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Hasuzawa Nao
Division of Endocrinology and Metabolism Department of Internal Medicine
Assistant Professor
Research activity information
■ Paper
■ Research Themes
- Vesicular nucleotide transporter (VNUT)-dependent ATP secretion by hepatic stellate cells promotes liver fibrosis.
Masaharu Kabashima; Nao Hasuzawa; Lixiang Wang; Junjiro Rikitake; Seiji Nomura; Tomohiro Niimoto; Rie Tokubuchi; Sawako Moriyama; Mizuki Gobaru; Yukihiro Inoguchi; Ayako Nagayama; Kenji Ashida; Keisuke Ohta; Yoshinori Moriyama; Masatoshi Nomura
Biochimica et biophysica acta. Molecular basis of disease, 04 Feb. 2026 - Drp1-mediated mitochondrial fission protects macrophages from mtDNA/ZBP1-mediated inflammation and inhibits post-infarct cardiac remodeling.
Yuki Kondo; Jun-Ichiro Koga; Nasanbadrakh Orkhonselenge; Lixiang Wang; Nao Hasuzawa; Shunsuke Katsuki; Tetsuya Matoba; Yosuke Nishimura; Masatoshi Nomura; Masaharu Kataoka
Cardiovascular research, 16 Jan. 2026 - Development of a questionnaire-based Dietary Inflammatory Index assessment for clinical implementation.
Mamiko Yano; Nao Hasuzawa; Natsumi Maruyama; Lixiang Wang; Mizuki Gobaru; Ayako Nagayama; Kenji Ashida; Hitoshi Obara; Kenta Murotani; Yoshinori Moriyama; Masatoshi Nomura
Journal of clinical biochemistry and nutrition, Jan. 2026 - Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells.
Seiji Nomura; Lixiang Wang; Nao Hasuzawa; Ayako Nagayama; Sawako Moriyama; Kenji Ashida; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
FEBS letters, Dec. 2025 - Extravesicular chloride ion regulates the uptake of ATP, sulfate, and inorganic phosphate by membrane vesicles from bovine adrenal chromaffin granules.
Yoshinori Moriyama; Seiji Nomura; Sawako Moriyama; Nao Hasuzawa; Masatoshi Nomura
The Journal of biological chemistry, Dec. 2025 - Alterations in gut microbiota and insights into the colonic function by clodronate: a study using short bowel syndrome rat model.
Ayaka Nagano; Yudai Tsuruno; Koshiro Sugita; Shun Onishi; Yumiko Tabata; Chihiro Kedoin; Masakazu Murakami; Keisuke Yano; Toshio Harumatsu; Takafumi Kawano; Nao Hasuzawa; Masatoshi Nomura; Tatsuru Kaji; Satoshi Ieiri
Pediatric surgery international, 18 Aug. 2025 - Vesicular nucleotide transporter inhibition via clodronate attenuates intestinal glucose transporter expression in short bowel syndrome rat model: A clear issue to nutritional adaptation.
Ayaka Nagano; Yudai Tsuruno; Koshiro Sugita; Shun Onishi; Yumiko Tabata; Chihiro Kedoin; Masakazu Murakami; Keisuke Yano; Toshio Harumatsu; Takafumi Kawano; Nao Hasuzawa; Masatoshi Nomura; Tatsuru Kaji; Satoshi Ieiri
Journal of pediatric surgery, 16 Jul. 2025 - Impact of Drp1 Loss on Organelle Interaction, Metabolism, and Inflammation in Mouse Liver.
Lixiang Wang; Seiji Nomura; Nao Hasuzawa; Sadaki Yokota; Ayako Nagayama; Kenji Ashida; Junjiro Rikitake; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
Cells, 08 May 2025 - Effect of imeglimin on metabolic dysfunction-associated steatotic liver disease in individuals with type 2 diabetes.
