SEARCH

Search Details

Ohnishi Nori Yoshinori
Department of Pharmacology
Assistant Professor

  • Profile

    1990年4月 - 1996年3月 九州大学医学部 学部生

    1996年4月 - 1997年3月 九州大学付属病院皮膚科学教室 研修医

    九州大学農学部大学院農学研究院 生物機能科学部門(伊東 信助教授)にて研究にも従事

    1997年4月 - 1998年3月 九州大学大学院医学研究院 分子細胞情報学部門(金出 英夫教授) 大学院生

    1998年4月 - 2002年3月 九州大学生体防御医学研究所 個体機能制御学部門 脳機能制御学分野(中別府 雄作教授) 大学院生

    2002年4月 - 2006年8月 九州大学九州大学生体防御医学研究所 個体機能制御学部門 脳機能制御学分野(中別府 雄作教授) ポスドク

    2006年9月 - 2008年8月 テキサス大学メディカルセンターサウスウェスタン校(Eric Nestler lab) ポスドク

    2008年9月 - 2011年9月 マウントサイナイ医科大学神経科学科(Eric Nestler lab) ポスドク

    2011年11月 - 久留米大学医学部薬理学講座(西 昭徳教授) 助教

Researcher information

■ Research Keyword
  • Cocaine addiction
  • Depression
  • behavior (esp. in romantic relationships)
  • Transcription factor
  • Creation of genetically engineered mice
  • Molecular biology
  • behavioral experiments
■ Field Of Study
  • Life sciences, Pharmacology
  • Life sciences, Physiology
  • Life sciences, Applied molecular and cellular biology
  • Life sciences, Animals: biochemistry, physiology, behavioral science
  • Life sciences, Dermatology
  • Life sciences, Cognitive neuroscience
  • Life sciences, Neuroscience - general
■ Research Keyword
  • 神経科学
  • 皮膚科学
  • 神経化学・神経薬理学
  • 遺伝学一般
  • 神経科学一般
■ Research Theme
  • メスが好みのオスを選ぶときの神経科学的なメカニズムの解明
  • モテるオスマウスになるための神経科学的なマスターキーの探索
  • うつ状態での依存症悪化における脳内分子メカニズムの解明
  • うつ病を防ぐ新規予防法の確立とそのメカニズム解明
  • fosB遺伝子のうつ病および依存症における役割の解明
  • 慈愛の心の脳内メカニズム

Career

■ Educational Background
  • Apr. 1998 - Mar. 2003, Kyushu University, Graduate school of medical sciences, Faculty of medical sciences

