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Hisaka Toru
Department of Surgery
Professor

Researcher information

■ Research Keyword
  • 肝臓
  • 胆道
  • 膵臓
  • 消化器の医学
  • 消化器の腫よう
■ Research Keyword
  • 医学
  • 消化器の医学
  • 消化器の腫よう
■ Research Theme
  • 肝胆膵領域における腫瘍外科病理
  • 転移性肝癌に対する治療
  • 肝細胞癌における治療の基礎的研究
  • 膵臓癌に対する治療
  • 胆道癌に対する治療

Research activity information

■ Paper
  • Synchronous Lung Metastasis and Hilar Lymph Node Metastasis from Rectal Cancer-A Case Report　　　　　　　　　　　　　　　
    Daisuke MuroyaKouji HayashiTakamichi Nishida,Toru Hisaka Toru
    Gan to kagaku ryoho. Cancer & chemotherapy, Dec. 2023
  • Minimally Invasive Conversion Hepatectomy for Advanced Hepatocellular Carcinoma　　　　　　　　　　　　　　　
    Hisamune SakaiYuichi GotoYuichi GotoShigeo ShimoseS higeo Toru Hisaka
    Gan to kagaku ryoho. Cancer & chemotherapy, Dec. 2023
  • Effects of Hyperbaric Oxygen Therapy for Clostridioides difficile-associated Colitis: A Retrospective Study　　　　　　　　　　　　　　　
    Daisuke Muroya, Shinya Nadayoshi, Koito Yamada, Yutaro Kai, Naoki Masuda, Takamichi Nishida, Masayuki Shimokobe, Toru Hisaka
    Journal of the Anus Rectum and Colon, Jul. 2023
  • Preoperative Chemotherapy Followed by Hepatectomy for Potentially Resectable UICC7 Stage IIIA, IIIB Hepatocellular Carcinoma; A Phase II Clinical Trial　　　　　　　　　　　　　　　
    YUICHI GOTO, TAKASHI NIIZEKI, SHOGO FUKUTOMI, TOMOTAKE SHIRONO, SHIGEO SHIMOSE, HIDEKI IWAMOTO, SATOKI KOJIMA, HIROKI KANNO, YOSHIHIRO UCHINO, SHIN SASAKI, NOBUHISA SHIRAHAMA, DAISUKE MUROYA, YORIKO NOMURA, MASANORI AKASHI, GOICHI NAKAYAMA, YUSUKE HIRAKAWA, TOSHIHIRO SATO, MUNEHIRO YOSHITOMI, HISAMUNE SAKAI, TORU HISAKA, TATSUYUKI KAKUMA, HIRONORI KOGA, TAKUJI TORIMURA, YOSHITO AKAGI, KOJI OKUDA
    The Kurume Medical Journal, Jul. 2023
  • Development of an Algorithm to Predict Recurrences After Resection of Liver Metastases in Patients With Metastatic Colorectal Cancer　　　　　　　　　　　　　　　
    MITSUHIRO KATAGIRI, TOMOYA SUDO, TATSUYUKI TOUNANN, TATSUYUKI KAKUMA, SUSUMU SHIMOMURA, SACHIKO NAGASU, KENSUKE TAJIRI, SHINYA FUJINO, KOUTAROU YUGE, HIDETSUGU MURAKAMI, KEISUKE MIWA, TORU HISAKA, FUMIHIKO FUJITA and YOSHITO AKAGI
    Anticancer Research, Jul. 2023
  • Significance of Desmoplastic Histopathological Growth Pattern for Colorectal Liver Metastases Treated With Preoperative Chemotherapy　　　　　　　　　　　　　　　
    HIROAKI HIRAKAWA, HISAMUNE SAKAI, HIROKI KANNO, YUICHI GOTO, MASANORI AKASHI, SHOGO FUKUTOMI, SHOICHIRO ARAI, TOSHIHIRO SATO, TOMOYA SUDO, SACHIKO NAGASU, KEISUKE MIWA, YOSHIKI NAITO, JUN AKIBA, HIROHISA YANO, FUMIHIKO FUJITA and TORU HISAKA
    Anticancer Research, Jul. 2023
  • Efficacy of laparoscopic liver resection for small hepatocellular carcinoma located in the posterosuperior segments: A multi-institutional study using propensity score matching by the Kyushu Study Group of Liver Surgery　　　　　　　　　　　　　　　
    Yukio Tokumitsu, Hiroaki Nagano, Yo-ichi Yamashita, Tomoharu Yoshizumi, Toru Hisaka, Atsushi Nanashima, Tamotsu Kuroki, Takao Ide, Yuichi Endo, Tohru Utsunomiya, Kenji Kitahara, Yota Kawasaki, Masahiko Sakota, Kohji Okamoto, Yuko Takami, Masatoshi Kajiwara, Mitsuhisa Takatsuki, Toru Beppu, Susumu Eguchi
    Hepatology Research, May 2023
  • Prepancreatic postduodenal portal vein: a case report and literature review　　　　　　　　　　　　　　　
    Masanori Akashi, Daiki Miyazaki, Kazuaki Hashimoto, Shogo Fukutomi, Shoichiro Arai, Yuichi Goto, Toshihiro Sato, Hisamune Sakai & Toru Hisaka
    Surgical Case Reports, Apr. 2023
  • Lymph node metastatic status could predict the prognosis of intracholecystic papillary neoplasm of gallbladder　　　　　　　　　　　　　　　
    Masamichi Nakayama , Yoshiki Naito, Eiji Sadashima, Yoshinao Kinjo, Akihiko Kawahara, Toru Hisaka, Yoshinobu Okabe , Jun Akiba , Hirohisa Yano .