Naruyoshi Gyoutoku; Yukihiro Inoguchi; Junjiro Rikitake; Mutsuyuki Demiya; Mizuki Gobaru; Ayako Nagayama; Shimpei Iwata; Nao Hasuzawa; Hitomi Nakayama; Kenji Ashida; Masatoshi Nomura
PloS one, 2025 - Sodium-glucose cotransporter 2 inhibitors-but not insulin-enhance renal branched-chain amino acid catabolism.
Moeko Sakamoto; Nao Hasuzawa; Lixiang Wang; Kyoko Tashiro; Miyuki Kitamura; Shimpei Iwata; Nobuhiko Wada; Seiji Nomura; Sawako Moriyama; Mizuki Gobaru; Yukihiro Inoguchi; Ayako Nagayama; Kenji Ashida; Yoshinori Moriyama; Masatoshi Nomura
Frontiers in endocrinology, 2025 - Favorable inhibitory effect of clodronate on hepatic steatosis in short bowel syndrome model rats.
Yudai Tsuruno; Ayaka Nagano; Koshiro Sugita; Shun Onishi; Yumiko Tabata; Chihiro Kedoin; Masakazu Murakami; Keisuke Yano; Takafumi Kawano; Nao Hasuzawa; Masatoshi Nomura; Tatsuru Kaji; Yuko Bitoh; Satoshi Ieiri
Pediatric surgery international, 13 Nov. 2024 - Preserved seasonal variation in glycemic control in patients with type 2 diabetes mellitus during COVID-19: a 3-year-long retrospective cohort study in older adults in Japan.
Shimpei Iwata; Kenji Ashida; Mutsuyuki Demiya; Ayako Nagayama; Nao Hasuzawa; Satoko Yoshinobu; Aya Sonezaki; Junichi Yasuda; Seiichi Motomura; Yoshio Katsuki; Kenzo Sugi; Masatoshi Nomura
BMC endocrine disorders, 17 May 2024 - Successful Superficial Blood Sampling to Localize a Fibroblast Growth Factor-23-Producing Tumor.
Junjiro Rikitake; Kenji Ashida; Ayako Nagayama; Yukihiro Inoguchi; Nao Hasuzawa; Masamichi Koganemaru; Tetsuya Hamada; Kanoko Moritaka; Mutsuyuki Demiya; Tomoki Sako; Jun Akiba; Koji Hiraoka; Masatoshi Nomura
The American journal of case reports, 13 Apr. 2024 - María Teresa Miras Portugal: a pioneer for vesicular nucleotide storage.
Yoshinori Moriyama; Nao Hasuzawa; Masatoshi Nomura
Purinergic signalling, Apr. 2024 - Mitochondrial fission is required for thermogenesis in brown adipose tissue.
Yuta Ibayashi; Nao Hasuzawa; Seiji Nomura; Masaharu Kabashima; Ayako Nagayama; Shimpei Iwata; Miyuki Kitamura; Kenji Ashida; Yoshinori Moriyama; Ken Yamamoto; Masatoshi Nomura; Lixiang Wang
PloS one, 2024 - Reduced Number of Remaining or Healthy Teeth in Patients with Type 2 Diabetes Mellitus: A Cross-sectional Study Assessed by Dentists or Dental Hygienists in Japan.
Noboru Kurinami; Kenji Ashida; Seigo Sugiyama; Yoko Morito; Nao Hasuzawa; Akira Yoshida; Ayami Morita; Kunio Hieshima; Fumio Miyamoto; Keizo Kajiwara; Katsunori Jinnouchi; Tomio Jinnouchi; Hideaki Jinnouchi; Masatoshi Nomura
Internal medicine (Tokyo, Japan), 2023 - Metyrosine-associated endocrinological changes in pheochromocytoma and paraganglioma.
Yuko Matsuo; Kenji Ashida; Ayako Nagayama; Kanoko Moritaka; Mizuki Gobaru; Junichi Yasuda; Naoyuki Ogasawara; Hirofumi Kurose; Katsuaki Chikui; Shimpei Iwata; Yukihiro Inoguchi; Nao Hasuzawa; Seiichi Motomura; Tsukasa Igawa; Masatoshi Nomura
Endocrine oncology (Bristol, England), 01 Jan. 2023 - Effects of Elobixibat, an Inhibitor of Ileal Bile Acid Transporter, on Glucose and Lipid Metabolism: A Single-arm Pilot Study in Patients with T2DM.
