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Ohnishi Nori Yoshinori
Department of Pharmacology
Assistant Professor
Profile
1990年4月 - 1996年3月 九州大学医学部 学部生
1996年4月 - 1997年3月 九州大学付属病院皮膚科学教室 研修医
九州大学農学部大学院農学研究院 生物機能科学部門(伊東 信助教授)にて研究にも従事
1997年4月 - 1998年3月 九州大学大学院医学研究院 分子細胞情報学部門(金出 英夫教授) 大学院生
1998年4月 - 2002年3月 九州大学生体防御医学研究所 個体機能制御学部門 脳機能制御学分野(中別府 雄作教授) 大学院生
2002年4月 - 2006年8月 九州大学九州大学生体防御医学研究所 個体機能制御学部門 脳機能制御学分野(中別府 雄作教授) ポスドク
2006年9月 - 2008年8月 テキサス大学メディカルセンターサウスウェスタン校(Eric Nestler lab) ポスドク
2008年9月 - 2011年9月 マウントサイナイ医科大学神経科学科(Eric Nestler lab) ポスドク
2011年11月 - 久留米大学医学部薬理学講座(西 昭徳教授) 助教
Researcher information
■ Research Keyword
■ Research Theme
- Cocaine addiction
- Depression
- behavior (esp. in romantic relationships)
- Transcription factor
- Creation of genetically engineered mice
- Molecular biology
- behavioral experiments
- Life sciences, Pharmacology
- Life sciences, Physiology
- Life sciences, Applied molecular and cellular biology
- Life sciences, Animals: biochemistry, physiology, behavioral science
- Life sciences, Dermatology
- Life sciences, Cognitive neuroscience
- Life sciences, Neuroscience - general
■ Research Theme
Research activity information
■ Paper
■ 研究者からの一言アピール
■ 関心を持って取組んでいる活動
- Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments
Ryusuke Sin; Naoki Sotogaku; Yoshinori N. Ohnishi; Takahide Shuto; Mahomi Kuroiwa; Yukie Kawahara; Keita Sugiyama; Yuki Murakami; Masaaki Kanai; Hiroshi Funakoshi; Ayanabha Chakraborti; James A Bibb; Akinori Nishi
Brain, Behavior, and Immunity, Aug. 2023 - Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity
Yuki Kishikawa; Yukie Kawahara; Yoshinori N. Ohnishi; Naoki Sotogaku; Tomoko Koeda; Hiroshi Kawahara; Akinori Nishi
Frontiers in Pharmacology, 08 Sep. 2022 - Distinct Role of Dopamine in the PFC and NAc During Exposure to Cocaine-Associated Cues
Yukie Kawahara; Yoshinori N Ohnishi; Yoko H Ohnishi; Hiroshi Kawahara; Akinori Nishi
International Journal of Neuropsychopharmacology, 08 Dec. 2021 - Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia.
Keita Sugiyama; Mahomi Kuroiwa; Takahide Shuto; Yoshinori N Ohnishi; Yukie Kawahara; Yuta Miyamoto; Takaichi Fukuda; Akinori Nishi
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 Jul. 2021 - Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward memory
Yukie Kawahara; Yoshinori Ohnishi; Yoko Ohnishi; Hiroshi Kawahara; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021 - Circuit-specific hippocampal ΔFosB underlies resilience to stress-induced social avoidance.
Andrew L Eagle; Claire E Manning; Elizabeth S Williams; Ryan M Bastle; Paula A Gajewski; Amber Garrison; Alexis J Wirtz; Seda Akguen; Katie Brandel-Ankrapp; Wilson Endege; Frederick M Boyce; Yoshinori N Ohnishi; Michelle Mazei-Robison; Ian Maze; Rachel L Neve; Alfred J Robison
Nature communications, 08 Sep. 2020, [Reviewed] - Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine.
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yong-Seok Oh; Jin-Hyeok Jang; Chang-Hoon Shin; Yoshinori N Ohnishi; Yuuki Hanada; Tsuyoshi Miyakawa; Yong Kim; Paul Greengard; Akinori Nishi
Molecular psychiatry, Jun. 2020, [Reviewed] - Can alcohol administration to female mice change their preference and attitude to unattractive male mouse?
Yoshinori Ohnishi; Yukie Kawahara; Yoko Ohnishi; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex
Yukie Kawahara; Yoshinori Ohnishi; Yoko Ohnishi; Hiroshi Kawahara; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Hippocampal Subgranular Zone FosB Expression Is Critical for Neurogenesis and Learning.
Claire E Manning; Andrew L Eagle; Christine C Kwiatkowski; Ridouane Achargui; Hillary Woodworth; Emily Potter; Yoshinori Ohnishi; Gina M Leinninger; A J Robison
Neuroscience, 15 May 2019, [Reviewed] - p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli.
