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Shuto Takahide
Department of Pharmacology
Associate Professor
Career
■ Career
- Jun. 2021 - Present
Kurume University, School of Medicine, Associate Professor - Apr. 2016 - May 2021
Kurume University, School of Medicine, Assistant Professor - Apr. 2007 - Mar. 2016
Kurume University, School of Medicine, 助教（職名変更） - Apr. 2005 - Mar. 2007
Kurume University, School of Medicine, 助手
Research activity information
■ Paper
- Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments
Ryusuke Sin; Naoki Sotogaku; Yoshinori N. Ohnishi; Takahide Shuto; Mahomi Kuroiwa; Yukie Kawahara; Keita Sugiyama; Yuki Murakami; Masaaki Kanai; Hiroshi Funakoshi; Ayanabha Chakraborti; James A Bibb; Akinori Nishi
Brain, Behavior, and Immunity, Aug. 2023 - DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum.
Mahomi Kuroiwa; Takahide Shuto; Taku Nagai; Mutsuki Amano; Kozo Kaibuchi; Angus C Nairn; Akinori Nishi
Neurochemistry international, Jan. 2023 - Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia.
Keita Sugiyama; Mahomi Kuroiwa; Takahide Shuto; Yoshinori N Ohnishi; Yukie Kawahara; Yuta Miyamoto; Takaichi Fukuda; Akinori Nishi
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 Jul. 2021 - Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine.
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yong-Seok Oh; Jin-Hyeok Jang; Chang-Hoon Shin; Yoshinori N Ohnishi; Yuuki Hanada; Tsuyoshi Miyakawa; Yong Kim; Paul Greengard; Akinori Nishi
Molecular psychiatry, Jun. 2020, [Reviewed] - Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice.
Takatoshi Hikida; Makiko Morita; Mahomi Kuroiwa; Tom Macpherson; Takahide Shuto; Naoki Sotogaku; Minae Niwa; Akira Sawa; Akinori Nishi
Neuroscience research, Feb. 2020, [Reviewed] - Differential regulation of dopamine D1 receptor signaling in subregions of the striatum
Sugiyama Keita; Kuroiwa Mahomi; Shuto Takahide; Fukuda Takaichi; Nishi Akinori
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Sex Differences in Dendritic Spine Formation in the Hippocampus and Animal Behaviors in a Mouse Model of Hyperthyroidism.
Tetsushi Niiyama; Mahomi Kuroiwa; Yusaku Yoshioka; Yosuke Kitahara; Takahide Shuto; Tatsuyuki Kakuma; Keisuke Ohta; Kei-Ichiro Nakamura; Akinori Nishi; Mami Noda
Frontiers in cellular neuroscience, 2020 - Region-specific regulation of dopamine signaling in the striatum
Sugiyama Keita; Kuroiwa Mahomi; Syuto Takahide; Fukuda Takaichi; Nishi Akinori
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019 - p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli.
