, M Sata, and K Itoh.
    Cancer Immunol. Immunother., 2007年
  • A Phase I Trial of Personalized Peptide Vaccination for Cytokine-refractory Metastatic Renal Cell Carcinoma Patients.               
    Suekane S, Nishitani M, Noguchi M, Komohara Y, Kokubu T, Naitoh M, Honma S, Yamada A, Itoh K, Matuoka K, Kanayama H.
    Cancer Sci., 2007年
  • Prostate-specific antigen-reactive cytotoxic T lymphocyte precursors in colon cancer patients.
    Wang Y, Harada M, Yano H, Ogasawara S, Tanaka M, Yamada A, Itoh K.
    Oncol Rep., 2006年02月, [査読有り]
  • High expression of APOBEC3G in patients infected with hepatitis C virus.               
    Komohara Y, Yano H, Shichijo S, Shimotohno K, Itoh K, Yamada A.
    J Mol Histol., 2006年
  • Personalized peptide vaccines: A new therapeutic modality for cancer.               
    Itoh K, Yamada A.
    Cancer Sci., 2006年
  • Anti-cancer vaccine candidates in specific immunotherapy for bladder carcinoma.               
    Komohara Y, Harada M, Arima Y, Suekane S, Noguchi M, Yamada A, Itoh K, Matsuoka K.
    Int J Oncol., 2006年
  • New epitope peptides derived from hepatitis C virus(HCV) 2a which have the capacity to induce cytotoxic T lymphocytes in HLA-A2+ HCV-infected patients.               
    Wang Y, Takao Y, Harada M, Yutani S, Ide T, Sata M, Itoh K, Yamada A.
    Microbiol Immunol., 2006年
  • Identification of hepatitis C virus (HCV) 2a-derived epitope peptides having the capacity to induce cytotoxic T lymphocytes in human leukocyte antigen-A24+ and HCV2a-infected patients.               
    Wang Y, Takao Y, Harada M, Komatsu N, Ono T, Sata M, Yamada A, Itoh K.
    Cell Immunol., 2006年
  • Anti-tumor effects of systemic and local immunization with a cytotoxic T lymphocyte-directed peptide in combination with a local injection of OK-432.               
    Ono T, Harada M, Yamada A, Tanaka M, Takao Y, Tanaka Y, Mine T, Sakamoto K, Nakashima T, Itoh K.
    Clin Cancer Res., 2006年
  • Immunological and clinical evaluation of personalized peptide vaccination for Patients with advanced malignant glioma.
    Yajima N, Yamanaka R, Mine T, Tsuchiya N, Honma J, Sano M, Kuramoto T, Obata Y, Komatsu N, Arima Y, Yamada A, Shigemori M, Itoh K, Tanaka R.
    Clin Cancer Res., 2005年08月, [査読有り]
  • Immunological evaluation of personalized peptide vaccination for patients with pancreatic cancer.
    Yamamoto K, Mine T, Katagiri K, Suzuki N, Kawaoka T, Ueno T, Matsueda S, Yamada A, Itoh K, Yamana H, Oka M.
    Oncol Rep., 2005年05月, [査読有り]
  • Immunological evaluation of individualized peptide vaccination with a low dose of estramustine for HLA-A24(+) HRPC patients.               
    Noguchi M, Itoh K, Yao A, Mine T, Yamada A, Obata Y, Furuta M, Harada M, Suekane S, Matsuoka K.
    Prostate., 2005年
  • Identification of hepatitis C virus 1b-derived peptides recognized by both cellular and humoral immune systems in HCV1b+ HLA-A24+ patients.               
    Tamura M, Yamada A, Takao Y, Matsueda S, Komatsu N, Yutani S, Ibe T, Sata M, Itoh K.
    Hepatol Res., 2005年
  • Prostatic acid phosphatase as a target molecule in specific immunotherapy for patients with non-prostate adenocarcinoma.               
