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Okada Toshiyuki
Department of Immunology
Assistant Professor
Research activity information
■ Paper
■ Research Themes
- Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?
Emiko Mizoguchi; Takayuki Sadanaga; Toshiyuki Okada; Takanori Minagawa; Jun Akiba
Intestinal Research, Jul. 2023, [Reviewed] - Chitinase 3-like 1, Carcinoembryonic Antigen-related Cell Adhesion Molecule 6, and Ectopic Claudin-2 in the Carcinogenic Processes of Ulcerative Colitis
Tetsushi Kinugasa; Toshiyuki Tsunoda; Emiko Mizoguchi; Toshiyuki Okada; Tomoya Sudo; Akihiko Kawahara; Jun Akiba; Yoshito Akagi
Anticancer Research, Aug. 2022, [Reviewed] - Landscape of inflammatory bowel disease in Singapore
Daren Low; Nidhi Swarup; Toshiyuki Okada; Emiko Mizoguchi
Intestinal Research, Jul. 2022, [Reviewed] - Biological Analyses-Derived Translational Findings in the T Cell Receptor Alpha Chain Knockout Mouse as an Experimental Model for Ulcerative Colitis
Emiko Mizoguchi; Takayuki Sadanaga; Toshiyuki Okada
International Journal of Translational Medicine, Dec. 2021, [Reviewed]
Last - A review of selected IBD biomarkers: From animal models to bedside
Emiko Mizoguchi; Renuka Subramaniam; Toshiyuki Okada; Atsushi Mizoguchi
Diagnostics, Feb. 2021, [Reviewed] - Role of xanthine derivatives during the development of chronic colitis-associated neoplasia
溝口恵美子; 溝口恵美子; 一万田莉麻; 衣笠哲矢; 岡田季之; 溝口充志
女性健康科学研究会誌, Apr. 2020 - Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models
Emiko Mizoguchi; Daren Low; Yui Ezaki; Toshiyuki Okada
Intestinal Research, Apr. 2020, [Reviewed]
Last - Rasal3-mediated T cell survival is essential for inflammatory responses
Muro Ryunosuke、Nitta Takeshi、Kitajima Masayuki、Okada Toshiyuki、Suzuki Harumi
Biochemical and Biophysical Research Communications, Jan. 2018, [Reviewed] - Genetically engineered mouse models for studying inflammatory bowel disease
Atsushi Mizoguchi; Takahito Takeuchi; Hidetomo Himuro; Toshiyuki Okada; Emiko Mizoguchi
Journal of Pathology, 01 Jan. 2016, [Reviewed] - The Ras GTPase-activating protein Rasal3 supports survival of na?ve T cells.
Ryunosuke Muro, Takeshi Nitta, Toshiyuki Okada, Hitoshi Ideta, T Tsubata, Harumi Suzuki.
PLOS ONE, Mar. 2015, [Reviewed] - Differential function of Themis CABIT domains during T cell development.
Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Akiko Takashima, Hiroyo Oda, Norimasa Tamehiro, Motohito Goto, Tadashi Okamura, Michael S Patrick and Harumi Suzuki.
PLOS ONE, Feb. 2014, [Reviewed]
Lead - Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas.
Toshiyuki Okada, Munetaka Nakamura, Jun Nishikawa, Kouhei Sakai, Yibo Zhang Mari Saito, Akihiro Morishige, Atsunori Oga, Kohsuke Sasaki, Yutaka Suehiro, Yuji Hinoda, and Isao Sakaida.
Cancer science., Jul. 2013, [Reviewed]
Lead - Role of DNA methylation in the development of Epstein-Barr virus-associated gastric carcinoma.
Mari Saito, Jun Nishikawa, Toshiyuki Okada, Akihiro Morishige, Kouhei Sakai, Munetaka Nakamura, Shu Kiyotoki, Kouichi Hamabe, Takeshi Okamoto, Atsunori Oga, Kohsuke Sasaki, Yutaka Suehiro, Yuji Hinoda, and Isao Sakaida.
Journal of Medical Virology., Jan. 2013, [Reviewed] - Possible involevemt of Wnt11 in colorectal cancer progression.
Mitsuaki Nishioka, Koji Ueno, Shoichi Hazama, Toshiyuki Okada, Kouhei Sakai, Yutaka Suehiro, Naoko Okayama, Hiroshi Hirata, Masaaki Oka, Kohzoh Imai, Rajvir Dahiya, and Yuji Hinoda.
