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Ohnishi Youko
Department of Pharmacology
Assistant Professor

Researcher information

■ Field Of Study
  • Life sciences, Neuroscience - general
■ Research Keyword
  • 神経科学一般
  • 生化学一般
  • 薬理学一般
■ Research Theme
  • コカイン依存症におけるエピジェネティクスの変化の役割解明
  • モテるオスマウスに出会ったときのメスマウスの脳で活性化している神経細胞の機能
  • 特定遺伝子発現誘導メカニズム解明のためのシステム開発

Research activity information

■ Paper
■ MISC
■ Lectures, oral presentations, etc.
  • The effect of cocaine on male mouse attractiveness and social ranking.　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西昭徳
    The 97th Annual Meeting of the Japanese Pharmacological Society, 14 Dec. 2023
  • Is the attractiveness of male mice from female mice inherited?　　　　　　　　　　　　　　　
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2023, 11 Nov. 2023
  • Female mice's nucleus accumbens dopamine responsiveness changes depending on the attractiveness of male mice.　　　　　　　　　　　　　　　
    大西 克典、河原 幸江、大西 陽子、西 昭徳
    The 25th Workshop on Active Amines, 26 Aug. 2023
  • Does repeated cocaine administration combined with encounters with male mice increase female mice's preference for those males?　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西昭徳
    The 96th Annual Meeting of the Japanese Pharmacological Society / The 43rd Annual Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics, 30 Nov. 2022
  • Can sexual experience enhance male attractiveness in mice?　　　　　　　　　　　　　　　
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2022, 12 Nov. 2022
  • Distinct role of dopamine in the PFC and NAc during Exposure to Cocaine-Associated Cues　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 24th Workshop on Biogenic Amines, 27 Aug. 2022
  • Distinct role of dopamine in the PFC and NAc during exposure to cocaine-associated cues　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 95th Annual Meeting of the Japanese Pharmacological Society, 08 Mar. 2022
  • Is male mouse attractiveness inherited?　　　　　　　　　　　　　　　
    大西克典、河原幸恵、大西陽子、西昭徳
    The 44th Annual Meeting of the Molecular Biology Society of Japan, 01 Dec. 2021
  • The role of dopamine in the prefrontal cortex and nucleus accumbens during exposure to cocaine-associated cues　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 74th Western Japan Division of the Japanese Pharmacological Society, 20 Nov. 2021
  • Different roles of dopamine in the prefrontal cortex and nucleus accumbens in cocaine-induced conditioned place preference　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 43rd Annual Meeting of the Japanese Biological Psychiatry Society and the 51st Annual Meeting of the Japanese Neuropsychopharmacology Society, 14 Jul. 2021
  • Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 32nd CINP Virtual World Congress, 26 Feb. 2021
  • Role of dopamine in regulating reward memory and behavior related to cocaine in the prefrontal cortex and nucleus accumbens　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 73rd Western Japan Division of the Japanese Pharmacological Society, 21 Nov. 2020
  • Does shaving an attractive male mouse cause him to lose his ability to attract female mice?　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西昭徳
    The 73rd Western Division Meeting of the Japanese Pharmacological Society, 21 Nov. 2020
  • Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The Japanese Pharmacological Society Annual Meeting, 17 Mar. 2020
  • Can alcohol make an unattractive male mouse capture the interest of female mice?　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西昭徳
    The 93rd Annual Meeting of the Japanese Pharmacological Society, 16 Mar. 2020
  • Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward memory　　　　　　　　　　　　　　　
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 94th Annual Meeting of the Japanese Pharmacological Society, 08 Mar. 2020
  • Exploring the molecular and neural basis of attractive males.　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西昭徳
    The 42nd Annual Meeting of the Molecular Biology Society of Japan, 03 Dec. 2019
  • How does alcohol consumption affect the preference of females for males and dopamine responsiveness?　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西昭徳
    The 72nd Western Division Meeting of the Japanese Pharmacological Society, 16 Nov. 2019
  • Does baldness of attractive male decrease his external and internal power to fascinate female in mice?　　　　　　　　　　　　　　　
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2019, 19 Oct. 2019
  • Does an attractive male mouse become less attractive if he goes bald?　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西 昭徳
    NEURO 2019, 25 Jul. 2019
  • How can a male become attractive?　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西 昭徳
    The 41st Annual Meeting of the Molecular Biology Society of Japan, 28 Nov. 2018
  • Is it possible that non-attractive male mouse can get attractive mind set?　　　　　　　　　　　　　　　
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2018, 03 Nov. 2018
  • The Ultimate Attraction Strategy! How to attract girls and how to lose their interest.　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、西 昭徳
    The 28th Microdialysis Research Meeting, 16 Dec. 2017
  • Is it possible that non-attractive male mouse could get female mind?　　　　　　　　　　　　　　　
