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Niizeki Takashi
Department of Regional Medical Cooperation
Assistant Professor

Researcher information

■ Field Of Study
  • Life sciences, Gastroenterology
■ Research Keyword
  • 消化器の腫よう
  • 消化器の疾患の治療
  • 消化器の医学
■ Research Theme
  • 進行肝細胞癌の治療

Research activity information

■ Paper
  • Changing from NAFLD to MASLD: Similar Prognosis of Patients with HCC Under Atezo/Bev treatment between NAFLD and MASLD               
    Suzuki H, Shimose S, Iwamoto H, Niizeki T, Kawaguchi T.
    CLINICAL AND MOLECULAR HEPATOLOGY, Jan. 2024
  • Minimally Invasive Conversion Hepatectomy for Advanced Hepatocellular Carcinoma               
    Sakai H, Goto Y, Shimose S, Niizeki T, Kawaguchi T, Akiba J, Yano H, Akagi Y, Fujita F, Hisaka T.
    Gan to kagakuryoho, Dec. 2023
  • Preoperative Chemotherapy Followed by Hepatectomy for Potentially Resectable UICC7 Stage IIIA, IIIB Hepatocellular Carcinoma; A Phase II Clinical Trial               
    Goto Y, Niizeki T, Fukutomi S, Shirono T, Shimose S, Iwamoto H, Kojima S, Kanno H, Uchino Y, Sasaki S, Shirahama N, Muroya D, Nomura Y, Akashi M, Nakayama G, Hirakawa Y, Sato T, Yoshitomi M, Sakai H, Hisaka T, Kakuma T, Koga H, Torimura T, Akagi Y, Okuda K.
    Kurume Medical Journal, Sep. 2023
  • Efficacy of Lenvatinib Combined with Transcatheter Intra-Arterial Therapies for Patients with Advanced-Stage of Hepatocellular Carcinoma: A Propensity Score Matching               
    Shimose S, Iwamoto H, Niizeki T, Tanaka M, Shirono T, Moriyama E, Noda Y, Nakano M, Suga H, Kuromatsu R, Torimura T, Koga H, Kawaguchi T.
    International Journal of Molecular Sciences, Sep. 2023
  • Telephone follow-up contributes to improving adherence and treatment duration in patients with hepatocellular carcinoma treated with lenvatinib               
    Tsumura S, Shimose S, Niizeki T, Kuboyama E, Iwamoto H, Tanaka M, Moriyama E, Shirono T, Takaki K, Noda Y, Nakano M, Inoue M, Tsustumi K, Kuromatsu R, Koga H, Higuchi K, Kawaguchi T.
    Journal of Gastroenterology and Hepatology, Jul. 2023
  • The impact of curative conversion therapy aimed at a cancer-free state in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab               
    Shimose S, Iwamoto H, Shirono T, Tanaka M, Niizeki T, Kajiwara M, Itano S, Yano Y, Matsugaki S, Moriyama E, Noda Y, Nakano M, Kuromatsu R, Koga H, Kawaguchi T.
    Cancer Medicine, Jun. 2023
  • Tumor-derived insulin-like growth factor-binding protein-1 contributes to resistance of hepatocellular carcinoma to tyrosine kinase inhibitors               
    Suzuki H, Iwamoto H, Seki T, Nakamura T, Masuda A, Sakaue T, Tanaka T, Imamura Y, Niizeki T, Nakano M, Shimose S, Shirono T, Noda Y, Kamachi N, Sakai M, Morita K, Nakayama M, Yoshizumi T, Kuromatsu R, Yano H, Cao Y, Koga H, Torimura T.
    Cancer Cmmunications, Apr. 2023
  • A case of difficult treatment of infected pseudoaneurysm of the femoral artery during hepatic arterial infusion chemotherapy for hepatocellular carcinoma               
    Suzuki H, Shirono T, Niizeki T, Iwamoto H, Shimose S, Noda Y, Nakao K, Yamaguchi S, Miyazaki K, Kawaguchi T.
    Nihon Syokakibyo Gakkai Zasshi, Mar. 2023
  • Hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma in the era of chemo-diversity               
    Iwamoto H, Shimose S, Shirono T, Niizeki T, Kawaguchi T.
    CLINICAL AND MOLECULAR HEPATOLOGY, Feb. 2023
  • Significance of ramucirumab following atezolizumab plus bevacizumab therapy for hepatocellular carcinoma using real-world data               
    Shimose S, Sugimoto R, Hiraoka A, Tanaka M, Iwamoto H, Tanaka Y, Tada F, Ohama H, Niizeki T, Shirono T, Moriyama E, Noda Y, Kamachi N, Nakano M, Kuromatsu R, Koga H, Kawaguchi T.
    Hepatology Research, Feb. 2023
  • The beneficial impact of metabolic dysfunction-associated fatty liver disease on lenvatinib treatment in patients with non-viral hepatocellular carcinoma               
    Shimose S, Hiraoka A, Casadei-Gardini A, Tsutsumi T, Nakano D, Iwamoto H, Tada F, Rimini M, Tanaka M, Torimura T, Suga H, Ohama H, Burgio V, Niizeki T, Moriyama E, Suzuki H, Shirono T, Noda Y, Kamachi N, Nakano M, Kuromatsu R, Koga H, Kawaguchi T.
    Cancers, Feb. 2023
  • Comparison of Efficacy and Safety of AtezorizumabPlus Bevacizumab and Lenvatinib as First-Line Therapy for Unresectable Hepatocellular Carcinoma: A Propencity Score Matching Analysis               
    Niizeki T, Takayasu Tokunaga, Yuko Takami et al.
    Target Oncology, Dec. 2022
  • The Clinical Impact of Hepatic Arterial Infusion Chemotherapy New-FP for Hepatocellular Carcinoma with Preserved Liver Function               
    Iwamoto H, Niizeki T, Nagamatsu H, Ueshima K, Tani J, Kuzuya T, Kasai K, Kooka Y, Hiraoka A, Sugimoto R, Yonezawa T, Tanaka S, Deguchi A, Shimose S, Shirono T, Sakai M, Suzuki H, Moriyama E, Koga H, Torimura T, Kawaguchi T,
    Cancers, Oct. 2022
  • Deterioration of liver function and aging disturb sequential systemic therapy for unresectable hepatocellular carcinoma               
    Shimose S, Hiraoka A, Tanaka M, Iwamoto H, Tanaka T, Noguchi K, Aino H, Yamaguchi T, Itano S, Suga H, Niizeki T, Moriyama E, Shirono T, Noda Y, Kamachi N, Okamura S, Nakano M, Kawaguchi T, Kuromatsu R, Koga H, Torimura T.
