Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles.
Yimeng Wang; Siyu Cao; Daisuke Tone; Hiroshi Fujishima; Rikuhiro G Yamada; Rei-Ichiro Ohno; Shoi Shi; Kyoko Matsuzawa; Saori Yada; Mari Kaneko; Hirokazu Sakamoto; Taichi Onishi; Maki Ukai-Tadenuma; Hideki Ukai; Carina Hanashima; Kenzo Hirose; Hiroshi Kiyonari; Kenta Sumiyama; Koji L Ode; Hiroki R Ueda
Nature, Dec. 2024

Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.
Kazuhiro Kon; Koji L Ode; Tomoyuki Mano; Hiroshi Fujishima; Riina R Takahashi; Daisuke Tone; Chika Shimizu; Shinnosuke Shiono; Saori Yada; Kyoko Matsuzawa; Shota Y Yoshida; Junko Yoshida Garçon; Mari Kaneko; Yuta Shinohara; Rikuhiro G Yamada; Shoi Shi; Kazunari Miyamichi; Kenta Sumiyama; Hiroshi Kiyonari; Etsuo A Susaki; Hiroki R Ueda
Nature communications, 18 Jul. 2024

Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep.
Arthur Millius; Rikuhiro G Yamada; Hiroshi Fujishima; Kazuhiko Maeda; Daron M Standley; Kenta Sumiyama; Dimitri Perrin; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 03 Oct. 2023

Distinct phosphorylation states of mammalian CaMKIIβ control the induction and maintenance of sleep.
Daisuke Tone; Koji L Ode; Qianhui Zhang; Hiroshi Fujishima; Rikuhiro G Yamada; Yoshiki Nagashima; Katsuhiko Matsumoto; Zhiqing Wen; Shota Y Yoshida; Tomoki T Mitani; Yuki Arisato; Rei-Ichiro Ohno; Maki Ukai-Tadenuma; Junko Yoshida Garçon; Mari Kaneko; Shoi Shi; Hideki Ukai; Kazunari Miyamichi; Takashi Okada; Kenta Sumiyama; Hiroshi Kiyonari; Hiroki R Ueda
PLoS biology, Oct. 2022

Advanced CUBIC tissue clearing for whole-organ cell profiling.
Katsuhiko Matsumoto; Tomoki T Mitani; Shuhei A Horiguchi; Junichi Kaneshiro; Tatsuya C Murakami; Tomoyuki Mano; Hiroshi Fujishima; Ayumu Konno; Tomonobu M Watanabe; Hirokazu Hirai; Hiroki R Ueda
Nature protocols, Dec. 2019

Leak potassium channels regulate sleep duration.
Kensuke Yoshida; Shoi Shi; Maki Ukai-Tadenuma; Hiroshi Fujishima; Rei-Ichiro Ohno; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 02 Oct. 2018

Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Yasutaka Niwa; Genki N Kanda; Rikuhiro G Yamada; Shoi Shi; Genshiro A Sunagawa; Maki Ukai-Tadenuma; Hiroshi Fujishima; Naomi Matsumoto; Koh-Hei Masumoto; Mamoru Nagano; Takeya Kasukawa; James Galloway; Dimitri Perrin; Yasufumi Shigeyoshi; Hideki Ukai; Hiroshi Kiyonari; Kenta Sumiyama; Hiroki R Ueda
Cell reports, 28 Aug. 2018

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock.
Yuta Shinohara; Yohei M Koyama; Maki Ukai-Tadenuma; Takatsugu Hirokawa; Masaki Kikuchi; Rikuhiro G Yamada; Hideki Ukai; Hiroshi Fujishima; Takashi Umehara; Kazuki Tainaka; Hiroki R Ueda
Molecular cell, 07 Sep. 2017

Involvement of Ca(2+)-Dependent Hyperpolarization in Sleep Duration in Mammals.
Fumiya Tatsuki; Genshiro A Sunagawa; Shoi Shi; Etsuo A Susaki; Hiroko Yukinaga; Dimitri Perrin; Kenta Sumiyama; Maki Ukai-Tadenuma; Hiroshi Fujishima; Rei-ichiro Ohno; Daisuke Tone; Koji L Ode; Katsuhiko Matsumoto; Hiroki R Ueda
Neuron, 06 Apr. 2016

Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene.
Genshiro A Sunagawa; Kenta Sumiyama; Maki Ukai-Tadenuma; Dimitri Perrin; Hiroshi Fujishima; Hideki Ukai; Osamu Nishimura; Shoi Shi; Rei-Ichiro Ohno; Ryohei Narumi; Yoshihiro Shimizu; Daisuke Tone; Koji L Ode; Shigehiro Kuraku; Hiroki R Ueda
Cell reports, 26 Jan. 2016

CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.
Yasushi Isojima; Masato Nakajima; Hideki Ukai; Hiroshi Fujishima; Rikuhiro G Yamada; Koh-hei Masumoto; Reiko Kiuchi; Mayumi Ishida; Maki Ukai-Tadenuma; Yoichi Minami; Ryotaku Kito; Kazuki Nakao; Wataru Kishimoto; Seung-Hee Yoo; Kazuhiro Shimomura; Toshifumi Takao; Atsuko Takano; Toshio Kojima; Katsuya Nagai; Yoshiyuki Sakaki; Joseph S Takahashi; Hiroki R Ueda
Proceedings of the National Academy of Sciences of the United States of America, 15 Sep. 2009