Hanada Y; Kawahara Y; Ohnishi YN; Shuto T; Kuroiwa M; Sotogaku N; Greengard P; Sagi Y; Nishi A
eNeuro, Sep. 2018, [Reviewed] - Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yoshinori Ohnishi; Yuuki Hanada; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018 - コカイン誘発性の行動感作と場所嗜好における前頭前野ドーパミン放出とD1受容体の役割(Involvement of conical dopamine release and D1 receptors in cocaine-induced sensitization and place preference)
河原 幸江; 大西 克典; 石橋 正敏; 河原 博; 西 昭徳
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2017 - Long-term antioxidant foods suppress cocaine addiction after social defeat stress
Yoshinori Ohnishi; Yukie Kawahara; Yoko Ohnishi; Rachael Neve; Nestler Eric; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017 - 社会的敗北ストレスは報酬刺激および侵害刺激に対する側坐核ドーパミン応答性を変化させる(Social defeat stress affects the dopamine responses in the nucleus accumbens to rewarding and aversive events)
河原 幸江; 大西 克典; 河原 博; 西 昭徳
日本神経精神薬理学会年会プログラム・抄録集, Jul. 2016 - Nrf exacerbates cocaine addiction after social defeat stress
Yoshinori Ohnishi; Yukie Kawahara; Yoko Ohnishi; Rachael Neve; Erie Nestler; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016 - PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens.
Yoko H Ohnishi; Yoshinori N Ohnishi; Takanori Nakamura; Mizuki Ohno; Pamela J Kennedy; Yasuyuki Ohkawa; Akinori Nishi; Rachael Neve; Teruhisa Tsuzuki; Eric J Nestler
PloS one, 2015, [Reviewed] - Correction: PSMC5, a 19S proteasomal ATPase, regulates cocaine action in the nucleus accumbens.
Yoko H Ohnishi; Yoshinori N Ohnishi; Takanori Nakamura; Mizuki Ohno; Pamela J Kennedy; Yasuyuki Ohkawa; Akinori Nishi; Rachael Neve; Teruhisa Tsuzuki; Eric J Nestler
PloS one, 2015, [Reviewed] - FUNCTIONAL ROLE OF THE N-TERMINAL DOMAIN OF Delta FOSB IN RESPONSE TO STRESS AND DRUGS OF ABUSE
Y. N. Ohnishi; Y. H. Ohnishi; V. Vialou; E. Mouzon; Q. Laplant; A. Nishi; E. J. Nestler
NEUROSCIENCE, Jan. 2015, [Reviewed] - Fosb gene products contribute to excitotoxic microglial activation by regulating the expression of complement C5a receptors in microglia.
Hiroko Nomaru; Kunihiko Sakumi; Atsuhisa Katogi; Yoshinori N Ohnishi; Kosuke Kajitani; Daisuke Tsuchimoto; Eric J Nestler; Yusaku Nakabeppu
Glia, Aug. 2014, [Reviewed] - Erratum FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior (Neuropsychopharmacology (2013) 38 (1374-1375) DOI: 10.1038/npp.2013.56)
Noriko Yutsudo; Takashi Kamada; Kosuke Kajitani; Hiroko Nomaru; Atsuhisa Katogi; Yoko H. Ohnishi; Yoshinori N. Ohnishi; Kei Ichiro Takase; Sakumi Kunihiko; Hiroshi Shigeto; Yusaku Nakabeppu
Neuropsychopharmacology, Jun. 2013, [Reviewed] - fosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior.
Noriko Yutsudo; Takashi Kamada; Kosuke Kajitani; Hiroko Nomaru; Atsuhisa Katogi; Yoko H Ohnishi; Yoshinori N Ohnishi; Kei-ichiro Takase; Kunihiko Sakumi; Hiroshi Shigeto; Yusaku Nakabeppu
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Apr. 2013, [Reviewed] - BDNF is a negative modulator of morphine action.
Ja Wook Koo; Michelle S Mazei-Robison; Dipesh Chaudhury; Barbara Juarez; Quincey LaPlant; Deveroux Ferguson; Jian Feng; Haosheng Sun; Kimberly N Scobie; Diane Damez-Werno; Marshall Crumiller; Yoshinori N Ohnishi; Yoko H Ohnishi; Ezekiell Mouzon; David M Dietz; Mary Kay Lobo; Rachael L Neve; Scott J Russo; Ming-Hu Han; Eric J Nestler
Science (New York, N.Y.), 05 Oct. 2012, [Reviewed] - FosB is essential for the enhancement of stress tolerance and antagonizes locomotor sensitization by ΔFosB.
Yoshinori N Ohnishi; Yoko H Ohnishi; Masaaki Hokama; Hiroko Nomaru; Katsuhisa Yamazaki; Yohei Tominaga; Kunihiko Sakumi; Eric J Nestler; Yusaku Nakabeppu
Biological psychiatry, 01 Sep. 2011, [Reviewed] - A silent synapse-based mechanism for cocaine-induced locomotor sensitization.
Travis E Brown; Brian R Lee; Ping Mu; Deveroux Ferguson; David Dietz; Yoshinori N Ohnishi; Ying Lin; Anna Suska; Masago Ishikawa; Yanhua H Huang; Haowei Shen; Peter W Kalivas; Barbara A Sorg; R Suzanne Zukin; Eric J Nestler; Yan Dong; Oliver M Schlüter
The Journal of neuroscience : the official journal of the Society for Neuroscience, 01 Jun. 2011, [Reviewed] - Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition.