Research activity information

■ Paper
■ MISC
■ Lectures, oral presentations, etc.
  • Ghrelin restores dopamine response via D1 receptor signaling in the PFC in MecP2-deficient mice, a model of Rett syndrome, and improves cognitive deficits               
    河原幸江, 大西克典, 高橋知之, 岸川由紀, 弓削康太郎, 河原博, 山下裕史朗, 松石豊次郎, 西昭徳
    The 77th Southwest Meeting of the Japanese Pharmacological Society, 16 Nov. 2024
  • The effect of cocaine on male mouse attractiveness and social ranking.               
    大西克典、河原幸江、大西陽子、西昭徳
    The 97th Annual Meeting of the Japanese Pharmacological Society, 14 Dec. 2023
  • Is the attractiveness of male mice from female mice inherited?               
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2023, 11 Nov. 2023
  • Anti-inflammatory drugs that suppress depression-like behavior in mice with systemic inflammation               
    西昭徳, 沈龍佑, 首藤隆秀, 大西克典, 黒岩真帆美, 杦山慶太, 河原幸江, 外角直樹
    The 76th Southwest Meeting of the Japanese Pharmacological Society, 07 Oct. 2023
  • Female mice's nucleus accumbens dopamine responsiveness changes depending on the attractiveness of male mice.               
    大西 克典、河原 幸江、大西 陽子、西 昭徳
    The 25th Workshop on Active Amines, 26 Aug. 2023
  • Ghrelin restores the dopamine responses in the PFC to external stimuli via dopamine D1 receptor signaling and attenuates cognitive deficit in MECP2 KO mice, a model mouse for Rett syndrome               
    河原幸江, 大西克典, 高橋知之, 岸川由紀, 弓削康太朗, 河原博, 山下裕史郎, 松石豊次郎, 西昭徳
    Japan Basic and Clinical Pharmacology Week 2022, 01 Dec. 2022
  • Does repeated cocaine administration combined with encounters with male mice increase female mice's preference for those males?               
    大西克典、河原幸江、大西陽子、西昭徳
    The 96th Annual Meeting of the Japanese Pharmacological Society / The 43rd Annual Meeting of the Japanese Society of Clinical Pharmacology and Therapeutics, 30 Nov. 2022
  • Can sexual experience enhance male attractiveness in mice?               
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2022, 12 Nov. 2022
  • Ghrelin adjusts the functional upregulation of D1 receptor signaling to inhibit dopamine release in the PFC and attenuates cognitive deficit in MECP2 KO mice, a model mouse for Rett syndrome               
    河原幸江, 大西克典, 高橋知之, 岸川由紀, 弓削康太朗, 河原博, 山下裕史郎, 松石豊次郎, 西昭徳
    The 52nd Annual Meeting of the Japanese Neuropsychopharmacology Society, 04 Nov. 2022
  • Distinct role of dopamine in the PFC and NAc during Exposure to Cocaine-Associated Cues               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 24th Workshop on Biogenic Amines, 27 Aug. 2022
  • Distinct role of dopamine in the PFC and NAc during exposure to cocaine-associated cues               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 95th Annual Meeting of the Japanese Pharmacological Society, 08 Mar. 2022
  • Regional-specific regulation of dopamine D1 receptor signaling in the striatum: relevance to L-DOPA-induced dyskinesia               
    杦山慶太, 黒岩真帆美, 首藤隆秀, 大西克典, 河原幸江, 宮本雄太, 福田孝一, 西昭徳
    The 48th Annual Meeting of the Japanese Brain Science Society, 04 Dec. 2021
  • Is male mouse attractiveness inherited?               
    大西克典、河原幸恵、大西陽子、西昭徳
    The 44th Annual Meeting of the Molecular Biology Society of Japan, 01 Dec. 2021
  • Regional-specific regulation of dopamine D1 receptor signaling in the striatum: relevance to L-DOPA-induced dyskinesia               
