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Shiimura Yuuki
Division of Molecular Genetics Institute of Life Science
Assistant Professor
Career
■ Career
- Apr. 2025 - Present
Kurume University, Molecular Genetics, Institute of Life Science, 講師 - Apr. 2017 - Present
Graduated school of medicine, Kyoto university, Cell Biology, Visiting Scholar - Apr. 2017 - Mar. 2025
Kurume University, Molecular Genetics, Institute of Life Science, 助教（任期制） - Jun. 2023 - Dec. 2023
School of Medicine, Stanford University, Molecular and Cellular Physiology (Kobilka Lab), Visiting Scholar - Sep. 2021 - Aug. 2022
School of Medicine, Stanford University, Molecular and Cellular Physiology (Kobilka lab), Visiting Scholar - Apr. 2016 - Mar. 2017
Kyoto University, Graduate School of Medicine, 特定研究員 - Apr. 2014 - Mar. 2016
Research Fellowships for Young Scientists (Japan Society for the Promotion of Science) - Apr. 2009 - Mar. 2011
Kyushu University of Health and Welfare, School of Pharmaceutical Sciences, 助手
- Apr. 2011 - Mar. 2015, Kurume University, Graduate School of Medicine
- Apr. 2007 - Mar. 2009, Kagoshima University, Graduate School of Medical and Dental Sciences
- Apr. 2003 - Mar. 2007, Kyushu University of Health and Welfare, School of Pharmaceutical Sciences
Research activity information
■ Award
■ 共同研究実績
- Jul. 2024
日本内分泌学会, 内分泌代謝学サマーセミナーポスター賞 - Nov. 2023
日本心血管内分泌代謝学会, 高峰譲吉研究奨励賞 - May 2019
GPCR研究会, 松尾研究奨励賞 - Apr. 2018
The Japan Endocrine Society, Young Investigator Award
- Discovery of Feeding Regulatory Peptides and The Importance of Peptide Discovery Research.
Takanori Ida; Kazuma Matsui; Sayaka Nagata; Tomoya Nakamachi; Yuki Shiimura; Takahiro Sato; Masayasu Kojima
The Kurume medical journal, 18 Apr. 2025, [Reviewed] - How the ghrelin receptor recognizes the acyl-modified orexigenic hormone
Yuki Shiimura; Masayasu Kojima; Takahiro Sato
Frontiers in Molecular Neuroscience, 07 Apr. 2025, [Reviewed], [Invited]
Lead, Corresponding - Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects.
Tia A Tummino; Christos Iliopoulos-Tsoutsouvas; Joao M Braz; Evan S O'Brien; Reed M Stein; Veronica Craik; Ngan K Tran; Suthakar Ganapathy; Fangyu Liu; Yuki Shiimura; Fei Tong; Thanh C Ho; Dmytro S Radchenko; Yurii S Moroz; Sian Rodriguez Rosado; Karnika Bhardwaj; Jorge Benitez; Yongfeng Liu; Herthana Kandasamy; Claire Normand; Meriem Semache; Laurent Sabbagh; Isabella Glenn; John J Irwin; Kaavya Krishna Kumar; Alexandros Makriyannis; Allan I Basbaum; Brian K Shoichet
Nature communications, 06 Mar. 2025, [Reviewed] - A cryptic pocket in CB1 drives peripheral and functional selectivity.
