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Higashimoto Yuichiro
Department of Chemistry
Professor
Research activity information
■ Paper
- Heme Regulatory Motif of Heme Oxygenase-2 Is Involved in the Interaction with NADPH–Cytochrome P450 Reductase and Regulates Enzymatic Activity
Masakazu Sugishima; Tomoichirou Kusumoto; Hideaki Sato; Hiroshi Sakamoto; Yuichiro Higashimoto; Ken Yamamoto; Junichi Taira
International Journal of Molecular Sciences, Mar. 2025 - Involvement of Mineralocorticoid Receptor Activation by High Mobility Group Box 1 and Receptor for Advanced Glycation End Products in the Development of Acute Kidney Injury.
Tomoyuki Otsuka; Seiji Ueda; Sho-Ichi Yamagishi; Hajime Nagasawa; Teruyuki Okuma; Keiichi Wakabayashi; Takashi Kobayashi; Maki Murakoshi; Masami Nakata; Tomohito Gohda; Takanori Matsui; Yuichiro Higashimoto; Yusuke Suzuki
Kidney360, 01 Feb. 2025 - Serum Levels of the C-terminal Fragment of Fibroblast Growth Factor 23 (C-FGF23) and Hepcidin in Patients with Hemodialysis Undergoing Treatment with a Proline Hydroxylase Domain (PHD) Inhibitor
Yoshihiro Motomiya; Yoshiteru Kaneko; Yasuki Motomiya; Yuichiro Higashimoto
Journal of Clinical Nephrology, 14 Oct. 2024
Last, Corresponding - DNA Aptamer Raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing Receptors for Advanced Glycation End Product-Induced Oxidative Stress and Inflammation in the Testes of Diabetic Mice
Yusaku Mori; Michishige Terasaki; Naoya Osaka; Tomoki Fujikawa; Hironori Yashima; Tomomi Saito; Yurie Kataoka; Makoto Ohara; Yuichiro Higashimoto; Takanori Matsui; Sho-ichi Yamagishi
International Journal of Molecular Sciences, 29 May 2024, [Reviewed] - Clinical Usefulness of the serum-Soluble Transferrin Receptor in Iron Dysregulation Associated with long-Term Hemodialysis
Yoshihiro Motomiya; Yoshiteru Kaneko; Yuichiro Higashimoto
International Journal of Clinical Case Reports and Reviews, 30 Apr. 2024, [Reviewed]
Last, Corresponding - Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice
Yusaku Mori; Makoto Ohara; Michishige Terasaki; Naoya Osaka; Hironori Yashima; Tomomi Saito; Yurie Otoyama-Kataoka; Takemasa Omachi; Yuichiro Higashimoto; Takanori Matsui; Tomoyasu Fukui; Sho-ichi Yamagishi
Biomedicines, 22 Nov. 2023, [Reviewed] - Circulating Levels of Fibroblast Growth Factor 23 Selective for C-Terminal (FGF23-CT) in Hemodialysis Patients
Tanaka Kenji; Higashimoto Yuichiro; Tomizawa Mituru; Motomiy Yasuki; Kaneko Yoshiteru
Journal of Clinical Nephrology, 13 Oct. 2023, [Reviewed] - SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis
Michishige Terasaki; Keita Shibata; Yusaku Mori; Tomomi Saito; Takanori Matsui; Makoto Ohara; Tomoyasu Fukui; Keiji Hasumi; Yuichiro Higashimoto; Koji Nobe; Sho-ichi Yamagishi
International Journal of Molecular Sciences, 30 Mar. 2023, [Reviewed] - Heparin and β2-microglobulin amyloidogenesis
Yuichiro Higashimoto; Yoshihiro Motomiya
GSC Biological and Pharmaceutical Sciences, 28 Feb. 2023, [Reviewed]
Lead, Corresponding - Serum Intact and Total Fibroblast Growth Factor 23 Levels and Iron-related Parameters in Hemodialysis Patients
Kenji Tanaka; Yasuki Motomiya; Yoshiteru Kaneko; Yuichiro Higashimoto; Tatsuo Yoneda
Journal of Clinical and Medical Research, 29 Oct. 2022, [Reviewed] - The Therapeutic Potential of DNA Aptamer for Dialysis-Related Amyloidosis
Yuichiro Higashimoto; Yoshihiro Motomiya
International Journal of Clinical Nephrology, 29 Sep. 2022, [Reviewed]
Lead, Corresponding - DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice
Yoshinori Koga; Ami Sotokawauchi; Yuichiro Higashimoto; Yuri Nishino; Naoki Hashizume; Tatsuyuki Kakuma; Jun Akiba; Yoshiaki Tanaka; Takanori Matsui; Minoru Yagi; Sho-ichi Yamagishi
Oxidative Medicine and Cellular Longevity, 07 Aug. 2021, [Reviewed] - Complex Formation of Heme Oxygenase-2 with Heme Is Competitively Inhibited by the Cytosolic Domain of Caveolin-1
Misaki Takemoto; Hiroshi Sakamoto; Yuichiro Higashimoto; Junichi Taira
Biochemistry, 27 Jul. 2021, [Reviewed] - Inhibitory effects of RAGE-aptamer on development of monocrotaline-induced pulmonary arterial hypertension in rats
Kazufumi Nakamura; Satoshi Akagi; Kentaro Ejiri; Masashi Yoshida; Toru Miyoshi; Masakiyo Sakaguchi; Naofumi Amioka; Luh Oliva Saraswati Suastika; Megumi Kondo; Rie Nakayama; Yoichi Takaya; Yuichiro Higashimoto; Kei Fukami; Hiromi Matsubara; Hiroshi Ito
Journal of Cardiology, Jul. 2021, [Reviewed] - DNA aptamer raised against receptor for advanced glycation end products suppresses renal tubular damage and improves insulin resistance in diabetic mice
Ami Sotokawauchi; Takanori Matsui; Yuichiro Higashimoto; Yuri Nishino; Yoshinori Koga; Minoru Yagi; Sho-ichi Yamagishi
Diabetes and Vascular Disease Research, Jan. 2021, [Reviewed] - Association of advanced glycation end products with sarcopenia and frailty in chronic kidney disease
Junko Yabuuchi; Seiji Ueda; Sho-ichi Yamagishi; Nao Nohara; Hajime Nagasawa; Keiichi Wakabayashi; Takanori Matsui; Yuichiro Higashimoto; Tomoyasu Kadoguchi; Tomoyuki Otsuka; Tomohito Gohda; Yusuke Suzuki
Scientific Reports, Dec. 2020, [Reviewed] - Erythropoiesis stimulating agents are associated with serum fibroblast growth factor 23 metabolism in patients on hemodialysis
Hirokazu Honda; Kenji Tanaka; Tetsuo Michihata; Keigo Shibagaki; Toshitaka Yuza; Keiichi Hirao; Naohisa Tomosugi; Tomas Ganz; Yuichiro Higashimoto
Clinical Kidney Journal, 23 Jun. 2020, [Reviewed]
Last, Corresponding - Heparin and Amyloid β2-Microglobulin
Yoshihiro Motomiya; Yuichiro Higashimoto
International Journal of Clinical Case Reports and Reviews, 05 May 2020, [Reviewed]
Last, Corresponding - Glyceraldehyde-Derived Pyridinium Evokes Renal Tubular Cell Damage via RAGE Interaction
Ami Sotokawauchi; Nobutaka Nakamura; Takanori Matsui; Yuichiro Higashimoto; Sho-ichi Yamagishi
International Journal of Molecular Sciences, Apr. 2020, [Reviewed] - Fructose causes endothelial cell damage via activation of advanced glycation end products-receptor system.
Sotokawauchi A; Matsui T; Higashimoto Y; Yamagishi SI
Diabetes & vascular disease research, Nov. 2019, [Reviewed] - Long-Term Local Injection of RAGE-Aptamer Suppresses the Growth of Malignant Melanoma in Nude Mice.
Nakamura N; Matsui T; Nishino Y; Sotokawauchi A; Higashimoto Y; Yamagishi SI
Journal of oncology, 2019, [Reviewed] - RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice
Kensei Taguchi; Sho-Ichi Yamagishi; Miyuki Yokoro; Sakuya Ito; Goh Kodama; Yusuke Kaida; Yosuke Nakayama; Ryotaro Ando; Nana Yamada-Obara; Katsuhiko Asanuma; Takanori Matsui; Yuichiro Higashimoto; Craig R. Brooks; Seiji Ueda; Seiya Okuda; Kei Fukami
Scientific Reports, 01 Dec. 2018, [Reviewed] - Advanced glycation end products evoke inflammatory reactions in proximal tubular cells via autocrine production of dipeptidyl peptidase-4.
Kaifu K; Ueda S; Nakamura N; Matsui T; Yamada-Obara N; Ando R; Kaida Y; Nakata M; Matsukuma-Toyonaga M; Higashimoto Y; Fukami K; Suzuki Y; Okuda S; Yamagishi SI
Microvascular research, Jul. 2018, [Reviewed] - Selection of DNA Aptamer That Blocks the Fibrillogenesis of a Proteolytic Amyloidogenic Fragment of β2m
Kanon Fukasawa; Yuichiro Higashimoto; Yukio Ando; Yoshihiro Motomiya
Therapeutic Apheresis and Dialysis, 01 Feb. 2018, [Reviewed]
Corresponding - Crucial role of RAGE in inappropriate increase of smooth muscle cells from patients with pulmonary arterial hypertension.