Mol Carcinogenesis, Dec. 2011, [Reviewed] - Methylation level of the RASSF1A promoter is an independent prognostic factor for clear cell renal cell carcinoma.
Y. Kawai, S. Sakano, Y. Suehiro, T. Okada, Y. Korenaga, T. Hara, K. Naito, H. Matsuyama & Y. Hinoda.
Annals of oncology., Aug. 2010, [Reviewed] - TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer.
Toshiyuki Okada, Yutaka Suehiro, Koji Ueno, Shoko Mitomori, Sayaka Kaneko, Mitsuaki Nishioka, Naoko Okayama, Kouhei Sakai, Shingo Higaki, Shoichi Hazama, Hiroshi Hirata, Isao Sakaida, Masaaki Oka, and Yuji Hinoda.
Genes, Chromosomes and Cancer., Aug. 2010, [Reviewed]
Lead - Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and Is Related to Lack of CDH13 Hypermethylation.
Yutaka Suehiro, Toshiyuki Okada, Takae Okada, Keiko Anno, Naoko Okayama, Koji Ueno, Mikako Hiura, Mikiko Nakamura, Tomoko Kondo, Atsunori Oga, Shigeto Kawauchi, Kei Hirabayashi, Fumitaka Numa, Takehisa Ito, Toshiaki Saito, Kohsuke Sasaki, and Yuji Hinoda.
Clinical Cancer Research., Jun. 2008, [Reviewed] - Hypermethylation Status of APC Inversely Correlates With the Presence of Submucosal Invasion in Laterally Spreading Colorectal Tumors.
Kazuo Hashimoto, Yoshihisa Shimizu, Yutaka Suehiro, Naoko Okayama, Shinichi Hashimoto, Toshiyuki Okada, Mikako Hiura, Koji Ueno, Shoichi Hazama, Shingo Higaki, Yuichiro Hamanaka, Masaaki Oka, Isao Sakaida, and Yuji Hinoda
Molecular Carcinogenesis, Jan. 2008, [Reviewed]
- これだけは読んでおきたい!消化器医のための重要論文240篇
筆頭著者 松本 主之 (編集主幹) その他の著者 光山慶一,角田洋一,江﨑幹宏,仲瀬裕志,飯島英樹,久松理一,畑 啓介(編) 岡田季之、溝口恵美子(共著), Contributor
シービーアール 筆頭著者 松本 主之 (編集主幹), Dec. 2019 - EBV感染と胃癌 Epstein?Barr Virus infection and gastric cancer. 『食道・胃の前癌病変、高発癌状態を巡って』
西川 潤、斉藤真理、岡田季之、三戸森祥子、金子紗耶佳、深川夕紀、清時 秀、浜辺功一、岡本健志、末広 寛、日野田裕治、坂井田功., Contributor
臨床消化器内科, Feb. 2010 - Epstein-Barr virus陽性胃がんにおけるDNAメチル化異常.
西川 潤、斉藤真理、岡田季之、三戸森祥子、金子紗耶佳、深川夕紀、清時 秀、浜辺功一、岡本健志、末広 寛、日野田裕治、坂井田功., Contributor
消化器科.化学評論社, May 2009
- CD8-dependent contact hyper sensitivity is regulated by Themis
Masayuki Kitajima; Toshiyuki Okada; Harumi Suzuki
The 53rd Annual Meeting of the Japanese Society for Immunology, 03 Dec. 2024 - Loss of AID expression under inflammatory conditions alters the Nid1 and Fbln2 induction and exacerbates intestinal injury
Toshiyuki Okada, Yusuke Toyoda, Takayuki Sadanaga, Tomoi Noda, Risako Onitsuka, Atsushi Mizoguchi, Emiko Mizoguchi, Shigeaki Saitoh
The 52nd Annual Meeting of the Japanese Society for Immunology., Jan. 2024 - Themis regulates CD8-dependent contact hyper sensitivity
〇 Masayuki Kitajima, Toshiyuki Okada, Harumi Suzuki
The 52nd Annual Meeting of the Japanese Society for Immunology., Jan. 2024 - 炎症により大腸上皮細胞に異所性発現するAIDは、DNAの脱メチル化を引き起こすことで標的遺伝子の発現に影響を与える
岡田季之, 豊田雄介、溝口充志、齋藤成昭
第46回日本分子生物学会年会, Dec. 2023 - AID, which is ectopically expressed in colonic epithelial cells under inflammatory conditions, regulates target gene expression by inducing DNA demethylation.
