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Honda Takeshi
Career
■ Career
- Dec. 2024 - Present
Kurume University, School of Medicine, Associate Professor - Sep. 2023 - Dec. 2024
Kurume University, School of Medicine, Department of Chemistry, 准教授 - Jul. 2012 - Aug. 2023
Yamaguchi University, Graduate School of Medicine, Department of Pharmacology, 講師 - Jul. 2007 - Jun. 2012
Yamaguchi University, Graduate School of Medicine, Department of Pharmacology, 助教 - Apr. 2004 - Jun. 2007
産業技術総合研究所, ナノテクノロジー部門マイクロ・ナノ空間化学グループ, 特別研究員
- Apr. 1999 - Mar. 2004, Kyushu University, Graduate School of Sciences, 分子化学専攻構造機能性化学研究室
- Apr. 1995 - Mar. 1999, Kyushu University, School of Sciences, Department of Chemistry
Research activity information
■ Award
■ Affiliated academic society
■ Research Themes
- Dec. 2021
山口大学, 令和3年度革新的研究の発掘と育成プロジェクト研究奨励賞
ハイブリッド型核酸アプタマーによる革新的心不全治療薬の開発・継続, Japan society
本田健 - Oct. 2021
山口大学医学会, 令和2年度山口大学医学会学会賞
PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression, Japan society
本田健 - Jun. 2021
宇部興産株式会社, 宇部興産学術振興財団第61回学術奨励賞
液-液相分離体パラスペックルを介したPDZRN3による心筋分化制御機構の解明, Publisher
本田健 - Dec. 2020
山口大学, 令和2年度革新的研究の発掘と育成プロジェクト（FOCSプロジェクト）研究奨励賞
ハイブリッド型核酸アプタマーによる革新的心不全治療薬の開発, Japan society
本田健 - Nov. 2009
日本薬理学会, 日本薬理学会西南部会優秀発表賞
BMP誘導骨芽細胞分化におけるWntシグナルを介したPDZRN3の制御機構, Japan society
本田健
- Dietary intake of whale oil-containing ω-3 long-chain polyunsaturated fatty acids attenuates choroidal neovascularization in mice.
Yanai R.; Yasunaga G.; Tsuji S.; Honda T.; Iwata A.; Miyagawa E.; Yoshida K.; Kishimoto M.; Sakai H.; Fujise Y.; Asagiri M.; Mitamura Y.
FASEB J., Feb. 2025, [Reviewed] - Methylglyoxal compromises callus mineralization and impairs fracture healing through suppression of osteoblast terminal differentiation
Seto T, Yukata K, Tsuji S, Takeshima Y, Honda T, Sakamoto A, Takemoto K, Sakai H, Matsuo M, Sasaki Y, Kaneda M, Yoshimura M, Mihara A, Uehara K, Matsugaki A, Nakano T, Harada K, Tahara Y, Iwaisako K, Yanai R, Takeda N, Sakai T, Asagiri M.
Biochem Biophys Res Commun., Feb. 2025, [Reviewed] - PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle
Iida H.; Kawai-Takaishi M.; Miyagawa Y.; Takegami Y.; Uezumi A.; Honda T.; Imagama S.; Hosoyama T.
Regenerative Therapy, Jan. 2025, [Reviewed] - Intracellular delivery of a phospholamban-targeting aptamer using cardiomyocyte-internalizing aptamers
Honda T.; Sakai H.; Inui M.
European Journal of Pharmacology, Dec. 2024, [Reviewed]
Lead, Corresponding - Role of type 2 ryanodine receptor stabilisation in autoimmune cell modulation
Takashi Nawata; Takeshi Honda; Akihiko Sakamoto; Hitoshi Uchinoumi; Takeshi Suetomi; Yoshihide Nakamura; Shunya Tsuji; Hiroki Sakai; Shigeki Kobayashi; Takeshi Yamamoto; Masataka Asagiri; Motoaki Sano; Masafumi Yano
Advances in Rheumatology, 22 Nov. 2024, [Reviewed] - Dantrolene, a ryanodine receptor stabilizer, is a candidate immunomodulator for treating rheumatic disease.
T Nawata; T Honda; H Sakai; S Tsuji; M Otsuka; H Uchinoumi; S Kobayashi; T Yamamoto; M Asagiri; M Yano
Scandinavian journal of rheumatology, May 2024, [Reviewed] - Renoprotective effects of laxative linaclotide;Inhibition of;acute kidney injury;fibrosis in a;ra;model of renal ischemia-reperfusion
Hitaka Y.; Isoyama N.; Tsuji S.; Honda T.; Nakayama Y.; Yamaguchi M.; Nakamura K.; Hirata H.; Shiraishi K.; Asagiri M.
Biochem Biophys Res Commun., Feb. 2024, [Reviewed] - Postnatal Pdzrn3 deficiency causes acute muscle atrophy without alterations in endplate morphology
Kawai-Takaishi M.; Miyagawa Y.; Honda T.; Inui M.; Hosoyama T.
Biochem Biophys Res Commun., Jan. 2024, [Reviewed] - Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.