Kazufumi Nakamura; Masakiyo Sakaguchi; Hiromi Matsubara; Satoshi Akagi; Toshihiro Sarashina; Kentaro Ejiri; Kaoru Akazawa; Megumi Kondo; Koji Nakagawa; Masashi Yoshida; Toru Miyoshi; Takeshi Ogo; Takahiro Oto; Shinichi Toyooka; Yuichiro Higashimoto; Kei Fukami; Hiroshi Ito
PloS one, 2018, [Reviewed] - Methylglyoxal-derived hydroimidazolone-1 evokes inflammatory reactions in endothelial cells via an interaction with receptor for advanced glycation end products
Yuji Ishibashi; Takanori Matsui; Nobutaka Nakamura; Ami Sotokawauchi; Yuichiro Higashimoto; Sho-ichi Yamagishi
DIABETES & VASCULAR DISEASE RESEARCH, Sep. 2017, [Reviewed] - Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor
Junichi Taira; Yutaka Kida; Kohei Inatomi; Hideyuki Komatsu; Yuichiro Higashimoto; Hiroshi Sakamoto
JOURNAL OF BIOCHEMISTRY, Aug. 2017, [Reviewed] - RAGE-Aptamer Blocks the Development and Progression of Experimental Diabetic Nephropathy
Takanori Matsui; Yuichiro Higashimoto; Yuri Nishino; Nobutaka Nakamura; Kei Fukami; Sho-ichi Yamagishi
DIABETES, Jun. 2017, [Reviewed] - N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties
Yuji Ishibashi; Takanori Matsui; Fumiyuki Isami; Yumi Abe; Tatsuya Sakaguchi; Yuichiro Higashimoto; Sho-ichi Yamagishi
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, Mar. 2017, [Reviewed] - Phytochemicals Against Advanced Glycation End Products (AGEs) and the Receptor System
Sho-ichi Yamagishi; Takanori Matsui; Yuji Ishibashi; Fumiyuki Isami; Yumi Abe; Tatsuya Sakaguchi; Yuichiro Higashimoto
CURRENT PHARMACEUTICAL DESIGN, 2017, [Reviewed]
Last - RAGE-aptamer Attenuates the Growth and Liver Metastasis of Malignant Melanoma in Nude Mice
Nobutaka Nakamara; Takanori Matsui; Yuji Ishibashi; Ami Sotokawauchi; Kei Fukami; Yuichiro Higashimoto; Sho-ichi Yamagishi
MOLECULAR MEDICINE, 2017, [Reviewed] - Influence of heparin molecular size on the induction of C- terminal unfolding in β2-microglobulin.
Fukasawa K; Higashimoto Y; Motomiya Y; Uji Y; Ando Y
Molecular biology research communications, Dec. 2016, [Reviewed]
Corresponding - Protective Role of PEDF-Derived Synthetic Peptide Against Experimental Diabetic Nephropathy
Y. Ishibashi; T. Matsui; J. Taira; Y. Higashimoto; S. Yamagishi
HORMONE AND METABOLIC RESEARCH, Sep. 2016 - Peptide Deformylase Processable Triazole-containing Formyl Peptide Mimetics
H. Osako; J. Taira; Y. Higashimoto; H. Kodama; S. Osada
Mar. 2016, [Reviewed] - AGE aptamer inhibits neointimal hyperplasia in balloon-injured rat carotid arteries
Higashimoto Yuichiro; Ojima Ayako; Oda Eriko; Matsui Takanori; Yamagishi Sho-ichi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016, [Reviewed]
Lead, Corresponding - Improvement of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples
Junichi Taira; Yukinori Nakashima; Shun Yoshihara; Shinya Koga; Shinji Sueda; Hideyuki Komatsu; Yuichiro Higashimoto; Toru Takahashi; Nohito Tanioka; Hiroko Shimizu; Hiroshi Morimatsu; Hiroshi Sakamoto
ANALYTICAL BIOCHEMISTRY, Nov. 2015, [Reviewed] - Development of a monoclonal antibody-based ELISA system for glyceraldehyde-derived advanced glycation end products
Takanori Matsui; Hoo Don Joo; Jae Min Lee; Sung Mi Ju; Wang Hong Tao; Yuichiro Higashimoto; Kei Fukami; Sho-ichi Yamagishi
IMMUNOLOGY LETTERS, Oct. 2015, [Reviewed] - Pigment epithelium-derived factor inhibits caveolin-induced interleukin-8 gene expression and proliferation of human prostate cancer cells
Takanori Matsui; Ayako Ojima; Yuichiro Higashimoto; Junichi Taira; Kei Fukami; Sho-Ichi Yamagishi
ONCOLOGY LETTERS, Oct. 2015, [Reviewed] - DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice
Higashimoto Yuichiro; Matsui Takanori; Ojima Ayako; Maeda Sayaka; Takeuchi Masayoshi; Inoue Hiroyoshi; Yamagishi Sho-ichi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, [Reviewed]
Lead, Corresponding - RAGE-DNA APTAMER IMPROVES ALDOSTERON-INDUCED RENAL INJURY POSSIBLY VIA INHIBITION OF RAC1-MR AXIS IN MICE WITH HYPERTENSIVE NEPHROPATHY
Kensei Taguchi; Kei Fukami; Sho-ichi Yamagishi; Yuichiro Higashimoto; Miyuki Yokoro; Ryotaro Ando; Nana Obara; Yosuke Nakayama; Takanori Matsui; Seiji Ueda; Seiya Okuda
NEPHROLOGY DIALYSIS TRANSPLANTATION, May 2015, [Reviewed] - DNA Aptamer Raised Against Advanced Glycation End Products (AGEs) Improves Glycemic Control and Decreases Adipocyte Size in Fructose-Fed Rats by Suppressing AGE-RAGE Axis
A. Ojima; T. Matsui; N. Nakamura; Y. Higashimoto; S. Ueda; K. Fukami; S. Okuda; S. Yamagishi
HORMONE AND METABOLIC RESEARCH, Apr. 2015 - C-terminal unfolding of an amyloidogenic beta(2)-microglobulin fragment: Delta N6 beta(2)-microglobulin
Yoshihiro Motomiya; Yuichiro Higashimoto; Yoshinori Uji; Genki Suenaga; Yukio Ando
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, Mar. 2015, [Reviewed] - Glyceraldehyde-derived pyridinium (GLAP) evokes oxidative stress and inflammatory and thrombogenic reactions in endothelial cells via the interaction with RAGE
Takanori Matsui; Eriko Oda; Yuichiro Higashimoto; Sho-ichi Yamagishi
CARDIOVASCULAR DIABETOLOGY, Jan. 2015, [Reviewed] - DNA Aptamer Raised against Advanced Glycation End Products Prevents Abnormalities in Electroretinograms of Experimental Diabetic Retinopathy
Satoshi Maeda; Takanori Matsui; Ayako Ojima; Mika Suematsu; Kuniyoshi Kaseda; Yuichiro Higashimoto; Ryoji Yannakawa; Sho-ichi Yamagishi
OPHTHALMIC RESEARCH, 2015, [Reviewed] - Evaluation of in vitro properties of predicted kinases that phosphorylate serine residues within nuclear localization signal 1 of high mobility group box 1
Junichi Taira; Yuichiro Higashimoto
JOURNAL OF PEPTIDE SCIENCE, Aug. 2014, [Reviewed]
Last - Phosphorylation of Grb14 BPS domain by GSK-3 correlates with complex forming of Grb14 and insulin receptor
Junichi Taira; Yuichiro Higashimoto
Journal of Biochemistry, Jun. 2014, [Reviewed]
Last - DNA-APTAMER RAISED AGAINST RAGE BLOCKS THE PROGRESSION OF EXPERIMENTAL DIABETIC NEPHROPATHY
Taguchi Kensei; Fukami Kei; Yamagishi Sho-Ichi; Higashimoto Yuichiro; Yokoro Miyuki; Obara Nana; Ando Ryotaro; Nakayama Yosuke; Matsui Takanori; Takeuchi Masayoshi; Ueda Seiji; Okuda Seiya
NEPHROLOGY, May 2014, [Reviewed] - DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice
Ayako Ojima; Takanori Matsui; Sayaka Maeda; Masayoshi Takeuchi; Hiroyoshi Inoue; Yuichiro Higashimoto; Sho-ichi Yamagishi