Herbert E Covington 3rd; Vincent F Vialou; Quincey LaPlant; Yoshinori N Ohnishi; Eric J Nestler
Neuroscience letters, 15 Apr. 2011, [Reviewed] - Delta FosB and/or Delta 2 Delta FosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures
Noriko Yutsudo; Takashi Kamada; Hiroko Nomaru; Yoko H. Ohnishi; Yoshinori N. Ohnishi; Kosuke Kajitani; Kunihiko Sakumi; Hiroshi Shigeto; Yusaku Nakabeppu
NEUROSCIENCE RESEARCH, 2011, [Reviewed] - DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses.
Vincent Vialou; Alfred J Robison; Quincey C Laplant; Herbert E Covington 3rd; David M Dietz; Yoshinori N Ohnishi; Ezekiell Mouzon; Augustus J Rush 3rd; Emily L Watts; Deanna L Wallace; Sergio D Iñiguez; Yoko H Ohnishi; Michel A Steiner; Brandon L Warren; Vaishnav Krishnan; Carlos A Bolaños; Rachael L Neve; Subroto Ghose; Olivier Berton; Carol A Tamminga; Eric J Nestler
Nature neuroscience, Jun. 2010, [Reviewed] - fosB-null mice exhibit impaired adult hippocampal neurogenesis and spontaneous epileptic seizures
Noriko Yutsudo; Takashi Kamada; Yoko Honda-Ohnishi; Yoshinori Ohnishi; Kosuke Kajitani; Kunihiko Sakumi; Hiroshi Shigeto; Yusaku Nakabeppu
NEUROSCIENCE RESEARCH, 2010, [Reviewed] - ITPase-deficient mice show growth retardation and die before weaning
M. Behmanesh; K. Sakumi; N. Abolhassani; S. Toyokuni; S. Oka; Y. N. Ohnishi; D. Tsuchimoto; Y. Nakabeppu
CELL DEATH AND DIFFERENTIATION, Oct. 2009 - Antidepressant actions of histone deacetylase inhibitors.
Herbert E Covington 3rd; Ian Maze; Quincey C LaPlant; Vincent F Vialou; Yoshinori N Ohnishi; Olivier Berton; Dan M Fass; William Renthal; Augustus J Rush 3rd; Emma Y Wu; Subroto Ghose; Vaishnav Krishnan; Scott J Russo; Carol Tamminga; Stephen J Haggarty; Eric J Nestler
The Journal of neuroscience : the official journal of the Society for Neuroscience, 16 Sep. 2009, [Reviewed] - FOSB proteins in the orbitofrontal and dorsolateral prefrontal cortices of human alcoholics.
Hiroyuki Watanabe; Richard Henriksson; Yoshinori N Ohnishi; Yoko H Ohnishi; Clive Harper; Donna Sheedy; Therese Garrick; Fred Nyberg; Eric J Nestler; Georgy Bakalkin; Tatjana Yakovleva
Addiction biology, Jul. 2009, [Reviewed] - Poor proliferation of neural progenitors in the dentate gyrus of hippocampus in adult fosB-null mice exhibiting increased susceptibility for spontaneous epileptic seizures
Noriko Yutsudo; Takashi Kamada; Yoko Honda-Ohnisi; Yoshi-Nori Ohnishi; Kosuke Kajitani; Kunihiko Sakumi; Hirsohi Shigeto; Yusaku Nakabeppu
NEUROSCIENCE RESEARCH, 2009, [Reviewed] - Antagonistic Regulation of Cell-Matrix Adhesion by FosB and Delta FosB/Delta 2 Delta FosB Encoded by Alternatively Spliced Forms of fosB Transcripts
Yoshinori N. Ohnishi; Kunihiko Sakumi; Katsuhisa Yamazaki; Yoko H. Ohnishi; Tomofumi Miura; Yohei Tominaga; Yusaku Nakabeppu
MOLECULAR BIOLOGY OF THE CELL, Nov. 2008, [Reviewed] - Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts.
Yoshinori N Ohnishi; Kunihiko Sakumi; Katsuhisa Yamazaki; Yoko H Ohnishi; Tomofumi Miura; Yohei Tominaga; Yusaku Nakabeppu
Molecular biology of the cell, Nov. 2008, [Reviewed] - Proteasome-dependent and -independent mechanisms for FosB destabilization: identification of FosB degron domains and implications for DeltaFosB stability.