Takashi Nawata; Hiroki Sakai; Takeshi Honda; Marina Otsuka; Hina Fujita; Hitoshi Uchinoumi; Shigeki Kobayashi; Takeshi Yamamoto; Masataka Asagiri; Masafumi Yano
Biochemical and biophysical research communications, 08 Oct. 2022, [Reviewed] - 筋分化時の一過性DNA鎖切断に対する新たな制御機構 PDZRN3は筋芽細胞をアポトーシスから保護する
本田 健; 酒井 大樹; 乾 誠; 朝霧 成挙
山口医学, Sep. 2021, [Reviewed], [Invited]
Lead - Calcium/calmodulin-dependent regulation of Rac GTPases and Akt in histamine-induced chemotaxis of mast cells.
Takeshi Honda; Yusuke Nishio; Hiroki Sakai; Masataka Asagiri; Kiyoshi Yoshimura; Makoto Inui; Atsuo Kuramasu
Cellular signalling, Jul. 2021, [Reviewed]
Lead - Development of Water Solubility of 2-Phenylsulfanylhydroquinone Dimer Dye
Kamimura A; Umemoto H; Kawamoto T; Honda T
ACS Omega, Mar. 2021, [Reviewed]
Last, Corresponding - PDZRN3 protects against apoptosis in myoblasts by maintaining cyclin A2 expression.
Honda Takeshi; Inui Makoto
Scientific reports, Jan. 2020, [Reviewed]
Lead - PDZRN3 regulates differentiation of myoblasts into myotubes through transcriptional and posttranslational control of Id2.
Honda Takeshi; Inui Makoto
Journal of cellular physiology, Mar. 2019, [Reviewed]
Lead - Application of Enzyme-Immobilization Technique for Microflow Reactor.
Yamaguchi Hiroshi; Honda Takeshi; Miyazaki Masaya
Journal of Flow Chemistry, Feb. 2016, [Reviewed]
Lead - Signaling Mechanism Underlying the Promotion of Keratinocyte Migration by Angiotensin II
Hiroki Sakai; Kenji Matsuura; Yoshie Tanaka; Takeshi Honda; Teruo Nishida; Makoto Inui
MOLECULAR PHARMACOLOGY, Feb. 2015, [Reviewed] - A cell-penetrating phospholamban-specific RNA aptamer enhances Ca2+ transients and contractile function in cardiomyocytes
Hiroki Sakai; Yasuhiro Ikeda; Takeshi Honda; Yoshie Tanaka; Kozo Shiraishi; Makoto Inui
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, Nov. 2014, [Reviewed] - Regulation of adipocyte differentiation of 3T3-L1 cells by PDZRN3
Takeshi Honda; Aiko Ishii; Makoto Inui
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Jun. 2013, [Reviewed]
Lead - Phosphatase assay for multi-phosphorylated substrates using phosphatase specific-motif antibody
Yoshiro Chuman; Kanako Iizuka; Takeshi Honda; Hitoshi Onoue; Yasuyuki Shimohigashi; Kazuyasu Sakaguchi
JOURNAL OF BIOCHEMISTRY, Sep. 2011, [Reviewed] - Stable horizontal interface formation and separation of a water/oil flow by microfluidic reactor analyzed by direct observation and numerical simulation
Miyazaki M; Yamaguchi Y; Honda T; Maeda H
Open Chemical Engineering Journal, Aug. 2011, [Reviewed] - PDZRN3 Negatively Regulates BMP-2-induced Osteoblast Differentiation through Inhibition of Wnt Signaling
Takeshi Honda; Hisato Yamamoto; Aiko Ishii; Makoto Inui
MOLECULAR BIOLOGY OF THE CELL, Sep. 2010, [Reviewed]
Lead - Rapid and efficient proteolysis for proteomic analysis by protease-immobilized microreactor
Hiroshi Yamaguchi; Masaya Miyazaki; Takeshi Honda; Maria Portia Briones-Nagata; Kazunari Arima; Hideaki Maeda
ELECTROPHORESIS, Sep. 2009, [Reviewed] - In Vitro Selection and Characterization of DNA Aptamers Specific for Phospholamban
Yoshie Tanaka; Takeshi Honda; Kenji Matsuura; Yoshihiro Kimura; Makoto Inui
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Apr. 2009, [Reviewed] - Enzymatic Processing in Microfluidic Reactors
Masaya Miyazaki; Takeshi Honda; Hiroshi Yamaguchi; Maria Portia P. Briones; Hideaki Maeda
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 25, 2008, [Reviewed] - Differential receptor binding characteristics of consecutive phenylalanines in mu-opioid specific peptide ligand endomorphin-2
Takeshi Honda; Naoto Shirasu; Kaname Isozaki; Michiaki Kawano; Daiki Shigehiro; Yoshiro Chuman; Tsugumi Fujita; Takeru Nose; Yasuyuki Shimohigashi
BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 2007, [Reviewed]
Lead - Influence of gravity on two-layer laminar flow in a microchannel
Yoshiko Yamaguchi; Takeshi Honda; Maria Portia Briones; Kenichi Yamashita; Masaya Miyazaki; Hiroyuki Nakamura; Hideaki Maeda