    Human Pathology, Apr. 2023
  • Prognostic Factors for Distal Bile Duct Carcinoma After Surgery　　　　　　　　　　　　　　　
    RYUICHI KAWAHARA, RYUUTA MIDORIKAWA, SHINICHI TANIWAKI, SATOKI KOJIMA, HIROKI KANNO, MUNEHIRO YOSHITOMI, YORIKO NOMURA, YUICHI GOTO, TOSHIHIRO SATOU, HISAMUNE SAKAI, HIROTO ISHIKAWA, TORU HISAKA, MASAFUMI YASUNAGA, TAKAHIKO SAKAUE, TOMOYUKI USHIJIMA, MAKIKO YASUMOTO, YOSHINOBU OKABE, MASAHIKO TANIGAWA, YOSHIKI NAITOU, HIROHISA YANO, KOJI OKUDA
    The Kurume Medical Journal, Mar. 2023
  • Risk Factors of Complications from Central Bisectionectomy (H458) for Hepatocellular Carcinoma: A Multi-Institutional Single-Arm Analysis　　　　　　　　　　　　　　　
    Atsushi Nanashima , Susumu Eguchi , Toru Hisaka , Yota Kawasaki , Yo-ichi Yamashita , Takao Ide, Tamotsu Kuroki , Tomoharu Yoshizumi Masatoshi Kajiwara , Kenji Kitahara , Yuichi Endo , Tohru Utsunomiya , , Masahiko Sakoda , Kohji Okamoto , Hiroaki Nagano , Yuko Takami and Toru Beppu.
    Cancers, Mar. 2023
  • Impact of Interferon on the Prognosis of Hepatitis C Virus-Related Hepatocellular Carcinoma Patients with a Sustained Virological Response ?An Additional Comparison Between Preoperative and Postoperative Sustained Virological Response?　　　　　　　　　　　　　　　
    DAISUKE MUROYA, TARO NISHIMURA, HIROKI KANNO, SATOKI KOJIMA, SHOGO FUKUTOMI, MASANORI AKASHI, YORIKO NOMURA, YUICHI GOTO, TOSHIHIRO SATO, HISAMUNE SAKAI, TORU HISAKA, YOSHITO AKAGI AND KOJI OKUDA
    Kurume Medical Journal, Feb. 2023
  • Prognostic Significance of the Histopathological Growth Pattern and Tumor-Infiltrating Lymphocytes in Stratifying Survival After Hepatectomy for Colorectal Liver Metastases.　　　　　　　　　　　　　　　
    Kanno H, Hisaka T, Fujiyoshi K, Akiba J, Hashimoto K, Fujita F, Akagi Y.
    Ann Surg Oncol., Dec. 2022
  • ASO Author Reflections: A Combination of the Histopathologic Growth Pattern and Tumor-Infiltrating Lymphocytes Can Stratify the Risk in Survival After Hepatectomy for Colorectal Liver Metastasis.　　　　　　　　　　　　　　　
    Kanno H, Hisaka T.
    Ann Surg Oncol., Dec. 2022
  • SUOX and GLUT1 are biomarkers for the prognosis in large duct type intrahepatic cholangiocarcinoma　　　　　　　　　　　　　　　
    Kinjo Y, Naito Y, Akiba J, Sadashima E, Nakayama M, Tanigawa M, Hisaka T, Okabe Y, Yano H.