LABORATORY INVESTIGATION, Apr. 2014, [Reviewed] - DNA aptamer raised against advanced glycation end products inhibits neointimal hyperplasia in balloon-injured rat carotid arteries
Ayako Ojima; Eriko Oda; Yuichiro Higashimoto; Takanori Matsui; Sho-ichi Yamagishi
INTERNATIONAL JOURNAL OF CARDIOLOGY, Feb. 2014, [Reviewed] - Structural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenase
Masakazu Sugishima; Hideaki Sato; Yuichiro Higashimoto; Jiro Harada; Kei Wada; Keiichi Fukuyama; Masato Noguchi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2014, [Reviewed] - DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy
Yuichiro Higashimoto; Yusuke Kaida; Takanori Matsui; Kei Fukami; Seiya Okuda; Sho-ichi Yamagishi; Masayoshi Takeuchi; Hiroyoshi Inoue
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, [Reviewed]
Lead - Laminin receptor mediates anti-inflammatory and anti-thrombogenic effects of pigment epithelium-derived factor in myeloma cells
Takanori Matsui; Yuichiro Higashimoto; Sho-ichi Yamagishi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2014, [Reviewed] - Pigment epithelium-derived factor (PEDF) binds to caveolin-1 and inhibits the pro-inflammatory effects of caveolin-1 in endothelial cells
Takanori Matsui; Yuichiro Higashimoto; Junichi Taira; Sho Ichi Yamagishi
Biochemical and Biophysical Research Communications, 15 Nov. 2013, [Reviewed] - Blockade by phosphorothioate aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells
Yuichiro Higashimoto; Takanori Matsui; Yuri Nishino; Junichi Taira; Hiroyoshi Inoue; Masayoshi Takeuchi; Sho ichi Yamagishi
Microvascular Research, Nov. 2013, [Reviewed]
Lead, Corresponding - DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy
Yusuke Kaida; Kei Fukami; Takanori Matsui; Yuichiro Higashimoto; Yuri Nishino; Nana Obara; Yosuke Nakayama; Ryotaro Ando; Maki Toyonaga; Seiji Ueda; Masayoshi Takeuchi; Hiroyoshi Inoue; Seiya Okuda; Sho-ichi Yamagishi
DIABETES, Sep. 2013, [Reviewed] - Protein phosphatase 2A dephosphorylates phosphoserines in nucleocytoplasmic shuttling and secretion of high mobility group box 1
Junichi Taira; Yutaka Kida; Koichi Kuwano; Yuichiro Higashimoto
JOURNAL OF BIOCHEMISTRY, Sep. 2013, [Reviewed]
Last - Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
Yuji Ishibashi; Takanori Matsui; Sayaka Maeda; Yuichiro Higashimoto; Sho-ichi Yamagishi
CARDIOVASCULAR DIABETOLOGY, Aug. 2013, [Reviewed] - EprS, an autotransporter protein of Pseudomonas aeruginosa, possessing serine protease activity induces inflammatory responses through protease-activated receptors
Yutaka Kida; Junichi Taira; Takeshi Yamamoto; Yuichiro Higashimoto; Koichi Kuwano
CELLULAR MICROBIOLOGY, Jul. 2013, [Reviewed] - Development of a heme sensor using fluorescently labeled heme oxygenase-1
Shinya Koga; Shun Yoshihara; Hiroki Bando; Kazuki Yamasaki; Yuichiro Higashimoto; Masato Noguchi; Shinji Sueda; Hideyuki Komatsu; Hiroshi Sakamoto
ANALYTICAL BIOCHEMISTRY, Feb. 2013, [Reviewed] - Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells
Junichi Taira; Yuichiro Higashimoto
Biochemical and Biophysical Research Communications, 2013, [Reviewed]
Last, Corresponding - Caveolin-1 Is a Competitive Inhibitor of Heme Oxygenase-1 (HO-1) with Heme: Identification of a Minimum Sequence in Caveolin-1 for Binding to HO-1
Junichi Taira; Masakazu Sugishima; Yutaka Kida; Eriko Oda; Masato Noguchi; Yuichiro Higashimoto
BIOCHEMISTRY, Aug. 2011, [Reviewed]
Last, Corresponding - Reduction of oxaporphyrin ring of CO-bound alpha-verdoheme complexed with heme oxygenase-1 by NADPH-cytochrome P450 reductase
Hideaki Sato; Yuichiro Higashimoto; Hiroshi Sakamoto; Masakazu Sugishima; Chizu Shimokawa; Jiro Harada; Graham Palmer; Masato Noguchi
JOURNAL OF INORGANIC BIOCHEMISTRY, Feb. 2011, [Reviewed] - Modifications on amphiphilicity and cationicity of unnatural amino acid containing peptides for the improvement of antimicrobial activity against pathogenic bacteria
Junichi Taira; Yutaka Kida; Hiroshi Yamaguchi; Koichi Kuwano; Yuichiro Higashimoto; Hiroaki Kodama
JOURNAL OF PEPTIDE SCIENCE, Nov. 2010, [Reviewed] - An improved anion-exchange high-performance liquid chromatography method for measuring oxidized form of LDLs in human plasma
Soichi Kitano; Yuichiro Higashimoto; Shoji Harada; Masaru Sano; Tsunehiko Kurata; Yu Yamaguchi; Masaru Kunitomo; Jun Haginaka; Sho-ichi Yamagishi
ANNALS OF CLINICAL BIOCHEMISTRY, Sep. 2010, [Reviewed] - Crystal structure of rat haem oxygenase-1 in complex with ferrous verdohaem: presence of a hydrogen-bond network on the distal side
Hideaki Sato; Masakazu Sugishima; Hiroshi Sakamoto; Yuichiro Higashimoto; Chizu Shimokawa; Keiichi Fukuyama; Graham Palmer; Masato Noguchi
BIOCHEMICAL JOURNAL, Apr. 2009, [Reviewed] - Involvement of Metals in Enzymatic and Nonenzymatic Decomposition of C-Terminal alpha-Hydroxyglycine to Amide: An Implication for the Catalytic Role of Enzyme-Bound Zinc in the Peptidylamidoglycolate Lyase Reaction
Kenichi Takahashi; Saori Harada; Yuichiro Higashimoto; Chizu Shimokawa; Hideaki Sato; Masakazu Sugishima; Yasuhiko Kaida; Masato Noguchi
BIOCHEMISTRY, Feb. 2009, [Reviewed] - A novel secreted protease from Pseudomonas aeruginosa activates NF-kappa B through protease-activated receptors
Yutaka Kida; Yuichiro Higashimoto; Hiroyoshi Inoue; Takashi Shimizu; Koichi Kuwano
CELLULAR MICROBIOLOGY, Jul. 2008, [Reviewed] - Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase
Yuichiro Higashimoto; Masakazu Sugishima; Hideaki Sato; Hiroshi Sakamoto; Keiichi Fukuyama; Graham Palmer; Masato Noguchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2008, [Reviewed]
Lead, Corresponding - 1P-115 Determination of structure of heme oxygenase-1 and cytochrome P450 reductase complex by electron cryo-microscopy(The 46th Annual Meeting of the Biophysical Society of Japan)
Nakao Ryota; Tutumi Yuka; Higashimoto Yuichiro; Noguchi Masato; Sakamoto Hiroshi; Yasunaga Takuo
Seibutsu Butsuri, 2008 - Electrochemical reduction of ferrous alpha-verdoheme in complex with heme oxygenase-1
Hideaki Sato; Yuichiro Higashimoto; Hiroshi Sakamoto; Masakazu Sugishima; Kenichi Takahashi; Graham Palmer; Masato Noguchi
JOURNAL OF INORGANIC BIOCHEMISTRY, Oct. 2007, [Reviewed] - In vitro selection of DNA aptamers that block toxic effects of AGE on cultured retinal pericytes
Yuichiro Higashimoto; Sho-ichi Yamagishi; Kazuo Nakamura; Takanori Matsui; Masayoshi Takeuchi; Masato Noguchi; Hiroyoshi Inoue
