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Shiozawa Seiji
Institute for Disease Modeling
Professor
Career
■ Career
- Apr. 2024 - Present
Keio University, School of Medicine, 特任教授 - Dec. 2023 - Present
Kurume University, School of Medicine, 教授 - Apr. 2018 - Present
日本大学生物資源科学部獣医学科, 非常勤講師 - Apr. 2019 - Mar. 2024
Keio University, School of Medicine, 特任准教授 - 2020 - Nov. 2023
Kurume University, School of Medicine, 准教授 - 2019 - 2021
RIKEN, 脳神経科学研究センター, 研究員 - 2015 - 2019
Keio University, School of Medicine, 特任講師 - 2006 - 2015
Keio University, School of Medicine, 特任助教
Research activity information
■ Paper
■ Courses
■ Research Themes
- Non-viral derivation of induced pluripotent stem cells from the canine umbilical cord
Atsushi Yamazaki; Seiji Shiozawa; Yuko Koushige; Hirotaka Kondo; Hisashi Shibuya; Kazuya Edamura
PLOS One, 18 Jun. 2025, [Reviewed] - AI-Driven System for Large-Scale Automated Collection of Mouse Profile Images
Naomitsu Ozawa; Yusuke Sakai; Yusuke Sakai; Chihiro Koshimoto; Seiji Shiozawa
bioRxiv, 01 Apr. 2025
Last, Corresponding - Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids
Tomoki Kodera; Ryosuke F. Takeuchi; Sara Takahashi; Keiichiro Suzuki; Hidetoshi Kassai; Atsu Aiba; Seiji Shiozawa; Hideyuki Okano; Fumitaka Osakada
Biochemical and Biophysical Research Communications, Mar. 2023, [Reviewed] - An efficient evaluation system for factors affecting the genome editing efficiency in mouse
Yusuke Sakai; Yuri Okabe; Gen Itai; Seiji Shiozawa
Experimental Animals, 2023
Last, Corresponding - Anti-tumor effect of aquaporin 3 monoclonal antibody on syngeneic mouse tumor model.
Manami Tanaka; Anmi Ito; Seiji Shiozawa; Mariko Hara-Chikuma
Translational oncology, Oct. 2022, [Reviewed] - Non-viral derivation of a transgene-free induced pluripotent stem cell line from a male beagle dog
Sho Yoshimatsu; Kazuya Edamura; Yumi Yoshii; Aozora Iguchi; Hirotaka Kondo; Hisashi Shibuya; Tsukika Sato; Seiji Shiozawa; Hideyuki Okano
Stem Cell Research, 01 May 2021 - Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species.
Sho Yoshimatsu; Mayutaka Nakajima; Aozora Iguchi; Tsukasa Sanosaka; Tsukika Sato; Mari Nakamura; Ryusuke Nakajima; Eri Arai; Mitsuru Ishikawa; Kent Imaizumi; Hirotaka Watanabe; Junko Okahara; Toshiaki Noce; Yuta Takeda; Erika Sasaki; Rüdiger Behr; Kazuya Edamura; Seiji Shiozawa; Hideyuki Okano
Stem cell reports, 13 Apr. 2021, [Reviewed] - Direct Neuronal Reprogramming of Common Marmoset Fibroblasts by ASCL1, microRNA-9/9*, and microRNA-124 Overexpression.
Akisa Nemoto; Reona Kobayashi; Sho Yoshimatsu; Yuta Sato; Takahiro Kondo; Andrew S Yoo; Seiji Shiozawa; Hideyuki Okano
Cells, 22 Dec. 2020, [Reviewed] - Primed to naïve-like conversion of the common marmoset embryonic stem cells.
Seiji Shiozawa; Mayutaka Nakajima; Junko Okahara; Yoko Kuortaki; Fumihiko Kisa; Sho Yoshimatsu; Mari Nakamura; Ikuko Koya; Mika Yoshimura; Yohei Sasagawa; Itoshi Nikaido; Erika Sasaki; Hideyuki Okano
Stem cells and development, 18 Mar. 2020, [Reviewed]
Lead, Corresponding - Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs.
Mari Nakamura; Seiji Shiozawa; Daisuke Tsuboi; Mutsuki Amano; Hirotaka Watanabe; Sumihiro Maeda; Taeko Kimura; Sho Yoshimatsu; Fumihiko Kisa; Celeste M Karch; Tomohiro Miyasaka; Akihiko Takashima; Naruhiko Sahara; Shin-Ichi Hisanaga; Takeshi Ikeuchi; Kozo Kaibuchi; Hideyuki Okano
Stem cell reports, 08 Oct. 2019, [Reviewed]
Corresponding - Evaluating the efficacy of small molecules for neural differentiation of common marmoset ESCs and iPSCs.