    杦山慶太, 黒岩真帆美, 首藤隆秀, 大西克典, 河原幸江, 宮本雄太, 福田孝一, 西昭徳
    The 74th Western Japan Division of the Japanese Pharmacological Society, 20 Nov. 2021
  • The role of dopamine in the prefrontal cortex and nucleus accumbens during exposure to cocaine-associated cues               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 74th Western Japan Division of the Japanese Pharmacological Society, 20 Nov. 2021
  • Different roles of dopamine in the prefrontal cortex and nucleus accumbens in cocaine-induced conditioned place preference               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 43rd Annual Meeting of the Japanese Biological Psychiatry Society and the 51st Annual Meeting of the Japanese Neuropsychopharmacology Society, 14 Jul. 2021
  • Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 32nd CINP Virtual World Congress, 26 Feb. 2021
  • Role of dopamine in regulating reward memory and behavior related to cocaine in the prefrontal cortex and nucleus accumbens               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 73rd Western Japan Division of the Japanese Pharmacological Society, 21 Nov. 2020
  • Does shaving an attractive male mouse cause him to lose his ability to attract female mice?               
    大西克典、河原幸江、大西陽子、西昭徳
    The 73rd Western Division Meeting of the Japanese Pharmacological Society, 21 Nov. 2020
  • Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The Japanese Pharmacological Society Annual Meeting, 17 Mar. 2020
  • Can alcohol make an unattractive male mouse capture the interest of female mice?               
    大西克典、河原幸江、大西陽子、西昭徳
    The 93rd Annual Meeting of the Japanese Pharmacological Society, 16 Mar. 2020
  • Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward memory               
    河原幸江, 大西克典, 大西陽子, 河原博, 西昭徳
    The 94th Annual Meeting of the Japanese Pharmacological Society, 08 Mar. 2020
  • Exploring the molecular and neural basis of attractive males.               
    大西克典、河原幸江、大西陽子、西昭徳
    The 42nd Annual Meeting of the Molecular Biology Society of Japan, 03 Dec. 2019
  • How does alcohol consumption affect the preference of females for males and dopamine responsiveness?               
    大西克典、河原幸江、大西陽子、西昭徳
    The 72nd Western Division Meeting of the Japanese Pharmacological Society, 16 Nov. 2019
  • Does baldness of attractive male decrease his external and internal power to fascinate female in mice?               
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2019, 19 Oct. 2019
  • Dopamine D1 Receptors in the Dentate Gyrus Amplify Therapeutic Action of SSRI               
    首藤隆秀, 黒岩真帆美, 外角直樹, 河原幸江, 大西克典, 花田雄樹, 西昭徳
    6th Congress of AsCNP/JSCNP/JSNP, 13 Oct. 2019
  • p11 in Cholinergic Interneurons of the Nucleus Accumbens is Essential for Dopamine Responses to Rewarding Stimuli               
    河原幸江, 花田雄樹, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 河原博, 西昭徳
    6th Congress of AsCNP/JSCNP/JSNP, 11 Oct. 2019
  • Does an attractive male mouse become less attractive if he goes bald?               
    大西克典、河原幸江、大西陽子、西 昭徳
    NEURO 2019, 25 Jul. 2019
  • p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli               
    河原幸江, 花田雄樹, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 河原博, 西昭徳
    The 29th Microdialysis Research Meeting, 15 Dec. 2018
  • How can a male become attractive?               
    大西克典、河原幸江、大西陽子、西 昭徳
    The 41st Annual Meeting of the Molecular Biology Society of Japan, 28 Nov. 2018
  • Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of an SSRI, fluoxetine in a mouse model of depression               
    首藤隆秀, 黒岩真帆美, 外角直樹, 河原幸江, 大西克典, 花田雄樹, 西昭徳
    Society for Neuroscience Annual Meeting, 05 Nov. 2018
  • Is it possible that non-attractive male mouse can get attractive mind set?               
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2018, 03 Nov. 2018
  • The Ultimate Attraction Strategy! How to attract girls and how to lose their interest.               
    大西克典、河原幸江、大西陽子、西 昭徳
    The 28th Microdialysis Research Meeting, 16 Dec. 2017
  • Is it possible that non-attractive male mouse could get female mind?               
    Ohnishi YN, Kawahara Y, Ohnishi YH, Nishi A
    Neuroscience 2017, 11 Nov. 2017
  • コカインの脳内局所還流によるマウスの行動変化及び細胞外ドーパミン量の評価               
    石橋正敏, 大西克典, 河原幸江, 西昭徳
    第18回ブレインサイエンス研究会, 04 Jun. 2017
  • Blockade of cortical D1 receptors inhibits cocaine-induced sensitization but not place preference.               
    河原幸江, 大西克典, 石橋正敏, 河原博, 西昭徳
    The 90th Annual Meeting of The Japanese Pharmacological Society, 16 Mar. 2017
  • p11 in cholinergic interneurons of the NAc is essential for dopamine responses to rewarding stimuli.               
    花田雄樹, 河原幸江, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 西昭徳
    The 90th Annual Meeting of The Japanese Pharmacological Society, 15 Mar. 2017
  • Long-term consumption of antioxidant foods suppresses cocaine dependence after social stress.               
    大西克典、河原幸江、大西陽子、Neve RL、Vialou VF、Nestler EJ、西 昭徳
    The 90th Annual Meeting of the Japanese Pharmacological Society, 15 Mar. 2017
  • 前頭前野D1受容体遮断はコカイン誘発性の行動感作を抑制するが条件付けによる場所嗜好性には影響しない               
    河原幸江, 大西克典, 河原博, 西昭徳
    第27回マイクロダイアリシス研究会, 17 Dec. 2016
  • Worsening of cocaine dependence after social defeat stress is caused by oxidative stress responses in the nucleus accumbens.               
    大西克典、河原幸江、大西陽子、Neve RL、Nestler EJ、西 昭徳
    The 39th Annual Meeting of the Molecular Biology Society of Japan, 30 Nov. 2016
  • Blockade of cortical D1 receptors inhibits cocaine-induced sensitization but not place preference.               
    河原幸江, 大西克典, 河原博, 西昭徳
    第69回日本薬理学会西南部会, 26 Nov. 2016
  • Nrf exacerbates cocaine addiction after social defeat stress.               
    Ohnishi YN, Kawahara Y, Ohnishi YH, Neve RL, Nestler EJ, Nishi A
    Neuroscience 2016, 12 Nov. 2016
  • Social defeat stress affects the dopamine responses in the nucleus accumbens to rewarding and aversive events.               
    河原幸江, 大西克典, 河原博, 西昭徳
    第46回日本神経精神薬理学会年会, 02 Jul. 2016
  • Social defeat stress enhances the dopamine responses in the nucleus accumbens to both rewarding and aversive events.               
    河原幸江, 大西克典, 河原博, 西昭徳
    The 89th Annual Meeting of The Japanese Pharmacological Society, 11 Mar. 2016
  • p11, a possible mood regulator, is essential for the reward-related dopamine responses.               
    花田雄樹, 河原幸江, 大西克典, 首藤隆秀, 黒岩真帆美, 外角直樹, 西昭徳
    The 89th Annual Meeting of The Japanese Pharmacological Society, 09 Mar. 2016
  • NRF protein promotes cocaine dependence after stress.               
    大西克典、河原幸江、大西陽子、Neve RL、Vialou VF、Nestler EJ、西 昭徳
    The 89th Annual Meeting of the Japanese Pharmacological Society, 09 Mar. 2016
  • Social defeat stress enhances the dopamine responses in the nucleus accumbens to both rewarding and aversive events.               