CHEMICAL ENGINEERING & TECHNOLOGY, Mar. 2007, [Reviewed] - Development of a microreactor for amino acid polymerization
Masaya Miyazaki; Takeshi Honda; Hiroyuki Nakamura; Hideaki Maeda
CHEMICAL ENGINEERING & TECHNOLOGY, Mar. 2007, [Reviewed] - Integrated microreaction system for optical resolution of racemic amino acids
Takeshi Honda; Masaya Miyazaki; Yoshiko Yamaguchi; Hiroyuki Nakamura; Hideaki Maeda
Lab on a Chip, 2007, [Reviewed]
Lead - Structural isoforms of the circadian neuropeptide PDF expressed in the optic lobes of the cricket Gryllus bimaculatus: Immunocytochemical evidence from specific monoclonal antibodies
Takeshi Honda; Ayami Matsushima; Kazunori Sumida; Yoshiro Chuman; Kazuyasu Sakaguchi; Hitoshi Onoue; Ian A. Meinertzhagen; Yasuyuki Shimohigashi; Miki Shimohigashi
JOURNAL OF COMPARATIVE NEUROLOGY, Nov. 2006, [Reviewed]
Lead - Influence of Gravity on a Laminar Flow in a Microbioanalysis System
Yamaguchi Y; Honda T; Briones MP; Yamashita K; Miyazaki M; Nakamura H; Maeda H
Measurement Science and Technology, Oct. 2006, [Reviewed] - A practical method for rapid microchannel fabrication in polydimethylsiloxane by replica molding without using silicon photoresist
Maria Portia P. Briones; Takeshi Honda; Yoshiko Yamaguchi; Masaya Miyazaki; Hiroyuki Nakamura; Hideaki Maeda
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, Oct. 2006, [Reviewed] - Facile preparation of an enzyme-immobilized microreactor using a cross-linking enzyme membrane on a microchannel surface
Honda T; Miyazaki M; Nakamura H; Maeda H
Advanced Synthesis and Catalysis, Oct. 2006, [Reviewed]
Lead - Efficient immobilization of enzymes on microchannel surface through his-tag and application for microreactor
M Miyazaki; J Kaneno; S Yamaori; T Honda; MPP Briones; M Uehara; K Arima; K Kanno; K Yamashita; Y Yamaguchi; H Nakamura; H Yonezawa; M Fujii; H Maeda
PROTEIN AND PEPTIDE LETTERS, Feb. 2005, [Reviewed] - Controllable polymerization of N-carboxy anhydrides in a microreaction system
Takeshi Honda; Masaya Miyazaki; Hiroyuki Nakamura; Hideaki Maeda
Lab on a Chip, 2005, [Reviewed]
Lead - Immobilization of enzymes on a microchannel surface through cross-linking polymerization
T Honda; M Miyazaki; H Nakamura; H Maeda
CHEMICAL COMMUNICATIONS, 2005, [Reviewed]
Lead - Differential regulation of chemical reactions in a microchannel reaction system
Miyazaki M; Yamashita K; Honda T; Nakamura H; Fujii M; Maeda H
New Journal of Chemistry, Nov. 2004, [Reviewed] - Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina
Matsushima, A; Yokotani, S; Liu, X; Sumida, K; Honda, T; Sato, S; Kaneki, A; Takeda, Y; Chuman, Y; Ozaki, M; Asai, D; Nose, T; Onoue, H; Ito, Y; Tominaga, Y; Shimohigashi, Y; Shimohigashi, M
Lett. Pept. Sci., 2003, [Reviewed] - Site-directed affinity-labeling of delta opioid receptors by SNpys-containing enkephalin and dynorphin analogues
K Isozaki; H Fukahori; T Honda; N Shirasu; K Okada; T Nose; K Sakaguchi; Y Shimohigashi
LETTERS IN PEPTIDE SCIENCE, 2003, [Reviewed] - Structural requirements of nociceptin antagonist Ac-RYYRIK-NH2 for receptor binding
M Kawano; K Okada; T Honda; T Nose; K Sakaguchi; T Costa; Y Shimohigashi
JOURNAL OF PEPTIDE SCIENCE, Oct. 2002, [Reviewed] - The Role of Deltorphin II Phenylalanine Residue in Binding to the δ Opioid Receptor
Honda T; Shirasu N; Chuman Y; Okada K; Fujita T; Nose T; Shimohigashi Y
Bulletin of the Chemical Society of Japan, Mar. 2000, [Reviewed]
Lead - Synthesis of a complete set of L-difluorophenylalanines, L-(F-2)Phe, as molecular explorers for the CH/-pi interaction between peptide ligand and receptor
T Fujita; T Nose; A Matsushima; K Okada; D Asai; Y Yamauchi; N Shirasu; T Honda; D Shigehiro; Y Shimohigashi
TETRAHEDRON LETTERS, Feb. 2000, [Reviewed]
- Fibroblast growth factor 23 contributes to regulation of hepcidin/ferroportin axis
Higashimoto Y.; Matsui T.; Honda T.; Sakaguchi T.; Tsuji M.; Motomiya Y.