    Hum Pathol, Oct. 2022
  • Liberal Application of Portal Vein Embolization for Right Hepatectomy Against Hepatocellular Carcinoma: Strategy to Achieve Zero Mortality for a Damaged Liver. Shirahama N, Goto Y, Sakai H, Fukutomi S, Akashi M, Sato T, Akagi Y, Okuda K, Hisaka T.　　　　　　　　　　　　　　　
    Mortality for a Damaged Liver. Shirahama N, Goto Y, Sakai H, Fukutomi S, Akashi M, Sato T, Akagi Y, Okuda K, Hisaka T.
    Anticancer Res., Aug. 2022
  • C-reactive protein/albumin ratio and Glasgow prognostic score are associated with prognosis and infiltration of Foxp3+ or CD3+ lymphocytes in colorectal liver metastasis.　　　　　　　　　　　　　　　
    Kanno H, Hisaka T, Akiba J, Hashimoto K, Fujita F, Akagi Y.
    BMC Cancer, Aug. 2022
  • Salvage PTBD With Chemotherapy Improves Survival in Patients With Unresectable Malignant Biliary Obstruction - A Single Center Retrospective Study　　　　　　　　　　　　　　　
    Muroya D, Tsuru H, Shimokobe H, Nagao Y, Yoshimoto Y, Wada Y, Hayashi K, Taniwaki S, Midorikawa R, Taniwaki S, Kojima S, Arai S, Shirahama T, Goto Y, Sakai H, Yoshitomi M, Hisaka T, Akagi Y, Okuda K.
    Anticancer Res, Aug. 2022
  • Tumour Budding as an Independent Prognostic Factor for Survival in Patients With Distal Bile Duct Cancer.　　　　　　　　　　　　　　　
    Nakayama G, Hisaka T, Sakai H, Akashi M, Yuichi G, Sato T, Naito Y, Akiba J, Yano H, Akagi Y.
    Anticancer Res., Aug. 2022
  • Hematogenous Dissemination of Tumor Cells in Hepatocellular Carcinoma: Comparing Anterior and Non-anterior Approach Hepatectomy.　　　　　　　　　　　　　　　
    Sasaki S, Nomura Y, Sudo T, Sakai H, Hisaka T, Akiba J, Nakashima O, Yano H, Kage M, Akagi Y, Okuda K.
    Anticancer Res., Aug. 2022
  • Fatty Liver Does Not Increase the Risk of Postoperative Liver Damage Following Hepatectomy.　　　　　　　　　　　　　　　
    Nomura Y, Akiba J, Yano H, Akagi Y, Hisaka T.
    Anticancer Res., Aug. 2022
  • Predictive and Prognostic Value of SUOX Expression in Pancreatic Ductal Adenocarcinoma. Predictive and Prognostic Value of SUOX Expression in Pancreatic Ductal Adenocarcinoma.　　　　　　　　　　　　　　　
    Naito Y, Akiba J, Kinjo Y, Sadashima E, Ogata T, Yano Y, Tanigawa M, Nakayama M, Kawahara A, Okabe Y, Sakai H, Hisaka T, Akagi Y, Yano H.
    Anticancer Res., Aug. 2022
  • Mass-forming adenomyomatosis in extrahepatic bile duct　　　　　　　　　　　　　　　
    Yusuke Ishida, Yoshinobu Okabe, Toru Hisaka, Yoshiki Naito, Takuji Torimura.
    Gastrointestinal Endoscopy, Sep. 2020
  • Prognostic Impact of Desmoplastic Reaction Evaluation for Intrahepatic Cholangiocarcinoma.　　　　　　　　　　　　　　　
    Kojima S, Hisaka T, Midorikawa R, Naito Y, Akiba J, Tanigawa M, Yano H, Akagi Y, Okuda K.
    Anticancer Research, Aug. 2020
  • Quercetin Suppresses Proliferation of Liver Cancer Cell Lines In Vitro.　　　　　　　　　　　　　　　
    Hisaka T, Sakai H, Sato T, Goto Y, Nomura Y, Fukutomi S, Fujita F, Mizobe T, Nakashima O, Tanigawa M, Naito Y, Akiba J, Ogasawara S, Nakashima K, Akagi Y, Okuda K, Yano H.
    Anticancer Research, Aug. 2020
  • Salvage Surgery for Initially Unresectable Locally Advanced Hepatocellular Carcinoma Downstaged by Hepatic Arterial Infusion Chemotherapy.　　　　　　　　　　　　　　　
    Goto Y, Hisaka T, Sakai H, Takagi K, Fukutomi S, Akagi Y, Okuda K.