    SCIENTIFIC REPORTS, Oct. 2022
  • Association between Adverse Events and Prognosis in Patients with Hepatocellular Carcinoma Treated with Atezolizumab Plus Bevacizumab: A Multicenter Retrospective Study               
    Shimose S, Iwamoto H, Tanaka M, Niizeki T, Kajiwara M, Itano S, Moriyama E, Shirono T, Noda Y, Kamachi N, Nakano M, Kuromatsu R, Koga H, Kawaguchi T.
    Cancers, Sep. 2022
  • Durable complete response is achieved by balloon-occluded transcatheter arterial chemoembolization for hepatocellular carcinoma               
    Shirono T, Iwamoto H, Niizeki T, Shimose S, Kajiwara A, Suzuki H, Kamachi N, Noda Y, Okamura S, Nakano M, Kuromatsu R, Murotani K, Koga H, Torimura T.
    Hepatology Communications, Sep. 2022
  • Usefulness of a novel transarterial chemoinfusion plus external-beam radiation therapy for advanced hepatocellular carcinoma with tumor thrombi in the inferior vena cava and right atrium: Case study               
    Shirono T, Koga H, Niizeki T, Nagamatsu H, Iwamoto H, Shimose S, Nakano M, Okamura S, Noda Y, Kamachi N, Kuromatsu R, Ogo E, Torimura T.
    Cancer Reports, Aug. 2022
  • Case Report: Exacerbation of varices following atezolizumab plus bevacizumab treatment of hepatocellular carcinoma: A case series and literature review               
    Suzuki H, Iwamoto H, Shimose S, Niizeki T, Shirono T, Noda Y, Kamachi N, Yamaguchi T, Nakano M, Kuromatsu R, Koga H, Kawaguchi T.
    frontiers in Oncology, Jul. 2022
  • Clinical significance of the discrepancy between radiological findings and biochemical responses in atezolizumab plus bevacizumab for hepatocellular carcinoma               
    Iwamoto H, Shimose S, Niizeki T, Koga H, Torimura T.
    CLINICAL AND MOLECULAR HEPTOLOGY, Jul. 2022
  • Robust Effect of Hepatic Arterial Infusion Chemotherapy and Radiation Therapy on Hepatocellular Carcinoma Arising from Fontan-associated Liver Disease               
    Suzuki H, Niizeki T, Shirono T, Koteda Y, Kinjyo Y, Mizukami N, Koda M, Ota S, Nakano M, Okamura S, Iwamoto H, Shimose S, Noda Y, Kamachi N, Kajiwara A, Suda K, Akiba J, Yano H, Kuromatsu R, Koga H, Torimura T.
    Internal Medicine, Apr. 2022
  • Percutaneous Radiofrequency Ablation with or without Chemolipiodolization for Hepatocellular Carcinoma: A Propensity-Score-Matched Analysis               
    Takaki K, Nakano M, Fukumori K, Yano Y, Zaizen Y, Niizeki T, Kuwaki K, Fukahori M, Sakaue T, Yoshimura S, Nakazaki M, Torimura T.
    Journal of Clinical Medicine, Mar. 2022
  • Feasibility and safety of a novel indwelling catheter system via the femoral artery for intermittent transarterial therapy for treating malignant liver tumors               
    Iwamoto H, Itano S, Itano O, Ishii M, Niizeki T, Shirono T, Shimose S, Suzuki H, Kajiwara A, Yamaguchi T, Koga H, Torimura T.
    JAPANEASE JPURNAL OF RADIOLOGY, Mar. 2022
  • Evaluating the therapeutic effect of lenvatinib against advanced hepatocellular carcinoma by measuring blood flow changes using contrast-enhanced ultrasound               
    Kamachi N, Nakano M, Okamura S, Niizeki T, Iwamoto H, Shimose S, Shirono T, Noda Y, Kuromatsu R, Koga H, Torimura T.
    Cancer Reports, Feb. 2022
  • Association between contrast enhancement on contrast-enhanced CT and lenvatinib effectiveness in hepatocellular carcinoma               
    Okamura S, Shimose S, Niizeki T, Kamachi N, Noda Y, Shirono T, Iwamoto H, Nakano M, Kuromatsu R, Koga H, Torimura T.
    MOLECULAR AND CLINICAL ONCOLOGY, Jan. 2022
  • First-line sorafenib sequential therapy and liver disease etiology for unresectable hepatocellular carcinoma using inverse probability weighting: A multicenter retrospective study               
    Shimose S, Hiraoka A, Nakano M, Iwamoto H, Tanaka M, Tanaka T, Noguchi K, Aino H, Ogata K, Kajiwara M, Itano S, Yokokura Y, Yamaguchi T, Kawano H, Matsukuma N, Suga H, Niizeki T, Shirono T, Noda Y, Kamachi N, Okamura S, Kawaguchi T, Koga H, Torimura T.
    Cancer Medicine, Dec. 2021
  • Efficacy and tolerability of Sorafenib plus metronomic chemotherapy S-1 for advanced hepatocellular carcinoma in preclinical and clinical assessments               
    Suzuki H, Iwamoto H, Nakano M, Nakamura T, Masuda A, Sakaue T, Tanaka T, Nakano D, Kuromatsu R, Niizeki T, Okamura S, Shimose S, Shirono T, Noda Y, Kamachi N, Yano H, Kawaguchi A, Koga H, Torimura T.