Hanada Y; Kawahara Y; Ohnishi YN; Shuto T; Kuroiwa M; Sotogaku N; Greengard P; Sagi Y; Nishi A
eNeuro, Sep. 2018, [Reviewed] - 甲状腺機能異常症におけるグリアと神経細胞の形態変化およびその性差
吉岡 優作; 片渕 俊彦; 北原 陽介; 首藤 隆秀; 西 昭徳; Semtner Marcus; Kettenmann Helmut; 野田 百美
日本生理学雑誌, May 2018 - Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yoshinori Ohnishi; Yuuki Hanada; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018 - Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders
Akinori Nishi; Takahide Shuto
EXPERT OPINION ON THERAPEUTIC TARGETS, Mar. 2017, [Reviewed] - 大脳皮質-大脳基底核回路におけるドーパミン系の新たな働きと精神疾患との関わり ドーパミンシグナルを制御するDARPP-32 神経タイプ特異的な機能と制御
西 昭徳; 首藤 隆秀
日本神経精神薬理学会年会プログラム・抄録集, Jul. 2016 - Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus
Yosuke Kitahara; Keisuke Ohta; Hiroshi Hasuo; Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Akinobu Togo; Kei-ichiro Nakamura; Akinori Nishi
PLOS ONE, Jan. 2016, [Reviewed] - Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum
Takahide Shuto; Mahomi Kuroiwa; Yuki Koga; Yukie Kawahara; Naoki Sotogaku; Koji Toyomasu; Akinori Nishi
NEUROSCIENCE LETTERS, May 2013, [Reviewed] - Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons
Mahomi Kuroiwa; Miho Hamada; Eriko Hieda; Takahide Shuto; Naoki Sotogaku; Marc Flajolet; Gretchen L. Snyder; Joseph P. Hendrick; Allen Fienberg; Akinori Nishi
NEUROPHARMACOLOGY, Dec. 2012, [Reviewed] - Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex
Mahomi Kuroiwa; Gretchen L. Snyder; Takahide Shuto; Atsuo Fukuda; Yuchio Yanagawa; David R. Benavides; Angus C. Nairn; James A. Bibb; Paul Greengard; Akinori Nishi
PSYCHOPHARMACOLOGY, Feb. 2012, [Reviewed] - Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake
Tomoyuki Mitsumori; Tomoyuki Furuyashiki; Toshihiko Momiyama; Akinori Nishi; Takahide Shuto; Takashi Hayakawa; Fumitaka Ushikubi; Shiho Kitaoka; Tomohiro Aoki; Haruhisa Inoue; Toshiyuki Matsuoka; Shuh Narumiya
EUROPEAN JOURNAL OF NEUROSCIENCE, Aug. 2011, [Reviewed] - Mechanisms for the modulation of dopamine D-1 receptor signaling in striatal neurons
Akinori Nishi; Mahomi Kuroiwa; Takahide Shuto
FRONTIERS IN NEUROANATOMY, Jul. 2011, [Reviewed] - Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia
Takahide Shuto; Akinori Nishi
CNS NEUROSCIENCE & THERAPEUTICS, 2011, [Reviewed], [Invited] - Role of phosphodiesterases in dopamine signal transduction.
Nishi A; Kuroiwa M; Shuto T
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Jan. 2010, [Reviewed] - Regulation of DARPP-32 phosphorylation by three distinct dopamine D(1)-like receptor signaling pathways in the neostriatum
Mahomi Kuroiwa; Helen S. Bateup; Takahide Shuto; Hideho Higashi; Masatoshi Tanaka; Akinori Nishi
JOURNAL OF NEUROCHEMISTRY, Nov. 2008, [Reviewed] - Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum
Akinori Nishi; Mahomi Kuroiwa; Diane B. Miller; James P. O'Callaghan; Helen S. Bateup; Takahide Shuto; Naoki Sotogaku; Takaichi Fukuda; Nathaniel Heintz; Paul Greengard; Gretchen L. Snyder
JOURNAL OF NEUROSCIENCE, Oct. 2008, [Reviewed] - Reversal of the expression pattern of Aldolase C mRNA in Purkinje cells and Ube 1x mRNA in Golgi cells by a dopamine D1 receptor agonist injections in the methamphetamine sensitized-rat cerebellum
Mitsuko Hamamura; Naotsugu Hirata; Kazuhiko Sawada; Takahide Shuto; Takao Shimazoe; Yoshihiro Terada; Yasuyuki Fukumaki
JOURNAL OF NEURAL TRANSMISSION, Jul. 2008, [Reviewed] - Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1(High) and D2(High) receptors in methamphetamine-sensitized rats
Takahide Shuto; Philip Seeman; Mahomi Kuroiwa; Akinori Nishi