Vipin Ashok Rangari; Evan S O'Brien; Alexander S Powers; Richard A Slivicki; Zachariah Bertels; Kevin Appourchaux; Deniz Aydin; Nokomis Ramos-Gonzalez; Juliet Mwirigi; Li Lin; Elizaveta Mangutov; Briana L Sobecks; Yaseen Awad-Agbaria; Manoj B Uphade; Jhoan Aguilar; Teja Nikhil Peddada; Yuki Shiimura; Xi-Ping Huang; Jakayla Folarin-Hines; Maria Payne; Anirudh Kalathil; Balazs R Varga; Brian K Kobilka; Amynah A Pradhan; Michael D Cameron; Kaavya Krishna Kumar; Ron O Dror; Robert W Gereau 4th; Susruta Majumdar
Nature, 05 Mar. 2025, [Reviewed] - The structure and function of the ghrelin receptor coding for drug actions
Yuki Shiimura; Dohyun Im; Ryosuke Tany; Hidetsugu Asada; Ryoji Kise; Eon Kurumiya; Hideko Wakasugi-Masuho; Satoshi Yasuda; Kazuma Matsui; Jun-ichi Kishikawa; Takayuki Kato; Takeshi Murata; Masayasu Kojima; So Iwata; Ikuo Masuho
Nature Structural & Molecular Biology, Mar. 2025, [Reviewed]
Lead, Corresponding - 心脈管疾患の予防と治療の新戦略 立体構造から探るグレリン受容体の分子認識機構と活性化機構
椎村 祐樹; 林 到げん; 谷猪 遼介; 浅田 秀基; 木瀬 亮二; 松井 一真; 佐藤 貴弘; 岩田 想; 増保 生郎; 児島 将康
血管, Jan. 2025 - Ghrelin–LEAP2 interactions along the stomach–liver axis
Katsuya Sakai; Yuki Nakazato; Yuki Shiimura; Weidong Zhang; Masamitsu Nakazato
Endocrine Journal, 2025, [Reviewed] - Neurotransmitter recognition by human vesicular monoamine transporter 2.
Dohyun Im; Mika Jormakka; Narinobu Juge; Jun-Ichi Kishikawa; Takayuki Kato; Yukihiko Sugita; Takeshi Noda; Tomoko Uemura; Yuki Shiimura; Takaaki Miyaji; Hidetsugu Asada; So Iwata
Nature communications, 16 Sep. 2024, [Reviewed] - A µ-opioid receptor modulator that works cooperatively with naloxone.
Evan S O'Brien; Vipin Ashok Rangari; Amal El Daibani; Shainnel O Eans; Haylee R Hammond; Elizabeth White; Haoqing Wang; Yuki Shiimura; Kaavya Krishna Kumar; Qianru Jiang; Kevin Appourchaux; Weijiao Huang; Chensong Zhang; Brandon J Kennedy; Jesper M Mathiesen; Tao Che; Jay P McLaughlin; Susruta Majumdar; Brian K Kobilka
Nature, Jul. 2024, [Reviewed] - Acyl modifications in bovine, porcine, and equine ghrelins.
Takanori Ida; Hatsumi Tominaga; Eri Iwamoto; Akito Kurogi; Ayaka Okura; Kengo Shimada; Johji Kato; Atsutoshi Kuwano; Hirotaka Ode; Sayaka Nagata; Kazuo Kitamura; Takashi Yazawa; Miho Sato-Hashimoto; Masahiro Yasuda; Mikiya Miyazato; Yuki Shiimura; Takahiro Sato; Masayasu Kojima
Frontiers in endocrinology, 2024, [Reviewed] - Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor.
Dohyun Im; Jun-Ichi Kishikawa; Yuki Shiimura; Hiromi Hisano; Akane Ito; Yoko Fujita-Fujiharu; Yukihiko Sugita; Takeshi Noda; Takayuki Kato; Hidetsugu Asada; So Iwata
Nature communications, 20 Oct. 2023, [Reviewed] - Insights Into the Regulation of Offspring Growth by Maternally Derived Ghrelin.
