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高橋 知之
高次脳疾患研究所
教授
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■ 論文
■ 産業財産権
- Attenuated orexinergic signaling underlies sleep–wake problems in a Mecp2-null mouse model of Rett syndrome
Kotaro Yuge; Tomoyuki Takahashi; Yukie Kawahara; Yusuke Sakai; Takahiro Sato; Tatsuyuki Kakuma; Akinori Nishi; Toyojiro Matsuishi; Yushiro Yamashita
Neurobiology of Disease, 2025年10月 - Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism
Kaori Fukui; Tomoyuki Takahashi; Hitomi Matsunari; Ayuko Uchikura; Masahito Watanabe; Hiroshi Nagashima; Naotada Ishihara; Tatsuyuki Kakuma; Yoriko Watanabe; Yushiro Yamashita; Makoto Yoshino
Journal of Inherited Metabolic Disease, 2022年11月 - Perampanel markedly improved clinical seizures in a patient with a Rett‐like phenotype and 960‐kb deletion on chromosome 9q34.11 including the STXBP1
Syun Yoshida; Masano Amamoto; Tomoyuki Takahashi; Ichiro Tomita; Kotaro Yuge; Munetsugu Hara; Kazuhiro Iwama; Naomichi Matsumoto; Toyojiro Matsuishi
Clinical Case Reports, 2022年05月15日 - Optimization of adenoviral gene transfer in human pluripotent stem cells
Kaoru Mitsui; Tomoyuki Takahashi; Kanako Ide; Eriko Matsuda; Ken ichiro Kosai
Biochemical and Biophysical Research Communications, 2021年02月19日 - Meaningful word acquisition is associated with walking ability over 10 years in Rett syndrome
Tomoko Saikusa; Machiko Kawaguchi; Tetsuji Tanioka (Tetsu T); Shin Nabatame (Shin N); Satoru Takahashi; Kotaro Yuge; Shin ichiro Nagamitsu; Tomoyuki Takahashi; Yushiro Yamashita; Yasuyuki Kobayashi; Chisato Hirayama; Tatsuyuki Kakuma; Toyojiro Matsuishi; Masayuki Itoh
Brain and Development, 2020年11月 - Cervical dystonia in Parkinson’s disease: Retrospective study of later-stage clinical features
Hiroshi Kida; Shiroh Miura; Yoshihiro Yamanishi; Tomoyuki Takahashi; Takashi Kamada; Akiko Yorita; Mitsuyoshi Ayabe; Hideki Kida; Tomoaki Hoshino; Takayuki Taniwaki
Neurology Asia, 2018年09月 - Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome
Hiroshi Kida; Tomoyuki Takahashi; Yuki Nakamura; Takashi Kinoshita; Munetsugu Hara; Masaki Okamoto; Satoko Okayama; Keiichiro Nakamura; Ken Ichiro Kosai; Takayuki Taniwaki; Yushiro Yamashita; Toyojiro Matsuishi
Scientific Reports, 2017年12月01日 - Viral Vector-Based Innovative Approaches to Directly Abolishing Tumorigenic Pluripotent Stem Cells for Safer Regenerative Medicine
Kaoru Mitsui; Kanako Ide; Tomoyuki Takahashi; Ken ichiro Kosai
Molecular Therapy Methods and Clinical Development, 2017年06月16日 - Intravenous administration of endothelial colonyforming cells overexpressing integrin b1 augments angiogenesis in ischemic legs
Kazuko Goto; Genzou Takemura; Tomoyuki Takahashi; Hideshi Okada; Hiromitsu Kanamori; Itta Kawamura; Takatomo Watanabe; Kentaro Morishita; Akiko Tsujimoto; Nagisa Miyazaki; Hiroaki Ushikoshi; Masanori Kawasaki; Atsushi Mikami; Ken Ichiro Kosai; Shinya Minatoguchi
Stem Cells Translational Medicine, 2016年 - Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse
Yoshiki Tsuchiya; Yoichi Minami; Yasuhiro Umemura; Hitomi Watanabe; Daisuke Ono; Wataru Nakamura; Tomoyuki Takahashi; Sato Honma; Gen Kondoh; Toyojiro Matsuishi; Kazuhiro Yagita
Genes to Cells, 2015年12月01日 - Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias
Munetsugu Hara; Tomoyuki Takahashi; Chiaki Mitsumasu; Sachiyo Igata; Makoto Takano; Tomoko Minami; Hideo Yasukawa; Satoko Okayama; Keiichiro Nakamura; Yasunori Okabe; Eiichiro Tanaka; Genzou Takemura; Ken Ichiro Kosai; Yushiro Yamashita; Toyojiro Matsuishi
Scientific Reports, 2015年06月15日 - Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice
Kentaro Yuge; Tomoyuki Takahashi; Ngin Cin Khai; Kazuko Goto; Takako Fujiwara; Hisayoshi Fujiwara; Ken Ichiro Kosai
International Journal of Molecular Medicine, 2014年05月 - Two neonatal cholestasis patients with mutations in the SRD5B1 (AKR1D1) gene: Diagnosis and bile acid profiles during chenodeoxycholic acid treatment
Yoshitaka Seki; Tatsuki Mizuochi; Akihiko Kimura; Tomoyuki Takahashi; Akira Ohtake; Shin Ichi Hayashi; Toshiya Morimura; Yasuharu Ohno; Takayuki Hoshina; Kenji Ihara; Hajime Takei; Hiroshi Nittono; Takao Kurosawa; Keiko Homma; Tomonobu Hasegawa; Toyojiro Matsuishi
Journal of Inherited Metabolic Disease, 2013年05月 - Characterization of urinary bile acids in a pediatric BRIC-1 patient: Effect of rifampicin treatment
Tatsuki Mizuochi; Akihiko Kimura; Atsushi Tanaka; Akina Muto; Hiroshi Nittono; Yoshitaka Seki; Tomoyuki Takahashi; Takao Kurosawa; Masayoshi Kage; Hajime Takikawa; Toyojiro Matsuishi
Clinica Chimica Acta, 2012年08月16日 - Alterations of gene expression and glutamate clearance in astrocytes derived from an mecp2-null mouse model of rett syndrome
Yasunori Okabe; Tomoyuki Takahashi; Chiaki Mitsumasu; Ken ichiro Kosai; Eiichiro Tanaka; Toyojiro Matsuishi
PLoS ONE, 2012年04月20日 - Increased plasma type B natriuretic peptide in the acute phase of Kawasaki disease
Shintaro Kishimoto; Kenji Suda; Yozo Teramachi; Hiroshi Nishino; Yoshiyuki Kudo; Haruka Ishii; Motofumi Iemura; Tomoyuki Takahashi; Hisayoshi Okamura; Toyojiro Matsuishi
Pediatrics International, 2011年10月 - Rett syndrome: The state of clinical and basic research, and future perspectives
Toyojiro Matsuishi; Yushiro Yamashita; Tomoyuki Takahashi; Shinichiro Nagamitsu
Brain and Development, 2011年09月 - Neural development of methyl-CpG-binding protein 2 null embryonic stem cells: A system for studying Rett syndrome
Yasunori Okabe; Akira Kusaga; Tomoyuki Takahashi; Chiaki Mitsumasu; Yoshinaka Murai; Eiichiro Tanaka; Hideho Higashi; Toyojiro Matsuishi; Ken Ichiro Kosai
Brain Research, 2010年11月11日 - Molecular genetic and bile acid profiles in two japanese patients with 3β-hydroxy-δ5-c
27 -steroid dehydrogenase/ isomerase deficiency
Tatsuki Mizuochi; Akihiko Kimura; Isao Ueki; Tomoyuki Takahashi; Takuji Hashimoto; Akira Takao; Yoshitaka Seki; Hajime Takei; Hiroshi Nittono; Takao Kurosawa; Toyojiro Matsuishi