第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会, 14 Dec. 2023 - キョウチクトウ科植物由来抽出物による炎症促進性型M1マクロファージ活性化と破骨細胞分化
Ishida Chika; Suzuki Miren; Seto Tetsuya; Otsuka Marina; Sakai Hiroki; Takeiri Masatoshi; Tsunekage Yukino; Arai Keiko; Honda Takeshi; Asagiri Masataka
Proceedings for Annual Meeting of The Japanese Pharmacological Society, Mar. 2022 - 炎症性破骨細胞形成に対するスペルミジンの抑制効果
Seiya Tanaka; Okamoto Asuka; Tsubaki Honoka; Seto Tetsuya; Sakai Hiroki; Honda Takeshi; Asagiri Masataka
Proceedings for Annual Meeting of The Japanese Pharmacological Society, Mar. 2022 - 合成レチノイド抗腫瘍薬ベキサロテンは炎症性破骨細胞の分化を阻害する
Hina Takegami; Hiyori Nakamura; Ayano Takeda; Mayu Matsuo; Hiroki Sakai; Takeshi Honda; Masataka Asagiri
Proceedings for Annual Meeting of The Japanese Pharmacological Society, Mar. 2022 - Novel Mechanisms Regulating Myogenic Differentiation in Skeletal Muscle
Takeshi Honda
Yamaguchi Medical Journal, Aug. 2021, [Reviewed], [Invited] - RNAアプタマーによる心筋細胞に特異的な細胞内薬物送達法の開発
Honda Takeshi; Sakai Hiroki; Inui Makoto
Proceedings for Annual Meeting of The Japanese Pharmacological Society, Mar. 2021
Lead - MMP阻害による筋分化の増強効果と老化細胞における増強効果の減弱
Sakai Hiroki; Honda Takeshi; Ogasawara Kouetsu; Asagiri Masataka
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021 - Anti-apoptotic function of PDZRN3 protein in myoblasts
Takeshi Honda; Ukyo Shinagawa; Yu Mizuno; Yuki Yokosuka; Makoto Inui
日本薬理学会年会要旨 93, Mar. 2020
Lead - PDZRN3蛋白質はサイクリンA2を介して筋芽細胞のアポトーシスを制御する
本田 健; 品川 右京; 水野 優; 横須賀 由季; 乾 誠
日本薬理学会西南部会プログラム/抄録集 72th, Nov. 2019
Lead - Regulation of apoptosis by PDZRN3 protein in myoblasts
Takeshi Honda; Ukyo Shinagawa; Yu Mizuno; Yuki Yokosuka; Makoto Inui
Proceedings for The 92nd Annual Meeting of the Japanese Pharmacological Society, Mar. 2019
Lead - PDZRN3蛋白質による筋芽細胞のアポトーシス制御
本田 健; 品川 右京; 水野 優; 横須賀 由季; 乾 誠
日本薬理学会西南部会プログラム/抄録集 71th, Nov. 2018
Lead - PDZRN3 regulates the differentiation of myoblasts into myotubes through Id2-mediated pathway
Takeshi Honda; Narumi Nakada; Ryoto Nagai; Makoto Inui
WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology), Mar. 2018
Lead - PDZRN3 regulates myogenic differentiation of myoblasts through modulation of the Id2-mediated pathway
Takeshi Honda; Narumi Nakada; Ryoto Nagai; Makoto Inui
日本薬理学会年会要旨集90, Mar. 2017
Lead - PDZRN3蛋白質によるId2を介した筋芽細胞分化制御
本田 健; 仲田 成美; 永井 涼人; 乾 誠
日本薬理学会西南部会プログラム/抄録集 69th, Nov. 2016
Lead - Regulation of myogenic differentiation by PDZRN3 through modification of Id2 expression
Takeshi Honda; Narumi Nakada; Ryoto Nagai; Makoto Inui
日本薬理学会年会要旨集89, Mar. 2016
Lead - IGF-1 promotes epithelial wound healing independently of IGF-1 receptors via angiotensin II signaling
Sakai Hiroki; Matsuura Kenji; Honda Takeshi; Nishida Teruo; Inui Makoto
Proceedings for Annual Meeting of The Japanese Pharmacological Society, Mar. 2016 - 皮膚創傷治癒過程におけるIGF‐1と知覚神経由来のサブスタンスPとの協調作用のメカニズム
酒井大樹; 松浦健二; 本田健; 西田輝夫; 乾誠
日本薬理学会西南部会プログラム/抄録集 68th, Mar. 2015 - ホスホランバン特異的RNAアプタマーによる心筋細胞のCa2+一時的収縮機能の増加
SAKAI Hiroki; IKEDA Yasuhiro; HONDA Takeshi; TANAKA Yoshie; SHIRAISHI Kozo; INUI Makoto
Journal of Pharmacological Sciences, 2015 - 筋芽細胞株の分化制御におけるPDZRN3蛋白質の役割
本田 健; 仲田 成美; 永井 涼人; 乾 誠
日本薬理学会西南部会プログラム/抄録集67th, Nov. 2014
Lead - Rac-ERK pathway mediates histamine-induced chemotaxis of mouse mast cells
Atsuo Kuramasu; Mie Wakabayashi; Takeshi Honda; Saaya Koguchi; Yurie Higuchi; Makoto Inui; Kazuhiko Yanai
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014 - Regulation of myogenic differentiation by PDZRN3 protein through Wnt signaling
Takeshi Honda; Narumi Nakada; Ryoto Nagai; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
Lead - 筋芽細胞の筋分化におけるPDZRN3蛋白質の役割
本田 健; 仲田 成美; 永井 涼人; 乾 誠
日本薬理学会西南部会プログラム/抄録集 66th, Nov. 2013
Lead - 間葉系前駆細胞分化におけるPDZRN3タンパク質の役割
本田健
第37回 蛋白質と酵素の構造と機能に関する九州シンポジウム講演要旨集, Sep. 2013, [Invited] - Signaling mechanism on the promotion of skin epithelial cell migration by angiotensin II