    Wang Y, Harada M, Yano H, Ogasawara S, Takedatsu H, Arima Y, Matsueda S, Yamada A, Itoh K.
    J Immunother., 2005年
  • Immunological evaluation of vaccination of peptides derived from epithelial cancer-related antigens in two patients with hematological malignancy.               
    Takedatsu H, Yoshimoto K, Okamura T, Yakushij K, Imamura R, Hashiguchi M, Seki R, Obata Y, Harada M, Yamada A, Yamana H, Sata M, Itoh K.
    Int J Oncol., 2005年
  • Phase I trial of patient-oriented vaccination in HLA-A2 positive patients with metastatic hormone refractory prostate cancer.               
    Noguchi M, Itoh K, Suekane S, Yao A, Suetsugu N, Katagiri K, Yamada A, Yamana H, Noda S.
    Cancer Sci., 2004年
  • Immunological monitoring during combination of patient-oriented peptide vaccination and estramustin phosphate I patients with metastatic hormone refractory prostate cancer.               
    M. Noguchi, K. Itoh, S. Suekane, A. Morinaga, A. Sukehiro, N. Suetsugu, K. Katagiri, A. Yamada, and S. Noda.
    Prostate, 2004年
  • Immunological evaluation of pre-designated vaccination of the peptides frequently vaccinated to cancer patients in an individualized peptide regimen.               
    Mochizuki K, Sato Y, Tsuda N, Shomura H, Sakamoto M, Matsuura K, Ushijima K, Maeda Y, Katagiri K, Yamada A, Todo S, Kamura T, Itoh K.
    Int. J. Oncol., 2004年
  • Antibody reactive to a hepatitis C virus (HCV)-derived peptide capable of inducing HLA-A2 rstricted cytotoxic T lymphocytes is detectable in the majority of HCV-infected individuals without HLA-A2 restriction.               
    Takao Y, Yamada A, Yutani S, Sata M, Itoh K.
    Microbiol. Immunol., 2004年
  • Humoral responses to peptides correlate with overall survival in advanced cancer patients vaccinated with peptides besed on pre-existing peptide-specific cellular responses.               
    T. Mine, Y. Sato, M. Noguchi, T. Sasatomi, R. Gouhara, N. Tsuda, S. Tanaka, H. Shomura, K. Katagiri, T. Rikimaru, S. Shichijo, T. Kamura, T. Hashimoto, K. Shirouze, A. Yamada, S. Todo, K. Itoh, and H. Yamana.
    Clin. Cancer Res., 2004年
  • A phase I trial of CTL-purecursor-oriented peptide vaccine for colorectal carcinoma patients.               
    Y. Sato, Y. Maeda, T. Sasatomi, M. Takahashi, Y. Une, M. Kondo, T. Shinohara, N. Hida, K. Katagiri, K. Sato, A. Yamada, H. Yamana, K. Itoh, and S. Todo.
    Br. J. Cancer, 2004年
  • Natural antibodies reactive to self peptides which had been identified as cytotoxic T-lymphocyte (CTL)-directed tumor antigens.               
    Fukuda K, Takao Y, Miyazaki Y, Itoh K, Yamada A.
    Immunobiology., 2004年
  • Vaccination with pre-designated or evidence-based peptides for patients with recurrent gynecologic cancers.
    N. Tsuda, K. Mochizuki, M. Harada, A. Sukehiro, K. Kawano, A. Yamada, K. Ushijima, T. Sugiyama, T. Nishida, H. Yamana, K. Itoh, and T. Kamura.
    J. Immunother., 2004年01月, [査読有り]
  • Peptide vaccination for patients with melanoma and other types of cancers based on pre-existing peptide-specific cytotoxic T lymphocyte precursors in the periphery.
    S. Tanaka, M. Harada, T. Mine, M. Noguchi, R. Gohara, K. Azuma, M. Tamura, A. Yamada, A. Morinaga, M. Nishikori, K. Katagiri, K. Itoh, H. Yamana, and T. Hashimoto.