Pediatric Research, 2010年09月 - Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis
Shusaku Miyata; Genzou Takemura; Ken Ichiro Kosai; Tomoyuki Takahashi; Masayasu Esaki; Longhu Li; Hiromitsu Kanamori; Rumi Maruyama; Kazuko Goto; Akiko Tsujimoto; Toshiaki Takeyama; Tomonori Kawaguchi; Takamasa Ohno; Kazuhiko Nishigaki; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
American Journal of Pathology, 2010年02月 - Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction
Longhu Li; Hideshi Okada; Genzou Takemura; Ken Ichiro Kosai; Hiromitsu Kanamori; Masayasu Esaki; Tomoyuki Takahashi; Kazuko Goto; Akiko Tsujimoto; Rumi Maruyama; Itta Kawamura; Tomonori Kawaguchi; Toshiaki Takeyama; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
American Journal of Physiology - Heart and Circulatory Physiology, 2009年10月 - Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure
Hideshi Okada; Genzou Takemura; Ken Ichiro Kosai; Akiko Tsujimoto; Masayasu Esaki; Tomoyuki Takahashi; Satoshi Nagano; Hiromitsu Kanamori; Shusaku Miyata; Yiwen Li; Takamasa Ohno; Rumi Maruyama; Atsushi Ogino; Longhu Li; Munehiro Nakagawa; Kenshi Nagashima; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
American Journal of Physiology - Heart and Circulatory Physiology, 2009年03月 - Application of an adenoviral vector encoding soluble transforming growth factor-β type II receptor to the treatment of diabetic nephropathy in mice
Takehito Kondo; Genzou Takemura; Ken Ichiro Kosai; Takamasa Ohno; Tomoyuki Takahashi; Masayasu Esaki; Kazuko Goto; Rumi Maruyama; Ichijiro Murata; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Clinical and Experimental Pharmacology and Physiology, 2008年11月 - Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy
Masayasu Esaki; Genzou Takemura; Ken Ichiro Kosai; Tomoyuki Takahashi; Shusaku Miyata; Longhu Li; Kazuko Goto; Rumi Maruyama; Hideshi Okada; Hiromitsu Kanamori; Atsushi Ogino; Hiroaki Ushikoshi; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
American Journal of Physiology - Heart and Circulatory Physiology, 2008年02月 - In Vivo Hepatocyte Growth Factor Gene Transfer Reduces Myocardial Ischemia-Reperfusion Injury Through Its Multiple Actions
Xue Hai Chen; Shinya Minatoguchi; Kenichiro Kosai; Kentaro Yuge; Tomoyuki Takahashi; Masazumi Arai; Ningyuan Wang; Yu Misao; Chuanjiang Lu; Hirohito Onogi; Hiroyuki Kobayashi; Shinji Yasuda; Masayasu Ezaki; Hiroaki Ushikoshi; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Journal of Cardiac Failure, 2007年12月 - Identification and Isolation of Embryonic Stem Cell-Derived Target Cells by Adenoviral Conditional Targeting
Tomoyuki Takahashi; Takao Kawai; Hiroaki Ushikoshi; Satoshi Nagano; Hatsue Oshika; Makoto Inoue; Takahiro Kunisada; Genzou Takemura; Hisayoshi Fujiwara; Ken ichiro Kosai
Molecular Therapy, 2006年11月 - Cell cycle-specific changes in hTERT promoter activity in normal and cancerous cells in adenoviral gene therapy: A promising implication of telomerase-dependent targeted cancer gene therapy