Tiffany L Carle; Yoshinori N Ohnishi; Yoko H Ohnishi; Imran N Alibhai; Matthew B Wilkinson; Arvind Kumar; Eric J Nestler
The European journal of neuroscience, May 2007, [Reviewed] - Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A
K. Miyata; T. Yasukawa; M. Fukuda; T. Takeuchi; K. Yamazaki; K. Sakumi; M. Tamamori-Adachi; Y. Ohnishi; Y. Ohtsuki; Y. Nakabeppu; S. Kitajima; S. Onishi; T. Aso
CELL DEATH AND DIFFERENTIATION, Apr. 2007, [Reviewed] - Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein
K Torisu; D Tsuchimoto; Y Ohnishi; Y Nakabeppu
JOURNAL OF BIOCHEMISTRY, Dec. 2005, [Reviewed] - Regulation of the neuronal fate by AFosB and its downstream target, galectin-1
T Miura; Y Ohnishi; H Kurushima; H Horie; T Kadoya; Y Nakabeppu
CURRENT DRUG TARGETS, Jun. 2005, [Reviewed] - Mammalian elongin A is not essential for cell viability but is required for proper cell cycle progression with limited alteration of gene expression
K Yamazaki; T Aso; Y Ohnishi; M Ohno; K Tamura; T Shuin; S Kitajima; Y Nakabeppu
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2003, [Reviewed] - Inhibitory effects of brefeldin A, a membrane transport blocker, on the bradykinin-induced hyperpolarization-mediated relaxation in the porcine coronary artery
Y Ohnishi; K Hirano; J Nishimura; M Furue; H Kanaide
BRITISH JOURNAL OF PHARMACOLOGY, Sep. 2001, [Reviewed] - Inhibitory effect of brefeldin A on the bradykinin-induced relaxation mediated by endothelium-dependent hyperpolarization in the porcine coronary artery.
Ohnishi Y; 平野勝也; Nishimura J; Furue M; Kanaide H
Br J Pharmacol., 2001, [Reviewed] - Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis
Y Ohnishi; N Okino; M Ito; S Imayama
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, Jan. 1999, [Reviewed]
- What methods are physiologically or pharmacologically effective for attracting female mice?
OHNISHI Yoshinori; KAWAHARA Yukie; KISHI Yuki; OHNISHI Yoko; NISHI Akinori
日本薬理学会年会要旨集(Web), 2022 - Distinct role of dopamine in the PFC and NAc during exposure to cocaine-associated cues
KAWAHARA Yukie; OHNISHI Yoshinori; OHNISHI Yoko; KAWAHARA Hiroshi; NISHI Akinori
日本薬理学会年会要旨集(Web), 2022 - Differential role of dopamine in the PFC and NAc in cocaine-associated reward memory and behavior
河原幸江; 大西克典; 大西陽子; 河原博; 西昭徳
日本薬理学雑誌, 2021 - 線条体におけるドパミンD1受容体シグナルの領域特異的な制御:L-ドパ誘発性ジスキネジアとの関連性
杉山慶太; 黒岩真帆美; 首藤隆秀; 大西克典; 河原幸江; 宮本雄太; 福田孝一; 西昭徳
日本脳科学会プログラム・講演抄録集, 2021 - Social defeat stress enhances the dopamine responses in the nucleus accumbens to both rewarding and aversive events
Yukie Kawahara; Yoshinori Ohnishi; Hiroshi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016 - Functional role of the N-terminal domain of Delta FosB in response to stress and drugs of abuse
Yoshinori Ohnishi; Yoko Ohnishi; Ezekiell Mouzon; Vincent Vialou; Quincey Laplant; Akinori Nishi; Eric Nestler
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - Fosb遺伝子産物は補体C5aレセプターの遺伝子発現を制御することにより,ミクログリアの活性化に寄与している
能丸寛子; 作見邦彦; 加藤木敦央; 大西克典; 梶谷康介; 土本大介; NESTLER Eric J; 中別府雄作
日本分子生物学会年会プログラム・要旨集(Web), 2013 - Comprehensive analysis of gene expression profiles regulated by fosB gene in brain
Hiroko Nomaru; Yoshinori N. Ohnishi; Masaaki Hokama; Noriko Yutsudo; Yusaku Nakabeppu
NEUROSCIENCE RESEARCH, 2011 - fosB欠損マウスは成体海馬における神経新生の低下を示し、てんかんを自然発症する(fosB-null mice exhibit impaired adult hippocampal neurogenesis and spontaneous epileptic seizures)
湯通堂 紀子; 鎌田 崇嗣; 大西 陽子[本田]; 大西 克典; 梶谷 康介; 作見 邦彦; 重藤 寛史; 中別府 雄作
神経化学, Aug. 2010 - Delta FosB promotes neurogenesis in the dentate gyrus of mouse hippocampus after brain damage caused by excitotoxicity
Noriko Yutsudo; Yoko Honda-Ohnishi; Yoshinori Ohnishi; Yusaku Nakabeppu
NEUROSCIENCE RESEARCH, 2007 - δFosBはカイニン酸により引き起こされる興奮毒性に対する抵抗性を決めている(δFosB determines resistance to excitotoxicity induced by kainic acid)
本田 陽子[大西]; 大西 克典; 高瀬 敬一郎; 石橋 仁; 江藤 圭; 梶谷 康介; 作見 邦彦; 後藤 純信; 野田 百美; 重藤 寛史; 中別府 雄作
神経化学, Aug. 2005 - ΔFosBのみ発現するfosBd/dマウスとFosBとΔFosBともに欠損するfosB-nullマウスの行動解析(Behavioral analysis of fosB d/d mice which express only ΔFosB and fosB-null mice lacking both FosB and ΔFosB)
大西 克典; 大西 陽子[本田]; 山崎 勝久; 山口 浩雄; 梶谷 康介; 冨永 洋平; 作見 邦彦; 中別府 雄作
神経化学, Aug. 2004 - 【アトピー性皮膚炎と黄色ブドウ球菌】 バリア機能と易感染性について 細菌由来セラミダーゼと角層のスフィンゴ脂質
大西 克典; 沖野 望; 伊東 信; 今山 修平
Derma., Sep. 1999
- Ghrelin restores dopamine response via D1 receptor signaling in the PFC in MecP2-deficient mice, a model of Rett syndrome, and improves cognitive deficits
河原幸江, 大西克典, 高橋知之, 岸川由紀, 弓削康太郎, 河原博, 山下裕史朗, 松石豊次郎, 西昭徳
The 77th Southwest Meeting of the Japanese Pharmacological Society, 16 Nov. 2024 - The effect of cocaine on male mouse attractiveness and social ranking.