    Translational Oncology, Nov. 2021
  • Hepatic Arterial Infusion Chemotherapy with Cisplatin versus Sorafenib for Intrahepatic Advanced Hepatocellular Carcinoma: A Propensity Score-Matched Analysis               
    Zaizen Y, Nakano M, Fukumori K, Yano Y, Takaki K, Niizeki T, Kuwaki K, Fukahori M, Sakaue T, Yoshimura S, Nakazaki M, Kuromatsu R, Okamura S, Iwamoto H, Shimose S, Shirono T, Noda Y, Kamachi N, Koga H, Torimura T
    Cancers, Oct. 2021
  • Impact of branched-chain amino acids and frailty on the management of lenvatinib-related fatigue in patients with hepatocellular carcinoma               
    Shimose S, Koya S, Kawaguchi T, Hirota K, Yoshio S, Niizeki T, Matsuse H, Torimura T.
    CLINICAL and MOLECULAR HEPATOLOGY, Oct. 2021
  • Successful Treatment with Hepatic Arterial Infusion Chemotherapy in a Breast Cancer Patient with Multiple Liver Metastases Who Declined Systemic Therapy               
    Masuda T, Niizeki O, Niizeki T, Fujiyoshi K, Ando Y, Niizeki H, Mimori K.
    Case Reports in Oncology, Sep. 2021
  • Multimolecular-Targeted Agents for Intermediate-Stage Hepatocellular Carcinoma Influence Time to Stage Progression and Overall Survival               
    Shimose S, Iwamoto H, Tanaka M, Niizeki T, Shirono T, Kajiwara A, Noda Y, Kamachi N, Okamura S, Nakano M, Kuromatsu R, Kawaguchi T, Koga H, Torimura T.
    Oncology, Sep. 2021
  • Clinical Importance of Regimens in Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Macrovascular Invasion               
    Niizeki T
    CANCERS, Sep. 2021
  • Initial Experience of Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice               
    Iwamoto H, Shimose S, Noda Y, Shirono T, Niizeki T, Nakano M, Okamura S, Kamachi N, Suzuki H, Sakai M, Kajiwara A, Itano S, Tanaka M, Yamaguchi T, Kuromatsu R, Koga H, Torimura T,
    Cancers, Jun. 2021
  • Prevalence and profiles of ramucirumab-associated severe ascites in patients with hepatocellular carcinoma               
    Kamachi N, Shimose S, Hirota K, Koya S, Iwamoto H, Niizeki T, Shirono T, Nakano M, Hashida R, Kawaguchi T, Matuse H, Noguchi K, Koga H, Torimura T.
    MPLECULAR AND CLINICAL ONCOLOGY, Apr. 2021
  • Therapeutic Outcomes and Prognostic Factors of Unresectable Intrahepatic Cholangiocarcinoma: A Data Mining Analysis               
    Shirono T, Niizeki T, Iwamoto H, Shimose S, Suzuki H, Kawaguchi T, Kamachi N, Noda Y, Okamura S, Nakano M, Kuromatu R, Koga H, Torimura T.
    Journal of Clinical medicine, Mar. 2021
  • Is Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma Superior Even to Lenvatinib? A Matching-Adjusted Indirect Comparison               
    Casadei-Gardini A, Tada T, Shimose S, Kumada T, Niizeki T, Cascinu S, Cucchetti A.
    Target Oncology, Mar. 2021
  • Survival Benefit of Hepatic Arterial Infusion Chemotherapy over Sorafenib in the Treatment of Locally Progressed Hepatocellular Carcinoma               
    Iwamoto H, Niizeki T, Nagamatsu H, Ueshima K, Nomura T, Kuzuya T, Kasai K, Kooka Y, Hiraoka A, Sugimoto R, Yonezawa T, Ishihara A, Deguchi A, Arai H, Shimose S, Shirono T, Nakano M, Okamura S, Noda Y, Kamachi N, Sakai M, Suzuki H, Aino H, Matsukuma N, Matsugaki S, Ogata K, Yano Y, Ueno T, Kajiwara M, Itano S, Fukuizumi K, Kawano H, Noguchi K, Tanaka M, Yamaguchi T, Kuromatsu R, Kawaguchi A, Koga H, Torimura T, New Fp Study Group, Kurume Liver Cancer Study Group Of Japan.
    Cancers, Feb. 2021
  • Immunological inflammatory biomarkers as prognostic predictors for advanced hepatocellular carcinoma               
    Nakano M, Kuromatsu R, Niizeki T, Okamura S, Iwamoto H, Shimose S, Shirono T, Noda Y, Kamachi N, Koga H, Torimura T; Kurume Liver Cancer Study Group of Japan.
    ESMO Open, Feb. 2021
  • Alternating Lenvatinib and Trans-Arterial Therapy Prolongs Overall Survival in Patients with Inter-Mediate Stage HepatoCellular Carcinoma: A Propensity Score Matching Study               
    Shimose S, Iwamoto H, Tanaka M, Niizeki T, Shirono T, Noda Y, Kamachi N, Okamura S, Nakano M, Suga H, Yamaguchi T, Kawaguchi T, Kuromatsu R, Noguchi K, Koga H, Torimura T.
    Cancers, Jan. 2021
  • Lenvatinib prolongs the progression-free survival time of patients with intermediate-stage hepatocellular carcinoma refractory to transarterial chemoembolization: A multicenter cohort study using data mining analysis               
    Shimose S, Kawaguchi T, Tanaka M, Iwamoto H, Miyazaki K, Moriyama E, Suzuki H, Niizeki T, Shirono T, Nakano M, Suga H, Yamaguchi T, Yokokura Y, Noguchi K, Koga H, Torimura T.
    Oncology Letter, Sep. 2020
  • Clinical utility of the Liver Frailty Index for predicting muscle atrophy in chronic liver disease patients with hepatocellular carcinoma               
    Hirota K, Kawaguchi T, Koya S, Nagamatsu A, Tomita M, Hashida R, Nakano D, Niizeki T, Matsuse H, Shiba N, Torimura T.
    Hepatology Research, May 2020
  • Increased Arterio-Portal Shunt Formation after Drug-Eluting Beads TACE for Hepatocellular Carcinoma               
    Shimose S, Iwamoto H, Tanaka M, Niizeki T, Shirono T, Nakano M, Okamura S, Noda Y, Kamachi N, Sakai M, Suzuki H, Nomiyama M, Kuromatsu R, Koga H, Torimura T.
