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Kuroiwa Mahomi
Department of Pharmacology
Assistant Professor
Career
■ Career
- Mar. 2025 - Present
Kurume University, 医学部薬理学講座, 講師 - Jan. 2009 - Feb. 2025
Kurume University School of Medicine, Department of Pharmacology, Research associate
- Apr. 2004 - Dec. 2008, Kurume University School of Medicine, 大学院医学研究科, Department of Pharmacology
- Apr. 2002 - Mar. 2004, Kyushu University, Faculty of Pharmaceutical Sciences, Department of Pharmacology
- Apr. 1996 - Mar. 2000, Nagasaki University, Faculty of Pharmaceutical Sciences, 薬科学科
Research activity information
■ Award
- Mar. 2009
久留米大学, 久留米大学学術奨励賞
Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum.
黒岩 真帆美 - Jun. 2006
日本脳科学会, 日本脳科学会奨励賞
ドーパミン D1 様受容体を介するホスホリパーゼＣ依存性および非依存性 DARPP-32 リン酸化調節
黒岩 真帆美
- 大脳基底核研究の最前線-機能と障害の脳基盤- 線条体の領域特異的なD1受容体シグナル L-ドパ誘発性ジスキネジアにおける役割
西 昭徳; 杉山 慶太; 黒岩 真帆美
日本神経精神薬理学会年会プログラム・抄録集, Sep. 2023 - Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments
Ryusuke Sin; Naoki Sotogaku; Yoshinori N. Ohnishi; Takahide Shuto; Mahomi Kuroiwa; Yukie Kawahara; Keita Sugiyama; Yuki Murakami; Masaaki Kanai; Hiroshi Funakoshi; Ayanabha Chakraborti; James A Bibb; Akinori Nishi
Brain, Behavior, and Immunity, Aug. 2023 - DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum.
Mahomi Kuroiwa; Takahide Shuto; Taku Nagai; Mutsuki Amano; Kozo Kaibuchi; Angus C Nairn; Akinori Nishi
Neurochemistry international, Jan. 2023, [Reviewed]
Lead - Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice.
Hideo Hagihara; Hirotaka Shoji; Mahomi Kuroiwa; Isabella A Graef; Gerald R Crabtree; Akinori Nishi; Tsuyoshi Miyakawa
Molecular brain, 22 Nov. 2022, [Reviewed] - Noradrenaline activation of hippocampal dopamine D1 receptors promotes antidepressant effects.
Katsunori Kobayashi; Kisako Shikano; Mahomi Kuroiwa; Mio Horikawa; Wakana Ito; Akinori Nishi; Eri Segi-Nishida; Hidenori Suzuki
Proceedings of the National Academy of Sciences of the United States of America, 16 Aug. 2022, [Reviewed] - Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia.
Keita Sugiyama; Mahomi Kuroiwa; Takahide Shuto; Yoshinori N Ohnishi; Yukie Kawahara; Yuta Miyamoto; Takaichi Fukuda; Akinori Nishi
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 Jul. 2021, [Reviewed] - Sex Differences in Dendritic Spine Formation in the Hippocampus and Animal Behaviors in a Mouse Model of Hyperthyroidism.
Tetsushi Niiyama; Mahomi Kuroiwa; Yusaku Yoshioka; Yosuke Kitahara; Takahide Shuto; Tatsuyuki Kakuma; Keisuke Ohta; Kei-Ichiro Nakamura; Akinori Nishi; Mami Noda
Frontiers in cellular neuroscience, 16 Sep. 2020, [Reviewed]
Lead - Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice.
Takatoshi Hikida; Makiko Morita; Mahomi Kuroiwa; Tom Macpherson; Takahide Shuto; Naoki Sotogaku; Minae Niwa; Akira Sawa; Akinori Nishi
Neuroscience research, Feb. 2020, [Reviewed] - Differential regulation of dopamine D1 receptor signaling in subregions of the striatum
Sugiyama Keita; Kuroiwa Mahomi; Shuto Takahide; Fukuda Takaichi; Nishi Akinori
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Region-specific regulation of dopamine signaling in the striatum
Sugiyama Keita; Kuroiwa Mahomi; Syuto Takahide; Fukuda Takaichi; Nishi Akinori
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019 - Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine.
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yong-Seok Oh; Jin-Hyeok Jang; Chang-Hoon Shin; Yoshinori N Ohnishi; Yuuki Hanada; Tsuyoshi Miyakawa; Yong Kim; Paul Greengard; Akinori Nishi
Molecular psychiatry, 10 Dec. 2018, [Reviewed] - p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli.