    J. Immunother., 2003年07月, [査読有り]
  • Depolymerization of actin filament by cytochalasin E induces interleukin-8 production and up-regulates CD54 in the Hela epithelial cell line.               
    N. Ikewaki, A. Yamada, and H. Inoko.
    Microbiol. Immunol., 2003年
  • Induction fo cellular and humoral immune responses to tumor cells and peptides in HLA-A24 positive hormone-refractory prostate cancer patients by peptide vaccination.               
    M. Noguchi, K. Kobayashi, N. Suetsugu, K. Tomiyasu, S. Suekane, A. Yamada, K. Itoh, and S. Noda.
    Prostate, 2003年
  • Immunological evaluation of peptide vaccination for patients with gastric cancer based on pre-existing cellular response to peptide.               
    Y. Sato, H. Shomura, Y. Maeda, T. Mine, Y. Une, Y. Akasaka, M. Kondo, S. Takahashi, T. Shinohara, K. Katagiri, M. Sato, S. Okada, K. Matsui, A. Yamada, H. Yamana, K. Itoh, and S. Todo.
    Cancer Sci., 2003年
  • IgG reactive to CTL-directed epitope peptides is either lacking or unbalanced in atopic dermatitis patients.               
    N. Kawamoto, S. Ohkouchi, T. Maeda, S. Tanaka, T. Hashimoto, S. Saijo, Y. Saijo, S. Shichijo, K. Itoh, and A. Yamada
    Tissue Antigens, 2003年
  • Cellular and humoral immune responses to tumor cells and peptides in lung cancer patients vaccinated with cyclophilinB peptide.               
    R. Gohara, N. Imai, T. Rikimaru, A. Yamada, M. Ichiki, M. Kawamoto, K. Matsunaga, J. Ashihara, S. Yano, S. Ohkouchi, H. Yamana, K. Oizumi, and K. Itoh.
    J. Immunother., 2002年
  • Expression of MAGE-1 and -4 proteins in normal tissues and various cancers
    K Itoh; Y Imai; T Kuramoto; A Yamada; H Yamana; S Shichijo
    MELANOGENESIS AND MALIGNANT MELANOMA: BIOCHEMISTRY, CELL BIOLOGY, MOLECULAR BIOLOGY, PATHOPHYSIOLOGY, DIAGNOSIS AND TREATMENT, 1996年, [査読有り]
  • Antigen-specific augmentation factor involved in murine delayed-type hypersensitivity
    I. Kawamura; K. Himeno; M. Sakumoto; A. Yamada; K. Nomoto
    International Journal of Immunopharmacology, 1988年, [査読有り]
■ MISC
■ 書籍等出版物
  • Peptide encoded by an intron of the putative tumor suppressor gene Testin of the common fragile site 7G is a cancer antigen recognized by cytotoxic T lymphocytes. In “FRAGILE SITES: New discoveries and changing perspectives”               
    Yamada A, Itoh K., 分担執筆
    Eds: Isabel Arrieta, Olga Penagarikano, and Mercedes Telez. Nova Science Publishers Inc. Hauppauge NY., 2007年
  • Peptide-based vaccines for cancer immunotherapy. In "Current Topics in Peptide & Protein Research"               
    A. Yamada, H. Yamana, K. Itoh. (R. M. Mohan, ed.), 分担執筆
    Research Trend, India, 2004年
  • Development of peptide-based vaccines for epithelial cancer. In "Research Progress in Cancer 2"               
    A. Yamada, H. Yamana, K. Itoh. (R. M. Mohan, ed.), 分担執筆
    Global Research Network, India., 2002年
  • A. Yamada, H. Yamana, K. Itoh. Development of peptide-based vaccines for epithelial cancer. In “Research Progress in Cancer 2”, R. M. Mohan (Ed), Global Research Network, India. pp. 241-247, 2002."               