    Oncology, May 2020
  • Weekends-Off Lenvatinib for Unresectable Hepatocellular Carcinoma Improves Therapeutic Response and Tolerability toward Adverse Events               
    Iwamoto H, Suzuki H, Shimose S, Niizeki T, Nakano M, Shirono T, Okamura S, Noda Y, Kamachi N, Nakamura T, Masuda A, Sakaue T, Tanaka T, Nakano D, Sakai M, Yamaguchi T, Kuromatsu R, Koga H, Torimura T.
    Cancers, Apr. 2020
  • Controlling Nutritional Status (CONUT) Score is Associated with Overall Survival in Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Cohort Study               
    Shimose S, Kawaguchi T, Iwamoto H, Tanaka M, Miyazaki K, Ono M, Niizeki T, Shirono T, Okamura S, Nakano M, Suga H, Yamaguchi T, Yokokura Y, Noguchi K, Koga H, Torimura T.
    Nutrients, Apr. 2020
  • Indication of suitable transarterial chemoembolization and multikinase inhibitors for intermediate stage hepatocellular carcinoma               
    Shimose S, Kawaguchi T, Iwamoto H, Niizeki T, Shirono T, Tanaka M, Koga H, Torimura T.
    Oncology Letter, Apr. 2020
  • Impact of Decorin on the Physical Function and Prognosis of Patients with Hepatocellular Carcinoma               
    Kawaguchi T, Yoshio S, Sakamoto Y, Hashida R, Koya S, Hirota K, Nakano D, Yamamura S, Niizeki T, Matsuse H, Torimura T.
    Journal of Clinical Medicine, Mar. 2020
  • Impact of cancer rehabilitation on the prognosis of patients with hepatocellular carcinoma               
    Hashida R, Kawaguchi T, Koya S, Hirota K, Goshima N, Yoshiyama T, Otsuka T, Bekki M, Iwanaga S, Nakano D, Niizeki T, Matsuse H, Kawaguchi A, Shiba N, Torimura T.
    Oncology Letter, Mar. 2020
  • A case of hemobilia due to the rupture of pancreaticoduodenal artery aneurysm with choledocholithiasis               
    Yasumoto M, Araki T, Okabe Y, Niizeki T, Shirono T, Ishida Y, Ushijima T, Sakaue T, Tsuruta O, Torimura T.
    Nihon Shokakibyo Gakkai Zassi, Jan. 2020
  • Slow walking speed overlapped with low handgrip strength in chronic liver disease patients with hepatocellular carcinoma               
    Nagamatsu A, Kawaguchi T, Hirota K, Koya S, Tomita M, Hashida R, Kida Y, Narao H, Manako Y, Tanaka D, Koga N, Nakano D, Niizeki T, Matsuse H, Torimura T, Shiba N.
    Hepatology Research, Dec. 2019
  • High serum interleukin-34 level is a predictor of poor prognosis in patients with non-viral hepatocellular carcinoma               
    Noda Y, Kawaguchi T, Korenaga M, Yoshio S, Komukai S, Nakano M, Niizeki T, Koga H, Kawaguchi A, Kanto T, Torimura T.
    Hepatology Research, Sep. 2019
  • Prognostic impact of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation in patients with unresectable hepatocellular carcinoma: Comparison with TACE alone using decision-tree analysis after propensity score matching               
    Shimose S, Tanaka M, Iwamoto H, Niizeki T, Shirono T, Aino H, Noda Y, Kamachi N, Okamura S, Nakano M, Kuromatsu R, Kawaguchi T, Kawaguchi A, Koga H, Yokokura Y, Torimura T.
    Hepatology Research, Aug. 2019
  • Prognostic profile of patients with non-viral hepatocellular carcinoma: A comparative study with hepatitis C virus-related hepatocellular carcinoma using data mining analysis               
    Noda Y, Kawaguchi T, Kuromatsu R, Komukai S, Nakano M, Niizeki T, Koga H, Kawaguchi A, Torimura T.
    Oncology Letter, Jun. 2019
  • Spontaneous regression of hepatocellular carcinoma with reduction in angiogenesis-related cytokines after treatment with sodium-glucose cotransporter 2 inhibitor in a cirrhotic patient with diabetes mellitus               
    Kawaguchi T, Nakano D, Okamura S, Shimose S, Hayakawa M, Niizeki T, Koga H, Torimura T.
    Hepatology Research, Apr. 2019
  • Effects of in-hospital exercise on sarcopenia in hepatoma patients who underwent transcatheter arterial chemoembolization               
    Koya S, Kawaguchi T, Hashida R, Hirota K, Bekki M, Goto E, Yamada M, Sugimoto M, Hayashi S, Goshima N, Yoshiyama T, Otsuka T, Nozoe R, Nagamatsu A, Nakano D, Shirono T, Shimose S, Iwamoto H, Niizeki T, Matsuse H, Koga H, Miura H, Shiba N, Torimura T.
    Journal of Gastroenterology and Hepatology, Mar. 2019
  • Dose and Location of Irradiation Determine Survival for Patients with Hepatocellular Carcinoma with Macrovascular Invasion in External Beam Radiation Therapy               
    Iwamoto H, Nomiyama M, Niizeki T, Shimose S, Shirono T, Nakano M, Satani M, Okamura S, Noda Y, Kamachi N, Sakai M, Suzuki H, Kuromatsu R, Ogo E, Abe T, Tanaka M, Koga H, Torimura T.
    Oncology, Jan. 2019
  • High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: Potential targets by sulfasalazine               
    Wada F, Koga H, Akiba J, Niizeki T, Iwamoto H, Ikezono Y, Nakamura T, Abe M, Masuda A, Sakaue T, Tanaka T, Kakuma T, Yano H, Torimura T.
    Cancer Science, Sep. 2018
  • Epirubicin is More Effective than Miriplatin in Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma               
    Shirono T, Iwamoto H, Niizeki T, Shimose S, Nakano M, Satani M, Okamura S, Noda Y, Kamachi N, Kuromatsu R, Sakai M, Nomiyama M, Kuwano T, Tanaka M, Koga H, Torimura T.
    Oncology, May 2018
  • Successful treatment of a patient with chyluria due to lymphangioleiomyomatosis using sirolimus               
    Sakaue T, Tominaga M, Niizeki T, Zaizen Y, Matsukuma K, Koganemaru M, Hoshino T, Torimura T.