大西克典、河原幸江、大西陽子、西昭徳
The 97th Annual Meeting of the Japanese Pharmacological Society, 14 Dec. 2023 - Is the attractiveness of male mice from female mice inherited?
Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
Neuroscience 2023, 11 Nov. 2023 - Anti-inflammatory drugs that suppress depression-like behavior in mice with systemic inflammation
西昭徳, 沈龍佑, 首藤隆秀, 大西克典, 黒岩真帆美, 杦山慶太, 河原幸江, 外角直樹
The 76th Southwest Meeting of the Japanese Pharmacological Society, 07 Oct. 2023 - Female mice's nucleus accumbens dopamine responsiveness changes depending on the attractiveness of male mice.
大西 克典、河原 幸江、大西 陽子、西 昭徳
The 25th Workshop on Active Amines, 26 Aug. 2023 - Ghrelin restores the dopamine responses in the PFC to external stimuli via dopamine D1 receptor signaling and attenuates cognitive deficit in MECP2 KO mice, a model mouse for Rett syndrome
河原幸江, 大西克典, 高橋知之, 岸川由紀, 弓削康太朗, 河原博, 山下裕史郎, 松石豊次郎, 西昭徳
Japan Basic and Clinical Pharmacology Week 2022, 01 Dec. 2022 - Does repeated cocaine administration combined with encounters with male mice increase female mice's preference for those males?
大西克典、河原幸江、大西陽子、西昭徳
The 96th Annual Meeting of the Japanese Pharmacological Society / The 43rd Annual Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics, 30 Nov. 2022 - Can sexual experience enhance male attractiveness in mice?
Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
Neuroscience 2022, 12 Nov. 2022 - Ghrelin adjusts the functional upregulation of D1 receptor signaling to inhibit dopamine release in the PFC and attenuates cognitive deficit in MECP2 KO mice, a model mouse for Rett syndrome
河原幸江, 大西克典, 高橋知之, 岸川由紀, 弓削康太朗, 河原博, 山下裕史郎, 松石豊次郎, 西昭徳
The 52nd Annual Meeting of the Japanese Neuropsychopharmacology Society, 04 Nov. 2022 - Distinct role of dopamine in the PFC and NAc during Exposure to Cocaine-Associated Cues
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The 24th Workshop on Biogenic Amines, 27 Aug. 2022 - Distinct role of dopamine in the PFC and NAc during exposure to cocaine-associated cues
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The 95th Annual Meeting of the Japanese Pharmacological Society, 08 Mar. 2022 - Regional-specific regulation of dopamine D1 receptor signaling in the striatum: relevance to L-DOPA-induced dyskinesia
杦山慶太, 黒岩真帆美, 首藤隆秀, 大西克典, 河原幸江, 宮本雄太, 福田孝一, 西昭徳
The 48th Annual Meeting of the Japanese Brain Science Society, 04 Dec. 2021 - Is male mouse attractiveness inherited?
大西克典、河原幸恵、大西陽子、西昭徳
The 44th Annual Meeting of the Molecular Biology Society of Japan, 01 Dec. 2021 - Regional-specific regulation of dopamine D1 receptor signaling in the striatum: relevance to L-DOPA-induced dyskinesia
杦山慶太, 黒岩真帆美, 首藤隆秀, 大西克典, 河原幸江, 宮本雄太, 福田孝一, 西昭徳
The 74th Western Japan Division of the Japanese Pharmacological Society, 20 Nov. 2021 - The role of dopamine in the prefrontal cortex and nucleus accumbens during exposure to cocaine-associated cues
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The 74th Western Japan Division of the Japanese Pharmacological Society, 20 Nov. 2021 - Different roles of dopamine in the prefrontal cortex and nucleus accumbens in cocaine-induced conditioned place preference
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The 43rd Annual Meeting of the Japanese Biological Psychiatry Society and the 51st Annual Meeting of the Japanese Neuropsychopharmacology Society, 14 Jul. 2021 - Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The 32nd CINP Virtual World Congress, 26 Feb. 2021 - Role of dopamine in regulating reward memory and behavior related to cocaine in the prefrontal cortex and nucleus accumbens
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The 73rd Western Japan Division of the Japanese Pharmacological Society, 21 Nov. 2020 - Does shaving an attractive male mouse cause him to lose his ability to attract female mice?