EUROPEAN JOURNAL OF NEUROSCIENCE, May 2008, [Reviewed] - Prostaglandin E-2 acts on EP1 receptor and amplifies both dopamine D-1 and D-2 receptor signaling in the striatum
Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Masayuki Miyasaka; Paul Greengard; Shuh Narumiya
JOURNAL OF NEUROSCIENCE, Nov. 2007, [Reviewed] - Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D-1 receptor agonist
Takahide Shuto; Mahomi Kuroiwa; Mitsuko Hamamura; Kenichi Yabuuchi; Takao Shimazoe; Shigenori Watanabe; Akinori Nishi; Tsuneyuki Yamamoto
NEUROPHARMACOLOGY, Jun. 2006, [Reviewed] - Role of adenosine A(1), receptors in the modulation of dopamine D-1, and adenosine A(2a) receptor signaling in the neostriatum
K. Yabuuchi; M. Kuroiwa; T. Shuto; N. Sotogaku; G. L. Snyder; H. Higashi; M. Tanaka; P. Greengard; A. Nishi
NEUROSCIENCE, 2006, [Reviewed]
- 線条体におけるドパミンD1受容体シグナルの領域特異的な制御:L-ドパ誘発性ジスキネジアとの関連性
杉山慶太; 黒岩真帆美; 首藤隆秀; 大西克典; 河原幸江; 宮本雄太; 福田孝一; 西昭徳
日本脳科学会プログラム・講演抄録集, 2021 - Social Isolated DISC1 Mutant Mice Displayed High Sensitivity to Chronic Cocaine Exposure and Rolipram Treatment
Takatoshi Hikida; Makiko Morita; Mahomi Kuroiwa; Tom Macpherson; Taichi Itou; Takahide Shuto; Naoki Sotogaku; Minae Niwa; Akira Sawa; Akinori Nishi
NEUROPSYCHOPHARMACOLOGY, Dec. 2015 - 抗うつ薬による歯状回-貫通線維シナプスの形態変化 FIB-SEMを用いた構造解析
北原 陽介; 太田 啓介; 首藤 隆秀; 黒岩 真帆美; 外角 直樹; 蓮尾 博; 都合 亜記暢; 中村 桂一郎; 西 昭徳
日本脳科学会プログラム・抄録集, Nov. 2015 - DISC1マウスの隔離飼育に対するドパミンシグナル応答 ホスホジエステラーゼの役割(Role of PDEs in alteration of dopamine signaling after isolation stress in DISC1 mutant mice)
黒岩 真帆美; 首藤 隆秀; 外角 直樹; 森田 真規子; 澤 明; 疋田 貴俊; 西 昭徳
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2015 - Role of PDE-mediated signaling and its crosstalk in brain function
A. Nishi; M. Kuroiwa; T. Shuto; S. Gretchen
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2014 - Effect of chronic fluoxetine on spine morphology of granule cells in the dentate gyrus: 3-dimensional reconstruction study using FIB/SEM
Yosuke Kitahara; Keisuke Ohta; Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Hiroshi Hasuo; Akinobu Togo; Kei-ichiro Nakamura; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014 - コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用
首藤 隆秀; 黒岩 真帆美; 古賀 夕貴; 西 昭徳
日本薬理学雑誌, Mar. 2013 - Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons
Mahomi Kuroiwa; Miho Hamada; Eriko Hieda; Takahide Shuto; Naoki Sotogaku; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - Acute effects of resveratrol on cocaine-induced dopamine neurotransmission in the striatum
Takahide Shuto; Mahomi Kuroiwa; Yuki Koga; Yukie Kawahara; Naoki Sotogaku; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - 抗うつ薬による海馬歯状回顆粒細胞の形態変化:FIB/SEMを用いた樹状突起の3D電顕解析
北原陽介; 首藤隆秀; 黒岩真帆美; 外角直樹; 蓮尾博; 都合亜記暢; 太田啓介; 中村桂一郎; 西昭徳
日本薬理学会西南部会プログラム/抄録集, 2013 - Effects of resveratrol on cocaine-induced dopamine D1 receptor signaling in the striatum
Takahide Shuto; Mahomi Kuroiwa; Yuki Koga; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012 - 抗うつ薬により誘導された脱成熟歯状回におけるドーパミンD1受容体機能
西 昭徳; 黒岩 真帆美; 首藤 隆秀
日本脳科学会プログラム・抄録集, Oct. 2011 - フルオキセチン慢性投与による海馬歯状回ドーパミンD1受容体シグナルの増強(Effect of chronic fluoxetine treatment on dopamine D1 receptor signaling in the hippocampal dentate gyrus)
黒岩 真帆美; 外角 直樹; 首藤 隆秀; 宮川 剛; 西 昭徳
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Oct. 2011 - Regulation of dopamine signaling by muscarinic receptors in the striatum
Mahomi Kuroiwa; Eriko Hieda; Miho Hamada; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - Effect of a sirtuin activator, resveratrol, on behavioral sensitization to cocaine
Yuki Koga; Takahide Shuto; Mahomi Kuroiwa; Kouji Toyomasu; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - 大脳皮質ドーパミンD1シグナルを制御するホスホジエステラーゼ4に関する研究(Role of phosphodiesterase 4 in dopamine D1 receptor/cAMP/PKA signaling in the frontal cortex)