    河原幸江, 大西克典, 河原博, 西昭徳
    第26回マイクロダイアリシス研究会, 19 Dec. 2015
  • Oxidative stress response exacerbates cocaine addiction after social defeat stress.               
    Ohnishi YN, Kawahara Y, Ohnishi YH, Kuroiwa M, Vialou VF, Neve RL, Nestler EJ, Nishi A
    Neuroscience 2015, 17 Oct. 2015
  • Toward understanding the mechanisms of love.               
    大西克典、河原幸江、黒岩真帆美、西昭徳
    The 17th Brain Science Research Meeting, 06 Jun. 2015
  • Functional role of the N-terminal domain of ΔFosB in responses to stress and drugs of abuse.               
    Ohnishi YN, Ohnishi YH, Vialou V, Mouzon E, Laplant Q, Nishi A, Nestler EJ.
    Neuroscience 2013, 09 Nov. 2013
  • Functional analysis of the N-terminal domain of ΔFosB protein in social stress and cocaine dependence.               
    大西克典、大西陽子、Mouzon E、Vialou VF、Laplant Q、西 昭徳、Nestler EJ.
    The 86th Annual Meeting of the Japanese Pharmacological Society, 21 Mar. 2013
  • Functional role of the N-terminal domain of deltaFosB in response to stress and drugs of abuse.               
    Ohnishi YN, Ohnishi YH, Mouzon E, Vialou V, Laplant Q, Nishi A, Nestler EJ.
    The 35th Annual Meeting of the Molecular Biology Society of Japan, 11 Dec. 2012
  • Functional role of the N-terminal domain of deltaFosB in response to stress and drugs of abuse.               
    Ohnishi YN, Ohnishi YH, Mouzon E, Vialou V, Laplant Q, Nishi A, Nestler EJ.
    Society for Neuroscience 2012, 13 Oct. 2012
  • The interaction between proteasome ATPase Sug1 and ΔFosB regulates cocaine-induced spontaneous locomotion.               
    大西 陽子、大西 克典、中村 崇規、Eric J. Nestler
    The 14th Brain Science Research Meeting, 02 Jun. 2012
  • Paternal transmission of stressed-induced pathologies.               
    D. M. DIETZ, Q. LAPLANT, V. VIALOU, E. L. WATTS, Y. N. OHNISHI, G. E. HODES, S. J. RUSSO, J. FENG, R. OOSTING, E. J. NESTLER
    Society for Neuroscience 2011, 16 Nov. 2011
  • Role of BDNF in the VTA in regulating molecular and behavioral responses to morphine.               
    J. KOO, M. S. MAZEI-ROBISON, M. LOBO, D. M. DIETZ, Q. LAPLANT, D. FERGUSON, J. FENG, H. SUN, D. DAMEZ-WERNO, K. SCOBIE, Y. N. OHNISHI, Y. H. OHNISHI, E. MOUZON, C. DIAS, A. J. ROBISON, V. VIALOU, R. L. NEVE, S. J. RUSSO, E. J. NESTLER
    Society for Neuroscience 2011, 13 Nov. 2011
  • Differential role of ΔFosB and Δ2ΔFosB in response to stress and drugs of abuse.               
    Y. N. OHNISHI, Y. H. OHNISHI, E. MOUZON, V. VIALOU, Q. LAPLANT, E. J. NESTLER
    Society for Neuroscience 2010, 16 Nov. 2010
  • ΔFosB and/or Δ2ΔFosB regulate proliferation of adult hippocampal neural progenitor cells and suppress spontaneous epileptic seizures.               
    N. YUTSUDO, T. KAMADA, H. NOMARU, Y. H. OHNISHI, Y. OHNISHI, K. KAJITANI, K. SAKUMI, H. SHIGETO, Y. NAKABEPPU
    Society for Neuroscience 2010, 16 Nov. 2010
  • Role of BDNF in the VTA in regulating molecular and behavioral responses to morphine.               
    J. KOO, M. S. MAZEI-ROBISON, Q. LAPLANT, D. M. DIETZ, D. FERGUSON, M. LOBO, Y. N. OHNISHI, J. FENG, Y. H. OHNISHI, E. MOUZON, M. B. WILKINSON, Y. L. HURD, S. J. RUSSO, E. J. NESTLER
    Society for Neuroscience 2010, 15 Nov. 2010
  • Screening and identification of protein binding partners of FosB, ΔFosB, and Δ2ΔFosB using yeast two hybrid system.               
    Y. HONDA-OHNISHI, Y. N. OHNISHI, A. SHIBATA, V. VIALOU, E. J. NESTLER