大西克典、河原幸江、大西陽子、西昭徳
The 73rd Western Division Meeting of the Japanese Pharmacological Society, 21 Nov. 2020 - Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The Japanese Pharmacological Society Annual Meeting, 17 Mar. 2020 - Can alcohol make an unattractive male mouse capture the interest of female mice?
大西克典、河原幸江、大西陽子、西昭徳
The 93rd Annual Meeting of the Japanese Pharmacological Society, 16 Mar. 2020 - Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward memory
河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
The 94th Annual Meeting of the Japanese Pharmacological Society, 08 Mar. 2020 - Exploring the molecular and neural basis of attractive males.
大西克典、河原幸江、大西陽子、西昭徳
The 42nd Annual Meeting of the Molecular Biology Society of Japan, 03 Dec. 2019 - How does alcohol consumption affect the preference of females for males and dopamine responsiveness?
大西克典、河原幸江、大西陽子、西昭徳
The 72nd Western Division Meeting of the Japanese Pharmacological Society, 16 Nov. 2019 - Does baldness of attractive male decrease his external and internal power to fascinate female in mice?
Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
Neuroscience 2019, 19 Oct. 2019 - Dopamine D1 Receptors in the Dentate Gyrus Amplify Therapeutic Action of SSRI
首藤隆秀, 黒岩真帆美, 外角直樹, 河原幸江, 大西克典, 花田雄樹, 西昭徳
6th Congress of AsCNP/JSCNP/JSNP, 13 Oct. 2019 - p11 in Cholinergic Interneurons of the Nucleus Accumbens is Essential for Dopamine Responses to Rewarding Stimuli
河原幸江, 花田雄樹, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 河原博, 西昭徳
6th Congress of AsCNP/JSCNP/JSNP, 11 Oct. 2019 - Does an attractive male mouse become less attractive if he goes bald?
大西克典、河原幸江、大西陽子、西 昭徳
NEURO 2019, 25 Jul. 2019 - p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli
河原幸江, 花田雄樹, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 河原博, 西昭徳
The 29th Microdialysis Research Meeting, 15 Dec. 2018 - How can a male become attractive?
大西克典、河原幸江、大西陽子、西 昭徳
The 41st Annual Meeting of the Molecular Biology Society of Japan, 28 Nov. 2018 - Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression
首藤隆秀, 黒岩真帆美, 外角直樹, 河原幸江, 大西克典, 花田雄樹, 西昭徳
Society for Neuroscience Annual Meeting, 05 Nov. 2018 - Is it possible that non-attractive male mouse can get attractive mind set?
Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
Neuroscience 2018, 03 Nov. 2018 - The Ultimate Attraction Strategy! How to attract girls and how to lose their interest.
大西克典、河原幸江、大西陽子、西 昭徳
The 28th Microdialysis Research Meeting, 16 Dec. 2017 - Is it possible that non-attractive male mouse could get female mind?
Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
Neuroscience 2017, 11 Nov. 2017 - コカインの脳内局所還流によるマウスの行動変化及び細胞外ドーパミン量の評価
石橋正敏, 大西克典, 河原幸江, 西昭徳
第18回ブレインサイエンス研究会, 04 Jun. 2017 - Blockade of cortical D1 receptors inhibits cocaine-induced sensitization but not place preference.
河原幸江, 大西克典, 石橋正敏, 河原博, 西昭徳
The 90th Annual Meeting of The Japanese Pharmacological Society, 16 Mar. 2017 - p11 in cholinergic interneurons of the NAc is essential for dopamine responses to rewarding stimuli.
花田雄樹, 河原幸江, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 西昭徳
The 90th Annual Meeting of The Japanese Pharmacological Society, 15 Mar. 2017 - Long-term consumption of antioxidant foods suppresses cocaine dependence after social stress.
大西克典、河原幸江、大西陽子、Neve RL、Vialou VF、Nestler EJ、西 昭徳
The 90th Annual Meeting of the Japanese Pharmacological Society, 15 Mar. 2017 - 前頭前野D1受容体遮断はコカイン誘発性の行動感作を抑制するが条件付けによる場所嗜好性には影響しない
河原幸江, 大西克典, 河原博, 西昭徳
第27回マイクロダイアリシス研究会, 17 Dec. 2016 - Worsening of cocaine dependence after social defeat stress is caused by oxidative stress responses in the nucleus accumbens.
大西克典、河原幸江、大西陽子、Neve RL、Nestler EJ、西 昭徳
The 39th Annual Meeting of the Molecular Biology Society of Japan, 30 Nov. 2016 - Blockade of cortical D1 receptors inhibits cocaine-induced sensitization but not place preference.
河原幸江, 大西克典, 河原博, 西昭徳
第69回日本薬理学会西南部会, 26 Nov. 2016 - Nrf exacerbates cocaine addiction after social defeat stress.
Ohnishi YN, Kawahara Y, Ohnishi YH, Neve RL, Nestler EJ, Nishi A
Neuroscience 2016, 12 Nov. 2016 - Social defeat stress affects the dopamine responses in the nucleus accumbens to rewarding and aversive events.