Hiroki Sakai; Kenji Matsuura; Takeshi Honda; Yoshie Tanaka; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - Regulation of adipocyte differentiation by PDZRN3 protein through STAT5b
Takeshi Honda; Aiko Ishii; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013
Lead - STAT5Bを介したPDZRN3の脂肪細胞分化制御
本田健; 石井愛子; 乾 誠
日本薬理学会西南部会プログラム/抄録集 65th, Nov. 2012
Lead - アンギオテンシンIIによる皮膚表皮細胞遊走促進の作用機序
酒井大樹; 松浦健二; 田中貴絵; 本田健, 乾誠
日本薬理学会西南部会プログラム/抄録集 65th, Nov. 2012 - Processing of Precursor Protein of the Cricket Gryllus bimaclatus Circadian Rhythm Neuropeptide PDF and PAP and Their Axonal Transport
SHIMOHIGASHI Miki; YONEMURA Marina; HONDA Takeshi; NAKAGAWA Hiroyuki; SHIMOHIGASHI Yasuyuki
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012 - Regulation of adipocyte differentiation by PDZRN3 protein
Takeshi Honda; Aiko Ishii; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012
Lead - RNA aptamers against phospholamban with improved stability and efficacy
Yoshie Tanaka; Takeshi Honda; Hiroki Sakai; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012 - 脂肪細胞分化におけるPDZRN3の役割
石井愛子; 本田健; 乾 誠
日本薬理学会西南部会プログラム/抄録集 64th, Nov. 2011 - Negative regulation of Wnt signaling by PDZRN3 protein in osteoblastic differentiation
Takeshi Honda; Aiko Ishii; Hisato Yamamoto; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011
Lead - Wntシグナルを介したPDZRN3による骨芽細胞分化の制御
本田 健; 石井 愛子; 山本 久人; 乾 誠
日本薬理学会西南部会プログラム/抄録集 63th, Nov. 2010
Lead - Negative regulation of Wnt signaling by PDZRN3 protein during osteoblastic differentiation
Takeshi Honda; Aiko Ishii; Hisato Yamamoto; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010
Lead - Mechanism of promotion of skin epithelial cell migration by a tetrapeptide derived from the C domain of IGF-1
Kenji Matsuura; Takeshi Honda; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - BMP誘導骨芽細胞分化におけるWntシグナルを介したPDZRN3の制御機構
本田健; 石井愛子; 山本久斗; 乾 誠
日本薬理学会西南部会プログラム/抄録集 62th, Nov. 2009
Lead - Rapid Protein Digestion by Protease-immobilized Microreactor
YAMAGUCHI Hiroshi; MIYAZAKI Masaya; HONDA Takeshi; MAEDA Hideaki
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009 - Modulation of BMP-2-induced osteoblastic differentiation by PDZRN3 protein
Takeshi Honda; Hisato Yamamoto; Aiko Ishii; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009
Lead - Molecular basis of infection and propagation in prion diseases
Yuji Horiuchi; Eriko Hattori; Satoru Yokotani; Takeshi Honda; Ayami Matsushima; Yasuyuki Shimohigashi
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, Dec. 2008 - BMP誘導骨芽細胞分化におけるPDZRN3の役割
本田 健、山本 久人、石井 愛子、乾 誠
日本薬理学会西南部会プログラム/抄録集 61th, Nov. 2008
Lead - Enhancement of cardiac sarcoplasmic reticulum calcium uptake by phospholamban aptamers
Yoshie Tanaka; Takeshi Honda; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Involvement of PDZRN3 in differentiation of osteoblasts induced by bone morphogenetic protein-2
Hisato Yamamoto; Takeshi Honda; Makoto Inui
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Controllable synthesis of peptide polymers in microfluidic reactor
M. Miyazaki; M. Miyazaki; J. Kaneno; H. Yamaguchi; T. Honda; E. Kanaumi; H. Maeda; H. Maeda
12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference, 01 Jan. 2008 - Difference of Peptide Chemistry in Micro- and Nanofluidics over Conventional Reaction
MIYAZAKI Masaya; HONDA Takeshi; BRIONES Maria Portia; YAMASHITA Kenichi; YAMAGUCHI Yoshiko; UEHARA Masato; NAKAMURA Hiroyuki; MAEDA Hideaki
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007 - Polyamino Acid Synthesis in Microfluidic Reactor
HONDA Takeshi; MIYAZAKI Masaya; NAKAMURA Hiroyuki; MAEDA Hideaki
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007
Lead - Micro enzymereaction system for continuous-flow optical resolution of amino acids.