Hanada Y; Kawahara Y; Ohnishi YN; Shuto T; Kuroiwa M; Sotogaku N; Greengard P; Sagi Y; Nishi A
eNeuro, Sep. 2018, [Reviewed] - Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yoshinori Ohnishi; Yuuki Hanada; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018 - Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution
Akinori Nishi; Miriam Matamales; Veronica Musante; Emmanuel Valjent; Mahomi Kuroiwa; Yosuke Kitahara; Heike Rebholz; Paul Greengard; Jean-Antoine Girault; Angus C. Nairn
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2017, [Reviewed] - Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus
Yosuke Kitahara; Keisuke Ohta; Hiroshi Hasuo; Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Akinobu Togo; Kei-ichiro Nakamura; Akinori Nishi
PLOS ONE, Jan. 2016, [Reviewed] - Social Isolated DISC1 Mutant Mice Displayed High Sensitivity to Chronic Cocaine Exposure and Rolipram Treatment
Takatoshi Hikida; Makiko Morita; Mahomi Kuroiwa; Tom Macpherson; Taichi Itou; Takahide Shuto; Naoki Sotogaku; Minae Niwa; Akira Sawa; Akinori Nishi
NEUROPSYCHOPHARMACOLOGY, Dec. 2015, [Reviewed] - Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia
Keizo Takao; Katsunori Kobayashi; Hideo Hagihara; Koji Ohira; Hirotaka Shoji; Satoko Hattori; Hisatsugu Koshimizu; Juzoh Umemori; Keiko Toyama; Hironori K. Nakamura; Mahomi Kuroiwa; Jun Maeda; Kimie Atsuzawa; Kayoko Esaki; Shun Yamaguchi; Shigeki Furuya; Tsuyoshi Takagi; Noah M. Walton; Nobuhiro Hayashi; Hidenori Suzuki; Makoto Higuchi; Nobuteru Usuda; Tetsuya Suhara; Akinori Nishi; Mitsuyuki Matsumoto; Shunsuke Ishii; Tsuyoshi Miyakawa
Neuropsychopharmacology, Jul. 2013, [Reviewed] - Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum
Takahide Shuto; Mahomi Kuroiwa; Yuki Koga; Yukie Kawahara; Naoki Sotogaku; Koji Toyomasu; Akinori Nishi
NEUROSCIENCE LETTERS, May 2013, [Reviewed] - Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons
Mahomi Kuroiwa; Miho Hamada; Eriko Hieda; Takahide Shuto; Naoki Sotogaku; Marc Flajolet; Gretchen L. Snyder; Joseph P. Hendrick; Allen Fienberg; Akinori Nishi
NEUROPHARMACOLOGY, Dec. 2012, [Reviewed]
Lead - Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex
Mahomi Kuroiwa; Gretchen L. Snyder; Takahide Shuto; Atsuo Fukuda; Yuchio Yanagawa; David R. Benavides; Angus C. Nairn; James A. Bibb; Paul Greengard; Akinori Nishi
Psychopharmacology, Feb. 2012, [Reviewed]
Lead - Mechanisms for the modulation of dopamine D-1 receptor signaling in striatal neurons
Akinori Nishi; Mahomi Kuroiwa; Takahide Shuto
FRONTIERS IN NEUROANATOMY, Jul. 2011, [Reviewed] - Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons
Masato Hara; Ryuichi Fukui; Eriko Hieda; Mahomi Kuroiwa; Helen S. Bateup; Tatsuhiko Kano; Paul Greengard; Akinori Nishi
JOURNAL OF NEUROCHEMISTRY, May 2010, [Reviewed] - Role of phosphodiesterases in dopamine signal transduction.
