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Hara Koyu
Department of Infection Control and Prevention
Associate Professor

Researcher information

■ Degree
  • Doctor of Philosophy, Kyushu University
■ Field Of Study
  • Life sciences, Virology
  • Life sciences, Molecular biology
■ Research Keyword
  • ウイルス学
■ Research Theme
  • インフルエンザウイルスの増殖機構に関する基礎研究
  • インフルエンザウイルスRNAポリメラーゼに関する研究
  • RSウイルスに関する基礎研究
  • パラミクソウイルスに関する基礎研究

Career

■ Career
  • 2001
    - Kurume University School of Medicine, Lecturer
  • 1998 - 2000
    Kurume University School of Medicine, Assistant Professor
  • 1996 - 1998
    Kumamoto Agricultural Research Center, Researcher
■ Educational Background
  • 1996, Kyushu University, Graduate School, Division of Agriculture
  • 1991, Kyushu University, Faculty of Agriculture
  • Kyushu University, School of Agriculture

Research activity information

■ MISC
  • 豊田哲也・原 好勇、インフルエンザウイルスの構造と遺伝子、臨床検査、46、2002、133-138.               
    2002
  • Iwahashi J., Kawasaki I., Kohara Y., Gengyo-Ando K., Mitani S.,Ohshima Y., Hamada N., Hara K., Kashiwagi T., and Toyoda T. Caenorhabditis elegans reticulon interacts with RME-1 during embryogenesis. Biochem Biophys. Res. Commun. 293, 2002, 698-704."               
    2002
  • Hamada N., Iwahashi J., Suzuki K., Ogi H., Kashiwagi T., Hara K., Tooda M., Yamada T., and Toyoda T. Molecular cloning and characterization of the mouse reticulon 3 cDNA. Cell. Mol. Biol. 48 (2), 2002, 163-172."               
    2002
  • Toyoda T. Hara K., Kashiwagi T., Iwahashi J., Honda H. and Hamada N. Molecular dissection of the transcription and replication machinery of influenza virus. Recent Advances in Influenza Virus Research. 2002, 1-13."               
    2002
  • Kashiwagi T., Hara K., Kohara M., Iwahashi J., Hamada N., Honda-Yoshino H. and Toyoda T. Promoter/origin structure of the complementary strand of hepatitis C virus genome. J. Biol. Chem., 277, 2002, 28700-28705."               
    2002
  • Kashiwagi T., Hara K., Kohara M., Kohara K., Iwahashi J., Hamada N., Yoshino H. and Toyoda T. Kinetic analysis of C-terminally truncated RNA dependent RNA polymerase of hepatitis Cvirus. Biochem Biophys. Res. Commun. 290, 2002, 1188-1194."               
    2002
  • Hara K., Shiota M., Kido H., Ohtsu Y., Kashiwagi T., Iwahashi J., Hamada N., Mizoue K., Tsumura N., Kato H., and Toyoda T. Influenza virus RNA polymerase PA subunit is a novel serine protease with Ser 624 in the active site. Genes to Cells, 6, 2001, 87・・・               
    2001
  • Hara K., Shiota M., Kido H., Ohtsu Y., and Toyoda T. Protease activity of influenza virus RNA polymerase PA subunit. In 'The world congress on options for the control of influenza IV.' ICS1219 (Albert D.M.E. Osterhaus, et al. eds.), Elsevier, Amsterdam・・・               
    2001
  • Hara K., Kawasaki T., Ohtsu Y., Masunaga K., Akasu Y., Tsumura N., Kato H., Iwahashi J., Hamada N., M. Toyoda and Toyoda T. Molecular evolution of echovirus type 9 isolated from patients with aseptic meningitis in Northern Kyushu during the summer of 1・・・               
    2001
  • Iwahashi J, Tsuji K, Ishicashi T, Kajiwara J, Imamura Y, Mori R, Hara K., Kawasaki T, Ohtsu Y, Hamada N, Maeda H, Toyoda T. Isolation of amantadine-resistant influenza a viruses (H3N2) from patients following administration of amautadine in Japan. J Cl・・・               
    2001
  • Protease activity of influenza virus RNA polymerase PA subunit.               
    The world congress on options for the control of influenza IV. 'ICS 1219, 2001
  • 豊田哲也・原 好勇、インフルエンザウイルスの分子生物学4・感染分子機構からみた治療薬開発の方向性、治療学、34、2000、44-49.               
    2000
  • 原 好勇・豊田哲也、抗インフルエンザウイルス薬、治療学、34、2000、981-986.               
    2000
  • Kashiwagi T., Hamada M., Iwahashi J., Hara K., Ueda T., Noguchi H., and Toyoda T. Emergence of new influenza A viruses which carry an escape mutation of the HLA-B27-restricted CTL epitope of NP in Japan. Microbiol. Immunol., 44: 867-870, 2000."               
    2000
  • Toyoda T., Imamura Y., Takaku H., Kashiwagi T., Hara K., Iwahashi J., Ohtsu Y., Tsumura N., Kato H., Hamada N.: Inhibition of Influenza virus replication in cultured cells by RNA-cleaving DNA enzyme. FEBS Lett., 481: 113-116, 2000."               
    2000
  • Toyoda T, Masunaga K, Ohtsu Y, Hara K, Hamada N, Kashiwagi T, Iwahashi J. Antibody-scanning and epitope-tagging methods: Molecular mapping of proteins using antibodies. Corr Protein Pepride Sci, 1: 303-8. 2000."               
    2000
  • Toyoda T., Ohtsu Y., Hara K., Masunaga K., Hamada N., Koga M., Kashiwagi T., and Iwahashi J. Molecular dissection of influenza virus RNA polymerase. Rec. Res. Dev. Virol. 1:839-847, 1999."               
    1999
■ Research Themes
  • Study on the Influenza Virus RNA Polymerase               
■ 共同研究希望
  • ウイルス学に関する研究
■ 共同研究実績
  • IインフルエンザウイルスRNAポリメラーザPAサブユニットのもつプロテアーゼ活性に関する研究(徳島大学およびオックスフォード大学)