岡田季之; 豊田雄介; 溝口充志; 齋藤成昭
日本分子生物学会年会プログラム・要旨集(Web), 2023 - Themis in peripheral CD8 T cells regulates hapten-induced allergic skin inflammation
〇 Masayuki Kitajima, Harumi Suzuki, Toshiyuki Okada
第51回日本免疫学会学術集会, Dec. 2022 - Low dose hapten-induced allergic skin inflammation is aggravated in Themis overexpressing mice
Masayuki Kitajima, Toshiyuki Okada, Harumi Suzuki.
第50回日本免疫学会学術集会, Dec. 2021 - Role of a putative cyclin-binding domain in nuclear localization sequence of Chitinase 3-like 1 in colonic epithelial cells.
Emiko Mizoguchi, Toshiyuki Okada, Atsushi Mizoguchi.
第50回日本免疫学会学術集会, Dec. 2021 - 潰瘍性大腸炎の炎症部位に認められる獲得免疫および上皮依存喘息関連機構
菅原 有紗、野明 俊裕、岡田季之、溝口 恵美子、荒木 靖三、光山 慶一、溝口 充志.
第58回 消化器免疫学会総会, Jul. 2021 - 口腔扁平上皮発癌におけるChitinase 3-like 1 の関与
寺谷由唯、楠川仁悟、岡田季之、溝口充志、溝口恵美子
第57回 日本消化器免疫学会総会, Jul. 2020 - 大腸炎によって異所性発現するAIDの役割
岡田季之、溝口充志、溝口恵美子、斉藤成昭
第57回日本消化器免疫学会総会, Jul. 2020 - 炎症条件下に異所性発現するAIDの生理学的意義の検討
溝口充志、溝口恵美子、齋藤成昭.
第10回日本炎症性腸疾患学会学術集会, Nov. 2019 - 炎症条件下に異所性発現するAIDの生理学的意義の検討
岡田季之、 溝口充志、 溝口恵美子、 豊田雄介、 齋藤成昭.
第56回日本消化器免疫学会総会, Aug. 2019 - The Ras GTPase-activating protein Rasal3 supports survival of naive T cells.
Ryunosuke Muro, Takeshi Nitta, Toshiyuki Okada Takeshi Tusbata, Harumi Suzuki.
第43回日本免疫学会学術集会, Dec. 2014 - ISC13 is essential for IL-2 production in T cells.
Hiroyo Oda , Masayuki Kitajima, Toshiyuki Okada, Harumi Suzuki.
第43回日本免疫学会学術集会, Dec. 2014 - Themis is important for differentiation of regulatory T cells.
Toshiyuki Okada, Takeshi Nitta, Masayuki Kitajima, Hiroyo Oda, Harumi Suzuki.
第43回日本免疫学会学術集会, Dec. 2014 - Survival of peripheral naive T cells in vivo requires Rasal3
1P-0727 室 龍之介, 新田 剛, 岡田 季之, 鍔田 武志, 鈴木 春巳
The 37th Annual Meeting of the Molecular Biology Society of Japan, Nov. 2014 - Differential function of two CABIT domains in Themis.
Toshiyuki Okada, Takeshi Nitta, Hiroyo Oda, Michael S. Patrick, Harumi Suzuki
第42回日本免疫学会学術集会, Dec. 2013 - Themis regulates cytokine production and differentiation of Th subsets.
Toshiyuki Okada, Michael S. Patrick, Kentaro Kaji, Harumi Suzuki.
第41回日本免疫学会学術集会, (於 神戸国際会議場), Aug. 2013 - Themis CABIT domains exert distinct functions in thymocyte positive selection.
Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Hiroyo Oda, Michael S Patrick and Harumi Suzuki
15th INTERNATIONAL CONGRESS OF IMMUNOLOGY., Aug. 2013 - Differential function of Themis CABIT domains during T cell development.
Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Hiroyo Oda, Michael Patrick, Harumi Suzuki
International Kyoto T cell conference, Jun. 2013 - Functional analysis of Themis protein domains.