    Anticancer Research, Aug. 2020
  • Sarcomatous component in pancreatic adenosquamous carcinoma: A clinicopathological series of 7 cases.　　　　　　　　　　　　　　　
    Taniwaki S, Hisaka T, Sakai H, Goto Y, Nomura Y, Kawahara R, Ishikawa H, Yasunaga M, Naito Y, Akiba J, Yano H, Tanaka H, Akagi Y, Okuda K.
    Anticancer Research, Aug. 2019
  • Sinusoidal obstruction syndrome and postoperative complications resulting from preoperative chemotherapy for colorectal cancer liver metastasis.　　　　　　　　　　　　　　　
    Hisaka T, Ishikawa H, Sakai H, Kawahara R, Goto Y, Nomura Y, Yasunaga M, Kinugasa T, Fujita F, Mizobe T, Fukahori M, Miwa K, Nakashima O, Tanigawa M, Naito Y, Akiba J, Yano H, Tanaka H, Akagi Y, Okuda K.
    Anticancer Research, Aug. 2019
  • Clinical and prognostic significance of neoplastic spindle cells in gallbladder cancer.　　　　　　　　　　　　　　　
    Midorikawa R, Hisaka T, Sakai H, Nomura Y, Goto Y, Sato T, Kawahara R, Ishikawa H, Fujita F, Yasunaga M, Tanigawa M, Naito Y, Akiba J, Yano H, Tanaka H, Akagi Y, Okuda K.
    Anticancer Research, Aug. 2019
  • Expression of matrix metalloproteinases in intraductal papillary mucinous neoplasm of the pancreas.　　　　　　　　　　　　　　　
    Akashi M, Hisaka T, Sakai H, Ishikawa H, Kawahara R, Goto Y, Nomura Y, Yasunaga M, Fujita F, Tanigawa M, Naito Y, Akiba J, Yano H, Tanaka H, Akagi Y, Okuda K.
    Anticancer Research, Aug. 2019
  • Clinicopathological Study of Resections of Intraductal Papillary Neoplasm of the Bile Duct.　　　　　　　　　　　　　　　
    Sato T, Hisaka T, Sakai H, Ishikawa H, Kawahara R, Goto Y, Nomura Y, Yasunaga M, Fujita F, Tanigawa M, Naito Y, Akiba J, Yano H, Tanaka H, Akagi Y, Okuda K.
    Anticancer Research, Aug. 2019
  • Laparoscopic liver resection using the silicone band uplift technique for tumors in segments 8 and 7 (with video)　　　　　　　　　　　　　　　
    Sakai H, Hisaka T, Okuda K.
    Journal of Visceral Surgery, Sep. 2017
  • Expression of HSP27 in hepatocellular carcinoma.　　　　　　　　　　　　　　　
    Eto D, Hisaka T, Horiuchi H, Uchida S, Ishikawa H, Kawashima Y, Kinugasa T, Nakashima O, Yano H, Okuda K, Akagi Y.
    Anticancer Research, Jul. 2016
  • The organo-and cytoprotective effects of heat-shock protein in response to injury due to radiofrequency ablation in rat liver.　　　　　　　　　　　　　　　
    Kawashima Y, Hisaka T, Horiuchi H, Ishikawa H, Uchida S, Kinugasa T, Etou D, Okuda K, Akagi Y.
    Anticancer Research, Jul. 2016
  • Neoplastic Spindle Cells Are an Independent Prognostic Factor in Pancreatic Cancer　　　　　　　　　　　　　　　
    Takahashi K, Hisaka T, Horiuchi H, Ishikawa H, Nakayama M, Nakashima, O, Kawahara A, Kage M, Yano H, Akagi Y, Yonemoto K, Kinoshita H, Shirouzu K.
    Pancreas, Apr. 2015
  • Potential usefulness of mucin immunohistochemical staining of preoperative pancreatic biopsy or juice cytology specimens in the determination of treatment strategies for intraductal papillary mucinous neoplasm　　　　　　　　　　　　　　　
    Hisaka T, Horiuchi H, Uchida S, Ishikawa H, Kawahara R, Kawashima Y, Akashi M, Mikagi K, Ishida Y, Okabe Y, Nakayama M, Naito Y, Yano H, Taira T, Kawahara A, Kage M, Kinoshita H, Shirozu K.
    Oncology Reports, Sep. 2013
  • Liver histology and surgical outcomes after preoperative chemotherapy in colorectal cancer liver metastases. 2011 Apr;38(4):585-9.　　　　　　　　　　　　　　　