Yoshiteru Murofushi; Satoshi Nagano; Junichi Kamizono; Tomoyuki Takahashi; Hisayoshi Fujiwara; Setsuro Komiya; Toyojiro Matsuishi; Ken Ichiro Kosai
International Journal of Oncology, 2006年09月 - Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF
Yu Misao; Genzou Takemura; Masazumi Arai; Takamasa Ohno; Hirohito Onogi; Tomoyuki Takahashi; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Cardiovascular Research, 2006年08月01日 - In vivo hepatic HB-EGF gene transduction inhibits Fas-induced liver injury and induces liver regeneration in mice: A comparative study to HGF
Ngin Cin Khai; Tomoyuki Takahashi; Hiroaki Ushikoshi; Satoshi Nagano; Kentaro Yuge; Masayasu Esaki; Takao Kawai; Kazuko Goto; Yoshiteru Murofushi; Takako Fujiwara; Hisayoshi Fujiwara; Ken ichiro Kosai
Journal of Hepatology, 2006年06月 - Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice
Tomoyo Kagawa; Genzou Takemura; Ken Ichiro Kosai; Ichijiro Murata; Takamasa Ohno; Tomoyuki Takahashi; Masayasu Esaki; Rumi Maruyama; Takako Fujiwara; Hiroshige Ohashi; Hisayoshi Fujiwara
Nephron - Physiology, 2006年02月 - Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma
Kentaro Yuge; Tomoyuki Takahashi; Satoshi Nagano; Yasuhiro Terazaki; Yoshiteru Murofushi; Hiroaki Ushikoshi; Takao Kawai; Ngin Cin Khai; Toshikazu Nakamura; Hisayoshi Fujiwara; Ken Ichiro Kosai
International Journal of Oncology, 2005年07月 - Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes
Hiroaki Ushikoshi; Tomoyuki Takahashi; Xuehai Chen; Ngin Cin Khai; Masayasu Esaki; Kazuko Goto; Genzou Takemura; Rumi Maruyama; Shinya Minatoguchi; Takako Fujiwara; Satoshi Nagano; Kentaro Yuge; Takao Kawai; Yoshiteru Murofushi; Hisayoshi Fujiwara; Ken Ichiro Kosai
Laboratory Investigation, 2005年07月 - Cyclophosphamide improves the function of post-infarct hearts by reducing old infarct area and accelerating the mobilization of CD34+ cells
Yu Misao; Masazumi Arai; Takamasa Ohno; Hiroaki Ushikoshi; Tomoyuki Takahashi; Genzou Takemura; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Circulation Journal, 2005年06月 - Postinfarction gene therapy against transforming growth factor-β signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure
Hideshi Okada; Genzou Takemura; Ken Ichiro Kosai; Yiwen Li; Tomoyuki Takahashi; Masayasu Esaki; Kentaro Yuge; Shusaku Miyata; Rumi Maruyama; Atsushi Mikami; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Circulation, 2005年05月17日 - Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure
Yiwen Li; Genzou Takemura; Ken Ichiro Kosai; Tomoyuki Takahashi; Hideshi Okada; Shusaku Miyata; Kentaro Yuge; Satoshi Nagano; Masayasu Esaki; Ngin Cin Khai; Kazuko Goto; Atsushi Mikami; Rumi Maruyama; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Circulation Research, 2004年09月17日 - Efficient cardiomyogenic differentiation of embryonic stem cell by fibroblast growth factor 2 and bone morphogenetic protein 2
Takao Kawai; Tomoyuki Takahashi; Masayasu Esaki; Hiroaki Ushikoshi; Satoshi Nagano; Hisayoshi Fujiwara; Ken Ichiro Kosai