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2017, 11 Nov. 2017
  • Long-term consumption of antioxidant foods suppresses cocaine dependence after social stress.　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、Neve RL、Vialou VF、Nestler EJ、西 昭徳
    The 90th Annual Meeting of the Japanese Pharmacological Society, 15 Mar. 2017
  • Worsening of cocaine dependence after social defeat stress is caused by oxidative stress responses in the nucleus accumbens.　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、Neve RL、Nestler EJ、西 昭徳
    The 39th Annual Meeting of the Molecular Biology Society of Japan, 30 Nov. 2016
  • Nrf exacerbates cocaine addiction after social defeat stress.　　　　　　　　　　　　　　　
    Ohnishi YN, Kawahara Y, Ohnishi YH, Neve RL, Nestler EJ, Nishi A
    Neuroscience 2016, 12 Nov. 2016
  • NRF protein promotes cocaine dependence after stress.　　　　　　　　　　　　　　　
    大西克典、河原幸江、大西陽子、Neve RL、Vialou VF、Nestler EJ、西 昭徳
    The 89th Annual Meeting of the Japanese Pharmacological Society, 09 Mar. 2016
  • Oxidative stress response exacerbates cocaine addiction after social defeat stress.　　　　　　　　　　　　　　　
    Ohnishi YN, Kawahara Y, Ohnishi YH, Kuroiwa M, Vialou VF, Neve RL, Nestler EJ, Nishi A
    Neuroscience 2015, 17 Oct. 2015
  • Functional role of the N-terminal domain of ΔFosB in responses to stress and drugs of abuse.　　　　　　　　　　　　　　　
    Ohnishi YN, Ohnishi YH, Vialou V, Mouzon E, Laplant Q, Nishi A, Nestler EJ.
    Neuroscience 2013, 09 Nov. 2013
  • Functional analysis of the N-terminal domain of ΔFosB protein in social stress and cocaine dependence.　　　　　　　　　　　　　　　
    大西克典、大西陽子、Mouzon E、Vialou VF、Laplant Q、西 昭徳、Nestler EJ.
    The 86th Annual Meeting of the Japanese Pharmacological Society, 21 Mar. 2013
  • Functional role of the N-terminal domain of deltaFosB in response to stress and drugs of abuse.　　　　　　　　　　　　　　　
    Ohnishi YN, Ohnishi YH, Mouzon E, Vialou V, Laplant Q, Nishi A, Nestler EJ.
    The 35th Annual Meeting of the Molecular Biology Society of Japan, 11 Dec. 2012
  • Functional role of the N-terminal domain of deltaFosB in response to stress and drugs of abuse.　　　　　　　　　　　　　　　
    Ohnishi YN, Ohnishi YH, Mouzon E, Vialou V, Laplant Q, Nishi A, Nestler EJ.
    Society for Neuroscience 2012, 13 Oct. 2012
  • The interaction between proteasome ATPase Sug1 and ΔFosB regulates cocaine-induced spontaneous locomotion.　　　　　　　　　　　　　　　
    大西 陽子、大西 克典、中村 崇規、Eric J. Nestler
    The 14th Brain Science Research Meeting, 02 Jun. 2012
  • Paternal transmission of stressed-induced pathologies.　　　　　　　　　　　　　　　
    D. M. DIETZ, Q. LAPLANT, V. VIALOU, E. L. WATTS, Y. N. OHNISHI, G. E. HODES, S. J. RUSSO, J. FENG, R. OOSTING, E. J. NESTLER
    Society for Neuroscience 2011, 16 Nov. 2011
  • Role of BDNF in the VTA in regulating molecular and behavioral responses to morphine.　　　　　　　　　　　　　　　
    J. KOO, M. S. MAZEI-ROBISON, M. LOBO, D. M. DIETZ, Q. LAPLANT, D. FERGUSON, J. FENG, H. SUN, D. DAMEZ-WERNO, K. SCOBIE, Y. N. OHNISHI, Y. H. OHNISHI, E. MOUZON, C. DIAS, A. J. ROBISON, V. VIALOU, R. L. NEVE, S. J. RUSSO, E. J. NESTLER
    Society for Neuroscience 2011, 13 Nov. 2011
  • Differential role of ΔFosB and Δ2ΔFosB in response to stress and drugs of abuse.　　　　　　　　　　　　　　　
    Y. N. OHNISHI, Y. H. OHNISHI, E. MOUZON, V. VIALOU, Q. LAPLANT, E. J. NESTLER
    Society for Neuroscience 2010, 16 Nov. 2010
  • ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures.　　　　　　　　　　　　　　　
    N. YUTSUDO, T. KAMADA, H. NOMARU, Y. H. OHNISHI, Y. OHNISHI, K. KAJITANI, K. SAKUMI, H. SHIGETO, Y. NAKABEPPU
    Society for Neuroscience 2010, 16 Nov. 2010
  • Role of BDNF in the VTA in regulating molecular and behavioral responses to morphine.　　　　　　　　　　　　　　　
    J. KOO, M. S. MAZEI-ROBISON, Q. LAPLANT, D. M. DIETZ, D. FERGUSON, M. LOBO, Y. N. OHNISHI, J. FENG, Y. H. OHNISHI, E. MOUZON, M. B. WILKINSON, Y. L. HURD, S. J. RUSSO, E. J. NESTLER
    Society for Neuroscience 2010, 15 Nov. 2010
  • Screening and identification of protein binding partners of FosB, ΔFosB, and Δ2ΔFosB using yeast two hybrid system.　　　　　　　　　　　　　　　