    Hisaka T, Horiuchi H, Uchida S, Ishikawa H, Ogata Y, Akagi Y, Ishibashi N, Kawahara R, Maruyama Y, Mikagi K, Kawashima Y, Fujishita M, Eto D, Yoshidomi M, Yamaguchi R, Kage M, Yano H, Kinoshita H, Shirozu K.
    Gan To Kagaku Ryoho., Apr. 2011
  • Interferon-alphaCon1 suppresses proliferation of liver cancer cell lines in vitro and in vivo.　　　　　　　　　　　　　　　
    Hisaka T, Yano H, Ogasawara S, Momosaki S, Nishida N, Takemoto Y, Kojiro S, Katafuchi Y, Kojiro M.
    J Hepatol., Nov. 2004
  • Expression of leukemia inhibitory factor (LIF) and its receptor gp190 in human liver and in cultured human liver myofibroblasts. Cloning of new isoforms of LIF mRNA.　　　　　　　　　　　　　　　
    Hisaka T, Desmouli?re A, Taupin JL, Daburon S, Neaud V, Senant N, Blanc JF, Moreau JF, Rosenbaum J.
    Comp Hepatol., Nov. 2004
  • Expression of tissue factor pathway inhibitor-2 in murine and human liver regulation during inflammation.　　　　　　　　　　　　　　　
    Hisaka T, Lardeux B, Lamireau T, W?estefeld T, Lalor PF, Neaud V, Maurel P, Desmouli?re A, Kisiel W, Trautwein C, Rosenbaum J.
    Thromb Haemost., Mar. 2004
  • cDNA cloning and tissue distribution of the rat ortholog of tissue factor pathway inhibitor-2.　　　　　　　　　　　　　　　
    Hisaka T, Kisiel W, Rosenbaum J.
    Thromb Haemost., Aug. 2002
  • Paradoxical pro-invasive effect of the serine proteinase inhibitor tissue factor pathway inhibitor-2 on human hepatocellular carcinoma cells.　　　　　　　　　　　　　　　
    Neaud V, Hisaka T, Monvoisin A, Bedin C, Balabaud C, Foster DC, Desmouli?re A, Kisiel W, Rosenbaum J.
    J Biol Chem., Nov. 2000
  • Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: relationship to cell proliferation.　　　　　　　　　　　　　　　
    Hisaka T, Yano H, Haramaki M, Utsunomiya I, Kojiro M.
    Int J Oncol., Mar. 1999
■ MISC
■ Lectures, oral presentations, etc.
  • 当科におけるIPMN切除例の治療成績　　　　　　　　　　　　　　　
    久下亨、堀内彦之、内田信治、石川博人、川原隆一、安永昌史、酒井久宗、川嶋裕資、御鍵和弘、福與健二郎、高橋健二郎、平川浩明、中山剛一、奥田康司、木下壽文、白水和雄
    第26回日本肝胆膵外科学会学術集会, Jun. 2014
  • 膵管内乳頭粘液腫瘍における術前 subtype 診断の試み　　　　　　　　　　　　　　　
    久下亨、堀内彦之、内田信治、石川博人、川原隆一、川嶋裕資、安永昌史、酒井久宗、奥田康司、木下壽文、白水和雄
    第114回日本外科学会定期学術集会, Apr. 2014
  • Japanese Currency on the Management of Liver Metastasis from Colorectal Cancer　　　　　　　　　　　　　　　
    Hisaka T, Okuda Y, Akagi Y
    37th Annual conference of hte association of colon and rectal surgeons of India, 2014
■ Affiliated academic society
  • 2002
    バイオ治療法学会　　　　　　　　　　　　　　　
  • 内視鏡外科学会　　　　　　　　　　　　　　　
  • 膵臓学会　　　　　　　　　　　　　　　
  • 胆道学会　　　　　　　　　　　　　　　
  • 肝臓学会　　　　　　　　　　　　　　　
  • 肝胆膵外科学会　　　　　　　　　　　　　　　
  • 臨床外科学会　　　　　　　　　　　　　　　
  • 消化器外科学会　　　　　　　　　　　　　　　
  • 日本外科学会　　　　　　　　　　　　　　　
■ 関心を持って取組んでいる活動
  • 1:肝胆膵領域における外科治療に関連した臨床研究2:肝胆膵領域における外科治療に関連した基礎的研究(外科病理)3:肝胆膵の外科手術、内視鏡手術、ロボット手術4:学生教育(OSCE, PCCE,RMCP)5:地域医師会での講演