Satoko Yoshinobu; Nao Hasuzawa; Ayako Nagayama; Shimpei Iwata; Junichi Yasuda; Rie Tokubuchi; Masaharu Kabashima; Mizuki Gobaru; Kento Hara; Kenta Murotani; Yoshinori Moriyama; Kenji Ashida; Masatoshi Nomura
Clinical therapeutics, Oct. 2022 - A simplified prediction model for end-stage kidney disease in patients with diabetes.
Toyoshi Inoguchi; Tasuku Okui; Chinatsu Nojiri; Erina Eto; Nao Hasuzawa; Yukihiro Inoguchi; Kentaro Ochi; Yuichi Takashi; Fujiyo Hiyama; Daisuke Nishida; Fumio Umeda; Teruaki Yamauchi; Daiji Kawanami; Kunihisa Kobayashi; Masatoshi Nomura; Naoki Nakashima
Scientific reports, 21 Jul. 2022 - Eruptive xanthomas as a marker for metabolic disorders: A specific form of xanthoma that reflects hypertriglyceridemia.
Sohichiroh Ohtaki; Kenji Ashida; Yuko Matsuo; Kanoko Moritaka; Shimpei Iwata; Ayako Nagayama; Aya Kawaguchi; Hiroshi Koga; Satoko Yoshinobu; Nao Hasuzawa; Seiichi Motomura; Jun Akiba; Takekuni Nakama; Masatoshi Nomura
Clinical case reports, Apr. 2022 - Case Report: Myxedema Coma Caused by Immunoglobulin A Vasculitis in a Patient With Severe Hypothyroidism.
Hiroshi Ito; Kenzo Fukuda; Kenji Ashida; Ayako Nagayama; Tomoki Sako; Kouichiro Mizuochi; Masaharu Kabashima; Satoko Yoshinobu; Shimpei Iwata; Nao Hasuzawa; Sumika Hayashi; Tomoyuki Akashi; Masatoshi Nomura
Frontiers in immunology, 2022 - Is the vesicular nucleotide transporter a molecular target of eicosapentaenoic acid?
Yoshinori Moriyama; Nao Hasuzawa; Masatoshi Nomura
Frontiers in pharmacology, 2022 - Quinacrine is not a vital fluorescent probe for vesicular ATP storage.
Nao Hasuzawa; Sawako Moriyama; Lixiang Wang; Ayako Nagayama; Kenji Ashida; Yoshinori Moriyama; Masatoshi Nomura
Purinergic signalling, Dec. 2021 - An Open-label Phase I/IIa Clinical Trial of 11β-HSD1 Inhibitor for Cushing's Syndrome and Autonomous Cortisol Secretion.
Satoko Oda; Kenji Ashida; Makiko Uchiyama; Shohei Sakamoto; Nao Hasuzawa; Ayako Nagayama; Lixiang Wang; Hiromi Nagata; Ryuichi Sakamoto; Junji Kishimoto; Koji Todaka; Yoshihiro Ogawa; Yoichi Nakanishi; Masatoshi Nomura
The Journal of clinical endocrinology and metabolism, 27 Sep. 2021 - Dynamin-related protein 1 deficiency accelerates lipopolysaccharide-induced acute liver injury and inflammation in mice.
Lixiang Wang; Xin Li; Yuki Hanada; Nao Hasuzawa; Yoshinori Moriyama; Masatoshi Nomura; Ken Yamamoto
Communications biology, 21 Jul. 2021 - Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
Nao Hasuzawa; Keita Tatsushima; Lixiang Wang; Masaharu Kabashima; Rie Tokubuchi; Ayako Nagayama; Kenji Ashida; Yoshihiro Ogawa; Yoshinori Moriyama; Masatoshi Nomura
Scientific reports, 04 Mar. 2021 - Vesicular ATP release from hepatocytes plays a role in the progression of nonalcoholic steatohepatitis.