Miyazaki, M; Honda, T; Yamaguchi, Y; Nakamura, H; Maeda, H
Peptide Science, 2007 - Development of micro enzyme reactor for optical resolution
Masaya Miyazaki; Takeshi Honda; Jun Kaneno; Hiroyuki Nakamura; Hideaki Maeda
WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, 2007, [Reviewed] - Biopolymer synthesis in a microfluidic system
Takeshi Honda; Masaya Miyazaki; Hiroyuki Nakamura; Hideaki Maeda
WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING, 2007, [Reviewed]
Lead - Development of micro enzyme reactor for optical resolution
Masaya Miyazaki; Takeshi Honda; Jun Kaneno; Hiroyuki Nakamura; Hideaki Maeda
WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING 2006, VOL 14, PTS 1-6, 2007, [Reviewed] - Immunocytochemical localization of the circadian neuropeptides PAP and PDF in the brain of the housefly Musca domestica
Kazunori Sumida; Takeshi Honda; Yukimasa Takeda; Ayami Matsushima; Yasuyuki Shimohigashi; Miki Shimohigashi
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, Nov. 2006 - Influence of gravity on a two-layer laminar flow in a microchannel
Yoshiko Yamaguchi; Takeshi Honda; Maria Portia Briones; Kenichi Yamashita; Masaya Miyazaki; Hiroyuki Nakamura; Hideaki Maeda
Topical Conference on Applications of Micro-Reactor Engineering 2006, Held at the 2006 AIChE Spring National Meeting, 2006 - Immobilization of enzymes on microchannel surface through cross-linking polymerization
Takeshi Honda; Masaya Miyazaki; Hiroyuki Nakamura; Hideaki Maeda
Topical Conference on Applications of Micro-Reactor Engineering 2006, Held at the 2006 AIChE Spring National Meeting, 2006 - Amino acid polymerization in micro-reactor
Masaya Miyazaki; Takeshi Honda; Hiroyuki Nakamura; Hideaki Maeda
AIChE Annual Meeting, Conference Proceedings, 2006 - Monoclonal Antibody Sensing Assay for Conformation Change Induced by Metal Binding to Prion Protein N-Terminal Octarepeat Domain
Satoru Yokotani; Takeshi Honda; Michiaki Kawano; Ayami Matsushima; Yasuyuki Shimohigashi
Peptide Science, 2006 - Characterization and Application of Monoclonal Antibody Specific for Ser(P)-Gln Phosphorylation Motif
Iizuka Kanako; Yoshiro Chuman; Takeshi Honda; Hitoshi Onoue; Yasuyuki Shimohigashi; Kazuyasu Sakaguchi
Peptide Science, 2006 - Immunocyto- and ristochemical analysis on the circadian neuropeptide PDF in Gryllus bimaculatus
Miki Shimohigashi; Takeshi Honda; Ayami Matsushima; Kazunori Sumida; Ian A. Meinertzhagen; Yoshiya Tominaga; Yasuyuki Shimohigashi
ZOOLOGICAL SCIENCE, Dec. 2005 - Partial chemical modification of a microchannel and stabilization of water-oil phase separation
Yamaguchi Y; Ogino K; Takagi F; Honda, T; Yamashita K; Miyazaki, M; Nakamura, H; Maeda, H
2005 AIChE Spring National Meeting, Conference Proceedings, 2005, [Reviewed] - Influence of solubility/mixing effects on chemical reactions in microfluidic systems
Honda, T; Miyazaki, M; Yamashita K; Yamaguchi Y; Uehara M; Nakamura, H; Maeda, H
2005 AIChE Spring National Meeting, Conference Proceedings, 2005, [Reviewed]
Lead - Immunological Evidences of Circadian Neuropeptide PDF Isoform Present at the Lamina Outer Cells and Varicose Network in the Optic Lobes of the Cricket Gryllus bimaculatus
Takeshi Honda; Ayami Matsushima; Daisuke Hiramura; Kazunori Sumida; Yukimasa Takeda; Seiji Sato; I. A. Meinertzagen; Yoshiya Tominaga; Yasuyuki Shimohigashi; Miki Shimohigashi
Peptide Science, 2005, [Reviewed]
Lead - Highly sensitive monoclonal antibodies to distinguish conformational changes induced by endocrine disrupting chemicals in the estrogen receptor.