MICROVASCULAR RESEARCH, Jul. 2007, [Reviewed]
Lead, Corresponding - X-ray crystallographic and biochemical characterization of the inhibitory action of an imidazole-dioxolane compound on heme oxygenase
Masakazu Sugishima; Yuichiro Higashimoto; Tohru Oishi; Hidenori Takahashi; Hiroshi Sakamoto; Masato Noguchi; Keiichi Fukuyama
BIOCHEMISTRY, Feb. 2007, [Reviewed] - The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase - Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN
Yuichiro Higashimoto; Hideaki Sato; Hiroshi Sakamoto; Kenichi Takahashi; Graham Palmer; Masato Noguchi
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2006, [Reviewed]
Lead - Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer
Y Higashimoto; Y Asanomi; S Takakusagi; MS Lewis; K Uosaki; Durell, SR; CW Anderson; E Appella; K Sakaguchi
BIOCHEMISTRY, Feb. 2006, [Reviewed]
Lead - A kinetic study of the mechanism of conversion of alpha-hydroxyheme to verdoheme while bound to heme oxygenase
H Sakamoto; K Takahashi; Y Higashimoto; S Harada; G Palmer; M Noguchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2005, [Reviewed] - Structure and mechanism of heme oxygenase
SAKAMOTO Hiroshi; SUGISHIMA Masakazu; HIGASHIMOTO Yuichiro; FUKUYAMA Keiichi; NOGUCHI Masato
Seikagaku. The Journal of Japanese Biochemical Society, 25 Jul. 2005 - Involvement of NADP(H) in the interaction between heme oxygenase-1 and cytochrome P450 reductase
Y Higashimoto; H Sakamoto; S Hayashi; M Sugishima; K Fukuyama; G Palmer; M Noguchi
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2005, [Reviewed]
Lead - Purification and characterization of human uroporphyrinogen III synthase expressed in Escherichia coli
Y Omata; H Sakamoto; Y Higashimoto; S Hayashi; M Noguchi
JOURNAL OF BIOCHEMISTRY, Aug. 2004, [Reviewed] - Hydroxylamine and hydrazine bind directly to the heme iron of the heme-heme oxygenase-1 complex
H Sakamoto; Y Higashimoto; S Hayashi; M Sugishima; K Fukuyama; G Palmer; M Noguchi
JOURNAL OF INORGANIC BIOCHEMISTRY, Jul. 2004, [Reviewed] - Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene
S Hayashi; Y Omata; H Sakamoto; Y Higashimoto; T Hara; Y Sagara; M Noguchi
GENE, Jul. 2004, [Reviewed] - Multiepitope Trojan antigen peptide vaccines for the induction of antitumor CTL and Th immune responses
J Lu; Y Higashimoto; E Appella; E Celis
JOURNAL OF IMMUNOLOGY, Apr. 2004, [Reviewed] - Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preference
JCD Houtman; Y Higashimoto; N Dimasi; SW Cho; H Yamaguchi; B Bowden; C Regan; EL Malchiodi; R Mariuzza; P Schuck; E Appella; LE Samelson
BIOCHEMISTRY, Apr. 2004, [Reviewed] - The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX
RQ Ye; AA Goodarzi; EU Kurz; S Saito; Y Higashimoto; MF Lavin; E Appella; CW Anderson; SP Lees-Miller
DNA REPAIR, Mar. 2004, [Reviewed] - Phosphorylation site interdependence of human p53 post-translational modifications in response to stress
S Saito; H Yamaguchi; Y Higashimoto; C Chao; Y Xu; AJ Fornace; E Appella; CW Anderson
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2003, [Reviewed] - Crystal structure of rat heme oxygenase-1 in complex with biliverdin-iron chelate - Conformational change of the distal helix during the heme cleavage reaction
M Sugishima; H Sakamoto; Y Higashimoto; M Noguchi; K Fukuyama
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2003, [Reviewed] - Dual phosphorylation controls Cdc25 phosphatases and mitotic entry
DV Bulavin; Y Higashimoto; ZN Demidenko; S Meek; P Graves; C Phillips; H Zhao; SA Moody; E Appella; H Piwnica-Worms; AJ Fornace
NATURE CELL BIOLOGY, Jun. 2003, [Reviewed] - p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity
M Shiseki; M Nagashima; RM Pedeux; M Kitahama-Shiseki; K Miura; S Okamura; H Onogi; Y Higashimoto; E Appella; J Yokota; CC Harris
CANCER RESEARCH, May 2003, [Reviewed] - Proteomic analysis of early melanosomes: Identification of novel melanosomal proteins
Basrur, V; F Yang; T Kushimoto; Y Higashimoto; K Yasumoto; J Valencia; J Muller; WD Vieira; H Watabe; J Shabanowitz; VJ Hearing; DF Hunt; E Appella
JOURNAL OF PROTEOME RESEARCH, Jan. 2003 - Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
LJ Hofseth; S Saito; SP Hussain; MG Espey; KM Miranda; Y Araki; C Jhappan; Y Higashimoto; PJ He; SP Linke; MM Quezado; Zurer, I; Rotter, V; DA Wink; E Appella; CC Harris
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2003, [Reviewed] - Crystal structure of rat heme oxygenase-1 in complex with heme bound to azide - Implication for regiospecific hydroxylation of heme at the alpha-meso carbon
M Sugishima; H Sakamoto; Y Higashimoto; Y Omata; S Hayashi; M Noguchi; K Fukuyama
JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2002, [Reviewed] - MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation
A Ito; Y Kawaguchi; CH Lai; JJ Kovacs; Y Higashimoto; E Appella; TP Yao
EMBO JOURNAL, Nov. 2002, [Reviewed] - Multiple Chlamydia pneumoniae antigens prime CD8(+) Tc1 responses that inhibit intracellular growth of this vacuolar pathogen
B Wizel; BC Starcher; B Samten; Z Chroneos; PF Barnes; J Dzuris; Y Higashimoto; E Appella; A Sette
JOURNAL OF IMMUNOLOGY, Sep. 2002, [Reviewed] - A rational strategy to design multiepitope immunogens based on multiple th lymphocyte epitopes
B Livingston; C Crimi; M Newman; Y Higashimoto; E Appella; J Sidney; A Sette
JOURNAL OF IMMUNOLOGY, Jun. 2002, [Reviewed] - ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation
S Saito; AA Goodarzi; Y Higashimoto; Y Noda; SP Lees-Miller; E Appella; CW Anderson
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2002, [Reviewed] - Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
G D'Orazi; B Cecchinelli; T Bruno; Manni, I; Y Higashimoto; S Saito; M Gostissa; S Coen; A Marchetti; G Del Sal; G Piaggio; M Fanciulli; E Appella; S Soddu
NATURE CELL BIOLOGY, Jan. 2002, [Reviewed] - Side chain effect on ion channel characters of Aib rich peptides
T Hara; H Kodama; Y Higashimoto; H Yamaguchi; M Jelokhani-Niaraki; T Ehara; M Kondo
JOURNAL OF BIOCHEMISTRY, Dec. 2001, [Reviewed] - TAP-Independent presentation of CTL epitopes by trojan antigens
J Lu; PJ Wettstein; Y Higashimoto; E Appella; E Celis
JOURNAL OF IMMUNOLOGY, Jun. 2001, [Reviewed] - Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase
DV Bulavin; Y Higashimoto; IJ Popoff; WA Gaarde; Basrur, V; O Potapova; E Appella; AJ Fornace
