A whole-brain single-cell atlas of circadian neural activity in mice
Katsunari Yamashita; Fukuaki L. Kinoshita; Shota Y. Yoshida; Katsuhiko Matsumoto; Tomoki T. Mitani; Hiroshi Fujishima; Yoichi Minami; Eiichi Morii; Rikuhiro G. Yamada; Seiji Okada; Hiroki R. Ueda
Science, 2025年11月13日

Isoflurane activates the type 1 ryanodine receptor to induce anesthesia in mice.
Hiroyuki J Kanaya; Ken Kuwajima; Yuko Ito; Yuta Shinohara; Yohei Okubo; Shinnosuke Shiono; Fumiya Tatsuki; Rei-Ichiro Ohno; Hideki Ukai; Maki Ukai-Tadenuma; Kenta Sumiyama; Hiroshi Fujishima; Rikuhiro G Yamada; Daisuke Tone; Hiroshi Kiyonari; Masaki Kikuchi; Takashi Umehara; Takashi Murayama; Kazunori Kanemaru; Masamitsu Iino; Koji L Ode; Takatsugu Hirokawa; Hiroki R Ueda
PLoS biology, 2025年06月

Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles.
Yimeng Wang; Siyu Cao; Daisuke Tone; Hiroshi Fujishima; Rikuhiro G Yamada; Rei-Ichiro Ohno; Shoi Shi; Kyoko Matsuzawa; Saori Yada; Mari Kaneko; Hirokazu Sakamoto; Taichi Onishi; Maki Ukai-Tadenuma; Hideki Ukai; Carina Hanashima; Kenzo Hirose; Hiroshi Kiyonari; Kenta Sumiyama; Koji L Ode; Hiroki R Ueda
Nature, 2024年12月

Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.
Kazuhiro Kon; Koji L Ode; Tomoyuki Mano; Hiroshi Fujishima; Riina R Takahashi; Daisuke Tone; Chika Shimizu; Shinnosuke Shiono; Saori Yada; Kyoko Matsuzawa; Shota Y Yoshida; Junko Yoshida Garçon; Mari Kaneko; Yuta Shinohara; Rikuhiro G Yamada; Shoi Shi; Kazunari Miyamichi; Kenta Sumiyama; Hiroshi Kiyonari; Etsuo A Susaki; Hiroki R Ueda
Nature communications, 2024年07月18日

Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep.
Arthur Millius; Rikuhiro G Yamada; Hiroshi Fujishima; Kazuhiko Maeda; Daron M Standley; Kenta Sumiyama; Dimitri Perrin; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 2023年10月03日

Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep.
Daisuke Tone; Koji L Ode; Qianhui Zhang; Hiroshi Fujishima; Rikuhiro G Yamada; Yoshiki Nagashima; Katsuhiko Matsumoto; Zhiqing Wen; Shota Y Yoshida; Tomoki T Mitani; Yuki Arisato; Rei-Ichiro Ohno; Maki Ukai-Tadenuma; Junko Yoshida Garçon; Mari Kaneko; Shoi Shi; Hideki Ukai; Kazunari Miyamichi; Takashi Okada; Kenta Sumiyama; Hiroshi Kiyonari; Hiroki R Ueda
PLoS biology, 2022年10月

Advanced CUBIC tissue clearing for whole-organ cell profiling.
Katsuhiko Matsumoto; Tomoki T Mitani; Shuhei A Horiguchi; Junichi Kaneshiro; Tatsuya C Murakami; Tomoyuki Mano; Hiroshi Fujishima; Ayumu Konno; Tomonobu M Watanabe; Hirokazu Hirai; Hiroki R Ueda
Nature protocols, 2019年12月

覚醒状態の維持に関わる新規遺伝子の発見
小野 宏晃; 昆 一弘; 上田 泰己; 山田 陸裕; 史 蕭逸; 鵜飼-蓼沼 磨貴; 藤島 博史; 鵜飼 英樹; 大野 怜一朗; 戸根 大輔; 神田 元紀
日本薬理学会年会要旨集, 2019年, ［査読有り］

Leak potassium channels regulate sleep duration.
Kensuke Yoshida; Shoi Shi; Maki Ukai-Tadenuma; Hiroshi Fujishima; Rei-Ichiro Ohno; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 2018年10月02日

Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Yasutaka Niwa; Genki N Kanda; Rikuhiro G Yamada; Shoi Shi; Genshiro A Sunagawa; Maki Ukai-Tadenuma; Hiroshi Fujishima; Naomi Matsumoto; Koh-Hei Masumoto; Mamoru Nagano; Takeya Kasukawa; James Galloway; Dimitri Perrin; Yasufumi Shigeyoshi; Hideki Ukai; Hiroshi Kiyonari; Kenta Sumiyama; Hiroki R Ueda
Cell reports, 2018年08月28日

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.
Yuta Shinohara; Yohei M Koyama; Maki Ukai-Tadenuma; Takatsugu Hirokawa; Masaki Kikuchi; Rikuhiro G Yamada; Hideki Ukai; Hiroshi Fujishima; Takashi Umehara; Kazuki Tainaka; Hiroki R Ueda
Molecular cell, 2017年09月07日

Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals.
Fumiya Tatsuki; Genshiro A Sunagawa; Shoi Shi; Etsuo A Susaki; Hiroko Yukinaga; Dimitri Perrin; Kenta Sumiyama; Maki Ukai-Tadenuma; Hiroshi Fujishima; Rei-ichiro Ohno; Daisuke Tone; Koji L Ode; Katsuhiko Matsumoto; Hiroki R Ueda
Neuron, 2016年04月06日

Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene.
Genshiro A Sunagawa; Kenta Sumiyama; Maki Ukai-Tadenuma; Dimitri Perrin; Hiroshi Fujishima; Hideki Ukai; Osamu Nishimura; Shoi Shi; Rei-Ichiro Ohno; Ryohei Narumi; Yoshihiro Shimizu; Daisuke Tone; Koji L Ode; Shigehiro Kuraku; Hiroki R Ueda
Cell reports, 2016年01月26日

CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.
Yasushi Isojima; Masato Nakajima; Hideki Ukai; Hiroshi Fujishima; Rikuhiro G Yamada; Koh-hei Masumoto; Reiko Kiuchi; Mayumi Ishida; Maki Ukai-Tadenuma; Yoichi Minami; Ryotaku Kito; Kazuki Nakao; Wataru Kishimoto; Seung-Hee Yoo; Kazuhiro Shimomura; Toshifumi Takao; Atsuko Takano; Toshio Kojima; Katsuya Nagai; Yoshiyuki Sakaki; Joseph S Takahashi; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 2009年09月15日