Nishi A; Kuroiwa M; Shuto T
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Jan. 2010, [Reviewed] - Regulation of DARPP-32 phosphorylation by three distinct dopamine D(1)-like receptor signaling pathways in the neostriatum
Mahomi Kuroiwa; Helen S. Bateup; Takahide Shuto; Hideho Higashi; Masatoshi Tanaka; Akinori Nishi
JOURNAL OF NEUROCHEMISTRY, Nov. 2008, [Reviewed]
Lead - Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum
Akinori Nishi; Mahomi Kuroiwa; Diane B. Miller; James P. O'Callaghan; Helen S. Bateup; Takahide Shuto; Naoki Sotogaku; Takaichi Fukuda; Nathaniel Heintz; Paul Greengard; Gretchen L. Snyder
JOURNAL OF NEUROSCIENCE, Oct. 2008, [Reviewed] - Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
Helen S. Bateup; Per Svenningsson; Mahomi Kuroiwa; Shiaoching Gong; Akinori Nishi; Nathaniel Heintz; Paul Greengard
NATURE NEUROSCIENCE, Aug. 2008, [Reviewed] - Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1(High) and D2(High) receptors in methamphetamine-sensitized rats
Takahide Shuto; Philip Seeman; Mahomi Kuroiwa; Akinori Nishi
EUROPEAN JOURNAL OF NEUROSCIENCE, May 2008, [Reviewed] - Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization
Chan Nguyen; Tomohisa Hosokawa; Mahomi Kuroiwa; Nancy Y. Ip; Akinori Nishi; Shin-ichi Hisanaga; James A. Bibb
JOURNAL OF NEUROCHEMISTRY, Nov. 2007, [Reviewed] - Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D-1 receptor agonist
Takahide Shuto; Mahomi Kuroiwa; Mitsuko Hamamura; Kenichi Yabuuchi; Takao Shimazoe; Shigenori Watanabe; Akinori Nishi; Tsuneyuki Yamamoto
NEUROPHARMACOLOGY, Jun. 2006, [Reviewed] - Role of adenosine A(1), receptors in the modulation of dopamine D-1, and adenosine A(2a) receptor signaling in the neostriatum
K. Yabuuchi; M. Kuroiwa; T. Shuto; N. Sotogaku; G. L. Snyder; H. Higashi; M. Tanaka; P. Greengard; A. Nishi
NEUROSCIENCE, 2006, [Reviewed] - Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons
S Niiyama; E Tanaka; S Tsuji; Y Murai; M Satani; H Sakamoto; K Takahashi; M Kuroiwa; A Yamada; M Noguchi; H Higashi
NEUROSCIENCE RESEARCH, Nov. 2005, [Reviewed] - Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons
M Hamada; JP Hendrick; GR Ryan; M Kuroiwa; H Higashi; M Tanaka; AC Nairn; P Greengard; A Nishi
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 2005, [Reviewed]
- 線条体におけるドパミンD1受容体シグナルの領域特異的な制御:L-ドパ誘発性ジスキネジアとの関連性
杉山慶太; 黒岩真帆美; 首藤隆秀; 大西克典; 河原幸江; 宮本雄太; 福田孝一; 西昭徳
日本脳科学会プログラム・講演抄録集, 2021 - 抗うつ薬による歯状回-貫通線維シナプスの形態変化 FIB-SEMを用いた構造解析
北原 陽介; 太田 啓介; 首藤 隆秀; 黒岩 真帆美; 外角 直樹; 蓮尾 博; 都合 亜記暢; 中村 桂一郎; 西 昭徳
日本脳科学会プログラム・抄録集, Nov. 2015 - DISC1マウスの隔離飼育に対するドパミンシグナル応答 ホスホジエステラーゼの役割(Role of PDEs in alteration of dopamine signaling after isolation stress in DISC1 mutant mice)
黒岩 真帆美; 首藤 隆秀; 外角 直樹; 森田 真規子; 澤 明; 疋田 貴俊; 西 昭徳
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2015 - 社会的ストレス下においてDISC1変異マウスのコカイン感受性はPDE4により制御される(Cocaine-induced behavioral sensitization is regulated by PDE4 in social stressed DISC1 mutant mice)
疋田 貴俊; 森田 真規子; マクファーソン・トム; 伊藤 大一; 丹羽 美苗; 黒岩 真帆美; 澤 明; 西 昭徳
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2015 - 抗うつ薬による歯状回‐貫通線維シナプスの形態変化:FIB‐SEMを用いた構造解析
北原陽介; 太田啓介; 首藤隆秀; 黒岩真帆美; 外角直樹; 蓮尾博; 都合亜記暢; 中村桂一郎; 西昭徳
日本脳科学会プログラム・講演抄録集, 2015 - Role of PDE-mediated signaling and its crosstalk in brain function
A. Nishi; M. Kuroiwa; T. Shuto; S. Gretchen
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2014 - コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用
首藤 隆秀; 黒岩 真帆美; 古賀 夕貴; 西 昭徳
日本薬理学雑誌, Mar. 2013 - 抗うつ薬による海馬歯状回顆粒細胞の形態変化:FIB/SEMを用いた樹状突起の3D電顕解析
北原陽介; 首藤隆秀; 黒岩真帆美; 外角直樹; 蓮尾博; 都合亜記暢; 太田啓介; 中村桂一郎; 西昭徳
日本薬理学会西南部会プログラム/抄録集, 2013 - 抗うつ薬により誘導された脱成熟歯状回におけるドーパミンD1受容体機能
西 昭徳; 黒岩 真帆美; 首藤 隆秀
日本脳科学会プログラム・抄録集, Oct. 2011 - フルオキセチン慢性投与による海馬歯状回ドーパミンD1受容体シグナルの増強(Effect of chronic fluoxetine treatment on dopamine D1 receptor signaling in the hippocampal dentate gyrus)
黒岩 真帆美; 外角 直樹; 首藤 隆秀; 宮川 剛; 西 昭徳
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Oct. 2011 - ドーパミン細胞質・核内DARPP-32シグナルのグルタミン酸による制御
西 昭徳; 黒岩 真帆美
日本薬理学雑誌, Mar. 2011 - 大脳皮質ドーパミンD1シグナルを制御するホスホジエステラーゼ4に関する研究(Role of phosphodiesterase 4 in dopamine D1 receptor/cAMP/PKA signaling in the frontal cortex)
黒岩 真帆美; 首藤 隆秀; 西 昭徳
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2010 - ホスホジエステラーゼ阻害薬による中枢ドーパミンシグナル調節
黒岩 真帆美; 首藤 隆秀; 西 昭徳
日本薬理学雑誌, Mar. 2010 - Roles of PDE4 and PDE10A in dopamine neurotransmission
A. Nishi; M. Kuroiwa; T. Shuto; S. Gretchen
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010 - ROLES OF PHOSPHODIESTERASES IN THE REGULATION OF DOPAMINERGIC SIGNALING
KUROIWA M.; NISHI A.
