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Murai Yoshinaka
Division of Integrated Autonomic Department of Physiology
Associate Professor
Researcher information
■ Research Keyword
■ Research Theme
- Patch clamp method
- electrophysiology
- ニューロン・シナプス機能連関
- Slice Patch-clamp method
- Electrophysiology
- Function of Neural and Synaptic Activities
- Life sciences, Clinical pharmacy
- Life sciences, Physiology, 神経生理
- Life sciences, Neuroscience - general, シナプス伝達
■ Research Theme
Career
■ Career
- 2009 - Present
Kurume University, School of Medicine, School of Medicine - 2009 - Present
- Associate Professor, Kurume University School of Medicine, Department of Physiology - 2004 - 2009
Kurume University, School of Medicine, School of Medicine - 2004 - 2009
Lecturer, Kurume University School of Medicine, Department of Physiology - 2000 - 2004
Hokkaido University, Graduate School of Dental Medicine - 2000 - 2004
Research Assistant, Graduate School Of Dental Medicine, University of Hokkaido. - 1998 - 2000
熊本大学 医学部 薬理学第ニ講座 特別研究員、財団法人ヒューマンサイエンス リサーチレジデント - 1998 - 2000
Research Resident, Faculity Of Medicine, University Of Kumamoto.
- 1998, Kyushu University, 医学系研究科, 生理学
- 1998, Kyushu University, Graduate School, Division of Medical Sciences
Research activity information
■ Paper
- The inhibition of evoked excitatory postsynaptic potentials produced by ammonium chloride in rat hippocampal CA1 neurons.
Naomitsu Kameyama; Yoshinaka Murai; Eiichiro Tanaka
Heliyon, Dec. 2020 - Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons
Shogo Kikuta; Yoshinaka Murai; Eiichiro Tanaka
NEUROSCIENCE LETTERS, Jan. 2017, [Reviewed] - Clinical Trials in Acute Ischemic Stroke
Kiyoshi Kikuchi; Eiichiro Tanaka; Yoshinaka Murai; Salunya Tancharoen
CNS DRUGS, Oct. 2014, [Reviewed] - Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke
Kiyoshi Kikuchi; Salunya Tancharoen; Takashi Ito; Yoko Morimoto-Yamashita; Naoki Miura; Ko-ichi Kawahara; Ikuro Maruyama; Yoshinaka Murai; Eiichiro Tanaka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Sep. 2013, [Reviewed] - Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke.
Kikuchi K; Miura N; Kawahara KI; Murai Y; Morioka M; Lapchak PA; Tanaka E
Biomedical reports, Jan. 2013, [Reviewed] - Clinical Neuroprotective Drugs for Treatment and Prevention of Stroke
Kiyoshi Kikuchi; Hisaaki Uchikado; Motohiro Morioka; Yoshinaka Murai; Eiichiro Tanaka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Jun. 2012, [Reviewed] - Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons
Mitsuru Saito; Yoshinaka Murai; Hajime Sato; Yong-Chul Bae; Tadashi Akaike; Masahiko Takada; Youngnam Kang
JOURNAL OF NEUROPHYSIOLOGY, Oct. 2006, [Reviewed]
- Potential of the Angiotensin Receptor Blockers (ARBs) Telmisartan, Irbesartan, and Candesartan for Inhibiting the HMGB1/RAGE Axis in Prevention and Acute Treatment of Stroke. (vol 14, pg 18899, 2013)
Kiyoshi Kikuchi; Salunya Tancharoen; Takashi Ito; Yoko Morimoto-Yamashita; Naoki Miura; Ko-ichi Kawahara; Ikuro Maruyama; Yoshinaka Murai; Eiichiro Tanaka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Apr. 2014 - The Efficacy of Edaravone (Radicut), a Free Radical Scavenger, for Cardiovascular Disease
Kiyoshi Kikuchi; Salunya Tancharoen; Nobuyuki Takeshige; Munetake Yoshitomi; Motohiro Morioka; Yoshinaka Murai; Eiichiro Tanaka
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Jul. 2013 - The efficacy of edaravone (radicut), a free radical scavenger, for cardiovascular disease
Kiyoshi Kikuchi; Salunya Tancharoen; Nobuyuki Takeshige; Munetake Yoshitomi; Motohiro Morioka; Yoshinaka Murai; Eiichiro Tanaka
International Journal of Molecular Sciences, Jul. 2013, [Reviewed] - The alteration of glutamate clearance in astrocytes derived from MeCP2-null mouse
