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Shima Kanako
Division of Microscopic and Developmental Anatomy
Assistant Professor
Research activity information
■ Paper
■ Research Themes
- NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms
Miki Inoue; Kanako Miyabayashi; Yuichi Shima
Reproductive Medicine and Biology, Jan. 2025, [Reviewed], [Invited] - Intronic Enhancer Is Essential for Nr5a1 Expression in the Pituitary Gonadotrope and for Postnatal Development of Male Reproductive Organs in a Mouse Model.
Yuichi Shima; Kanako Miyabayashi; Takami Mori; Koji Ono; Mizuki Kajimoto; Hae Lim Cho; Hitomi Tsuchida; Yoshihisa Uenoyama; Hiroko Tsukamura; Kentaro Suzuki; Man Ho Choi; Kazunori Toida
International journal of molecular sciences, 22 Dec. 2022 - Gene expression and functional abnormalities in XX/Sry Leydig cells.
Shogo Yanai; Takashi Baba; Kai Inui; Kanako Miyabayashi; Soyun Han; Miki Inoue; Fumiya Takahashi; Yoshiakira Kanai; Yasuyuki Ohkawa; Man Ho Choi; Ken-Ichirou Morohashi
Scientific reports, 12 Jan. 2021 - Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells.
Yuichi Shima; Kanako Miyabayashi; Tetsuya Sato; Mikita Suyama; Yasuyuki Ohkawa; Masao Doi; Hitoshi Okamura; Kentaro Suzuki
Development (Cambridge, England), 05 Dec. 2018 - Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids.
Takashi Baba; Hiroyuki Otake; Miki Inoue; Tetsuya Sato; Yasuhiro Ishihara; Ju-Yeon Moon; Megumi Tsuchiya; Kanako Miyabayashi; Hidesato Ogawa; Yuichi Shima; Lixiang Wang; Ryuichiro Sato; Takeshi Yamazaki; Mikita Suyama; Masatoshi Nomura; Man Ho Choi; Yasuyuki Ohkawa; Ken-Ichirou Morohashi
Communications biology, 2018 - Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells.
Bing Li; Takashi Baba; Kanako Miyabayashi; Tetsuya Sato; Yuichi Shima; Tomomi Ichinose; Daisuke Miura; Yasuyuki Ohkawa; Mikita Suyama; Ken-Ichirou Morohashi
Endocrine journal, 31 Mar. 2017 - Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.
Yurina Shishido; Takashi Baba; Tetsuya Sato; Yuichi Shima; Kanako Miyabayashi; Miki Inoue; Haruhiko Akiyama; Hiroshi Kimura; Yoshiakira Kanai; Yasuhiro Ishihara; Shogo Haraguchi; Akira Miyazaki; Damjana Rozman; Takeshi Yamazaki; Man-Ho Choi; Yasuyuki Ohkawa; Mikita Suyama; Ken-Ichirou Morohashi
Scientific reports, 02 Feb. 2017 - Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development.
Kanako Miyabayashi; Yuichi Shima; Miki Inoue; Tetsuya Sato; Takashi Baba; Yasuyuki Ohkawa; Mikita Suyama; Ken-Ichirou Morohashi
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation, 2017 - Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.
Miki Inoue; Yuichi Shima; Kanako Miyabayashi; Kaori Tokunaga; Tetsuya Sato; Takashi Baba; Yasuyuki Ohkawa; Haruhiko Akiyama; Mikita Suyama; Ken-ichirou Morohashi
Endocrinology, Mar. 2016 - Fetal Leydig Cells Persist as an Androgen-Independent Subpopulation in the Postnatal Testis.
Yuichi Shima; Sawako Matsuzaki; Kanako Miyabayashi; Hiroyuki Otake; Takashi Baba; Shigeaki Kato; Ilpo Huhtaniemi; Ken-ichirou Morohashi
Molecular endocrinology (Baltimore, Md.), Nov. 2015 - Heterogeneity of ovarian theca and interstitial gland cells in mice.
Kanako Miyabayashi; Kaori Tokunaga; Hiroyuki Otake; Takashi Baba; Yuichi Shima; Ken-Ichirou Morohashi
PloS one, 2015 - Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1.
Takashi Baba; Hiroyuki Otake; Tetsuya Sato; Kanako Miyabayashi; Yurina Shishido; Chia-Yih Wang; Yuichi Shima; Hiroshi Kimura; Mikako Yagi; Yasuhiro Ishihara; Shinjiro Hino; Hidesato Ogawa; Mitsuyoshi Nakao; Takeshi Yamazaki; Dongchon Kang; Yasuyuki Ohkawa; Mikita Suyama; Bon-Chu Chung; Ken-Ichirou Morohashi
Nature communications, 14 Apr. 2014 - Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes.