Keita Tatsushima; Nao Hasuzawa; Lixiang Wang; Miki Hiasa; Shohei Sakamoto; Kenji Ashida; Nobuyuki Sudo; Yoshinori Moriyama; Masatoshi Nomura
Biochimica et biophysica acta. Molecular basis of disease, 01 Mar. 2021 - [VNUT Is a Therapeutic Target for Type 2 Diabetes and NASH].
Nao Hasuzawa; Keita Tatsushima; Rie Tokubuchi; Masaharu Kabashima; Masatoshi Nomura
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2021 - Case Report: Metreleptin and SGLT2 Inhibitor Combination Therapy Is Effective for Acquired Incomplete Lipodystrophy.
Ayako Nagayama; Kenji Ashida; Miki Watanabe; Kanoko Moritaka; Aya Sonezaki; Yoichiro Kitajima; Hirokazu Takahashi; Satoko Yoshinobu; Shimpei Iwata; Junichi Yasuda; Nao Hasuzawa; Shuichi Ozono; Seiichi Motomura; Masatoshi Nomura
Frontiers in endocrinology, 2021 - Physiopathological roles of vesicular nucleotide transporter (VNUT), an essential component for vesicular ATP release.
Nao Hasuzawa; Sawako Moriyama; Yoshinori Moriyama; Masatoshi Nomura
Biochimica et biophysica acta. Biomembranes, 01 Dec. 2020 - Pasireotide-induced hyperglycemia in a patient with Cushing's disease: Potential use of sodium-glucose cotransporter 2 inhibitor and glucagon-like peptide-1 receptor agonist for treatment.
Masato Shikata; Kenji Ashida; Yuka Goto; Ayako Nagayama; Shimpei Iwata; Mamiko Yano; Nao Hasuzawa; Kento Hara; Kazutoshi Mawatari; Kiyohiko Sakata; Munehisa Tsuruta; Nobuhiko Wada; Masatoshi Nomura
Clinical case reports, Dec. 2020 - Macrophage (Drp1) Dynamin-Related Protein 1 Accelerates Intimal Thickening After Vascular Injury.
Ryuta Umezu; Jun-Ichiro Koga; Tetsuya Matoba; Shunsuke Katsuki; Lixiang Wang; Nao Hasuzawa; Masatoshi Nomura; Hiroyuki Tsutsui; Kensuke Egashira
Arteriosclerosis, thrombosis, and vascular biology, Jul. 2020 - Improvement of skeletal muscle insulin sensitivity by 1 week of SGLT2 inhibitor use.
Yuka Goto; Yoshie Otsuka; Kenji Ashida; Ayako Nagayama; Nao Hasuzawa; Shimpei Iwata; Kento Hara; Munehisa Tsuruta; Nobuhiko Wada; Seiichi Motomura; Yuji Tajiri; Masatoshi Nomura
Endocrine connections, Jul. 2020 - Necessity of Utilizing Physiological Glucocorticoids for Managing Familial Mediterranean Fever.
Kenji Ashida; Eriko Terada; Ayako Nagayama; Shohei Sakamoto; Nao Hasuzawa; Masatoshi Nomura
The American journal of case reports, 23 Mar. 2020 - Human Leukocyte Antigen (HLA) Subtype-Dependent Development of Myasthenia Gravis, Type-1 Diabetes Mellitus, and Hashimoto Disease: A Case Report of Autoimmune Polyendocrine Syndrome Type 3.
Mizuki Gobaru; Kenji Ashida; Satoko Yoshinobu; Ayako Nagayama; Masaharu Kabashima; Shimpei Iwata; Nao Hasuzawa; Munehisa Tsuruta; Nobuhiko Wada; Hitomi Nakayama; Seiichi Motomura; Yuji Tajiri; Masatoshi Nomura
The American journal of case reports, 20 Nov. 2019 - Metreleptin Supplementation for Improving Lipid and Glycemic Profiles in Acquired Diabetes Lipodystrophy: A Case Report.