NATURE, May 2001, [Reviewed] - Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes
CC Wilson; B Palmer; S Southwood; J Sidney; Y Higashimoto; E Appella; R Chesnut; A Sette; BD Livingston
JOURNAL OF VIROLOGY, May 2001, [Reviewed] - Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents
Y Higashimoto; S Saito; XH Tong; A Hong; K Sakaguchi; E Appella; CW Anderson
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2000, [Reviewed] - PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
M Pearson; R Carbone; C Sebastiani; M Cioce; M Fagioli; S Saito; Y Higashimoto; E Appella; S Minucci; PP Pandolfi; PG Pelicci
NATURE, Jul. 2000, [Reviewed] - HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
DL Doolan; S Southwood; R Chesnut; E Appella; E Gomez; A Richards; YI Higashimoto; A Maewal; J Sidney; RA Gramzinski; C Mason; D Koech; SL Hoffman; A Sette
JOURNAL OF IMMUNOLOGY, Jul. 2000, [Reviewed] - Inactivation of HIV-1 nucleocapsid protein P7 by pyridinioalkanoyl thioesters - Characterization of reaction products and proposed mechanism of action
Basrur, V; YS Song; SJ Mazur; Y Higashimoto; JA Turpin; WG Rice; JK Inman; E Appella
JOURNAL OF BIOLOGICAL CHEMISTRY, May 2000, [Reviewed] - Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase - Effect on Mdm2 binding
K Sakaguchi; S Saito; Y Higashimoto; S Roy; CW Anderson; E Appella
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2000, [Reviewed] - Ovalbumin in developing chicken eggs migrates from egg white to embryonic organs while changing its conformation and thermal stability
Y Sugimoto; S Sanuki; S Ohsako; Y Higashimoto; M Kondo; J Kurawaki; HR Ibrahim; T Aoki; T Kusakabe; K Koga
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1999, [Reviewed] - Calcium-dependent interaction of S100B with the C-terminal domain of the tumor suppressor p53
C Delphin; M Ronjat; JC Deloulme; G Garin; L Debussche; Y Higashimoto; K Sakaguchi; J Baudier
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1999, [Reviewed] - Structure-function relationship of model Aib-containing peptides as ion transfer intermembrane templates
Y Higashimoto; H Kodama; M Jelokhani-Niaraki; F Kato; M Kondo
JOURNAL OF BIOCHEMISTRY, Apr. 1999, [Reviewed] - Effect of environment on the stability of helical Aib-model peptides
H Kodama; T Hara; Y Higashimoto; H Yamaguchi; M Jelokhani-Niaraki; S Osada; M Kondo
PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, [Reviewed] - Effects of mutations on tetramer formation of tumor suppressor protein p53
Y Higashimoto; MS Lewis; P Kennedy; AM Gronenborn; GM Clore; E Appella; K Sakaguchi
PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, [Reviewed] - A urokinase-sensitive region of the human urokinase receptor is responsible for its chemotactic activity
F Fazioli; M Resnati; N Sidenius; Y Higashimoto; E Appella; F Blasi
EMBO JOURNAL, Dec. 1997, [Reviewed] - Determinants of T cell reactivity to the Mycobacterium leprae GroES homologue
J Kim; A Sette; S Rodda; S Southwood; PA Sieling; Mehra, V; JD Ohmen; J Oliveros; E Appella; Y Higashimoto; TH Rea; BR Bloom; RL Modlin
JOURNAL OF IMMUNOLOGY, Jul. 1997, [Reviewed] - Chemical synthesis of phosphorylated peptides of the carboxy-terminal domain of human p53 by a segment condensation method
H Sakamoto; H Kodama; Y Higashimoto; M Kondo; MS Lewis; CW Anderson; E Appella; K Sakaguchi
INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, Nov. 1996, [Reviewed]
- 終末糖化産物受容体を阻害するDNAアプタマーはLPS誘導性敗血症マウスの生存率を改善する
外川内 亜美; 古賀 義法; 東元 祐一郎; 西野 友梨; 松井 孝憲; 山岸 昌一
糖尿病, Apr. 2023 - Fibroblast growth factor 23 contributes to regulation of hepcidin/ferroportin axis
HIGASHIMOTO Yuichiro; MATSUI Takanori; SAKAGUCHI Tatsuya; TANAKA Yu; MOTOMIYA Yoshihiro
日本分子生物学会年会プログラム・要旨集(Web), 2023 - 終末糖化産物受容体を阻害するRAGEアプタマーはヒト単球細胞の細胞死を改善する
古賀 義法; 外川内 亜美; 東元 祐一郎; 西野 友梨; 松井 孝憲; 角間 辰之; 秋葉 純; 田中 芳明; 八木 実; 加治 建; 山岸 昌一
外科と代謝・栄養, 2023 - DNA aptamers against AGE-RAGE axis inhibit growth and metastasis of malignant melanoma in mice
松井孝憲; 東元祐一郎; 外川内亜美; 山岸昌一
日本分子生物学会年会プログラム・要旨集(Web), 2023 - 終末糖化産物受容体を阻害するRAGEアプタマーは敗血症マウスの生存率を改善する
古賀義法; 外川内亜美; 東元祐一郎; 西野友梨; 松井孝憲; 角間辰之; 秋葉純; 田中芳明; 八木実; 加治建; 山岸昌一
日本抗加齢医学会総会プログラム・抄録集, 2023 - SMTP-44DはApoE欠損マウスの動脈硬化進展を抑制する
寺崎道重; 柴田佳太; 柴田佳太; 森雄作; 斎藤智美; 松井孝憲; 八島広典; 大坂直也; 藤川大輝; 高畑洋; 広村宗範; 竹鼻伸晃; 高橋範之; 江波戸彩乃; 小原信; 福井智康; 蓮見惠司; 蓮見惠司; 東元祐一郎; 野部浩司; 野部浩司; 山岸昌一
日本抗加齢医学会総会プログラム・抄録集, 2023 - 終末糖化産物受容体を阻害するDNAアプタマーは敗血症マウスの生存率を改善する
古賀 義法; 外川内 亜美; 東元 祐一郎; 西野 友梨; 松井 孝憲; 角間 辰之; 秋葉 純; 八木 実; 加治 建; 山岸 昌一
外科と代謝・栄養, Jun. 2022 - DNAアプタマーによる終末糖化産物受容体の阻害は老年疾患を包括的に抑制する
外川内 亜美; 東元 祐一郎; 古賀 義法; 西野 友梨; 松井 孝憲; 山岸 昌一
日本抗加齢医学会総会プログラム・抄録集, Jun. 2022 - 終末糖化産物(AGEs)の阻害による老年病の包括的抑制
松井 孝憲; 東元 祐一郎; 山岸 昌一
日本抗加齢医学会総会プログラム・抄録集, Jun. 2022 - 終末糖化産物受容体を阻害するDNAアプタマーは敗血症マウスの生存率を改善する
古賀 義法; 外川内 亜美; 東元 祐一郎; 西野 友梨; 橋詰 直樹; 角間 辰之; 秋葉 純; 田中 芳明; 松井 孝憲; 八木 実; 山岸 昌一
日本小児外科学会雑誌, Apr. 2022 - DNAアプタマーを用いた終末糖化産物(AGE)および受容体(RAGE)の阻害は糖尿病合併症を包括的に抑制する
外川内 亜美; 東元 祐一郎; 松井 孝憲; 山岸 昌一
糖尿病, Apr. 2022 - 核酸医薬 終末糖化産物受容体阻害薬の敗血症への臨床応用
古賀 義法; 外川内 亜美; 松井 孝憲; 東元 祐一郎; 八木 実; 山岸 昌一
日本集中治療医学会雑誌, Sep. 2021 - 終末糖化産物受容体の阻害は2型糖尿病マウスのインスリン抵抗性および腎尿細管障害を改善する
外川内 亜美; 松井 孝憲; 西野 友梨; 東元 祐一郎; 山岸 昌一
日本抗加齢医学会総会プログラム・抄録集, Jun. 2021 - 終末糖化産物受容体RAGEを阻害するDNAアプタマーは、2型糖尿病マウスのインスリン抵抗性および腎尿細管障害を改善する
外川内 亜美; 松井 孝憲; 西野 友梨; 東元 祐一郎; 山岸 昌一
糖尿病, May 2021 - 内皮細胞におけるグリセルアルデヒド由来AGEsのRAGEを介した炎症作用はDNAアプタマーにより抑制しうる
松井 孝憲; 外川内 亜美; 東元 祐一郎; 山岸 昌一
糖尿病, May 2021 - 終末糖化産物受容体RAGEを阻害するDNAアプタマーは、2型糖尿病マウスのインスリン抵抗性および腎尿細管障害を改善する
外川内 亜美; 松井 孝憲; 西野 友梨; 東元 祐一郎; 山岸 昌一
糖尿病, May 2021 - 内皮細胞におけるグリセルアルデヒド由来AGEsのRAGEを介した炎症作用はDNAアプタマーにより抑制しうる
松井 孝憲; 外川内 亜美; 東元 祐一郎; 山岸 昌一
糖尿病, May 2021 - 新規敗血症治療薬の開発 終末糖化産物受容体阻害薬は敗血症モデルマウスの生存率を改善させる
古賀 義法; 外川内 亜美; 松井 孝憲; 東元 祐一郎; 角間 辰之; 八木 実; 山岸 昌一
日本外科学会定期学術集会抄録集, Apr. 2021 - Fibroblast growth factor 23 contributes to regulation of hepcidin/ferroportin axis.
Yuichiro Higashimoto; Kenji Tanaka; Takanori Matsui; Tatsuya Sakaguchi; Sho-ichi Yamagishi; Yoshihiro Motomiya
Austin J. Pharmacol. Ther., Dec. 2020, [Reviewed]
Lead, Corresponding - FGF23はヘプシジン・フェロポーチン鉄代謝制御系に影響をあたえるか
田中 賢治; 本宮 善恢; 江里口 雅裕; 東元 祐一郎
日本透析医学会雑誌, Oct. 2020 - グリセルアルデヒド由来ピリジニウムは終末糖化産物受容体を介して腎尿細管細胞を障害する
外川内 亜美; 中村 信孝; 松井 孝憲; 東元 祐一郎; 山岸 昌一
日本生化学会大会プログラム・講演要旨集, Sep. 2020 - グリセルアルデヒド由来AGEsであるGLAPとMG-H1の内皮細胞に対する炎症作用はDNAアプタマーにより抑制しうる
松井 孝憲; 外川内 亜美; 東元 祐一郎; 山岸 昌一
日本抗加齢医学会総会プログラム・抄録集, Sep. 2020 - フルクトースは終末糖化産物形成を介して内皮細胞を障害する
外川内 亜美; 松井 孝憲; 東元 祐一郎; 山岸 昌一
糖尿病, Aug. 2020 - 血液透析患者における腎性貧血治療と鉄代謝、FGF23との関係