    Y. HONDA-OHNISHI, Y. N. OHNISHI, A. SHIBATA, V. VIALOU, E. J. NESTLER
    Society for Neuroscience 2009, 18 Oct. 2009
  • ΔFosB-induced synaptic plasticity in the NAc mediates resiliency to stress.　　　　　　　　　　　　　　　
    V. F. VIALOU, Q. LAPLANT, H. COVINGTON, D. DIETZ, Y. OHNISHI, A. ROBISON, D. WALLACE-BLACK, Y. OHNISHI, A. J. RUSH, S. INIGUEZ, V. KRISHNAN, S. GHOSE, O. BERTON, C. TAMMINGA, E. J. NESTLER
    Society for Neuroscience 2009, 20 Oct. 2009
  • Functional activation of the medial prefrontal cortex in depressive-like behaviors.　　　　　　　　　　　　　　　
    H. E. COVINGTON III, M. K. LOBO, V. VIALOU, I. MAZE, J. M. HYMAN, K. BRADBURY, Q. LAPLANT, Y. OHNISHI, E. GREENBERG, R. L. NEVE, S. J. HAGGARTY, K. DEISSEROTH, E. J. NESTLER
    Society for Neuroscience 2009, 18 Oct. 2009
  • Differential role of ΔFosB and Δ2ΔFosB in response to stress and drugs of abuse.　　　　　　　　　　　　　　　
    Y. N. OHNISHI, Y. H. OHNISHI, V. VIALOU, E. J. NESTLER
    Society for Neuroscience 2009, 17 Oct. 2009
  • The N-terminal domain of ΔFosB is functional in behavioral responses.　　　　　　　　　　　　　　　
    Y. OHNISHI, Y. H. OHNISHI, A. GRAHAM, C. COWAN, C. STEFFEN, S. BIRNBAUM, Y. NAKABEPPU, E. J. NESTLER
    Society for Neuroscience 2008, 16 Nov. 2008
  • ΔFosB promotes neurogenesis in the dentate gyrus of mouse hippocampus after brain damage caused by excitotoxicity.　　　　　　　　　　　　　　　
    N. YUTSUDO, Y. H. OHNISHI, Y. OHNISHI, Y. NAKABEPPU
    Society for Neuroscience 2007, 06 Nov. 2007
  • FosB and ΔFosB determine susceptibility to excitotoxicity induced by kainate.　　　　　　　　　　　　　　　
    Y. HONDA-OHNISHI, Y. N. OHNISHI, H. ISHIBASHI, K. ETO, K. SAKUMI, M. NODA, Y. NAKABEPPU
    Society for Neuroscience 2006, 16 Oct. 2006
  • FosB efficiently suppresses hyperlocomotor activity and fearless behavior induced by upregulation of ΔFosB and also attenuates exploratory behavior.　　　　　　　　　　　　　　　
    Y. OHNISHI, Y. H. OHNISHI, H. KURUSHIMA, K. SAKUMI, Y. NAKABEPPU
    Society for Neuroscience 2006, 14 Oct. 2006
  • ΔFosB determines resistance to excitotoxicity induced by kainic acid.　　　　　　　　　　　　　　　
    Y. HONDA-OHNISHI, Y. OHNISHI, K. TAKA, H. ISHIBASHI, K. ETO, K. KAJITANI, K. SAKUMI, M. NODA, S. GOTO, Y. NAKABEPPU
    Society for Neuroscience 2005, 16 Nov. 2005
  • Behavioral and microarray analysis of knock-in mouse, which express only ΔFosB from fosB gene.　　　　　　　　　　　　　　　
    Y. OHNISHI, K. SAKUMI, Y. KATSUHISA, Y. HONDA-OHNISHI, T. MIURA, Y. NAKABEPPU
    Society for Neuroscience 2005, 15 Nov. 2005
  • Expression of a multi-functional lectin, Galectin-1 is dependent on ΔFosB.　　　　　　　　　　　　　　　
    Y. OHNISHI, K. SAKUMI, T. MIURA, K. YAMAZAKI, Y. OHNISHI, Y. TOMINAGA, H. HORIE, T. KADOYA, Y. NAKABEPPU
    Society for Neuroscience 2002, 05 Nov. 2002
■ Research Themes
  • Elucidating the mechanisms by which female mice identify attractive male mice.
    Grant-in-Aid for Scientific Research (C)
    Kurume University
    01 Apr. 2022 - 31 Mar. 2025
  • Novel approaches for treatment of addiction after social defeat stress　　　　　　　　　　　　　　　
    2018 - 2020
  • 複数のエピジェネティクス解析を用いたコカイン感受性亢進責任遺伝子の同定　　　　　　　　　　　　　　　
    2016 - 2019
  • Does oxdative stress reaction in nucleus accumbes exacerbate cocaine addiction after social defeat stress?　　　　　　　　　　　　　　　
    2015 - 2017
■ 共同研究希望
  • ChIPアッセイ
  • 分子生物学的なアプローチ