河原幸江, 大西克典, 河原博, 西昭徳
第46回日本神経精神薬理学会年会, 02 Jul. 2016 - Social defeat stress enhances the dopamine responses in the nucleus accumbens to both rewarding and aversive events.
河原幸江, 大西克典, 河原博, 西昭徳
The 89th Annual Meeting of The Japanese Pharmacological Society, 11 Mar. 2016 - p11, a possible mood regulator, is essential for the reward-related dopamine responses.
花田雄樹, 河原幸江, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 西昭徳
The 89th Annual Meeting of The Japanese Pharmacological Society, 09 Mar. 2016 - NRF protein promotes cocaine dependence after stress.
大西克典、河原幸江、大西陽子、Neve RL、Vialou VF、Nestler EJ、西 昭徳
The 89th Annual Meeting of the Japanese Pharmacological Society, 09 Mar. 2016 - Social defeat stress enhances the dopamine responses in the nucleus accumbens to both rewarding and aversive events.
河原幸江, 大西克典, 河原博, 西昭徳
第26回マイクロダイアリシス研究会, 19 Dec. 2015 - Oxidative stress response exacerbates cocaine addiction after social defeat stress.
Ohnishi YN, Kawahara Y, Ohnishi YH, Kuroiwa M, Vialou VF, Neve RL, Nestler EJ, Nishi A
Neuroscience 2015, 17 Oct. 2015 - Toward understanding the mechanisms of love.
大西克典、河原幸江、黒岩真帆美、西昭徳
The 17th Brain Science Research Meeting, 06 Jun. 2015 - Functional role of the N-terminal domain of ΔFosB in responses to stress and drugs of abuse.
Ohnishi YN, Ohnishi YH, Vialou V, Mouzon E, Laplant Q, Nishi A, Nestler EJ.
Neuroscience 2013, 09 Nov. 2013 - Functional analysis of the N-terminal domain of ΔFosB protein in social stress and cocaine dependence.
大西克典、大西陽子、Mouzon E、Vialou VF、Laplant Q、西 昭徳、Nestler EJ.
The 86th Annual Meeting of the Japanese Pharmacological Society, 21 Mar. 2013 - Functional role of the N-terminal domain of deltaFosB in response to stress and drugs of abuse.
Ohnishi YN, Ohnishi YH, Mouzon E, Vialou V, Laplant Q, Nishi A, Nestler EJ.
The 35th Annual Meeting of the Molecular Biology Society of Japan, 11 Dec. 2012 - Functional role of the N-terminal domain of deltaFosB in response to stress and drugs of abuse.
Ohnishi YN, Ohnishi YH, Mouzon E, Vialou V, Laplant Q, Nishi A, Nestler EJ.
Society for Neuroscience 2012, 13 Oct. 2012 - The interaction between proteasome ATPase Sug1 and ΔFosB regulates cocaine-induced spontaneous locomotion.
大西 陽子、大西 克典、中村 崇規、Eric J. Nestler
The 14th Brain Science Research Meeting, 02 Jun. 2012 - Paternal transmission of stressed-induced pathologies.
D. M. DIETZ, Q. LAPLANT, V. VIALOU, E. L. WATTS, Y. N. OHNISHI, G. E. HODES, S. J. RUSSO, J. FENG, R. OOSTING, E. J. NESTLER
Society for Neuroscience 2011, 16 Nov. 2011 - Role of BDNF in the VTA in regulating molecular and behavioral responses to morphine.
J. KOO, M. S. MAZEI-ROBISON, M. LOBO, D. M. DIETZ, Q. LAPLANT, D. FERGUSON, J. FENG, H. SUN, D. DAMEZ-WERNO, K. SCOBIE, Y. N. OHNISHI, Y. H. OHNISHI, E. MOUZON, C. DIAS, A. J. ROBISON, V. VIALOU, R. L. NEVE, S. J. RUSSO, E. J. NESTLER
Society for Neuroscience 2011, 13 Nov. 2011 - Differential role of ΔFosB and Δ2ΔFosB in response to stress and drugs of abuse.
Y. N. OHNISHI, Y. H. OHNISHI, E. MOUZON, V. VIALOU, Q. LAPLANT, E. J. NESTLER
Society for Neuroscience 2010, 16 Nov. 2010 - ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures.
N. YUTSUDO, T. KAMADA, H. NOMARU, Y. H. OHNISHI, Y. OHNISHI, K. KAJITANI, K. SAKUMI, H. SHIGETO, Y. NAKABEPPU
Society for Neuroscience 2010, 16 Nov. 2010 - Role of BDNF in the VTA in regulating molecular and behavioral responses to morphine.
J. KOO, M. S. MAZEI-ROBISON, Q. LAPLANT, D. M. DIETZ, D. FERGUSON, M. LOBO, Y. N. OHNISHI, J. FENG, Y. H. OHNISHI, E. MOUZON, M. B. WILKINSON, Y. L. HURD, S. J. RUSSO, E. J. NESTLER
Society for Neuroscience 2010, 15 Nov. 2010 - Screening and identification of protein binding partners of FosB, ΔFosB, and Δ2ΔFosB using yeast two hybrid system.