    Respirtory Medicine Case Reports, Jan. 2018
  • Clinical effects and safety of intra-arterial infusion therapy of cisplatin suspension in lipiodol combined with 5-fluorouracil versus sorafenib, for advanced hepatocellular carcinoma with macroscopic vascular invasion without extra-hepatic spread: A prospective cohort study               
    Nakano M, Niizeki T, Nagamatsu H, Tanaka M, Kuromatsu R, Satani M, Okamura S, Iwamoto H, Shimose S, Shirono T, Noda Y, Koga H, Torimura T; Kurume Liver Cancer Study Group of Japan.
    MOLECULAR AND CLINICAL ONCOLOGY, Dec. 2017
  • Rapidly growing hepatocellular carcinoma after direct-acting antiviral treatment of chronic hepatitis C               
    Kawaguchi T, Ide T, Koga H, Kondo R, Miyajima I, Arinaga-Hino T, Kuwahara R, Amano K, Niizeki T, Nakano M, Kuromatsu R, Torimura T.
    Clinical Journal of Gastroenterology, Oct. 2017
  • Effects of in-hospital exercise on liver function, physical ability, and muscle mass during treatment of hepatoma in patients with chronic liver disease               
    Koya S, Kawaguchi T, Hashida R, Goto E, Matsuse H, Saito H, Hirota K, Taira R, Matsushita Y, Imanaga M, Nagamatsu A, Shirono T, Shimose S, Iwamoto H, Niizeki T, Kuromatsu R, Miura H, Shiba N, Torimura T.
    Hepatology Research, Mar. 2017
  • Alternative treatments in advanced hepatocellular carcinoma patients with progressive disease after sorafenib treatment: a prospective multicenter cohort study               
    Nakano M, Tanaka M, Kuromatsu R, Nagamatsu H, Satani M, Niizeki T, Okamura S, Iwamoto H, Shimose S, Shirono T, Noda Y, Koga H, Torimura T; Kurume Liver Cancer Study Group Of Japan.
    Oncotarget, Sep. 2016
  • Diffusion-weighted magnetic resonance imaging predicts malignant potential in small hepatocellular carcinoma.               
    Okamura S, Sumie S, Tonan T, Nakano M, Satani M, Shimose S, Shirono T, Iwamoto H, Aino H, Niizeki T, Tajiri N, Kuromatsu R, Okuda K, Nakashima O, Torimura T.
    Digestive and Liver Disease, Aug. 2016
  • The systemic inflammatory response as a prognostic factor for advanced hepatocellular carcinoma with extrahepatic metastasis               
    Aino H, Sumie S, Niizeki T, Kuromatsu R, Tajiri N, Nakano M, Satani M, Okamura S, Shimose S, Miyahara K, Torimura T.
    MOLECULAR AND CLINICAL ONCOLOGY, Jun. 2016
  • Efficacy of peritoneovenous shunt for treating tolvaptan-resistant refractory ascites in a cirrhotic patient with portal vein thrombosis: A case report               
    Shigeto K, Kawaguchi T, Niizeki T, Kunitake Y, Takedatsu H, Tonan T, Fujimoto K, Tanaka M, Abe T, Naito H, Torimura T.
    Oncology Letter, May 2016
  • Hepatic arterial infusion chemoembolization therapy for advanced hepatocellular carcinoma: multicenter phase II study               
    Nagamatsu H, Sumie S, Niizeki T, Tajiri N, Iwamoto H, Aino H, Nakano M, Shimose S, Satani M, Okamura S, Kuromatsu R, Matsugaki S, Kurogi J, Kajiwara M, Koga H, Torimura T.
    Cancer Chemotherapy and Pharmacology, Jan. 2016
  • Sorafenib for the treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a prospective multicenter cohort study               
    Nakano M, Tanaka M, Kuromatsu R, Nagamatsu H, Tajiri N, Satani M, Niizeki T, Aino H, Okamura S, Iwamoto H, Shimose S, Shirono T, Koga H, Torimura T; Kurume Liver Cancer Study Group of Japan.
    Cancer Medicine, Oct. 2015
  • Clinical characteristics and prognostic factors for advanced hepatocellular carcinoma with extrahepatic metastasis               
    Aino H, Sumie S, Niizeki T, Kuromatsu R, Tajiri N, Nakano M, Satani M, Yamada S, Okamura S, Shimose S, Sumie H, Torimura T, Sata M.
    MOLECULAR AND CLINICAL ONCOLOGY, May 2014
  • Efficacy, safety, and survival factors for sorafenib treatment in Japanese patients with advanced hepatocellular carcinoma               
    Nakano M, Tanaka M, Kuromatsu R, Nagamatsu H, Sakata K, Matsugaki S, Kajiwara M, Fukuizumi K, Tajiri N, Matsukuma N, Sakai T, Ono N, Yano Y, Koga H, Kurogi J, Takata A, Sumie S, Satani M, Yamada S, Niizeki T, Aino H, Iwamoto H, Torimura T, Sata M.
    Oncology, Sep. 2013
  • Intrahepatic cholangiocarcinoma with sarcomatous change producing granulocyte-colony stimulating factor               
    Takenaka M, Akiba J, Kawaguchi T, Niizeki T, Arinaga-Hino T, Sata M, Nakashima O, Yano H, Kage M
    Pathology International, Apr. 2013
  • Serum vascular endothelial growth factor as a predictor of response and survival in patients with advanced hepatocellular carcinoma undergoing hepatic arterial infusion chemotherapy               
    Niizeki T, Sumie S, Torimura T, Kurogi J, Kuromatsu R, Iwamoto H, Aino H, Nakano M, Kawaguchi A, Kakuma T, Sata M
    J Gastroenterol, Jun. 2012
  • Total and high molecular weight adiponectin and hepatocellular carcinoma with HCV infection               
    Sumie S, Kawaguchi T, Kuromatsu R, Takata A, Nakano M, Satani M, Yamada S, Niizeki T, Torimura T, Sata M.
    PLoS One, Nov. 2011
  • Metronomic S-1 chemotherapy and vandetanib: an efficacious and nontoxic treatment for hepatocellular carcinoma               
    Iwamoto H, Torimura T, Nakamura T, Hashimoto O, Inoue K, Kurogi J, Niizeki T, Kuwahara R, Abe M, Koga H, Yano H, Kerbel RS, Ueno T, Sata M.
