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Hoshino Tomoaki
Division of Respirology Neurology and Rheumatology Department of Internal Medicine
Professor

Researcher information

■ Research Keyword
  • サイトカイン
  • 呼吸器免疫
  • Tumor Immunology
■ Field Of Study
  • Life sciences, Respiratory medicine
  • Life sciences, Immunology
■ Research Keyword
  • 呼吸器の疾患
  • 呼吸器の腫よう
■ Research Theme
  • 呼吸器疾患およびアレルギー性疾患
  • COPD
  • 肺障害・間質性肺炎
  • マウス疾患モデル
  • 肺がん
  • サイトカイン

Career

■ Educational Background
  • 1993, Kurume University, Graduate School, Division of Medicine
  • 1989, Kurume University, Faculty of Medicine
  • Kurume University, School of Medicine

Research activity information

■ Award
  • 1997
    福岡県対ガン協会賞
■ MISC
  • Kinjo, Y., K. Kawakami, K. Uezu, S. Yara, K. Miyagi, Y. Koguchi, T. Hoshino, M. Okamoto, Y. Kawase, K. Yokota, K. Yoshino, K. Takeda, S. Akira, and A. Saito. 2002. Contribution of IL-18 to Th1 response and host defense against infection by Mycobacteriu・・・               
    2002
  • Shimoda, K., H. Tsutsui, K. Aoki, K. Kato, T. Matsuda, A. Numata, K. Takase, T. Yamamoto, H. Nukina, T. Hoshino, Y. Asano, H. Gondo, T. Okamura, S.Okamura, K. I. Nakayama, K. Nakanishi, Y. Niho, and M. Harada. 2002. Partial impairment of interleukin-12・・・               
    2002
  • Okamoto, M., S. Kato, K. Oizumi, M. Kinoshita, Y. Inoue, K. Hoshino, S. Akira, A. N. McKenzie, H. A. Young, and T. Hoshino. 2002. Interleukin 18 (IL-18) in synergy with IL-2 induces lethal lung injury in mice: a potential role for cytokines, chemokines・・・               
    2002
  • Hoshino, T., Y. Kawase, M. Okamoto, K. Yokota, K. Yoshino, K. Yamamura, J. Miyazaki, H. A. Young, and K. Oizumi. 2001. Cutting edge: IL-18-transgenic mice: in vivo evidence of a broad role for IL-18 in modulating immune function. J Immunol 166: 7014-70・・・               
    2001
  • Kim, S. H., L. L. Reznikov, R. J. Stuyt, C. H. Selzman, G. Fantuzzi, T. Hoshino, H. A. Young, and C. A. Dinarello. 2001. Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain. J Immunol 166: 148-154."               
    2001
  • Lee, S. J., Y. S. Cho, M. C. Cho, J. H. Shim, K. A. Lee, K. K. Ko, Y. K. Choe, S. N. Park, T. Hoshino, S. Kim, C. A. Dinarello, and D. Y. Yoon. 2001. Both E6 and E7 oncoproteins of human papillomavirus 16 inhibit IL-18-induced IFN-gamma production in h・・・               
    2001
  • Sayers, T. J., A. D. Brooks, J. M. Ward, T. Hoshino, W. E. Bere, G. W. Wiegand, J. M. Kelley, and M. J. Smyth. 2001. The restricted expression of granzyme M in human lymphocytes. J Immunol 166: 765-771."               
    2001
  • Hiromatsu, T., T. Hoshino, H. Yagita, M. Koga, S. Sakisaka, J. Honda, D. Yang, N. Kayagaki, K. Okumura, and K. Nonaka. 1999. Functional Fas ligand expression in thyrocytes from patients with Graves' disease. J Clin Endocrinol Metab 84: 2896-2902."               
    1999
  • Hoshino, T., R. H. Wiltrout, and H. A. Young. 1999. IL-18 is a potent coinducer of IL-13 in NK and T cells: a new potential role for IL-18 in modulating the immune response. J Immunol 162: 5070-5077."               
    1999
  • Hoshino, T., R. T. Winkler-Pickett, A. T. Mason, J. R. Ortaldo, and H. A. Young. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells sre present in vivo in the absence of IFN-gamma. J Immunol 162: 51-59."               
    1999
  • Yang, D., Y. Hiromatsu, T. Hoshino, Y. Inoue, K. Itoh, and K. Nonaka. 1999. Dominant infiltration of T (H) 1-type CD4+ T cells at the retrobulbar space of patients with thyroid-associated ophthalmopathy. Thyroid 9: 305-310."               
    1999
  • Gotoh, M., S. Shichijo, T. Hoshino, Y. Imai, T. Imaizumi, Y. Inoue, H. Takasu, T. Yamaoka, and K. Itoh. 1998. Sequence analysis of genes encoding rodent homologues of the human tumor-rejection antigen SART-1. Jpn J Cancer Res 89: 849-854."               