Ayako Nagayama; Kenji Ashida; Kanoko Moritaka; Mami Hidaka; Mizuki Gobaru; Seiji Tanaka; Nao Hasuzawa; Shoko Akasu; Yuka Goto; Seiichi Motomura; Kento Hara; Munehisa Tsuruta; Nobuhiko Wada; Hitomi Nakayama; Yuji Tajiri; Masatoshi Nomura
Journal of the Endocrine Society, 01 Nov. 2019 - Brown adipose activation and reversible beige coloration in adipose tissue with multiple accumulations of 18F-fluorodeoxyglucose in sporadic paraganglioma: A case report.
Eriko Terada; Kenji Ashida; Kenji Ohe; Shohei Sakamoto; Nao Hasuzawa; Masatoshi Nomura
Clinical case reports, Jul. 2019 - A case of nivolumab-induced acute-onset type 1 diabetes mellitus in melanoma
Sakaguchi C; Ashida K; Yano S; Ohe K; Nagata H; Wada N; Hasuzawa N; Matsuda Y; Sakamoto S; Sakamoto R; Uchi H; Furue M; Ogawa Y; Nomura M
Curr Oncol., Feb. 2019, [Reviewed] - Autoimmune-Related Primary Hypoparathyroidism Possibly Induced by the Administration of Pembrolizumab: A Case Report.
Hitomi Umeguchi; Hiromasa Takenoshita; Hiroshi Inoue; Yuki Kurihara; Chihiro Sakaguchi; Seiichi Yano; Nao Hasuzawa; Shohei Sakamoto; Ryuichi Sakamoto; Kenji Ashida
Journal of oncology practice, Jul. 2018 - 神経因性・炎症性疼痛に有効な小胞型ヌクレオチドトランスポーターの特異的阻害剤の同定
加藤 百合, 日浅 未来, 市川 玲子, 蓮澤 奈央, 門脇 敦志, 岩槻 健, 島 和弘, 遠藤 康男, 北原 吉朗, 井上 剛, 野村 政壽, 表 弘志, 森山 芳則, 宮地 孝明.
脂質生化学研究, 2018 - Identification of a vesicular ATP release inhibitor for the treatment of neuropathic and inflammatory pain.
Yuri Kato; Miki Hiasa; Reiko Ichikawa; Nao Hasuzawa; Atsushi Kadowaki; Ken Iwatsuki; Kazuhiro Shima; Yasuo Endo; Yoshiro Kitahara; Tsuyoshi Inoue; Masatoshi Nomura; Hiroshi Omote; Yoshinori Moriyama; Takaaki Miyaji
Proceedings of the National Academy of Sciences of the United States of America, 01 Aug. 2017 - Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity.
Masatoshi Nomura; Hidetaka Morinaga; Hai-Lei Zhu; Lixiang Wang; Nao Hasuzawa; Ryoichi Takayanagi; Noriyoshi Teramoto
Biochemical and biophysical research communications, 18 Jul. 2014 - Two rare cases of familial (mother and daughter) adrenocorticotropic hormone-independent Cushing's syndrome due to adrenal adenoma, as well as the asynchronous development of another contralateral adrenal adenoma in the mother.
Atsushi Ogo; Yuka Sakaki; Nao Hasuzawa; Ryoko Saitou; Yuka Matoba; Takeshi Usui; Mitsuhide Naruse
Internal medicine (Tokyo, Japan), 2014
■ Research Themes
- Molecular mechanisms underlying hepatic VLDL secretion induced by extracellular ATP.
Grant-in-Aid for Early-Career Scientists
Kurume University
01 Apr. 2021 - 31 Mar. 2024 - ATP signaling controlled by mitochondrial dynamics
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2020 - 31 Mar. 2023 - The regulation of glucose metabolism affected by purinergic chemical transmission
Grant-in-Aid for Young Scientists (B)
Kyushu University
01 Apr. 2016 - 31 Mar. 2019