Kuwata, O; Honda, T; Asai, D; Tokunaga, T; Shibuya, A; Shirasu, N; Nose, T; Shimohigashi, Y
Peptide Science 2004, 2005 - Structural Characteristics of the N-Terminal Octapeptide Repeat Region of Prion Protein in Self-Polymerization
Horiuchi, Y; Kawano, M; Yokotani, S; Honda, T; Matsushima, A; Nose, T; Shimohigashi, Y
Peptide Science 2004, 2005 - Conformation Change-senseing Assay Using Monoclonal Antibody for N-terminal Octapeptide Repreat Region of Prion Protein
Kawano, M; Honda, T; Horiuchi, Y; Yokotani, S; Matsushima, A; Nose, T; Shimohigashi, Y
Peptide Science, 2005 - Immunocytochemical Identification of Mature Peptide Formation for the Circadian Neuromodulator PDF in the Housefly Musca domestica
Sumida, K; Honda, T; Matsushima, A; Tominaga, Y; Shimohigashi, Y; Shimohigashi, M
Peptide Science 2004, 2005 - Localization profiles of circadian neuropeptide PDF in the brain of flies, Musca domestica
Miki Shimohigashi; Kazunori Sumida; Takeshi Honda; Ayarmi Matsushima; Takeru Nose; Yasuyuki Shimohigashi; Yoshiya Tominaga
ZOOLOGICAL SCIENCE, Dec. 2004, [Reviewed] - Structural Requirement of the Acyl Group of Ac-RYYRIK-NH_2, an Antagonist of Algesic Neuropeptide Nociceptin
ISOZAKI Kaname; OKADA Kazushi; KAWANO Michiaki; HONDA Takeshi; NOSE Takeru; COSTA Tommaso; SHIMOHIGASHI Yasuyuki
Peptide science, 01 Mar. 2004 - Specific Affinity Labeling of Cys60 in the δ Opioid Receptor by Npys-containing Dynorphin A Analog
ISOZAKI Kaname; FUKAHORI Hidehiko; OKADA Kazushi; SHIRASU Naoto; HONDA Takeshi; NOSE Takeru; SAKAGUCHI Kazuyasu; COSTA Tommaso; SHIMOHIGASHI Yasuyuki
Peptide Science, 2004 - Development of Enzyme Microreactor for Multistep Enzyme Reaction
Miyazaki Masaya; Kohama Ryo; Honda Takeshi; Yamaguchi Yoshiko; Yamashita Kenichi; Uehara Masato; Nakamura Hiroyuki; Maeda Hideaki
Asian Pacific Confederation of Chemical Engineering congress program and abstracts, 2004 - Structural Requirements of the N-terminal Octapeptide Repeat of Prion Protein
M. Kawano; Y. Horiuchi; T Honda; S. Yokotani; A. Matushima; T, Nose; Y. Shimohigashi
Peptide Science, 2004 - Localization profiles of circadian neuropeptide PDF in brain of the cricket Gryllus Bimaculatus.
Honda, T; Chuman, Y; Matsushima, A; Asai, D; Sumida, T; Nose, T; Sakaguchi, K; Onoue, H; Tominaga, Y; Shimohigashi, Y; Shimohigashi, M
Peptide Science, 2004
Lead - Phosphorylation Site-Specific Monoclonal Antibody Recognizing Ser(P)-Gln Sequence
Sakaguchi K; Honda T; Onoue H; Shimohigashi Y
Peptide Science, 2003 - The Attempt to Identify the Binding Sites of Nociceptin Antagonist Ac-RYYRIK-NH2 in ORL1 Receptor
KAWANO Michiaki; OKADA Kazushi; KIM Young Hwa; HONDA Takeshi; FUJITA Tsugumi; CHUMAN Yoshiro; NOSE Takeru; COSTA Tommaso; SHIMOHIGASHI Yasuyuki
Peptide Science, 2003 - Localization Profiles of the Precursor Protein of Circadian Rhythm Pacemaker Hormone PDF in Gryllus Brain
T. Honda; Y. Chuman; A. Matsushima; D. Asai; T. Nose; K. Sakaguchi; H. Onoue; Y. Tominaga; Y. Shimohigashi; M. Shimohigashi
Peptide Science 2002, 2003
Lead - Structure-Activity Studies on the Nociceptin Peptidic Antagonist Ac-RYYRIK-NH2
KAWANO Michiaki; HONDA Takeshi; OKADA Kazushi; CHUMAN Yoshiro; NOSE Takeru; SAKAGUCHI Kazuyasu; COSTA Tommaso; SHIMOHIGASHI Yasuyuki
Peptide Science, 2002 - Differential Receptor Binding Characteristics of the Phenylalanine Residues at Position 3-4 Endomorphine 2
HONDA Takeshi; SHIGEHIRO Daiki; OKADA Kazushi; SHIRASU Naoto; CHUMAN Yoshiro; FUJITA Tsugumi; NOSE Takeru; SAKAGUCHI Kazuyasu; SHIMOHIGASHI Yasuyuki
Peptide Science, 2001
Lead - The Mode of Molecular Interaction of Phe-3 of Deltorphon II and Endomorphin-2 in Opioid Receptor Binding
HONDA Takeshi; SHIGEHIRO Daiki; SHIRASU Naoto; CHUMAN Yoshiro; FUJITA Tsugumi; NOSE Takeru; SHIMOHIGASHI Yasuyuki