    1998
  • Hoshino, T., A. Ohta, D. Yang, M. Kawamoto, M. Kikuchi, Y. Inoue, S. Kamizono, T. Ota, K. Itoh, and K. Oizumi. 1998. Elevated serum interleukin 6, interferon-gamma, and tumor necrosis factor-alpha levels in patients with adult Still's disease. J Rheuma・・・               
    1998
  • Hoshino, T., N. Seki, M. Kikuchi, T. Kuramoto, O. Iwamoto, I. Kodama, K. Koufuji, J. Takeda, and K. Itoh. 1997. HLA class-I-restricted and tumor-specific CTL in tumor-infiltrating lymphocytes of patients with gastric cancer. Int Cancer 70: 631-638."               
    1997
  • Ohba, H., T. Toyokawa, S. Yasuda, T. Hoshino, K. Itoh, and N. Yamasaki. 1997. Spectroscopic analysis of the cytoagglutinating activity of abrin-b isolated from Abrus precatorius seeds against leukemic cells. Biosci Biotechnol Biochem 61: 737-739."               
    1997
  • Seki, N., T. Hoshino, M. Kikuchi, A. Hayashi, and K. Itoh. 1997. HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer. Cell Immunol 175: 101-110."               
    1997
  • Shichijo, S., T. Hoshino, K. Koufuji, A. Hayashi, M. Kawamoto, M. Kikuchi, T. Higuchi, M. Ichiki, K. Oizumi, and K. Itoh. 1997. Detection of MAGE-4 protein in sera of lung cancer patients. Jpn J Cancer Res 88: 414-419."               
    1997
  • J.Biochem.(共著)               
    1996
  • TCRgd+T cells in peripheral blood of patients with adult Still's disease.(共著)               
    J.Rheumatol., 1996
  • Human histocompatibility leukocyte antigen-DR and heat shock protein-70 expression in eye muscle tissue in thyroid-associated ophthalmopathy.(共著)               
    J.Clin.Endocrinol.Metabolism, 1995
  • Spontaneous production of various cytokines except IL-4 from CD4+T cells in the affected organs of sarcoidosis.(共著)               
    Clin.Exp.Immunol., 1995
  • Rapid and sensitive diagnosis of Cytomegalovirus and Pneumocystis carinii pneumonia in patients with hematologic neoplasma by using capillary polymerase chain reaction.(共著)               
    British J.Haematol., 1994
  • Elevated adenosine deaminase activities in serum of patients with diabetes mellitus.(共著)               
    Diabetes Research Clin.Practice, 1994
  • HLA-DR antigen expression on eye muscle in thyroid-associated ophthalmopathy.In 80 years of Hashimoto Disease.(共著)               
    Elsevier Science Publishers B.V.(共編), 1993
  • Tissue specific distribution and age-dependent increase of human CD11b+T cells.(共著)               
    J.Immunol., 1993
  • Anti-eye muscle antibodies and hypothyroid Graves' disease(共著)
    YUJI HIROMATSU; MASAYUKI SATO; KIYOKO TANAKA; KYOHEI NONAKA; KAZUYUKI KOJIMA; KIMINORI SATO; SHINICHI KUROSE; TOMOAKI HOSHINO; AKIHIKO NAKASHIMA
    A case report.Endocrinol.Jpn., 1992
  • Flow cytometric measurement of NK cell cytotoxicity.(共著)               
    J.Clin.Lab.Immunol., 1991
  • Effect of serum derived blocking factor(SDBF)on platelet associates-IgG.(共著)               
    J.Clin.Lab.Immunol., 1990
  • Kawase, Y., T. Hoshino, K. Yokota, A. Kuzuhara, M. Nakamura, Y. Maeda, E. Nishiwaki, M. Zenmyo, H. Aizawa, and K. Yoshino. Bone Malformations in IL-18 Transgenic Mice. J. Bone Mineral Res. In press."               
■ Research Themes
  • Study on Tumor Rejection Antigen               
■ 共同研究実績
  • NCI/NIH/USA Dr. Youngらとの共同研究
  • UCHSC/コロラド大/USA Dr. Dinarelloらとの共同研究
  • Do-Young Yoon, Ph.D.Kor. Res. Institute of Bioscience and Biotechnologyらとの共同研究 Eoeun Dong 52, Yuseong-Gu, Daejeon 305-333, Korea
  • 順天堂大学、東北大、大阪大、京都大、兵庫医大、九州大、琉球大等国内の大学との共同研究
  • 日本オルガノン(大阪)との共同研究
  • 佐賀大学とシノテストとのぺりオスチンに関する共同研究
■ 研究者からの一言アピール
  • 前任の相澤教授が“肺年齢”を考案しました
■ 関心を持って取組んでいる活動
  • 肺癌治療の地域における均てん化