Yasunori Okabe; Tomoyuki Takahashi; Chiaki Mitsumasu; Yoshinaka Murai; Toyojiro Matsuishi; Eiichiro Tanaka
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013 - Activation of protein kinase A and C prevents recovery from persistent depolarization produced by oxygen and glucose deprivation in rat hippocampal neurons
Y. Murai; Y. Okabe; E. Tanaka
JOURNAL OF NEUROPHYSIOLOGY, May 2012, [Reviewed] - Neural development of methyl-CpG-binding protein 2 null embryonic stem cells: A system for studying Rett syndrome
Yasunori Okabe; Akira Kusaga; Tomoyuki Takahashi; Chiaki Mitsumasu; Yoshinaka Murai; Eiichiro Tanaka; Hideho Higashi; Toyojiro Matsuishi; Ken-ichiro Kosai
BRAIN RESEARCH, Nov. 2010, [Reviewed] - Thiamylal antagonizes the inhibitory effects of dorsal column stimulation on dorsal horn activities in humans
Eiichiro Tanaka; Toshiyuki Tobita; Yoshinaka Murai; Yasunori Okabe; Aya Yamada; Tatsuhiko Kano; Hideho Higashi; Koki Shimoji
NEUROSCIENCE RESEARCH, Aug. 2009, [Reviewed] - Two opposing roles of 4-AP-sensitive K+ current in initiation and invasion of spikes in rat mesencephalic trigeminal neurons
Mitsuru Saito; Yoshinaka Murai; Hajime Sato; Yong-Chul Bae; Tadashi Akaike; Masahiko Takada; Youngnam Kang
JOURNAL OF NEUROPHYSIOLOGY, Oct. 2006, [Reviewed] - Neuroprotective mechanisms of lidocaine against in vitro ischemic insult of the rat hippocampal CA1 pyramidal neurons
S Niiyama; E Tanaka; S Tsuji; Y Murai; M Satani; H Sakamoto; K Takahashi; M Kuroiwa; A Yamada; M Noguchi; H Higashi
NEUROSCIENCE RESEARCH, Nov. 2005 - Excitatory GABAergic synaptic potentials in the mesencephalic trigerninal nucleus of adult rat in vitro
Y Yokomizo; Y Murai; E Tanaka; H Inokuchi; J Kusukawa; H Higashi
NEUROSCIENCE RESEARCH, Apr. 2005 - Orexins cause depolarization via nonselective cationic and K+ channels in isolated locus coeruleus neurons
Y Murai; T Akaike
NEUROSCIENCE RESEARCH, Jan. 2005 - Functional, metabolic, and histological changes of vascular tissues after warm ischemia.
Moriyama. S; Utoh. J; Murai. Y; Hagiwara. S; Kunitomo. R; Nishi. K; Kitamura. N
Ann Thorac Cardiovasc Surg., 2001 - Functional, metabolic, and histological changes of vascular tissues after warm ischemia.
Moriyama. S; Utoh. J; Murai. Y; Hagiwara. S; Kunitomo. R; Nishi. K; Kitamura. N
Ann Thorac Cardiovasc Surg., 2001 - Noradrenaline receptor-mediated potentiation of caffeine-induced Ca2+-activated K+ currents in bovine ciliary muscle cells
T Okuda; N Tokutomi; Y Tokutomi; Y Murai; A Negi; K Nishi
CURRENT EYE RESEARCH, 2001 - The prostaglandin E series modulates high-voltage-activated calcium channels probably through the EP3 receptor in rat paratracheal ganglia
Y Ito; Y Murai; H Ishibashi; H Onoue; N Akaike
NEUROPHARMACOLOGY, 2000 - Preferential inhibition of L- and N-type calcium channels in the rat hippocampal neurons by cilnidipine
Y Murai; H Uneyama; H Ishibashi; K Takahama; N Akaike
BRAIN RESEARCH, Jan. 2000 - Effect of nilvadipine on the voltage-dependent Ca2+ channels in rat hippocampal CA1 pyramidal neurons
H Ishibashi; Y Murai; N Akaike
BRAIN RESEARCH, Nov. 1998 - Acetylcholine modulation of high-voltage-activated calcium channels in the neurones acutely dissociated from rat paratracheal ganglia
Y Murai; H Ishibashi; N Akaike; Y Ito
BRITISH JOURNAL OF PHARMACOLOGY, Apr. 1998 - Acetylcholine modulation of high-voltage-activated calcium channels in the neurones acutely dissociated from rat paratracheal ganglia
Y Murai; H Ishibashi; N Akaike; Y Ito
BRITISH JOURNAL OF PHARMACOLOGY, Apr. 1998 - Different effect of oxytocin on membrane potential of supraoptic oxytocin neurons in virgin female and male rats in vitro
M Yoshinaka; T Nakashima; S Miyata; T Kiyohara
NEUROSCIENCE RESEARCH, Jan. 1998 - Ca2+-activated K+ currents in rat locus coeruleus neurons induced by experimental ischemia, anoxia, and hypoglycemia