Peptide Science, 2000
Lead - Receptor Interaction Mode of the Phe-phenyl Group of Opioid Peptides
SHIRASU Naoto; OKADA Kazushi; CHUMAN Yoshiro; FUJITA Tsugumi; HONDA Takeshi; SHIGEHIRO Daiki; NOSE Takeru; SHIMOHIGASHI Yasuyuki
Peptide Science, 2000
- Applied Bioengineering: Innovations and Future Directions
Honda T; Yamaguchi H; Miyazaki M, Contributor, 5. Development of enzymatic reactions in miniaturized reactors
Wiley-VCH, Jun. 2017, Not reviewed
9783527340750 - Microreactors in Organic Chemistry and Catalysis, Second Edition
Miyazaki M; Briones-Nagata MP; Honda T; Yamaguchi H, Contributor, Chapter 10 Bioorganic and Biocatalytic Reactions
Wiley-VCH, Apr. 2013, Not reviewed
9783527332991 - Micro Process Engineering Micro Process Engineering: A Comprehensive Handbook
Honda T; Maeda H, Contributor, Chapter 32: Polycondensation
Wiley-VCH, Apr. 2009, Not reviewed
9783527315505 - 酵素の開発・利用の最新技術
宮崎真佐也; 本田 健; 前田英明, Contributor, 第４編 酵素の反応場・反応促進、第５章 マイクロリアクターを用いる酵素反応
シーエムシー出版, Dec. 2006, Not reviewed
4882316633
■ Affiliated academic society
■ Research Themes
- Development of aptamers targeting cell adhesion factors characteristically highly expressed in "combined hepatocellular-cholangiocarcinoma" and evaluation of their anti-tumour effects
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2024 - Mar. 2027 - ポリアミン類による加齢関連マクロファージの細胞死誘導効果
加齢・発生分化・生体防御の基盤的研究
山口大学
Apr. 2022 - Mar. 2023 - ハイブリッド型核酸アプタマーによる革新的心不全治療薬の開発（ステップアップ継続採用）
Dec. 2021 - Mar. 2022 - 液-液相分離体パラスペックルを介したPDZRN3による心筋分化制御機構の解明
山口大学
Apr. 2021 - Mar. 2022 - 加齢に伴う筋骨格系細胞の細胞外マトリックス関連因子における変調とその作用解析（継続採用）
加齢・発生分化・生体防御の基盤的研究
山口大学
Apr. 2021 - Mar. 2022 - ハイブリッド型核酸アプタマーによる革新的心不全治療薬の開発
Dec. 2020 - Mar. 2021 - 加齢に伴う筋骨格系細胞の細胞外マトリックス関連因子における変調とその作用解析
加齢・発生分化・生体防御の基盤的研究
Apr. 2020 - Mar. 2021 - Development of Novel Cyclic Peptide Drugs Targeting Phospholamban for the Treatment of Heart Failure
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
Apr. 2018 - Mar. 2021 - Ultrastructural analysis of calcium transport system of cardiac sarcoplasmic reticulum for drug development
Grant-in-Aid for Scientific Research (B)
Yamaguchi University
Apr. 2017 - Mar. 2020 - Elucidation of the molecular mechanisms by a cyclic peptide, SEK-1005 promotes skin wound healing
Grant-in-Aid for Challenging Exploratory Research
Yamaguchi University
Apr. 2016 - Mar. 2019 - Development of cardiomyocyte-specific intracellular drug-delivery system for therapy of cardiac diseases
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
Apr. 2015 - Mar. 2018 - 心臓特異的に細胞内部へ薬物を導入するための新たな分子標的型薬物送達システムの開発と心不全治療への応用
Apr. 2016 - Mar. 2017 - Development of a new drug for heart failure targeting phospholamban
Grant-in-Aid for Scientific Research (B)
Yamaguchi University
Apr. 2013 - Mar. 2016 - Study on the functions of PDZRN3, a novel regulator of adipogenesis, for the development of therapy for diabetes
Grant-in-Aid for Scientific Research (C)
Yamaguchi University
Apr. 2012 - Mar. 2015 - 心筋細胞特異的な細胞内薬物送達システムの開発
Apr. 2013 - Mar. 2014 - 高感度・高選択性化学的手法を用いたインスリン様増殖因子の新たな細胞遊走制御シグナルの探索
Apr. 2012 - Mar. 2013 - Study on the function of a novel Wnt-signaling regulator PDZRN3 and the development of bone regeneration therapy
Grant-in-Aid for Young Scientists (B)
Yamaguchi University
Apr. 2010 - Mar. 2012 - Development of a novel inotropic and lucitorpic agent for treatment of heart failure
Grant-in-Aid for Scientific Research (B)
Yamaguchi University
2010 - 2012 - PDZRN3による新たなWntシグナル制御機構とその細胞分化における役割の解明
Apr. 2010 - Mar. 2011 - Localization mechanism of a Ca^<2+> pump modulator, phospholamban in cardiac sarcoplasmic reticulum
Grant-in-Aid for Young Scientists (B)
Yamaguchi University
Apr. 2008 - Mar. 2010