Sho Yoshimatsu; Mari Nakamura; Mayutaka Nakajima; Akisa Nemoto; Tsukika Sato; Erika Sasaki; Seiji Shiozawa; Hideyuki Okano
Neuroscience research, 03 Oct. 2019, [Reviewed] - マーモセット脳で発現するタウのアイソフォームとリン酸化
カク 安ニ; Sharma Govinda; 木村 妙子; 塩澤 誠司; 小林 玲央奈; 佐原 成彦; 石橋 みなか; 石垣 診祐; 斎藤 太郎; 安藤 香奈絵; 村山 繁雄; 長谷川 成人; 祖父江 元; 岡野 栄之; 久永 眞市
日本生化学会大会プログラム・講演要旨集, Sep. 2019 - Establishment of induced pluripotent stem cells from common marmoset fibroblasts by RNA-based reprogramming.
Mayutaka Nakajima; Sho Yoshimatsu; Tsukika Sato; Mari Nakamura; Junko Okahara; Erika Sasaki; Seiji Shiozawa; Hideyuki Okano
Biochemical and biophysical research communications, 06 Aug. 2019, [Reviewed]
Corresponding - A versatile toolbox for knock-in gene targeting based on the Multisite Gateway technology.
Sho Yoshimatsu; Takefumi Sone; Mayutaka Nakajima; Tsukika Sato; Ryotaro Okochi; Mitsuru Ishikawa; Mari Nakamura; Erika Sasaki; Seiji Shiozawa; Hideyuki Okano
PloS one, Aug. 2019, [Reviewed]
Corresponding - Tau isoform expression and phosphorylation in marmoset brains.
Govinda Sharma; Anni Huo; Taeko Kimura; Seiji Shiozawa; Reona Kobayashi; Naruhiko Sahara; Minaka Ishibashi; Shinsuke Ishigaki; Taro Saito; Kanae Ando; Shigeo Murayama; Masato Hasegawa; Gen Sobue; Hideyuki Okano; Shin-Ichi Hisanaga
The Journal of biological chemistry, 26 Jul. 2019 - Robust and efficient knock-in in embryonic stem cells and early-stage embryos of the common marmoset using the CRISPR-Cas9 system.
Sho Yoshimatsu; Junko Okahara; Takefumi Sone; Yuta Takeda; Mari Nakamura; Erika Sasaki; Noriyuki Kishi; Seiji Shiozawa; Hideyuki Okano
Scientific reports, 06 Feb. 2019, [Reviewed]
Corresponding - Naive-like ESRRB+ iPSCs with the Capacity for Rapid Neural Differentiation.
Fumihiko Kisa; Seiji Shiozawa; Keisuke Oda; Sho Yoshimatsu; Mari Nakamura; Ikuko Koya; Kenji Kawai; Sadafumi Suzuki; Hideyuki Okano
Stem cell reports, 12 Dec. 2017, [Reviewed]
Lead - Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice.
Hirotake Ichise; Akiko Hori; Seiji Shiozawa; Saki Kondo; Yumi Kanegae; Izumu Saito; Taeko Ichise; Nobuaki Yoshida
Experimental animals, 29 Jul. 2016, [Reviewed] - α-Synuclein aggregation in the olfactory bulb of middle-aged common marmoset.
Reona Kobayashi; Junko Takahashi-Fujigasaki; Seiji Shiozawa; Chikako Hara-Miyauchi; Takashi Inoue; Hirotaka James Okano; Erika Sasaki; Hideyuki Okano
Neuroscience research, May 2016, [Reviewed] - Establishment of ES cells from inbred strain mice by dual inhibition (2i).
Akifumi Kanda; Yusuke Sotomaru; Seiji Shiozawa; Eiso Hiyama
The Journal of reproduction and development, 2012, [Reviewed] - Gene targeting and subsequent site-specific transgenesis at the β-actin (ACTB) locus in common marmoset embryonic stem cells.
Seiji Shiozawa; Kenji Kawai; Yohei Okada; Ikuo Tomioka; Takuji Maeda; Akifumi Kanda; Haruka Shinohara; Hiroshi Suemizu; Hirotaka James Okano; Yusuke Sotomaru; Erika Sasaki; Hideyuki Okano
Stem cells and development, Sep. 2011, [Reviewed]
Lead - Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28
Tomioka, Ikuo; Maeda, Takuji; Shimada, Hiroko; Kawai, Kenji; Okada, Yohei; Igarashi, Hiroshi; Oiwa, Ryo; Iwasaki, Tsuyoshi; Aoki, Mikio; Kimura, Toru; Shiozawa, Seiji; Shinohara, Haruka; Suemizu, Hiroshi; Sasaki, Erika; Okano, Hideyuki
GENES TO CELLS, Sep. 2010, [Reviewed] - Preimplantation development of somatic cell cloned embryos in the common marmoset (Callithrix jacchus).