本田 浩一; 田中 賢治; 平尾 圭市; 柴垣 圭吾; 油座 利貴; 道端 哲郎; 友杉 直久; Ganz Tomas; 東元 祐一郎
日本透析医会雑誌, Apr. 2020 - Cellulose‐derived charcoal binds to glyceraldehyde‐driven advanced glycation end products in vitro
西野友梨; 坂口達也; 東元祐一郎; 松井孝憲; 山岸昌一
Diabetes Frontier Online (Web), Dec. 2018 - 終末糖化産物受容体(RAGE)アプタマーは動物モデルの糖尿病腎症の発症・増悪,悪性黒色腫の増殖・転移を抑制する
松井孝憲; 中村信孝; 東元祐一郎; 山岸昌一
日本核酸医薬学会年会講演要旨集, 25 Jun. 2018 - 終末糖化産物受容体(RAGE)アプタマーは動物の糖尿病腎症の発症・増悪と悪性黒色腫の増殖・転移を阻害する
松井孝憲; 中村信孝; 東元祐一郎; 山岸昌一
日本分子生物学会年会プログラム・要旨集(Web), 2018 - 変異型β2ミクログロブリン(ΔN6β2m)特異的DNAアプタマーによるアミロイド凝集抑制効果の検討
深澤 伽音; 東元 祐一郎; 安東 由喜雄; 本宮 善恢
生命科学系学会合同年次大会, Dec. 2017 - マイクロアレイのメタ解析による色素上皮由来因子PEDFの関連遺伝子探索
坂口 達也; 東元 祐一郎
生命科学系学会合同年次大会, Dec. 2017 - 癌代謝物である2-ヒドロキシグルタル酸がヒト由来ペプチドC末端アミド化酵素PAMに与える影響
下川 千寿; 城田 沙織; 田; 佐藤 秀明; 杉島 正一; 原田 二朗; 東元 祐一郎; Amzel Mario; 野口 正人
生命科学系学会合同年次大会, Dec. 2017 - 腎症 終末糖化産物受容体(RAGE)アプタマーによるラットの糖尿病腎症の阻止
松井 孝憲; 東元 祐一郎; 山岸 昌一
糖尿病合併症, Oct. 2017 - 核酸アプタマーの医薬診断薬としての可能性
東元 祐一郎
久留米医学会雑誌, Jul. 2017 - 終末糖化産物受容体(RAGE)アプタマーによるラットの糖尿病腎症治療効果
松井 孝憲; 東元 祐一郎; 山岸 昌一
日本循環制御医学会総会プログラム・抄録集, Jun. 2017 - 終末糖化産物受容体(RAGE)アプタマーは、糖尿病ラット腎症の発症・進展を抑制する
松井 孝憲; 東元 祐一郎; 山岸 昌一
糖尿病, Apr. 2017 - 癌代謝物である2‐ヒドロキシグルタル酸がヒト由来ペプチドC末端アミド化酵素PAMに与える影響
下川千寿; 城田(原田)沙織; 佐藤秀明; 杉島正一; 原田二朗; 東元祐一郎; AMZEL Mario; 野口正人
日本生化学会大会(Web), 2017 - ループス腎炎におけるRAGEの機能的役割と発症予測因子としての可能性
田口 顕正; 前嶋 明人; 山岸 昌一; 東元 祐一郎; 中山 陽介; 深水 圭
日本高血圧学会総会プログラム・抄録集, Sep. 2016 - 終末糖化産物受容体(RAGE)のDNAアプタマーはラットの糖尿病腎症を改善する
松井 孝憲; 東元 祐一郎; 山岸 昌一
日本生化学会大会プログラム・講演要旨集, Sep. 2016 - RAGE-DNA aptamerはAGEs-RAGE系を抑制しMR活性腎障害を改善する
田口 顕正; 山岸 昌一; 松井 孝憲; 東元 祐一郎; 淺沼 克彦; 山本 靖彦; 上田 誠二; 深水 圭
日本腎臓学会誌, May 2016 - エリスロフェロン測定系での血清中夾雑タンパクの影響
田中 賢治; 東元 祐一郎; 深澤 伽音; 本宮 康樹; 益田 眞理; 大貫 雅弘; 本宮 善恢
日本透析医学会雑誌, May 2016 - 創薬を目指した糖尿病性腎症研究の展望 糖尿病性神経障害の進行に対して有望な治療標的としてのRAGE(Drug Discovery and Development for Diabetic Nephropathy RAGE as a promising therapeutic target for the progression of diabetic nephropathy)
深水 圭; 東元 祐一郎; 松井 孝憲; 田口 顕正; 山岸 昌一
糖尿病, Apr. 2016 - HUVECにおいてグリセルアルデヒド由来ピリジニウム(GLAP)はRAGEを介し酸化ストレスと炎症性・血栓性反応を惹起する
松井 孝憲; 東元 祐一郎; 山岸 昌一
糖尿病, Apr. 2016 - Surface Plasmon Resonance Study on the Interaction between the N-terminal Region of Heme Oxygenase-2 and NADPH-Cytochrome P450 Reductase
Junichi Taira; Shota Wada; Yuya Fukushima; Shinji Sueda; Hideyuki Komatsu; Yuichiro Higashimoto; Hiroshi Sakamoto
Peptide Science 2015, 2016 - RAGE-DNAアプタマーはRac1-MR経路を抑制しアルドステロン誘導性ポドサイト障害を改善する
田口 顕正; 山岸 昌一; 東元 祐一郎; 中山 陽介; 淺沼 克彦; 山本 靖彦; 上田 誠二; 深水 圭
血管, Jan. 2016 - AGEアプタマーはバルーンにより損傷したラット頸動脈中における新生血管内膜の過形成を抑制する
東元 祐一郎; 尾嶋 亜弥子; 小田 えり子; 松井 孝憲; 山岸 昌一
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015 - グリセルアルデヒド由来ピリジニウム(GLAP)はHUVECにおいてRAGEを介した酸化ストレスと炎症性反応と血栓性反応の増悪を引き起こす
松井 孝憲; 東元 祐一郎; 小田 えり子; 山岸 昌一
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015 - RAGE-DNAアプタマーはRac1-MR経路を抑制しアルドステロン誘導性ポドサイト障害を改善させる
田口 顕正; 山岸 昌一; 東元 祐一郎; 中山 陽介; 山本 靖彦; 淺沼 克彦; 上田 誠二; 深水 圭
日本高血圧学会総会プログラム・抄録集, Oct. 2015 - 高血圧性腎障害モデルにおけるAldosterone-RAGE系の役割とRAGE-aptamerの効果
田口 顕正; 深水 圭; 山岸 昌一; 松井 孝則; 東元 祐一郎; 山本 靖彦; 上田 誠二; 奥田 誠也
日本腎臓学会誌, Apr. 2015 - ヒト由来ペプチドC末端アミド化酵素の結晶構造解析を目指して
下川千寿; 城田(原田)沙織; RUDZKA Katarzyna; 杉島正一; 佐藤秀明; 東元祐一郎; AMZEL L. Mario; 野口正人
日本化学会講演予稿集, 11 Mar. 2015 - Effect of glycogen synthase kinase 3 on the complex forming between growth factor receptor bound protein 14 and insulin receptor
J. Taira; H. Sakamoto; Y. Higashimoto
Peptide Science 2014, 2015 - NADPH-シトクロムP450還元酵素とヘム-ヘムオキシゲナーゼ複合体との相互作用および電子伝達機構
杉島 正一; 小松 将大; 坂本 寛; 安永 卓生; 佐藤 秀明; 東元 祐一郎; 原田 二朗; 和田 啓; 福山 恵一; 山本 健; 野口 正人
日本生化学会大会プログラム・講演要旨集, Oct. 2014 - PEDFは内皮細胞のカベオリン-1による炎症誘発作用を阻害する
松井 孝憲; 東元 祐一郎; 平 順一; 山岸 昌一
日本生化学会大会プログラム・講演要旨集, Oct. 2014 - 終末糖化産物(AGEs)特異的DNAアプタマーはヌードマウスにおけるメラノーマ増殖を抑制する
東元 祐一郎; 松井 孝憲; 尾嶋 亜弥子; 前田 沙耶香; 竹内 正義; 井上 浩義; 山岸 昌一
日本生化学会大会プログラム・講演要旨集, Oct. 2014 - DNA-APTAMER RAISED AGAINST RAGE BLOCKS THE PROGRESSION OF EXPERIMENTAL DIABETIC NEPHROPATHY
K. Taguchi; K. Fukami; S. Yamagishi; Y. Higashimoto; M. Yokoro; N. Obara; R. Ando; Y. Nakayama; T. Matsui; M. Takeuchi; S. Ueda; S. Okuda
ATHEROSCLEROSIS, Aug. 2014 - RAGE-DNA-aptamerはAGEs-RAGE系を抑制し抗線維化作用を発揮する
田口 顕正; 深水 圭; 横路 三有紀; 山岸 昌一; 松井 孝憲; 東元 祐一郎; 竹内 正義; 上田 誠二; 奥田 誠也
日本腎臓学会誌, May 2014 - NADPH-シトクロムP450還元酵素からヘムオキシゲナーゼへの電子移動に関する構造基盤
杉島正一; 佐藤秀明; 東元祐一郎; 原田二朗; 和田啓; 福山恵一; 野口正人
日本蛋白質科学会年会プログラム・要旨集, 2014 - 糖尿病性腎症進展阻止をめざした次世代分子標的治療薬AGEs-aptamerの開発
甲斐田 裕介; 深水 圭; 松井 孝憲; 竹内 正義; 上田 誠二; 井上 浩義; 東元 祐一郎; 山岸 昌一; 奥田 誠也
日本内分泌学会雑誌, Sep. 2013 - Hinge欠損型NADPH-シトクロムP450還元酵素とヘムオキシゲナーゼ間の相互作用
杉島 正一; 東元 祐一郎; 佐藤 秀明; 原田 二朗; 下川 千寿; 城田 沙織; 野口 正人
日本生化学会大会プログラム・講演要旨集, Sep. 2013 - ヘムオキシゲナーゼ-2とシトクロムP450還元酵素の相互作用におけるビリベルジンの影響
和田 翔太; 東元 祐一郎; 末田 慎二; 小松 英幸; 坂本 寛
日本生化学会大会プログラム・講演要旨集, Sep. 2013 - 糖尿病腎症治療薬としてのAGEs-DNA aptamer
深水 圭; 山岸 昌一; 甲斐田 裕介; 東元 祐一郎; 竹内 正義; 井上 浩義; 松井 孝憲; 奥田 誠也
糖尿病合併症, Aug. 2013 - Functional Analysis Of Proline Of Heme Regulatory Motifs Of Heme Oxygenase-2
TSURUSAWA Ryoya; KOGA Shinya; HIGASHIMOTO Yuichiro; NOGUCHI Masato; SAKAMOTO Hiroshi
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2013 - Protein phosphatase 2A in macrophage dephosphorylates phosphoserines involved in nucleocytoplasmic shuttling and secretion of high mobility group box 1
J. Taira; Y. Kida; Y. Higashimoto
Peptide Science 2012, 2013 - Caveolin-1 interacts with protein phosphatase 5 and modulates its activity in prostate cancer cells
Junichi Taira; Yuichiro Higashimoto
Biochemical and Biophysical Research Communications, 2013 - ヘムオキシゲナーゼ分子表面に存在するF79の変異導入解析から見出された電子伝達機構
原田 二朗; 原田 英里砂; 東元 祐一郎; 佐藤 秀明; 杉島 正一; 平 順一; 福山 恵一; 菅瀬 謙治; 野口 正人
日本生化学会大会プログラム・講演要旨集, Dec. 2012 - ヘムオキシゲナーゼのヘム結合の熱力学 置換等温滴定熱測定による精密解析
小松 英幸; 奥田 真孝; 山本 真平; 東元 祐一郎; 野口 正人; 坂本 寛
日本生化学会大会プログラム・講演要旨集, Dec. 2012 - 表面プラズモン共鳴法によるヘムオキシゲナーゼ-2とシトクロムP450還元酵素の相互作用の検討
和田 翔太; 東元 祐一郎; 野口 正人; 末田 慎二; 小松 英幸; 坂本 寛
日本生化学会大会プログラム・講演要旨集, Dec. 2012 - マクロファージからのhigh mobility group box-1の分泌はセリン/スレオニンプロテインホスファターゼ2Aによって負に制御される
平 順一; 木田 豊; 東元 祐一郎
日本生化学会大会プログラム・講演要旨集, Dec. 2012 - グリセルアルデヒド由来AGEs特異的チオ核酸アプタマーのスクリーニングと糖尿病性腎症モデルマウスへの応用
東元 祐一郎; 甲斐田 裕介; 松井 孝憲; 深水 圭; 奥田 誠也; 山岸 昌一; 竹内 正義; 井上 浩義
日本生化学会大会プログラム・講演要旨集, Dec. 2012 - 表面プラズモン共鳴法を用いたヘムオキシゲナーゼ-2変異体とシトクロムP450還元酵素との相互作用解析
和田 翔太; 福嶋 祐也; 東元 祐一郎; 野口 正人; 末田 慎二; 小松 英幸; 坂本 寛
生化学, Oct. 2012 - ヘムオキシゲナーゼ-1とヘムとの結合における静電的相互作用の熱力学的解析
山本 真平; 奥田 真孝; 山下 耕平; 東元 祐一郎; 野口 正人; 小松 英幸; 坂本 寛
生化学, Oct. 2012 - Role of Proline in Heme Regulatory Motifs of Heme Oxygenase-2
TSURUSAWA Ryoya; KOGA Shinya; HIGASHIMOTO Yuichiro; NOGUCHI Masato; SAKAMOTO Hiroshi
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012 - Identification of essential amino acid residues involved in the interaction of heme oxygenase-1 with caveolin-1