黒岩 真帆美; 首藤 隆秀; 西 昭徳
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2010 - ホスホジエステラーゼ阻害薬による中枢ドーパミンシグナル調節
黒岩 真帆美; 首藤 隆秀; 西 昭徳
日本薬理学雑誌, Mar. 2010 - Regulation of D1 receptor/DARPP-32 signaling by muscarinic receptors via the release of dopamine in the striatum
Eriko Hieda; Miho Hamada; Mahomi Kuroiwa; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Roles of PDE4 and PDE10A in dopamine neurotransmission
A. Nishi; M. Kuroiwa; T. Shuto; S. Gretchen
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010 - Role of phosphodiesterase 4 and 10A in dopaminergic signaling
Mahomi Kuroiwa; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Three distinct dopamine D-1-like receptor signaling pathways
Mahorni Kuroiwa; Helen S. Bateup; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Regulation of DARRP-32 phosphorylation by muscarinic receptors via presynaptic and postsynaptic mechanisms in the striatum
Eriko Hieda; Miho Hamada; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Prostaglandin E-2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum
Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Masayuki Miyasaka; Paul Greengard; Shuh Narumiya
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Reversal of methamphetamine sensitization by repeated administration of dopamine D1 receptor agonism: Effect on the affinity of dopamine D1 and D2 receptor
Takahide Shuto; Philip Seeman; Akinciri Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Prostaglandin E receptor EP1 amplifies dopaminergic signaling in the striatum
Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Paul Greengard; Shuh Narumiya
NEUROSCIENCE RESEARCH, 2008 - Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice
Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Prostaglandin e receptor subtype EP1 regulates dopamine receptor signaling in the striatum.
Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Shuh Narumiya
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Role of DARPP-32 Thr34 phosphorylation in methamphetamine-induced behavioral sensitization
T Shuto; A Nishi; T Yamamoto; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Adaptation of pre- and postsynaptic dopaminergic signaling in methamphetamine-sensitized rats
M Kuroiwa; T Shuto; A Nishi; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005
- Development of treatments for post traumatic stress disorder related to surgery and intensive care.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2023 - 31 Mar. 2026 - Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2022 - 31 Mar. 2025 - Involvement of dopamine and noradrenaline signaling mechanisms in depression and schizophrenia.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathy
Grant-in-Aid for Scientific Research (C)
01 Apr. 2017 - 31 Mar. 2020 - Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2016 - 31 Mar. 2020 - 海馬ドパミン・ノルアドレナリン入力バランス制御によるうつ病治療戦略の確立
Apr. 2018 - Mar. 2020 - Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2016 - 31 Mar. 2019 - Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2016 - 31 Mar. 2019 - Role of chondroitin sulfate-E in the modulation of neuronal morphology
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2014 - 31 Mar. 2017 - ドーパミンD1受容体シグナルに着目した薬物依存および統合失調症の治療法開発
Apr. 2011 - Mar. 2012 - 薬物依存症の治療法開発：逆耐性を消失させるドーパミンD1 受容体シグナル
Apr. 2009 - Mar. 2010 - 薬物依存症の治療法開発:逆耐性を消失させるドーパミンD1受容体シグナル
Apr. 2009 - Mar. 2010 - Map of dopamine signaling in the neostriatum under normal and pathophysiological conditions
Grant-in-Aid for Scientific Research (B)
Kurume University
2006 - 2007