Takahiro Sato; Takanori Ida; Yuki Shiimura; Kazuma Matsui; Kanae Oishi; Masayasu Kojima
Frontiers in endocrinology, 2022, [Reviewed] - Endogenous agonist–bound S1PR3 structure reveals determinants of G protein–subtype bias
Shintaro Maeda; Yuki Shiimura; Hidetsugu Asada; Kunio Hirata; Fangjia Luo; Eriko Nango; Nobuo Tanaka; Masayasu Toyomoto; Asuka Inoue; Junken Aoki; So Iwata; Masatoshi Hagiwara
Science Advances, Jun. 2021, [Reviewed] - Structure of the dopamine D2 receptor in complex with the antipsychotic drug spiperone
Dohyun Im; Asuka Inoue; Takaaki Fujiwara; Takanori Nakane; Yasuaki Yamanaka; Tomoko Uemura; Chihiro Mori; Yuki Shiimura; Kanako Terakado Kimura; Hidetsugu Asada; Norimichi Nomura; Tomoyuki Tanaka; Ayumi Yamashita; Eriko Nango; Kensuke Tono; Francois Marie Ngako Kadji; Junken Aoki; So Iwata; Tatsuro Shimamura
Nature Communications, Dec. 2020, [Reviewed] - Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode
Yuki Shiimura; Shoichiro Horita; Akie Hamamoto; Hidetsugu Asada; Kunio Hirata; Misuzu Tanaka; Kenji Mori; Tomoko Uemura; Takuya Kobayashi; So Iwata; Masayasu Kojima
Nature Communications, Aug. 2020, [Reviewed]
Lead - The Crystal Structure of Angiotensin II Type 2 Receptor with Endogenous Peptide Hormone
Hidetsugu Asada, Asuka Inoue, Francois Marie Ngako Kadji, Kunio Hirata, Yuki Shiimura, Dohyun Im, Tatsuro Shimamura, Norimichi Nomura, Hiroko Iwanari, Takao Hamakubo, Osamu Kusano-Arai, Hiromi Hisano, Tomoko Uemura, Chiyo Suno, Junken Aoki, So Iwata
Structure, Apr. 2020, [Reviewed] - Expression of the ghrelin/growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas
Hiroko Muta, Yasuo Sugita, Takuya Furuta, Yuki Shiimura, Koichi Ohshima, Kazutaka Nakashima, Kensaku Sato, Motohiro Morioka, Hideyuki Abe, Takanori Nozawa, Yukihiko Fujii, Akiyoshi Kakita
Neuropathology, 10 Jan. 2020, [Reviewed] - Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface
Yosuke Toyoda; Kazushi Morimoto; Ryoji Suno; Shoichiro Horita; Keitaro Yamashita; Kunio Hirata; Yusuke Sekiguchi; Satoshi Yasuda; Mitsunori Shiroishi; Tomoko Shimizu; Yuji Urushibata; Yuta Kajiwara; Tomoaki Inazumi; Yunhon Hotta; Hidetsugu Asada; Takanori Nakane; Yuki Shiimura; Tomoya Nakagita; Kyoshiro Tsuge; Suguru Yoshida; Tomoko Kuribara; Takamitsu Hosoya; Yukihiko Sugimoto; Norimichi Nomura; Miwa Sato; Takatsugu Hirokawa; Masahiro Kinoshita; Takeshi Murata; Kiyoshi Takayama; Masaki Yamamoto; Shuh Narumiya; So Iwata; Takuya Kobayashi
Nature Chemical Biology, Jan. 2019, [Reviewed] - Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Hidetsugu Asada; Shoichiro Horita; Kunio Hirata; Mitsunori Shiroishi; Yuki Shiimura; Hiroko Iwanari; Takao Hamakubo; Tatsuro Shimamura; Norimichi Nomura; Osamu Kusano-Arai; Tomoko Uemura; Chiyo Suno; Takuya Kobayashi; So Iwata
Nature Structural & Molecular Biology, Jul. 2018, [Reviewed] - Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-kappa B and Nkx2.2
Yuki Shiimura; Hideko Ohgusu; Takahiro Sato; Masayasu Kojima
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2015, [Reviewed]
Lead - FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1
Yuki Nakamura; Takahiro Sato; Yuki Shiimura; Yoshiki Miura; Masayasu Kojima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2013, [Reviewed] - I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions
Shuichi Kusano; Yuki Shiimura; Yoshito Eizuru
BIOCHIMIE, Sep. 2011, [Reviewed]
- Ghrelin and its receptor: a gut–brain hormone system as a therapeutic target for cancer cachexia
Yuki Shiimura; Taito Inoue; Takahiro Sato
Folia Pharmacologica Japonica, 01 Nov. 2025, [Reviewed], [Invited]
Lead - グレリン（ghrelin）
佐藤貴弘; 椎村祐樹; 児島将康
（一社）日本神経科学学会 脳科学辞典, Oct. 2025, [Invited] - Novel small molecule GPCR drug discovery utilizing DNA-encoded library
椎村祐樹; 椎村祐樹; 伊藤幸裕; 林到けん; 岡田咲良; 岩田想; 鈴木孝禎; 佐藤貴弘
日本解剖学会総会・全国学術集会抄録集(CD-ROM), 2025 - 立体構造から探るグレリン受容体の分子認識機構と活性化機構
椎村祐樹; 椎村祐樹; 林到けん; 谷猪遼介; 浅田秀基; 木瀬亮二; 松井一真; 佐藤貴弘; 岩田想; 増保生郎; 児島将康
血管(Web), 2025 - Protein Crystallography: Crystal structure of an antagonist-bound ghrelin receptor.