    Neoplasia, Mar. 2011
  • Recent progress in the management of hepatocellular carcinoma detected during a surveillance program in Japan               
    Nakano M, Ando E, Kuromatsu R, Torimura T, Sumie S, Takata A, Fukushima N, Kurogi J, Niizeki T, Iwamoto H, Tanaka M, Sata M.
    Hepatology Research, Oct. 2010
  • Serum C-reactive protein levels predict survival in hepatocellular carcinoma               
    Nagaoka S, Yoshida T, Akiyoshi J, Akiba J, Torimura T, Adachi H, Kurogi J, Tajiri N, Inoue K, Niizeki T, Koga H, Imaizumi T, Kojiro M, Sata M.
    Liver International, Oct. 2007
  • Clinical features of acute respiratory infections associated with the Streptococcus milleri group in the elderly               
    Sugihara E, Kido Y, Okamoto M, Koyanagi T, Niizeki T, Hirota N, Minami S, Kinoshita T, Uehara Y, Koga H, Ono N, Rikimaru T, Aizawa H.
    Kurume Medical Journal, Jan. 2004
  • Usefulness of bronchial lavage for the diagnosis of pulmonary disease caused by Mycobacterium avium-intracellulare complex (MAC) infection               
    Sugihara E, Hirota N, Niizeki T, Tanaka R, Nagafuchi M, Koyanagi T, Ono N, Rikimaru T, Aizawa H.
    Journal of Infection and Chemotherapy, Dec. 2003
  • Macrolide antibiotics directly reduce active oxygen generation by neutrophils in human peripheral blood               
    Sugihara E, Koyanagi T, Niizeki T, Hirota N, Nagafuchi M, Yamada K, Kido Y, Ono N, Rikimaru T, Aizawa H.
    Kurume Medical Journal, Nov. 2003
■ MISC
  • 切除不能進行肝細胞癌に対するAtezolizumab+Bevacizumab併用療法に、肝動注化学療法や肝動脈化学塞栓術が及ぼす影響               
    新関 敬、岩本 英希、鈴木 浩之、下瀬 茂男、城野 智毅、野田 悠、森山 悦子、 黒松 亮子、古賀 浩徳、川口 巧
    第60回 日本消化器免疫学会総会ワークショップ- 1, Nov. 2023
  • Robust efficacy of hepatic arterial infusion chemotherapy for advanced HCC with macroscopic vascular invasion : a comparative study with sorafenib               
    Niizeki T
    APASL single topic conference, May 2018
  • Oral Session(2)Efficacy of radiation therapy targeted on macroscopic vascular invasion for advanced HCC               
    Niizeki T
    Agenda for HCC Workshop (YKTB Universities), Dec. 2015
  • 当科における肉眼的脈管侵襲合併肝癌に対する集学的治療の取り組み               
    新関 敬、田尻能祥、岩本英希、下瀬茂男、城野智毅、鳥村拓司
    第17回九州肝癌研究会学術講演会, Sep. 2015
  • ワークショップ(5)肉眼的脈管侵襲合併肝癌に対するNew FP療法による肝動注療法の有用性               
    新関 敬、中野聖士、相野 一、田尻能祥、下瀬茂男、岩本英希、鳥村拓司
    第51回日本肝癌研究会, Jul. 2015
  • Poster Viering and Presentation Session: Efficacy of radiation therapy for macroscopic vascular invasion of advanced hepatocellular carcinom               
    Niizeki T, Aino H, Torimura T
    The 6nd Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE), Jul. 2015
  • 肝疾患の病態に及ぼす血小板の意義:肝動注化学療法を施行された進行肝細胞癌の治療効果および予後予測における血小板の意義               
    新関 敬、住江修治、鳥村拓司、佐田通夫
    消化器内科, Aug. 2013
  • 当科における高度脈管浸潤合併肝癌に対する放射線治療の成績               
    新関 敬、田尻能祥、相野 一、鳥村拓司、佐田通夫
    第49回日本肝癌研究会, Jul. 2013
  • Hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma               
    Niizeki T, Sumie S, Torimura T, Sata M
    6th International Liver Cancer Association (ILCA) 2012, Sep. 2012
  • 切除不能脈管浸潤合併進行肝細胞癌(Stage IV-AHCC)に対する治療方針についての検討               
    新関 敬、黒木淳一、相野 一、岩本英希、永松洋明、鳥村拓司、佐田通夫
    第17回筑後肝癌研究会, Feb. 2012
  • 当院での脈管浸潤陽性肝癌に対する治療の取り組み               
    新関 敬、住江修治、鳥村拓司、黒木淳一、相野 一、岩本英希、黒松亮子、高田晃男、佐谷 学、中野聖士、山田慎吾、佐田通夫
    第26回筑後DDF, Oct. 2011
  • 進行肝癌に対するLow dose FP療法の治療効果、予後予測因子の為のバイオマーカーとしての血清VEGF値の意義               
    新関 敬、住江修治、鳥村拓司、黒木淳一、相野 一、岩本英希、黒松亮子、高田晃男、中野聖士、佐谷 学、山田慎吾、佐田通夫
    第47回日本肝癌研究会, Jul. 2011
  • Sorafenib投与後4日目に間質性肺炎を発症し、早期死亡した1例               
    新関 敬、大野美紀、黒木淳一、相野 一、岩本英希、秋葉 純、鳥村拓司、佐田通夫
    第46回日本肝癌研究会, Jul. 2010
  • Sorafenib投与後、早期に呼吸不全を発症した下大静脈腫瘍栓を伴った肝細胞癌の1例               
    新関 敬、黒木淳一、大野美紀、相野 一、岩本英希、黒松亮子、高田晃男、住江修治、中野聖士、佐谷 学、鳥村拓司、佐田通夫
    第1回日本肝がん分子標的治療研究会, Jan. 2010
  • Anti-tumor effect of hepatic arterial infusion chemotherapy for advanced HCC with macro vascular invasion               
    Takashi Niizeki, Shuji Sumie, Junichi Kurogi, Hideki Iwamoto, Takuji Torimura, Michio Sata
    International Liver Cancer Association Third Annual Conference 2009, Sep. 2009
  • 切除不能脈管浸潤陽性肝癌に対するリザーバー動注療法の有用性および予後因子               
    新関 敬、住江修治、黒木淳一、井上欣哉、岩本英希、鳥村拓司、佐田通夫
    第45回日本肝癌研究会, Jul. 2009
  • Anti-tumor effect and prognostic factors of hepatic arterial infusion chemotherapy for advanced HCC with Macro vascular invasion               
    Takashi Niizeki, Shuji Sumie, Hideki Iwamoto, Junichi Kurogi, Takuji Torimura, Michio Sata
    3rd International Kobe Liver Symposium on HCC with a JSH-ILCA Joint Scientific Session, Jun. 2009
  • 非アルコール性脂肪肝炎(NASH)に合併した限局性結節性過形成(FNH)の一切除例               
    新関 敬、長岡 栄、井上欣哉、黒木淳一、田尻能祥、奥田康司、秋葉 純、篠崎広嗣、西村 寛、鳥村拓司、神代正道、佐田通夫
    第43回日本肝癌研究会, Jun. 2007
■ Books and other publications
  • Part 3 各論 Sorafenib投与後4日目に急性発症した薬剤性肺障害にて早期死亡した1症例               
    岩本英希、永松洋明、鳥村拓司、吉田 博、佐田通夫.工藤正俊 編, Contributor
    肝細胞癌の分子標的治療、アークメディア, Aug. 2010
■ Lectures, oral presentations, etc.