J. Taira; M. Sugishima; Y. Kida; E. Oda; M. Noguchi; Y. Higashimoto
Peptide Science 2011, 2012 - 糖尿病性血管合併症治療薬としてのaptamer AGEs-DNA aptamerは糖尿病性糸球体障害を改善する
甲斐田 裕介; 深水 圭; 小原 奈々; 中山 陽介; 安藤 亮太郎; 竹内 正義; 上田 誠二; 井上 浩義; 東元 祐一郎; 山岸 昌一; 奥田 誠也
血管, Jan. 2012 - カベオリン-1によるヘムオキシゲナーゼ-1の阻害機構
平 順一; 杉島 正一; 木田 豊; 小田 えり子; 野口 正人; 東元 祐一郎
日本生化学会大会プログラム・講演要旨集, Sep. 2011 - ヘムオキシゲナーゼ-2とシトクロムP450還元酵素の相互作用の検討
福嶋 祐也; 東元 祐一郎; 野口 正人; 末田 慎二; 小松 英幸; 坂本 寛
日本生化学会大会プログラム・講演要旨集, Sep. 2011 - ヘムオキシゲナーゼの変異体の解析から考察される電子伝達経路
原田 二朗; 原田 英里砂; 東元 祐一郎; 佐藤 秀明; 杉島 正一; 平 順一; 福山 恵一; 菅瀬 謙治; 野口 正人
日本生化学会大会プログラム・講演要旨集, Sep. 2011 - 医薬化学 アプタマーによる標的分子捕捉機構の解明
東元 祐一郎
ファルマシア, May 2011 - Structural modification of 2-aminoisobutylic acid containing peptides toward an acquiring of antimicrobial activities against pathogenic bacteria
TAIRA Junichi; KIDA Yutaka; YAMAGUCHI Hiroshi; KUWANO Koichi; HIGASHIMOTO Yuichiro; KODAMA Hiroaki
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011 - Screening of natural sources inhibiting xanthine oxidase - Quercetin and Luteolin
Tomoko Endoh; Yuichiro Higashimoto; Hiroyoshi Inoue
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - Sensitive heme sensor using fluorescent-labeled heme oxygenase-1 "jointly worked"
S. Koga; Y. Higashimoto; M; Noguchi; H. Komatsu; H. Sakamoto
Peptide Science 2010, 2011 - バイオヘムセンサーを用いたヘム蛋白質の新規スクリーニング定量法の提案
古賀 真也; 山崎 一樹; 東元 祐一郎; 野口 正人; 小松 英幸; 坂本 寛
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010 - Heme Binding Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2
T. Ueda; S. Koga; Y. Higashimoto; M. Noguchi; H. Sakamoto
Peptide Science 2009, 2010 - Peptidylamidoglycolate lyase反応における亜鉛および鉄イオンの役割
下川千寿; 原田沙織; 東元祐一郎; 佐藤秀明; 杉島正一; 野口正人
日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 13 Sep. 2009 - 微量ヘム定量法に向けたバイオセンサーの開発
古賀 真也; 東元 祐一郎; 野口 正人; 小松 英幸; 坂本 寛
日本生化学会大会プログラム・講演要旨集, Sep. 2009 - ヘムオキシゲナーゼ-2とシトクロムP450還元酵素との相互作用におけるヘムとNADP(H)の影響
吉永 篤史; 東元 祐一郎; 野口 正人; 末田 慎二; 小松 英幸; 坂本 寛
日本生化学会大会プログラム・講演要旨集, Sep. 2009 - ラットヘムオキシゲナーゼ-1と基質ヘムとの結合における誘導適合モデルのカロリメトリー解析
岩崎 浩之; 杉島 正一; 東元 祐一郎; 野口 正人; 小松 英幸; 坂本 寛
日本生化学会大会プログラム・講演要旨集, Sep. 2009 - Functional Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2
S. Nakashima; Y. Higashimoto; M. Noguchi; H. Sakamoto
Peptide Science 2008, 2009 - クライオ電子顕微鏡法によるヘムオキシゲナーゼ-1・シトクロムP450還元酵素複合体の結合様式の解明(Determination of structure of heme oxygenase-1 and cytochrome P450 reductase complex by electron cryo-microscopy)
中尾 亮太; 堤 由佳; 東元 祐一郎; 野口 正人; 坂本 寛; 安永 卓生
生物物理, Nov. 2007 - α-ベルドヘム-ラットヘムオキシゲナーゼ-1複合体の電気化学的還元(Electrochemical reduction of ferrous α-verdoheme-rat heme oxygenase-1 complex)
佐藤 秀明; 東元 祐一郎; 坂本 寛; 野口 正人
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2007 - FMN欠失NADPH-シトクロムP450還元酵素を用いたヘムオキシゲナーゼ反応における電子授受機構の検討
東元祐一郎; 佐藤秀明; 杉島正一; 坂本寛; 野口正人
日本蛋白質科学会年会プログラム・要旨集, 2007 - Interaction between Heme and Synthetic Peptides Containing Heme Regulatory Motifs of Rat Heme Oxygenase-2
S. Nakashima; Y. Higashimoto; M; Sakamoto; H. Sakamoto
Peptide Science 2007, 2007 - グリセルアルデヒド由来終末糖化産物に対するDNAアプタマーの応用
東元 祐一郎; 山岸 昌一; 井上 浩義; 野口 正人
臨床化学, Oct. 2005 - ヘムオキシゲナーゼの立体構造からみた反応機構
坂本 寛; 杉島 正一; 東元 祐一郎; 福山 恵一; 野口 正人
生化学, Jul. 2005 - Ion-channel properties of cyclic hexapeptide cyclo(Pro-Xxx-Yyy)2
J. Taira; M. Sugishima; Y. Kida; E. Oda; M. Noguchi; Y. Higashimoto
Peptide Science 2004, 2005 - Solid-phase synthesis of tyrosine-containing cyclic peptides
J. Taira; M. Sugishima; Y. Kida; E. Oda; M. Noguchi; Y. Higashimoto
Peptide Science 2004, 2005 - ラットヘムオキシゲナーゼ-3遺伝子の解析
林 俊介; 小俣 義明; 坂本 寛; 東元 祐一郎; 原 孝之; 相良 康弘; 野口 正人
生化学, Nov. 2004 - 表面プラズモン共鳴法によるヘムオキシゲナーゼとNADPH-シトクロムP450還元酵素との相互作用の検討
東元 祐一郎; 坂本 寛; 林 俊介; 杉島 正一; 福山 恵一; 野口 正人
生化学, Nov. 2004 - NADP(H)-mediated association of heme oxygenase with NADPH-cytochrome P450 reductase
M Noguchi; Y Higashimoto; H Sakamoto
PROTEIN SCIENCE, Aug. 2004 - Destabilization and Oligomer Formation of p53 Tetramer Mutant Associated with Human Lung Carcinoma
HIGASHIMOTO Yuichiro; ASANOMI Yuya; LEWIS Marc S.; APPELLA Ettore; SAKAGUCHI Kazuyasu
Peptide Science, 01 Mar. 2004 - Mutant p53 Peptide Forms Amyloid under Physiological Condition
ASANOMI Yuya; HIGASHIMOTO Yuichiro; IMAGAWA Toshiaki; KAYA Shunji; APPELLA Ettore; SAKAGUCHI Kazuyasu
Peptide Science, 01 Mar. 2004 - シトクロムP450還元酵素からヘムオキシゲナーゼへの電子伝達機構の検討
東元 祐一郎; 坂本 寛; 小俣 義明; 林 俊介; 原田 沙織; 野口 正人
生化学, Mar. 2004 - ウロポルフィリノーゲン合成酵素活性に関係するCys残基
小俣 義明; 坂本 寛; 東元 祐一郎; 林 俊介; 原田 沙織; 野口 正人
生化学, Mar. 2004 - ヘムオキシゲナーゼによる酸素活性化モデルとしてのヒドロキシルアミン及びヒドラジンのヘム鉄結合体
坂本 寛; 東元 祐一郎; 小俣 義明; 林 俊介; 野口 正人
生化学, Aug. 2002 - Studies of pyridinioalkanoyl thioesthers (PATEs) that target HIV-1 nueleocapsid protein zinc fingers
Y Song; A Goel; Basrur, V; SJ Mazur; Y Higashimoto; J Mikovits; JA Turpin; WG Rice; JK Inman; E Appella
FASEB JOURNAL, May 2000 - Interacions of Amphiphilic Aib-containing Helical Peptides with Phospholipid Membrane
YAMAGUCHI Hiroshi; KODAMA Hiroaki; HIGASHIMOTO Yuichiro; NIARAKI Masood Jelokhani; KONDO Michio
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2000 - Stabilization of Tumor Suppressor Protein p53 through a Phosphorylation Cascade Mediated by DNA Damage
SAKAGUCHI Kazuyasu; SAITO Shin'ichi; HIGASHIMOTO Yuichiro; ROY Siddhartha; ANDERSON Carl W.; APPELLA Ettore
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2000 - DNA損傷によって誘起されるp53の18位スレオニンのリン酸化によるMDM2結合の阻害
坂口 和靖; 斎藤 伸一; 東元 祐一郎; Roy Siddhartha; Anderson Carl W; Appella Ettore
生化学, Aug. 1999 - Interaction of Alanine-based Peptides with Fluoresceins and Their Fluorescence Quenching Behavior
YAMAGUCHI Hiroshi; KODAMA Hiroaki; HIGASHIMOTO Yuichiro; NISHIMOTO Jun; JELOKHANI-NIARAKI Masood; SAKAGUCHI Kazuyasu; KONDO Michio
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Oct. 1998 - Pore-Forming Properties and Ion Selectivity of Amphiphilic Helical Aib-containing Model Peptides
HIGASHIMOTO Yuichiro; YOSHIKI Masahiro; KODAMA Hiroaki; HARA Toshiaki; YAMAGUCHI Hiroshi; JELOKHANI-NIARAKI Masood; KONDO Michio
Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Oct. 1998 - Solid-phase Synthesis and Chain-length Dependence of The Secondary Structure of α-Helical Model Peptides Containing Aib Residues
HIGASHIMOTO Yuichiro; KODAMA Hiroaki; HARA Toshiaki; JELOKHANI NIARAKI Masood; KONDO Michio
Peptide Chemistry 1996, 01 Oct. 1996 - Chemical Synthesis of Phosphorylated Peptides of The Carboxy-Terminal Domain of Human p53 by A Segment Condensation Method