Yuki Shiimura; So Iwata; Masayasu Kojima
Spring-8/SACLA Research Frontiers 2020, 2021
Lead - Physiological roles of ghrelin on obesity
Takahiro Sato; Takanori Ida; Yuki Nakamura; Yuki Shiimura; Kenji Kangawa; Masayasu Kojima
OBESITY RESEARCH & CLINICAL PRACTICE, Sep. 2014, [Reviewed] - Structure, regulation and function of ghrelin
Takahiro Sato; Yuki Nakamura; Yuki Shiimura; Hideko Ohgusu; Kenji Kangawa; Masayasu Kojima
JOURNAL OF BIOCHEMISTRY, Feb. 2012, [Reviewed]
- 〔Major achievements〕Structural Life Science
Contributor, 構造から読み解くグレリン受容体のリガンド応答の多様性
YODOSHA, Sep. 2025
9784758104296
- 〔主要な業績〕幹細胞に作用する未知のホルモン探索
椎村祐樹
獣医生理学研究セミナー（宮崎大学農学部獣医学科）, 09 Feb. 2026, [Invited] - Discovery of Positive Allosteric Modulators Targeting the Ghrelin Receptor
Yuki Shiimura; Dohyun Im; Yukihiro Itoh; Sakura Okada; Ryoji Kise; Asuka Inoue; Takayoshi Suzuki; So Iwata; Takahiro Sato
GPCR Workshop 2025, 12 Dec. 2025 - グレリン受容体を標的としたポジティブアロステリックモデュレーター探索の試み
椎村 祐樹; 伊藤 幸裕; イム ドヒョン; 岡田 咲良; 木瀬 亮次; 岩田 想; 井上 飛鳥; 鈴木 孝禎; 佐藤 貴弘
第78回 日本薬理学会西南部会, 08 Nov. 2025 - グレリン受容体を標的としたPAM 探索のためのDEL スクリーニング
椎村祐樹; イムドヒョン; 伊藤幸裕; 岡田咲良; 鈴木 孝禎; 岩田想; 佐藤 貴弘
第51回 日本神経内分泌学会学術集会, 25 Oct. 2025 - 〔主要な業績〕内分泌研究におけるAIの活用：AlphaFoldを正しく理解して活用するために
椎村祐樹
第43回 内分泌代謝学サマーセミナー, 10 Jul. 2025, [Invited] - グレリン受容体を標的とした低分子化合物創製の試み
椎村祐樹; 伊藤幸裕; 林到炫; 岡田咲良; 岩田想; 鈴木孝禎; 佐藤 貴弘
第98回 日本内分泌学会学術総会, 07 Jun. 2025 - DNA-encoded libraryを活用した新しいGPCR低分子創薬
椎村祐樹; 伊藤幸裕; 林到炫; 岡田咲良; 岩田想; 鈴木孝禎; 佐藤貴弘
APPW2025, 19 Mar. 2025 - 〔主要な業績〕グレリン受容体のStructure-Based Drug Designに向けた取り組み
椎村祐樹
24th MPRC seminar（千葉大学 膜タンパク質研究センター）, 17 Mar. 2025 - 〔主要な業績〕立体構造から探るグレリン受容体の分子認識機構と活性化機構
椎村祐樹
第54回 日本心脈管作動物質学会, 01 Feb. 2025, [Invited] - 成長ホルモン分泌促進因子受容体のリガンド認識機構とその活性化機構
椎村祐樹; 林到炫; 谷猪遼介; 浅田秀基; 木瀬亮次; 松井一真; 岩田想; 増保生郎; 児島将康
第28回 日本心血管内分泌代謝学会学術総会, Sep. 2024 - 構造情報に立脚したグレリン受容体アゴニストの薬理プロファイル解析
椎村祐樹; イムドヒョン; 谷猪遼介; 浅田秀基; 松井一真; 岩田想; 増保生郎; 児島将康
第42回 日本内分泌代謝学サマーセミナー, Jul. 2024 - グレリン受容体のリガンド認識機構および活性化機構の構造学的洞察
椎村祐樹; 林到炫; 浅田秀基; 松井一真; 岩田想; 児島将康
日本薬学会 第144年会, Mar. 2024 - 〔Major achievements〕Structural Insights into Ghrelin Receptor
Yuki Shiimura; Dohyun Im; Ryosuke Tany; Hidetsugu Asada; Kazuma Matsui; Ikuo Masuho; So Iwata; Masayasu Kojima
JKT Symposium on "The 5Gs in Obesity (GLP-1, GIP, Glucagon, Ghrelin and Gut hormone):Basic and Clinical Research", 26 Nov. 2023, [Invited] - グレリン受容体のリガンド認識機構の構造基盤