  • New FP療法の奏効例に対する、局所療法の組み合わせが 長期予後に与える影響               
    新関敬 岩本英希 下瀬茂男 城野智毅 中野聖士 野田悠 森山悦子 黒松亮子 古賀浩徳 川口巧
    第45回日本肝臓学会西部会 ワークショップ 1, Dec. 2023
  • New FP療法、およびAtezolizumab+Bevacizumab併用療法を用いた集学的治療でCRを得られた症例の特徴               
    新関敬、下瀬茂男、岩本英希、城野智毅、森山悦子、中野聖士、野田悠、黒松亮子 古賀浩徳、川口巧
    第59回 日本肝癌研究会, Jul. 2023
  • A novel tumor staging for curative treatment of unresectable hepatocellular carcinoma (HCC) with hepatic arterial infusion chemotherapy               
    Takashi Niizeki, Shigeo Shimose, Hideki Iwamoto, tomotake shirono, Etsuko Moriyama, Masahito Nakano, Yuu Noda, Ryoko Kuromatsu, Hironori Koga, Takumi Kawaguchi
    第59回日本肝臓学会総会 シンポジウム5, Jun. 2023
  • New FP療法、またはAtezolizumab+Bevacizumab併用療法を用いた集学的治療でCRを得られた症例の特徴               
    新関敬、下瀬茂男、岩本英希、城野智毅、森山悦子、中野聖士、野田悠、黒松亮子 古賀浩徳、川口巧
    第121回日本消化器病学会九州支部例会 シンポジウム1, May 2023
  • 切除不能進行肝細胞癌に対する一次治療としてのAtezolizumab+Bevacizumab併用療法とLenvatinibの比較               
    新関敬(1)、徳永尭之(2)、和田幸之(2)、原田大(2)、柴田道彦(2)、中尾一彦(2)、佐々木龍(2)、平井郁人(2)、釈迦堂敏(2)、吉住明晴(2)、伊藤心二(2)、八橋弘(2)、井戸章雄(2)、馬渡誠一(2)、杉本理恵(2)、桑代卓也(2)、前城達次(2)、下瀬茂男(1)、田中靖人(2) 久留米大学医学部内科学講座消化器内科部門 九州肝癌研究会
    第27回日本肝がん分子標的治療研究会 プレリミナリーセッション, Jan. 2023
  • Prognostic factors for patients with advanced HCC beyond up-to-7 criteria treated with the hepatic arterial infusion chemotherapy “New FP”               
    Takashi Niizeki, Hideki Iwamoto, Tomotake Shirono, Shigeo Shimose, Hironori Koga, Takuji Torimura
    JSH International Liver Conference 2021 Session 5, Oct. 2021
  • A DECISION-TREE ANALYSIS OF PROGNOSTIC FACTORS IN HEPATIC ARTERIAL INFUSION CHEMOTHERAPY FOR ADVANCED HEPATOCELLULAR CARCINOMA EXCEEDING UP-TO-7 CRITERIA               
    Niizeki T
    AASLD, Oct. 2019
  • Robust efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma with macroscopic vascular invasion: a comparative study with sorafenib               
    Niizeki T
    AASLD, Nov. 2017
  • 当院における肉眼的脈管浸潤を合併する進行肝細胞癌の予後因子と治療戦略               
    Niizeki T
    日本消化器病学会総会, Apr. 2017
  • Poster Session: HCC treatment(5)Efficacy of hepatic arterial chemotherapy of CDDP suspension in lipiodol and 5-FU for advanced HCC               
    Niizeki T, Nakano M, Torimura T
    Hepatology International、25th Conference of the Asian Pacific Association for the Study of the Liver (APASL), Feb. 2016
  • シンポジウム(2)進行肝細胞癌に対する肝動注化学療法の治療効果予測因子としての血小板値の意義               
    新関 敬、相野 一、鳥村拓司
    肝臓、第41回日本肝臓学会西部会, Dec. 2015
  • Poster Sessions: Clinical: Hepatocellular Carcinoma and Colangiocarcinoma:Prospective cohort study for evaluating clinical effects and safety of intra-arterial infusion therapy of cisplatin suspension in lipiodol combined with 5-fluorouracil and sorafenib for advanced hepatocellular carcinoma with macroscopic vascular invasion, without extra-hepatic spread               
    Takashi N, Nakano M, Torimura T
    Hepatology、The 66th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), Nov. 2015
  • 当科における肝細胞癌の胆管内腫瘍塞栓に対する治療成績               
    新関 敬、相野 一、田尻能祥、岩本英希、下瀬茂男、城野智毅、岡部義信、黒松亮子、鳥村拓司
    肝臓、23rd JDDW(第19回日本肝臓学会大会), Oct. 2015