Yuichi Shima; Kanako Miyabayashi; Shogo Haraguchi; Tatsuhiko Arakawa; Hiroyuki Otake; Takashi Baba; Sawako Matsuzaki; Yurina Shishido; Haruhiko Akiyama; Taro Tachibana; Kazuyoshi Tsutsui; Ken-ichirou Morohashi
Molecular endocrinology (Baltimore, Md.), Jan. 2013 - Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells.
Kanako Miyabayashi; Yuko Katoh-Fukui; Hidesato Ogawa; Takashi Baba; Yuichi Shima; Noriyuki Sugiyama; Kunio Kitamura; Ken-ichirou Morohashi
PloS one, 2013 - Identification of an Enhancer in the Ad4BP/SF-1 Gene Specific for Fetal Leydig Cells (vol 153, pg 417, 2012)
Yuichi Shima; Kanako Miyabayashi; Takashi Baba; Hiroyuki Otake; Yukako Katsura; Sanae Oka; Mohamad Zubair; Ken-inchirou Morohashi
ENDOCRINOLOGY, Nov. 2012 - Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Yuko Katoh-Fukui; Kanako Miyabayashi; Tomoko Komatsu; Akiko Owaki; Takashi Baba; Yuichi Shima; Tomohide Kidokoro; Yoshiakira Kanai; Andreas Schedl; Dagmar Wilhelm; Peter Koopman; Yasushi Okuno; Ken-ichirou Morohashi
Endocrinology, Feb. 2012 - Identification of an enhancer in the Ad4BP/SF-1 gene specific for fetal Leydig cells.
Yuichi Shima; Kanako Miyabayashi; Takashi Baba; Hiroyuki Otake; Yukako Katsura; Sanae Oka; Mohamad Zubair; Ken-ichirou Morohashi
Endocrinology, Jan. 2012 - Abnormal epithelial cell polarity and ectopic epidermal growth factor receptor (EGFR) expression induced in Emx2 KO embryonic gonads.
Masatomo Kusaka; Yuko Katoh-Fukui; Hidesato Ogawa; Kanako Miyabayashi; Takashi Baba; Yuichi Shima; Noriyuki Sugiyama; Yukihiko Sugimoto; Yasushi Okuno; Ryuji Kodama; Akiko Iizuka-Kogo; Takao Senda; Toshikuni Sasaoka; Kunio Kitamura; Shinichi Aizawa; Ken-ichirou Morohashi
Endocrinology, Dec. 2010 - Implication of Ad4BP/SF-1 into adrenal development
Ken-ichirou Morohashi; Yuichi Shima; Kanako Miyabayashi; Hiroyuki Otake; Takashi Baba; Mohamad Zubair
ENDOCRINE JOURNAL, Mar. 2010 - Thyroxine treatment stimulated ovarian follicular angiogenesis in immature hypothyroid rats.
Jin-Yi Jiang; Kanako Miyabayashi; Stefania A Nottola; Motoaki Umezu; Sandra Cecconi; Eimei Sato; Guido Macchiarelli
Histology and histopathology, Nov. 2008 - Importance of forkhead transcription factor Fkhl18 for development of testicular vasculature.
Yuko Sato; Takashi Baba; Mohamad Zubair; Kanako Miyabayashi; Yoshiro Toyama; Mamiko Maekawa; Akiko Owaki; Hirofumi Mizusaki; Tatsuya Sawamura; Kiyotaka Toshimori; Ken-Ichirou Morohashi; Yuko Katoh-Fukui
Molecular reproduction and development, Sep. 2008 - Effect of direct ovarian injection of vascular endothelial growth factor gene fragments on follicular development in immature female rats.
Takashi Shimizu; Koji Iijima; Kanako Miyabayashi; Yoshinori Ogawa; Hitoshi Miyazaki; Hiroshi Sasada; Eimei Sato
Reproduction (Cambridge, England), Nov. 2007 - CXorf6 is a causative gene for hypospadias.
Maki Fukami; Yuka Wada; Kanako Miyabayashi; Ichizo Nishino; Tomonobu Hasegawa; Agneta Nordenskjöld; Giovanna Camerino; Christine Kretz; Anna Buj-Bello; Jocelyn Laporte; Gen Yamada; Ken-Ichirou Morohashi; Tsutomu Ogata
Nature genetics, Dec. 2006 - Changes of mRNA expression of vascular endothelial growth factor, angiopoietins and their receptors during the periovulatory period in eCG/hCG-treated immature female rats.
Kanako Miyabayashi; Takashi Shimizu; Chiaki Kawauchi; Hiroshi Sasada; Eimei Sato
Journal of experimental zoology. Part A, Comparative experimental biology, 01 Jul. 2005 - Induction of follicular development by direct single injection of vascular endothelial growth factor gene fragments into the ovary of miniature gilts.
Takashi Shimizu; Jin-Yi Jiang; Koji Iijima; Kanako Miyabayashi; Yoshinori Ogawa; Hiroshi Sasada; Eimei Sato
Biology of reproduction, Oct. 2003
■ Research Themes