Takeshi Nitta, Toshiyuki Okada, Kentaro Kaji, Hiroyo Oda, Akiko Takashima, Michael S. Patrick, Harumi Suzuki
ThymUS international conference 2012, Nov. 2012 - Epstein-Barr virus関連胃癌の発生におけるDNAメチル化の意義
西川 潤、齋藤真理、岡田季之、末広 寛、坂井田功
第71回日本癌学会、ロイトン札幌(札幌), Sep. 2012 - Themis分子内ドメインの機能解析
新田 剛、岡田季之、加地健太郎、小田浩代、高島明子、Michael S. Patrick、鈴木春巳.
第22回Kyoto T cell conference., Jul. 2012 - Analysis of Themis (Gasp) Transgenic mice.
Toshiyuki Okada, Michael S. Patrick, Kentaro Kaji, Harumi Suzuki.
第40回日本免疫学会総会, Nov. 2011 - Themis (Gasp) is indispensable in early thymocyte positive selection.
Michael S. Patrick, Toshiyuki Okada, Hiroyo oda, Norimasa Tamehiro, Harumi Suzuki.
第40回日本免疫学会総会, Nov. 2011 - Possible involvement of Wnt11 in colorectal cancer progression.
Mitsuaki Nishioka, Koji Ueno, Shoichi Hazama, Toshiyuki Okada, Kouhei Sakai, Yutaka Suehiro, Masaaki Oka, Kohzoh Imai, Yuji Hinoda.
第70回日本癌学会学術総, Oct. 2011 - The role of TWIST1 expression in colorectal carcinomas.
Kouhei Sakai, Toshiyuki Okada, Yutaka Suehiro, Akihiro Morishige, Mitsuaki Nishioka, Shoichi Hazama, Isao Sakaida, Masaaki Oka, Yuji Hinoda.
第70回日本癌学会学術総, Oct. 2011 - Gasp(Themis)トランスジェニックマウスの解析
岡田季之、パトリックマイケル、加地健太郎、吉本拓矢、岡村匡史、鈴木春巳
第21回Kyoto T cell conference, Jun. 2011 - Association between KRAS mutation and hypermethylation of APC and E-cadherin in colorectal carcinoma
三戸森祥子, 末広寛, 岡田季之, 金子紗耶佳, 日野田裕治
68th Annual meeting of the Japanese Cancer 2009年10月, Oct. 2009 - Comprehensive DNA methylation analysis in Epstein-Barr virus-associated gastric carcinoma
金子紗耶子, 西川潤, 末広寛, 齋藤真理, 岡田季之, 三戸森祥子, 坂井田功, 日野田裕治
68th Annual meeting of the Japanese Cancer 2009年10月, Oct. 2009 - RASSF1A遺伝子プロモーター領域のメチル化レベルは淡明細胞型腎癌患者の独立予後予測因子となる
川井禎久, 坂野滋, 末広寛, 岡田季之, 原智彦, 長尾一公, 原貴彦, 松山豪泰, 日野田裕治
第68回日本癌学会学術集会, Oct. 2009 - Genetic and epigenetic alterations in laterally spreading colorectal tumors (LSTs)
Yoshihisa Shimizu, Yutaka Suehiro, Toshiyuki Okada, Yuji Hinoda
Program 66th Annual Meeting of the Japanese Cancer Association 2007年10月, Oct. 2007
- RMCP(M3) : 研究に関する基礎知識と手技の指導
Apr. 2024 - RMCP(M3) : 研究に関する基礎知識と手技の指導
Feb. 2023 - 海外留学者に対する研究に関する基礎知識と手技の指導
Mar. 2022 - RMCP(M3) : 研究に関する基礎知識と手技の指導
Aug. 2019
■ Research Themes
- Novel function "regulation of extracellular matrix construction" of ectopic AID expression in wound healing process.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2020 - 31 Mar. 2023 - Role of epigenetic modification by bile acid
Grant-in-Aid for Young Scientists (B)
Kurume University
01 Apr. 2016 - 31 Mar. 2019 - Studies on nuclear signaling proteins required for T cell development
Grant-in-Aid for Scientific Research (C)
The University of Tokyo
01 Apr. 2013 - 31 Mar. 2016 - クローン病患者特異的に変化する細胞集団が病態形成へ与える影響の解明
2015