SAKAMOTO Hiroshi; KODAMA Hiroaki; HIGASHIMOTO Yuichiro; KONDO Michio; LEWIS Marc S.; ANDERSON Carl W.; APPELLA Ettore; SAKAGUCHI Kazuyasu
Peptide chemistry : proceedings of the ... Symposium on Peptide Chemistry, 01 Oct. 1996 - Structural change in elastin model peptides upon interaction with biologically important metal ions
H Kodama; Y Higashimoto; S Kajiyama; Y Uemura; K Kaibara; K Okamoto; M JelokhaniNiaraki; M Kondo
PEPTIDE CHEMISTRY 1995, 1996
- THE JAPANESE PHARMACOLOGICAL SOCIETY
- THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
- THE JAPANESE SOCIETY FOR DIALYSIS THERAPY
- THE CHEMICAL SOCIETY OF JAPAN
- THE JAPANESE BIOCHEMICAL SOCIETY
- Elucidation of Drug Response Mechanisms in Bacteria Based on Endogenous Protein-Protein Interaction Network Analysis
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2025 - 31 Mar. 2028 - Development of aptamers targeting cell adhesion factors characteristically highly expressed in "combined hepatocellular-cholangiocarcinoma" and evaluation of their anti-tumour effects
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2024 - 31 Mar. 2027 - 家畜感染症拡大防止を目的とする現場で迅速に判断できる高速・高感度簡易病原体検出キットの開発
Apr. 2023 - Mar. 2026 - Development of a novel therapeutic approach for diabetic nephropathy by nucleic acid medicine (DNA aptamer).
Grant-in-Aid for Scientific Research (C)
Fukui Prefectural University
Apr. 2023 - Mar. 2026 - Functional optimization and establishment of comprehensive evaluation of membrane-permeable aptamers for drug development using AI technology
Grant-in-Aid for Scientific Research (B)
Niigata University
01 Apr. 2022 - 31 Mar. 2025 - 高速・高感度ワンタッチイムノアッセイキットの開発と応用
Apr. 2022 - Mar. 2023 - Development of Next-Generation Platform for Light-induced Drugs
Challenging Research (Exploratory)
Niigata University
Jul. 2020 - Mar. 2023 - 水質・土壌分析向けその場計測用試薬キットの開発
Apr. 2021 - Mar. 2022 - Elucidation of the mechanism for auto-penetrating DNA aptamers and their application as post-antibody drugs
Grant-in-Aid for Scientific Research (B)
Niigata University
Apr. 2019 - Mar. 2022 - Identification of structures of advanced glycation end-products responsible for proatherosclerotic effects - analysis using aptamers.
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2019 - Mar. 2022 - Post-translational modifications regulating the activity and function of carbon monoxide synthase
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2019 - Mar. 2022 - Development of novel treatment for diabetic nephropathy originate from functional modified peptides of pigment epitherium-derived factor.
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2016 - Mar. 2019 - 翻訳後修飾によるヘムオキシゲナーゼの機能調節とその破綻による疾患発症との関係
Apr. 2016 - Mar. 2019 - Development of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples
Grant-in-Aid for Scientific Research (C)
Kyushu Institute of Technology
Apr. 2015 - Mar. 2018 - Substrate identification method for protein phosphatases through the induction of enzyme-substrate intermediate
Grant-in-Aid for Scientific Research (C)
Niigata University
Apr. 2015 - Mar. 2018 - Investigation of biosynthetic mechanism of cyclic tetrapyrrole: Construction and cyclization of hydroxymethylbilane
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2015 - Mar. 2018 - Studies on structural biology of the enzymes involved in porphyria
Grant-in-Aid for Scientific Research (C)
Yokohama College of Pharmacy
Apr. 2014 - Mar. 2017 - Research of scientific cognition and social cognition for radiation and nuclear and construction of their education system
Grant-in-Aid for Scientific Research (C)
Keio University
Apr. 2013 - Mar. 2016 - ヘムオキシゲナーゼの翻訳後修飾による量的・質的制御と細胞保護との関係
Apr. 2013 - Mar. 2016 - Electron transfer sytem to heme oxygenase from cytochrome P450
Grant-in-Aid for Scientific Research (C)
01 Apr. 2012 - 31 Mar. 2015 - The mechanism of construction and cyclization of tetrapyrrole in the heme biosynthetic pathway
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2012 - Mar. 2015 - The role of the ubiquitin-proteasome pathway in heme oxygenase system
Grant-in-Aid for Young Scientists (B)
Kurume University
Apr. 2009 - Mar. 2012 - Investigation of the intermediary steps and electron transfer mechanism of heme degradation by heme oxygenase
Grant-in-Aid for Scientific Research (C)
Kurume University
2009 - 2011 - Regulation of heme oxygenase activity by caveolin
Grant-in-Aid for Young Scientists (B)
Kurume University
Apr. 2006 - Mar. 2009 - Enzyme chemical study of heme oxygenase and development for machinery of heme catabolism
Grant-in-Aid for Scientific Research (C)
Kyushu Institute of Technology
2006 - 2008 - PHYSIOLOGICAL ROLE OF THE SIDE-CHAIN ASYMMETRY OF PORPHYRINES THAT ARE UTILIZED IN NATURE
Grant-in-Aid for Scientific Research (C)
2006 - 2008 - The intermediate steps of heme oxygenase reaction and the physiological significance of carbon monoxide as a gaseous transmitter
Grant-in-Aid for Scientific Research (C)
Kurume University
2006 - 2008 - リン酸化によるヘムオキシゲナーゼの機能調節機構の検討
Apr. 2003 - Mar. 2006 - Functional Structure Analysis of Ion-channel Oligomer and Production of regulating Peptides.
Grant-in-Aid for Scientific Research (C)
Saga University
2004 - 2005 - Studies of heme degradation mechanism by heme oxygenase based on the crystal structures.
Grant-in-Aid for Scientific Research (C)
Kurume University school of Medicine
2003 - 2005 - How does heme degrade ? -Studies of the catalytic mechanism of heme oxygenase based on its crystal structures-
Grant-in-Aid for Scientific Research (C)
2003 - 2005
- 特許第6050654号, 特開2014-090669, 特願2012-240930, グリセルアルデヒド由来終末糖化産物(AGE)認識アプタマー
井上 浩義; 東元 祐一郎 - 特開2016-079184, 特願2015-206555, RAGEアプタマーおよびその用途
山岸 昌一; 深水 圭; 東元 祐一郎; 松井 孝憲; 田口 顕正 - 特許第5873027号, 特願2012-545791, AGE特異的アプタマーの腎疾患治療用途
深水 圭; 東元 祐一郎; 山岸 昌一; 奥田 誠也; 井上 浩義 - 特許第5696830号, 特開2011-229452, 特願2010-102444, PAR−2活性化阻害物質
木田 豊; 東元 祐一郎; 井上 浩義 - 特開2014-090669, 特願2012-240930, グリセルアルデヒド由来終末糖化産物(AGE)認識アプタマー
井上 浩義; 東元 祐一郎 - 特許第5414975号, 特開2008-224453, 特願2007-063947, 細胞または組織内のAGE−2を免疫組織化学的に検出する方法およびそのためのキット
東元 祐一郎; 山岸 昌一; 竹内 正義; 井上 浩義 - WO2012-070621, JP2011077062, AGE特異的アプタマーの腎疾患治療用途
深水 圭; 東元 祐一郎; 山岸 昌一; 奥田 誠也; 井上 浩義 - 特開2011-229452, 特願2010-102444, PAR−2活性化阻害物質
木田 豊; 東元 祐一郎; 井上 浩義 - 特開2008-224453, 特願2007-063947, 細胞または組織内のAGE−2を免疫組織化学的に検出する方法およびそのためのキット
東元 祐一郎; 山岸 昌一; 竹内 正義; 井上 浩義 - WO2006-080262, JP2006300922, AGE−2アプタマー
井上 浩義; 東元 祐一郎; 竹内 正義; 山岸 昌一