Journal of brain science, 12 Jun. 2009 - 線条体によるドーパミンD1様受容体を介するDARPP-32リン酸化調節
黒岩 真帆美
久留米医学会雑誌, Feb. 2009 - Phosphodiesteraseによる線条体リン酸化シグナルの制御:ドーパミン神経終末とmedium spiny neuronの比較
西 昭徳; 黒岩 真帆美
日本薬理学雑誌, Mar. 2008 - 線条体ドーパミン情報伝達におけるDARPP-32とRCSの機能的役割
西 昭徳; 黒岩 真帆美; 田中 正敏
日本薬理学雑誌, Feb. 2006 - SKF83959 regulates DARPP-32 phosphorylation by activating PLC-dependent and independent cascades
M Kuroiwa; A Nishi; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Adaptation of pre- and postsynaptic dopaminergic signaling in methamphetamine-sensitized rats
M Kuroiwa; T Shuto; A Nishi; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - コレシストキニン受容体ノックアウトマウスにおける光同調機能及び発振機能の検討
森田 光貴; 島添 隆雄; 黒岩 真帆美; 森尾 文; 宮坂 京子; 瀧口 総一; 河野 彬; 船越 顕博; 渡辺 繁紀
日本薬理学雑誌, Mar. 2003
- Jul. 2021 - Present
The Japanese Society of Clinical Pharmacology and Therapeutics - Nov. 2014 - Present
THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY - Mar. 2006 - Present
THE JAPAN NEUROSCIENCE SOCIETY - Dec. 2002 - Present
THE JAPANESE PHARMACOLOGICAL SOCIETY - Society for Neuroscience
- Enhancement of antidepressant responsiveness by stress via reorganization of noradrenergic signaling
Grant-in-Aid for Scientific Research (B)
Nippon Medical School
01 Apr. 2023 - 31 Mar. 2027 - Enhancement of antidepressant responsiveness by stress via reorganization of noradrenergic signaling
Grant-in-Aid for Scientific Research (B)
Nippon Medical School
01 Apr. 2023 - 31 Mar. 2027 - Development of treatments for post traumatic stress disorder related to surgery and intensive care.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2023 - 31 Mar. 2026 - Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2022 - 31 Mar. 2025 - Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2022 - 31 Mar. 2025 - Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Involvement of dopamine and noradrenaline signaling mechanisms in depression and schizophrenia.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Investigation of the interaction between dopamine and noradrenaline signaling in the hippocampus to develop novel treatment of depression
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2018 - 31 Mar. 2021 - Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2016 - 31 Mar. 2019 - Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2016 - 31 Mar. 2019 - Role of PDEs in antipsychotic effects in hippocampal dentate gyrus.
Grant-in-Aid for Young Scientists (B)
Kurume University
01 Apr. 2014 - 31 Mar. 2016 - ホスホジエステラーゼに着目した精神疾患の病態解明および治療法開発
Apr. 2015 - Mar. 2016 - Role of PDEs in antidepressant effects in the hippocampal dentate gyrus.
Grant-in-Aid for Young Scientists (B)
Kurume University
01 Apr. 2012 - 31 Mar. 2014 - ホスホジエステラーゼを標的としたうつ病新規治療法の探索：海馬歯状回における検討
Apr. 2012 - Mar. 2013 - ホスホジエステラーゼ機能の解明:認知機能障害治療薬としての可能性を探る
2010 - Mar. 2012 - Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA signaling cascade in frontal cortex.
Grant-in-Aid for Research Activity start-up
Kurume University
2010 - 2011