Yusuke Sotomaru; Reiko Hirakawa; Akiko Shimada; Seiji Shiozawa; Ayako Sugawara; Ryo Oiwa; Asako Nobukiyo; Hideyuki Okano; Norikazu Tamaoki; Tatsuji Nomura; Eiso Hiyama; Erika Sasaki
Cloning and stem cells, Dec. 2009, [Reviewed] - Generation of transgenic non-human primates with germline transmission.
Erika Sasaki; Hiroshi Suemizu; Akiko Shimada; Kisaburo Hanazawa; Ryo Oiwa; Michiko Kamioka; Ikuo Tomioka; Yusuke Sotomaru; Reiko Hirakawa; Tomoo Eto; Seiji Shiozawa; Takuji Maeda; Mamoru Ito; Ryoji Ito; Chika Kito; Chie Yagihashi; Kenji Kawai; Hiroyuki Miyoshi; Yoshikuni Tanioka; Norikazu Tamaoki; Sonoko Habu; Hideyuki Okano; Tatsuji Nomura
Nature, 28 May 2009, [Reviewed] - Efficient sequential gene regulation via FLP-and Cre-recombinase using adenovirus vector in mammalian cells including mouse ES cells
Kondo S; Takahashi Y; Shiozawa S; Ichise H; Yoshida N; Kanegae Y; Saito I
Microbiology and Immunology, 2006, [Reviewed]
- ヒト及びサル多能性幹細胞におけるナイーブ化技術とその応用
塩澤 誠司
久留米医学会雑誌, 2024
Lead, Corresponding - ヒト及び非ヒト霊長類多能性幹細胞におけるナイーブ型多能性状態の獲得.
塩澤 誠司
九州実験動物雑誌, Oct. 2021
Lead - ウイルスおよびフィーダー細胞を使用しない臨床グレードの犬iPS細胞の創生
枝村 一弥; 井口 青空; 吉井 友見; 吉松 祥; 近藤 広孝; 渋谷 久; 関 真美子; 浅野 和之; 塩澤 誠司; 岡野 栄之
Twig's, Sep. 2019 - FTDP-17患者由来iPS細胞を用いたin vitro病態モデルの確立及び表現型解析
中村 真理; 渡部 博貴; 塩澤 誠司; 久永 眞市; 佐原 成彦; 木村 妙子; 宮坂 知宏; 高島 明彦; 池内 健; 岡野 栄之
Dementia Japan, Oct. 2017 - Moesin遺伝子発現の可視化による体細胞クローン胚におけるX染色体リプログラミングの評価
若井拓哉; 森園倫成; 渡辺大士; 外丸祐介; 神田暁史; 塩沢誠司; 河野友宏
Journal of Reproduction and Development, 10 Aug. 2014 - マーモセットES細胞における標的遺伝子組み換え技術の確立
塩澤誠司; 塩澤誠司; 塩澤誠司; 佐々木えりか; 前田拓志; 前田拓志; 末水洋志; 江袋美和; 後藤一雄; 外丸祐介; 岡野栄之
生化学, 2008
Lead
■ Courses
■ Research Themes
- Generation of feline pluripotent stem cell-derived renal progenitors and kidney organoids for the treatment of chronic kidney disease.
Grant-in-Aid for Scientific Research (B)
Osaka Metropolitan University
01 Apr. 2022 - 31 Mar. 2026 - Establishment of regenerative medicine for musculoskeletal system using clinical-grade canine iPS cells
Grant-in-Aid for Scientific Research (B)
Nihon University
01 Apr. 2020 - 31 Mar. 2023 - Evaluation of homologous recombination enhancers in genome editing
Grant-in-Aid for Scientific Research (C)
01 Apr. 2019 - 31 Mar. 2022 - Gene targeting in common marmoset embryonic stem cells
Grant-in-Aid for Young Scientists (B)
Keio University
2007 - 2008
- 特開2021-023228, 特願2019-144808, タウ関連疾患モデルの製造方法
中村 真理; 塩澤 誠司; 岡野 栄之 - 特許第6719449号, WO2016-148253, 特願2017-506204, ナイーブ型多能性幹細胞の製造方法
岡野 栄之; 塩澤 誠司; 木佐 文彦 - WO2020-050294, JP2019034705, 相同組換え効率上昇剤及びその使用
岡野 栄之; 塩澤 誠司; 吉松 祥 - WO2016-148253, JP2016058577, ナイーブ型多能性幹細胞の製造方法
岡野 栄之; 塩澤 誠司; 木佐 文彦