椎村祐樹
第27回 日本心血管内分泌代謝学会学術総会, Nov. 2023 - 構造情報に基づいたグレリン受容体アゴニストのシグナル活性の比較
椎村祐樹; 林到炫; 谷猪遼介; 浅田秀基; 増保生郎; 松井一真; 岩田想; 児島将康
第49回 神経内分泌学会, Oct. 2023 - Insights into the structure of the agonist-bound ghrelin receptor
Shiimura Y.;Im D.;Tany R.;Kise R.;Asada H.;Iwata S.;Ikuo M.;Kojima M., Jun. 2023, [Invited] - グレリン受容体のX線結晶構造解析
椎村祐樹
第15回 GPCR研究会, May 2019 - X線結晶構造解析を基盤とした活性型グレリン認識機構の解明
椎村祐樹; 堀田彰一朗; 浅田秀基; 平田邦生; 小林拓也; 児島将康; 岩田想
日本薬学会 第126回年会, Mar. 2019 - グレリン受容体の結晶構造解析による活性型グレリン認識機構の解明
椎村祐樹; 堀田彰一朗; 浅田秀基; 平田邦生; 小林拓也; 児島将康; 岩田想
第91回 日本内分泌学会学術総会, Apr. 2018 - Sarpogrelate, a selective serotonin 5-HT2A receptor antagonist, improves ischemia/reperfusion-induced renal injury in mice
椎村祐樹; 武藤純平; 佐藤圭創; 比佐博彰
第115回 日本薬理学会, Mar. 2011 - Renal ischemia transiently activates renal tissue RhoA
椎村祐樹; 武藤純平; 比佐博彰
第130回 日本薬学会, Mar. 2010 - I-mfa ドメインタンパク質はSERTAD ドメインタンパク質と相互作用しその機能を抑制する
椎村祐樹; 草野秀一; 栄鶴義人
第31回 日本分子生物学会年会, Dec. 2008
- Jan. 2026 - Present
久留米大学 - Sep. 2025 - Present
久留米大学 - Aug. 2024 - Present
久留米大学 - Apr. 2022 - Present
久留米大学 - Apr. 2019 - Mar. 2021
久留米大学
- Jul. 2024 - Present
日本心脈管作動物質学会 - Jun. 2024 - Present
The Japanese Pharmacological Society - Sep. 2023 - Present
日本肥満学会 - 2020 - Present
The Society of Cardiovascular Endocrinology and Metabolism - 2019 - Present
Japan Neuroendocrine Society - 2019 - Present
The Pharmaceutical Society of Japan - 2016 - Present
The Japan Endocrine Society
- Structural study of the initial transducer engagement by GPCR
Apr. 2024 - Mar. 2028 - 新規サルコペニア治療薬の開発
2025 - 2026 - Why is the acyl-modification of ghrelin necessary for activity?
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2020 - 31 Mar. 2023 - Cryo-EM structure of the ghrelin receptor coupled to an engineered heterotrimeric G protein
Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
Kurume University
Sep. 2021 - Nov. 2022 - グレリン受容体の結晶構造解析: なぜオクタン酸グレリンが受容体を刺激できるのか？
Apr. 2018 - Mar. 2021 - グレリン受容体発現細胞の免疫による立体構造認識抗体および機能性抗体の作出.
Apr. 2016 - Mar. 2018 - Monoclonal antibody that activates the ghrelin receptor and its application to the crystal structure analysis
Grant-in-Aid for Challenging Exploratory Research
Kurume University
Apr. 2014 - Mar. 2017 - GOAT及びグレリン受容体の立体構造に基づいたグレリン脂肪酸修飾・認識機構の解明.
Apr. 2014 - Mar. 2016 - 消化管幹細胞に特異的に発現するオーファン受容体LGR5のリガンド探索.
Apr. 2012 - Mar. 2013
■ 共同研究実績