Y Murai; H Ishibashi; S Koyama; N Akaike
JOURNAL OF NEUROPHYSIOLOGY, Nov. 1997 - Effects of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, on recombinant human GABA(A) receptors
SE WesthHansen; K Noguchi; MR Witt; Y Murai; M Nielsen; N Akaike
NEUROSCIENCE LETTERS, Jul. 1997 - Ca2+-activated K+ currents in rat locus coeruleus neurons induced by experimental ischemia, anoxia, and hypoglycemia
Yoshinaka Murai; Hitoshi Ishibashi; Susumu Koyama; Norio Akaike
Journal of Neurophysiology, 1997 - Two components of metabotropic glutamate responses in acutely dissociated CA3 pyramidal neurons of the rat
N Harata; J Katayama; Y Takeshita; Y Murai; N Akaike
BRAIN RESEARCH, Mar. 1996 - Two components of metabotropic glutamate responses in acutely dissociated CA3 pyramidal neurons of the rat
N Harata; J Katayama; Y Takeshita; Y Murai; N Akaike
BRAIN RESEARCH, Mar. 1996 - NALOXONE SUPPRESSES THE RISING PHASE OF FEVER INDUCED BY INTERFERON-ALPHA
T NAKASHIMA; T MURAKAMI; Y MURAI; T HORI; S MIYATA; T KIYOHARA
BRAIN RESEARCH BULLETIN, 1995 - NALOXONE SUPPRESSES THE RISING PHASE OF FEVER INDUCED BY INTERFERON-ALPHA
T NAKASHIMA; T MURAKAMI; Y MURAI; T HORI; S MIYATA; T KIYOHARA
BRAIN RESEARCH BULLETIN, 1995
- Apr. 2023 - Present
久留米大学医学部医学科 - Sep. 2022 - Present
久留米大学医学部医学科 - May 2004 - Present
久留米大学医学部医学科 - Apr. 2016 - Mar. 2023
- Apr. 2016 - Mar. 2023
- Apr. 2006 - Mar. 2016
久留米大学医学部医学科 - Apr. 2006 - Mar. 2016
久留米大学医学部医学科 - 久留米大学医学部看護学科
- Apr. 1990 - Present
日本神経科学会 - Apr. 1990 - Present
日本生理学会 - Apr. 1990 - Present
The Japanese Neuroscience Society - Apr. 1990 - Present
The Physiological Society of Japan
- 虚血性神経細胞死に関与する細胞内機序
2008 - Activation of protein kinase A contributes to the persistent depolarization induced by in vitro ischemia
2008 - 機械的単離法を用いた三叉神経中脳路核ニューロンのシナプス電流解析
2002 - GABAergic synaptic responses recorded from neurons in rat mesencephalic trigeminal nucleus in vitro.
2002 - 三叉神経中脳路核ニューロンの活動電位生成に対するA型K+チャネルの関与
2001 - A role of A-type K+ channel in regulation of spike generation in Rat mesencephalic trigeminal neurons.
2001
- The study about ion channel disorder of central nervous system in Rett's syndrome
Grant-in-Aid for Young Scientists (B)
Kurume University
Apr. 2015 - Mar. 2019 - 統合失調症の発現過程にオキシトシンはどのように関与するのか
Apr. 2014 - Mar. 2016 - Glial cells differentiation of MeCP2 deficient ES/iPS cells and pathophysiology of Rett syndrome
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2013 - Mar. 2016 - Effects of monoamine on the prefrontal cortical neurons and amygdaloid nuclei neurons
Grant-in-Aid for Scientific Research (C)
Kurume University
Apr. 2011 - Mar. 2013 - Generation of iPS cells derived form an Rett syndrome model mouse and drug screening for Rett syndrome using MeCP2 deficient iPS cells
Grant-in-Aid for Scientific Research (C)
Kurume University
2010 - 2012 - Health effect evaluation based on characteristics of nanoparticles
Grant-in-Aid for Scientific Research (C)
Kurume University
2007 - 2009 - Dose aromatase regulate the feeding behavior and induce the sexual difference on appetite?
Grant-in-Aid for Scientific Research (C)
Kurume University
2007 - 2008 - 虚血性神経細胞死に関与する細胞内機序
2008 - Activation of protein kinase A contributes to the persistent depolarization induced by in vitro ischemia
2008 - Do androgen receptors contribute to the expression of sex differences in the brain?
Grant-in-Aid for Scientific Research (C)
Kurume University
2006 - 2007 - 機械的単離法を用いた三叉神経中脳路核ニューロンのシナプス電流解析
2002 - GABAergic synaptic responses recorded from neurons in rat mesencephalic trigeminal nucleus in vitro
2002 - 三叉神経中脳路核ニューロンの活動電位生成に対するA型K+チャネルの関与
2001 - A role of A-type K+ channel in regulation of spike generation in Rat mesencephalic trigeminal neurons
2001