    Society for Neuroscience 2009, 18 Oct. 2009
  • ΔFosB-induced synaptic plasticity in the NAc mediates resiliency to stress.               
    V. F. VIALOU, Q. LAPLANT, H. COVINGTON, D. DIETZ, Y. OHNISHI, A. ROBISON, D. WALLACE-BLACK, Y. OHNISHI, A. J. RUSH, S. INIGUEZ, V. KRISHNAN, S. GHOSE, O. BERTON, C. TAMMINGA, E. J. NESTLER
    Society for Neuroscience 2009, 20 Oct. 2009
  • Functional activation of the medial prefrontal cortex in depressive-like behaviors.               
    H. E. COVINGTON III, M. K. LOBO, V. VIALOU, I. MAZE, J. M. HYMAN, K. BRADBURY, Q. LAPLANT, Y. OHNISHI, E. GREENBERG, R. L. NEVE, S. J. HAGGARTY, K. DEISSEROTH, E. J. NESTLER
    Society for Neuroscience 2009, 18 Oct. 2009
  • Differential role of ΔFosB and Δ2ΔFosB in response to stress and drugs of abuse.               
    Y. N. OHNISHI, Y. H. OHNISHI, V. VIALOU, E. J. NESTLER
    Society for Neuroscience 2009, 17 Oct. 2009
  • The N-terminal domain of ΔFosB is functional in behavioral responses.               
    Y. OHNISHI, Y. H. OHNISHI, A. GRAHAM, C. COWAN, C. STEFFEN, S. BIRNBAUM, Y. NAKABEPPU, E. J. NESTLER
    Society for Neuroscience 2008, 16 Nov. 2008
  • ΔFosB promotes neurogenesis in the dentate gyrus of mouse hippocampus after brain damage caused by excitotoxicity.               
    N. YUTSUDO, Y. H. OHNISHI, Y. OHNISHI, Y. NAKABEPPU
    Society for Neuroscience 2007, 06 Nov. 2007
  • FosB and ΔFosB determine susceptibility to excitotoxicity induced by kainate.               
    Y. HONDA-OHNISHI, Y. N. OHNISHI, H. ISHIBASHI, K. ETO, K. SAKUMI, M. NODA, Y. NAKABEPPU
    Society for Neuroscience 2006, 16 Oct. 2006
  • FosB efficiently suppresses hyperlocomotor activity and fearless behavior induced by upregulation of ΔFosB and also attenuates exploratory behavior.               
    Y. OHNISHI, Y. H. OHNISHI, H. KURUSHIMA, K. SAKUMI, Y. NAKABEPPU
    Society for Neuroscience 2006, 14 Oct. 2006
  • ΔFosB determines resistance to excitotoxicity induced by kainic acid.               
    Y. HONDA-OHNISHI, Y. OHNISHI, K. TAKA, H. ISHIBASHI, K. ETO, K. KAJITANI, K. SAKUMI, M. NODA, S. GOTO, Y. NAKABEPPU
    Society for Neuroscience 2005, 16 Nov. 2005
  • Behavioral and microarray analysis of knock-in mouse, which express only ΔFosB from fosB gene.               
    Y. OHNISHI, K. SAKUMI, Y. KATSUHISA, Y. HONDA-OHNISHI, T. MIURA, Y. NAKABEPPU
    Society for Neuroscience 2005, 15 Nov. 2005
  • Expression of a multi-functional lectin, Galectin-1 is dependent on ΔFosB.               
    Y. OHNISHI, K. SAKUMI, T. MIURA, K. YAMAZAKI, Y. OHNISHI, Y. TOMINAGA, H. HORIE, T. KADOYA, Y. NAKABEPPU
    Society for Neuroscience 2002, 05 Nov. 2002
■ Affiliated academic society
  • Sep. 2011 - Present
    Japan Neuroscience Society               
  • May 2002 - Present
    Society of Neuroscience               
  • Jul. 1998 - Present
    The Molecular Biology Society of Japan               
  • Apr. 1997 - Present
    The Japanese Pharmacological Society               
  • Apr. 1996 - Present
    The Japanese Dermatological Association               
■ Research Themes
■ 共同研究希望
  • うつ病モデル、依存症モデル、そのほかマウスの行動実験全般
  • オプトジェネティクスなどAAVウイルスの脳内インジェクション
  • 遺伝子改変マウス作製の設計からコンストラクト作製までサポートできます
■ 研究者からの一言アピール
  • 研究業績はresearchmapをご参照下さい。http://researchmap.jp/norinoriyo
■ 関心を持って取組んでいる活動
  • アフターコロナで急増するうつ病からの自殺予防、ストレス下での依存症予防、メスが好みのオスを選ぶメカニズムなどの研究をしています。修士や大学院希望、久留米大学の医学生だけでなく、他大学の医学生であっても基礎配置の1カ月の出稽古など興味がある人は連絡してください。