    2002年, 査読無し
  • A. Yamada, H. Yamana, K. Itoh. Development of Peptide-Based Vaccines for Epithelial Cancer. In “ Research Progress in Cancer 2”, R. M. Mohan(Ed), Global               
    Research Network, Ind, 2002年, 査読無し
  • Immunopotentiating effects of a glycoprotein from Chlorella vulgaris strain CK and its characteristics.               
    K. Tanaka, Y. Shoyama, A. Yamada, K. Noda, F. Konishi, and K. Nomoto. (Atta-ur-Rahman, eds.), 分担執筆
    Bioactive Natural Products (Part F). Elsevier Science, Oxford., 2001年
  • K. Tanaka, Y. Shoyama, A. Yamada, K. Noda, F. Konishi, and K. Nomoto. Immunopotentiating Effects of a Glycoprotein from Chlorella Vulgaris Strain CK and its Characteristics In “ Studies in Natural Products Chemistry (Atta-ur-Rahman, eds), Vol25 Bioacti・・・               
    Elsevier Science, Oxford, 2001年, 査読無し
  • K. Itoh, Y. Imai, T. Kuramoto, A. Yamada, H. Yamana, and S. Shichijo. Exprssion of MAGE-1 and –4 Proteins in Normal Tissues and Various Cancers. In “ Melanogenesis and Malignant Melanoma” , Y. Hori, V. J. Hearing, J. Nakayama (Eds)               
    Elsevier Science, Amsterdam, 1996年, 査読無し
  • Expression of MAGE-1 and -4 proteins in normal tissues and various cancers.               
    "Melanogenesis and malignant melanoma", Y. Hori, V. J. Hearing, J. Nakayama (Eds). Elsevier Science, Amsterdam., 1996年, 査読無し
■ 担当経験のある科目_授業
  • 講義や実習、試験に関する情報のブログを利用した提供。学生にもっとも身近な携帯電話での情報提供が可能となった。               
    2004年
  • 教育ワークショップに参加               
    2003年07月
■ 所属学協会
  • 1980年 - 2022年
    日本免疫学会               
  • 2001年 - 2021年
    日本癌治療学会               
  • 2002年 - 2020年
    日本臨床薬理学会               
  • 2001年 - 2020年
    日本薬学会               
  • 2004年
    米国癌学会               
  • 1997年
    日本がん免疫学会               
  • 1993年
    日本癌学会               
  • 1992年
    米国免疫学会               
  • 基盤的癌免疫研究会               
  • 日本生体防御学会               
  • 日本細菌学会               
■ Works_作品等
  • クロレラの免疫作用の研究               
  • 医療用漢方薬の免疫作用の研究               
■ 共同研究・競争的資金等の研究課題
  • HMGB1の抗腫瘍免疫における機能解明とがん免疫療法への応用               
    2020年
  • HMGB1の抗腫瘍免疫における機能解明とがん免疫療法への応用               
    2019年
  • すこやかな次代と人を創る研究拠点大学へ:先端的がん治療研究による挑戦               
    2017年
  • 次世代経皮カクテルワクチンの開発基礎研究               
    2016年
  • 次世代経皮カクテルワクチンの開発基礎研究               
    2015年
  • 次世代経皮カクテルワクチンの開発基礎研究               
    2014年
  • マルチペプチド混合がんワクチンの開発基礎研究               