Y. HONDA-OHNISHI, Y. N. OHNISHI, A. SHIBATA, V. VIALOU, E. J. NESTLER
Society for Neuroscience 2009, 18 Oct. 2009 - ΔFosB-induced synaptic plasticity in the NAc mediates resiliency to stress.
V. F. VIALOU, Q. LAPLANT, H. COVINGTON, D. DIETZ, Y. OHNISHI, A. ROBISON, D. WALLACE-BLACK, Y. OHNISHI, A. J. RUSH, S. INIGUEZ, V. KRISHNAN, S. GHOSE, O. BERTON, C. TAMMINGA, E. J. NESTLER
Society for Neuroscience 2009, 20 Oct. 2009 - Functional activation of the medial prefrontal cortex in depressive-like behaviors.
H. E. COVINGTON III, M. K. LOBO, V. VIALOU, I. MAZE, J. M. HYMAN, K. BRADBURY, Q. LAPLANT, Y. OHNISHI, E. GREENBERG, R. L. NEVE, S. J. HAGGARTY, K. DEISSEROTH, E. J. NESTLER
Society for Neuroscience 2009, 18 Oct. 2009 - Differential role of ΔFosB and Δ2ΔFosB in response to stress and drugs of abuse.
Y. N. OHNISHI, Y. H. OHNISHI, V. VIALOU, E. J. NESTLER
Society for Neuroscience 2009, 17 Oct. 2009 - The N-terminal domain of ΔFosB is functional in behavioral responses.
Y. OHNISHI, Y. H. OHNISHI, A. GRAHAM, C. COWAN, C. STEFFEN, S. BIRNBAUM, Y. NAKABEPPU, E. J. NESTLER
Society for Neuroscience 2008, 16 Nov. 2008 - ΔFosB promotes neurogenesis in the dentate gyrus of mouse hippocampus after brain damage caused by excitotoxicity.
N. YUTSUDO, Y. H. OHNISHI, Y. OHNISHI, Y. NAKABEPPU
Society for Neuroscience 2007, 06 Nov. 2007 - FosB and ΔFosB determine susceptibility to excitotoxicity induced by kainate.
Y. HONDA-OHNISHI, Y. N. OHNISHI, H. ISHIBASHI, K. ETO, K. SAKUMI, M. NODA, Y. NAKABEPPU
Society for Neuroscience 2006, 16 Oct. 2006 - FosB efficiently suppresses hyperlocomotor activity and fearless behavior induced by upregulation of ΔFosB and also attenuates exploratory behavior.
Y. OHNISHI, Y. H. OHNISHI, H. KURUSHIMA, K. SAKUMI, Y. NAKABEPPU
Society for Neuroscience 2006, 14 Oct. 2006 - ΔFosB determines resistance to excitotoxicity induced by kainic acid.
Y. HONDA-OHNISHI, Y. OHNISHI, K. TAKA, H. ISHIBASHI, K. ETO, K. KAJITANI, K. SAKUMI, M. NODA, S. GOTO, Y. NAKABEPPU
Society for Neuroscience 2005, 16 Nov. 2005 - Behavioral and microarray analysis of knock-in mouse, which express only ΔFosB from fosB gene.
Y. OHNISHI, K. SAKUMI, Y. KATSUHISA, Y. HONDA-OHNISHI, T. MIURA, Y. NAKABEPPU
Society for Neuroscience 2005, 15 Nov. 2005 - Expression of a multi-functional lectin, Galectin-1 is dependent on ΔFosB.
Y. OHNISHI, K. SAKUMI, T. MIURA, K. YAMAZAKI, Y. OHNISHI, Y. TOMINAGA, H. HORIE, T. KADOYA, Y. NAKABEPPU
Society for Neuroscience 2002, 05 Nov. 2002
- Sep. 2011 - Present
Japan Neuroscience Society - May 2002 - Present
Society of Neuroscience - Jul. 1998 - Present
The Molecular Biology Society of Japan - Apr. 1997 - Present
The Japanese Pharmacological Society - Apr. 1996 - Present
The Japanese Dermatological Association
- Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2022 - 31 Mar. 2025 - Elucidating the mechanisms by which female mice identify attractive male mice.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2022 - 31 Mar. 2025 - Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Involvement of dopamine and noradrenaline signaling mechanisms in depression and schizophrenia.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Therapeutic action of ghrelin in a mouse model of Rett syndrome -Role of central dopaminergic neurons-
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Novel approaches for treatment of addiction after social defeat stress
2018 - 2020 - ホスホジエステラーゼを標的とした精神疾患の新規治療法開発
2016 - 2018 - ドパミン神経系を標的とした精神疾患治療薬の創薬基盤研究
2016 - 2018 - Does oxdative stress reaction in nucleus accumbes exacerbate cocaine addiction after social defeat stress?
2015 - 2017 - Regulation of reward-related neural pathways and behavior by ghrelin
2014 - 2016 - Functional role of the N-terminal domain of DFosB in response to stress and drugs of abuse.
2012 - 2014 - うつ状態で悪化する依存症を抑制する分子メカニズムの解明
2013 - 2013
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