Circulation Journal, 2004年07月 - Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment
Shinya Minatoguchi; Genzou Takemura; Xue Hai Chen; Ningyuan Wang; Yoshihiro Uno; Masahiko Koda; Masazumi Arai; Yu Misao; Chuanjiang Lu; Koji Suzuki; Kazuko Goto; Ai Komada; Tomoyuki Takahashi; Kenichiro Kosai; Takako Fujiwara; Hisayoshi Fujiwara
Circulation, 2004年06月01日 - A Definitive Role of RhoC in Metastasis of Orthotopic Lung Cancer in Mice
Tetsuro Ikoma; Tomoyuki Takahashi; Satoshi Nagano; Yun Mo Li; Yasushi Ohno; Kazuki Ando; Takako Fujiwara; Hisayoshi Fujiwara; Ken Ichiro Kosai
Clinical Cancer Research, 2004年02月01日 - Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice
Yiwen Li; Genzou Takemura; Ken ichiro Kosai; Kentaro Yuge; Satoshi Nagano; Masayasu Esaki; Kazuko Goto; Tomoyuki Takahashi; Kenji Hayakawa; Masahiko Koda; Yukinori Kawase; Rumi Maruyama; Hideshi Okada; Shinya Minatoguchi; Hiroyuki Mizuguchi; Takako Fujiwara; Hisayoshi Fujiwara
Circulation, 2003年05月20日 - Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes
Takuma Aoyama; Genzou Takemura; Rumi Maruyama; Ken ichiro Kosai; Tomoyuki Takahashi; Masahiko Koda; Kenji Hayakawa; Yukinori Kawase; Shinya Minatoguchi; Hisayoshi Fujiwara
Cardiovascular Research, 2002年 - Molecular cloning and characterization of Kremen, a novel kringle-containing transmembrane protein
Takahiro Nakamura; Shunsuke Aoki; Keiko Kitajima; Tomoyuki Takahashi; Kunio Matsumoto; Toshikazu Nakamura
Biochimica et Biophysica Acta - Gene Structure and Expression, 2001年03月19日 - Functional involvement of Xenopus LIM kinases in progression of oocyte maturation
Tomoyuki Takahashi; Uichi Koshimizu; Hiroshi Abe; Takashi Obinata; Toshikazu Nakamura
Developmental Biology, 2001年01月15日 - Aggregation Independent of N-Cadherin and Neural Cell Adhesion Molecule on Quail Myoblasts Transformed with Temperature-Sensitive Rous Sarcoma Virus
Toshiyuki Adachi; Tomoyuki Takahashi; Jeman Kim
Cell Communication and Adhesion, 1998年 - Xenopus LIM motif-containing protein kinase, Xlimk1, is expressed in the developing head structure of the embryo
Tomoyuki Takahashi; Shunsuke Aoki; Takahiro Nakamura; Uichi Koshimizu; Kunio Matsumoto; Toshikazu Nakamura
Developmental Dynamics, 1997年06月, ［査読有り］ - Cloning and Expression of Xenopus HGF-Like Protein (HLP) and Ron/HLP Receptor Implicate Their Involvement in Early Neural Development
Takahiro Nakamura; Shunsuke Aoki; Tomoyuki Takahashi; Kunio Matsumoto; Toshikazu Kiyohara; Toshikazu Nakamura
Biochemical and Biophysical Research Communications, 1996年07月
■ 産業財産権
- 特開2024-102296, 特願2024-076867, 高アンモニア血症を治療するための医薬組成物
芳野 信; ▲高▼橋 知之; 福井 香織; 石原 直忠; 長嶋 比呂志 - 特許第7510694号, JP2020013220, 高アンモニア血症を治療するための医薬組成物
芳野 信; ▲高▼橋 知之; 福井 香織; 石原 直忠; 長嶋 比呂志 - 特開2013-240308, 特願2012-117128, ヒトES/iPS細胞における遺伝子発現方法
小戝 健一郎; 三井 薫; 高橋 知之 - 特許第4839476号, 特願2007-537770, ヘパリン結合性上皮増殖因子様増殖因子の新規医薬用途
小戝 健一郎; ニン・チン・カイ; 高橋 知之 - WO2007-037514, JP2006319915, ヘパリン結合性上皮増殖因子様増殖因子の新規医薬用途
小戝 健一郎; ニン・チン・カイ; 高橋 知之