    2013年
  • マルチペプチド混合がんワクチンの開発基礎研究               
    2012年
  • がんペプチドワクチンの研究開発拠点               
    2011年
  • マルチペプチド混合がんワクチンの開発基礎研究               
    2011年
  • 肺がん、肝臓がん及び膀胱がん症例に対するテーラーメイドがんペプチドワクチン療法の実用化研究               
    2010年
  • C型肝炎ウイルスに対するペプチドワクチン開発の基盤的研究               
    2010年
  • 癌およびC型肝炎ウイルス感染症へのペプチドワクチン開発の基礎及び臨床研究               
    2010年
  • 肺がん、肝臓がん及び膀胱がん症例に対するテーラーメイドがんペプチドワクチン療法の実用化研究               
    2009年
  • C型肝炎ウイルスに対するペプチドワクチン開発の基盤的研究               
    2009年
  • 癌およびC型肝炎ウイルス感染症へのペプチドワクチン開発の基礎及び臨床研究               
    2009年
  • C型肝炎ウイルスに対するペプチドワクチン開発の基盤的研究               
    2008年
  • マルチペプチド混合がんワクチンの開発基礎研究:ポストテーラーメイドワクチンの開発               
    2008年
  • 癌およびC型肝炎ウイルス感染症へのペプチドワクチン開発の基礎及び臨床研究               
    2008年
  • C型肝炎ウイルスに対するペプチドワクチン開発の基盤的研究               
    2007年
  • 癌およびC型肝炎ウイルス感染症へのペプチドワクチン開発の基礎及び臨床研究               
    2007年
  • C型肝炎ウイルスに対するペプチドワクチン開発の基盤的研究               
    2006年
  • 癌およびC型肝炎ウイルス感染症へのペプチドワクチン開発の基礎及び臨床研究               
    2006年
  • C型肝炎ウイルス感染者への治療用ペプチドワクチン開発               
    2006年
  • 先端的な癌治療研究の拠点               
    2006年
  • 新規肺癌抗原の同定とそれらを分子標的としたペプチドワクチンの開発               
    2005年
  • C型肝炎ウイルスに対する新規診断薬と治療法の開発               
    2005年
  • 先端的な癌治療研究の拠点               
    2005年
  • 新規肺癌抗原の同定とそれらを分子標的としたペプチドワクチンの開発               
    2004年
  • C型肝炎ウイルスに対する新規診断薬と治療法の開発               
    2004年
  • 先端的な癌治療研究の拠点               
    2004年
  • 婦人科領域上皮性癌拒絶抗原の同定とがんワクチン分子開発               
    2003年
  • 癌ワクチン療法に関する研究               
    2003年
  • 新規肺癌抗原の同定とそれらを分子標的としたペプチドワクチンの開発               
    2003年
  • 先端的な癌治療研究の拠点               
    2003年
  • C型肝炎ウイルスに対する新規診断薬と治療法の開発               
    2003年
  • 婦人科領域上皮性癌拒絶抗原の同定と癌ワクチン分子開発               
    2002年
  • 婦人科領域上皮性癌拒絶抗原の同定と癌ワクチン分子開発               
    2001年
  • 婦人科領域上皮性癌拒絶抗原の同定と癌ワクチン分子開発               
    2000年
  • ヒトリンパ球上の細胞接着因子(VLA抗原)とその調節               
    1991年
  • 白血病細胞の実質臓器内への浸潤機構、インテグリン分子による白血病細胞血管内皮細胞相互作用の解析               
    1990年
  • 免疫関連の新規医薬品(機能性食品を含む)開発               
  • がんワクチンの開発研究               
■ 産業財産権
■ 共同研究希望
  • 免疫関連の新規医薬品/機能性食品の開発
■ 共同研究実績
  • がんペプチドワクチンの開発((株)ブライトパスバイオ取締役)
  • 医療用漢方薬の免疫作用の研究
  • 天然物の免疫作用の研究
  • 経皮ワクチンの開発
  • 機能性食品の免疫作用の研究
■ 研究者からの一言アピール
  • がんワクチンの開発では、遺伝子クローニングから非臨床・臨床試験、更にはベンチャー起業まですべてを行ってきました。この経験を生かす新たなシーズ探索中です。
■ 関心を持って取組んでいる活動
  • 研究以外では、カフェで学ぼうがんのこと:一般の方を対象としたがんセミナー。がん教育出前授業: 高校へ出向いてがん教育を行っています。