  • パネルディスカッション(5)肉眼的脈管侵襲を有する進行肝細胞癌における腫瘍塞栓を標的とした放射線療法の評価               
    新関 敬、相野 一、鳥村拓司
    肝臓、第51回日本肝臓学会総会, May 2015
  • シンポジウム(8)脈管侵襲を伴う進行肝細胞癌に対するNew FP療法とSorafenib療法の比較               
    新関 敬、中野聖士、鳥村拓司
    日本消化器病学会雑誌、第101回日本消化器病学会総会, Apr. 2015
  • 当院における切除不能脈管浸襲合併肝癌に対する治療成績               
    新関 敬、住江修治、鳥村拓司
    肝臓、22nd JDDW(第18回日本肝臓学会大会), Oct. 2014
  • 全身化学療法無効の肝細胞癌肺転移に対し気管支動脈からのシスプラチン動注療法が有効であった一例               
    中野 暖、新関 敬、佐田通夫
    第103回日本消化器病学会九州支部例会、第97回日本消化器内視鏡学会九州支部例会 合同, Jul. 2014
  • 当科におけるChild-Pugh class Aの進行肝細胞癌に対する集学的治療成績               
    新関 敬、鳥村拓司、佐田通夫
    日本消化器病学会雑誌、第100回日本消化器病学会総会, Apr. 2014
  • パネルディスカッション(13)進行肝癌に対する集学的治療の標準化に向けて:当科における切除不能脈管浸潤合併肝細胞癌に対する治療成績               
    新関 敬、田尻能祥、佐田通夫
    日本消化器病学会雑誌、JDDW 2013(第10回日本消化器外科学会大会、第55回日本消化器病学会大会、第17回日本肝臓学会大会 合同), Oct. 2013
  • 切除不能脈管浸潤合併肝細胞癌に対する肝動注化学療法とSorafenib療法の前向きコーホート研究               
    新関 敬、中野聖士、佐田通夫
    肝臓、第49回日本肝臓学会総会, Jun. 2013
  • パネルディスカッション(7) 肝動注化学療法を施行された進行脈管浸潤合併肝細胞癌の治療効果及び予後予測における血小板の意義               
    新関 敬、住江修治、佐田通夫
    肝臓、20th JDDW(第16回日本肝臓学会大会、第54回日本消化器病学会大会、第50回日本消化器がん検診学会大会 合同), Oct. 2012
  • 切除不能脈管浸潤合併進行肝細胞癌(Stage IvA HCC)に対するNew FP療法の適応についての検討               
    新関 敬、黒木淳一、相野 一、岩本英希、永松洋明、住江修治、鳥村拓司、佐田通夫
    肝臓、第48回日本肝臓学会総会, Jun. 2012
  • 血清VEGF値に基づく切除不能脈管浸潤合併進行肝細胞癌に対する治療選択               
    新関 敬、住江修治、鳥村拓司、黒木淳一、相野 一、岩本英希、佐田通夫
    肝臓、19th JDDW (第15回日本肝臓学会大会), Oct. 2011
  • Impact of vascular endothelial growth factor (VEGF) on predictor of poor response and survival in advanced HCC patients with HAIC               
    Takashi Niizeki, Shuji Sumie, Takuji Torimura, Michio Sata
    The 2nd Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE), Jul. 2011
  • 当院におけるStage4-A HCCに対するNew FP療法の短期治療成績               
    新関 敬、黒木淳一、相野 一、岩本英希、鳥村拓司、佐田通夫
    肝臓、18th JDDW(第14回日本肝臓学会大会), Oct. 2010
  • Stage IV-A肝細胞癌に対する肝動注化学療法の予後良好群の層別化               
    新関 敬、黒木淳一、岩本英希、住江修治、黒松亮子、高田晃男、中野聖士、佐谷 学、鳥村拓司、佐田通夫
    肝臓、第38回日本肝臓学会西部会, Dec. 2009
  • 切除不能脈管浸潤陽性肝細胞癌に対するリザーバー動注化学療法の予後因子               
    新関 敬、住江修治、黒木淳一、井上欣哉、岩本英希、鳥村拓司、佐田通夫
    肝臓、17th JDDW(第13回日本肝臓学会大会), Oct. 2009
■ Courses
  • 大分肝胆膵研究会 肝細胞癌のトピックス 演者               
    05 Mar. 2024
  • 茨城県 進行肝細胞癌の治療と副作用マネジメント ~多職種連携の取組み~ 演者               
    27 Feb. 2024
  • 日本消化器病学会九州支部 第29回 教育講演会 講演5 肝細胞癌治療のup to date 演者               
    18 Feb. 2024
  • 久留米医師会 肝癌検診講習会 肝細胞癌のトピックス 演者               
    09 Feb. 2024
  • 久留米リハビリテーション学院 社会性向上セミナー 最近の肝細胞癌トピックスおよび、肝疾患における運動療法の役割 演者               
    09 Nov. 2023
  • 筑後消化器疾患セミナー 近年の進行肝細胞癌治療 演者               
    06 Oct. 2023
  • 肝細胞癌薬物療法の新たな選択肢 ~イミフィンジ・イジュド併用療法の臨床導入とこれから~ 演者               
    16 May 2023
  • 熊本県北の肝癌を考える会 ~根治を目指す治療戦略 IVRとレンバチニブを使いこなす~ 演者               
    03 Mar. 2023
  • HCC- Meeting in 和歌山 ~根治を目指す治療戦略 IVRとレンバチニブを使いこなす~ 演者               
    09 Feb. 2023
■ Affiliated academic society
  • 日本内科学会 認定内科医・指導医 日本消化器病学会 専門医・九州支部評議員 日本肝臓学会 専門医・指導医 日本消化器内視鏡学会 専門医               
  • 日本内科学会 認定内科医・指導医 日本消化器病学会 専門医・九州支部評議員 日本肝臓学会 専門医・指導医 日本消化器内視鏡学会 専門医               
■ 共同研究実績
  • リアルワールドデータを用いた切除不能進行肝細胞癌に対する薬物療法に関する多施設共同観察研究 
■ 関心を持って取組んでいる活動
  • 切除不能進行肝細胞癌の根治性を高めるための臨床、研究