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Yanagi (Ishihara) Keiko
Division of Brain Science Department of Physiology
Associate Professor
Career
■ Career
- 2013 - Present
Kurume University School of Medicine, Department of Physiology, Associate Professor - 2004 - 2013
Saga University School of Medicine, Department of Physiology, Associate Professor - 1999 - 2004
Saga Medical School, Department of Physiology, Associate Professor - 1995 - 1999
Saga Medical School, Department of Physiology, Research Assistant - 1994 - 1995
Juntendo University School of Medicine, Department of Physiology, Research Associate - 1992 - 1994
Tokyo Dental and Medical University, Department of Cardiovascular Diseases, 専攻生 - 1991 - 1992
University of California San Diego, Cardiology, Postdoctoral Fellow
Research activity information
■ Paper
■ 共同研究実績
- External K+ dependence of strong inward rectifier K+ channel conductance is caused not by K+ but by competitive pore blockade by external Na+
Keiko Ishihara
Journal of General Physiology, Jun. 2018, [Reviewed] - Clinical Concentrations of Local Anesthetics Bupivacaine and Lidocaine Differentially Inhibit Human Kir2.x Inward Rectifier K+ Channels
Nakahira K; Oshita K; Itoh M; Takano M; Sakaguchi Y; Ishihara K
Anesthesia & Analgesia, Apr. 2016, [Reviewed] - Neuronal and glial expression of inward rectifier potassium channel subunits Kir2.x in rat dorsal root ganglion and spinal cord
Murata Y; Yasaka T; Takano M; Ishihara K
Neurosci Lett, 2016, [Reviewed] - The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contain multiple S-palmitoylation sites
Itoh M; Ishihara K; Nakashima N; Takano M
J Physiol Sci, 2016, [Reviewed] - Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2
Takano M; Ushijima K; Oshita K; Hirashima S; Itoh M; Ishihara K; Kuwabara Y; Nakao K; Kuwahara K; Nakamura K.-I; Kimura T
Journal of Molecular and Cellular Cardiology, 2015, [Reviewed] - Heteromeric assembly of inward rectifier channel subunit Kir2.1 with Kir3.1 and with Kir3.4.
Ishihara K; Yamamoto T; Kubo Y
Biochem Biophys Res Commun, 2009, [Reviewed] - Role of Mg2+ block of the inward rectifier K+ current in cardiac repolarization reserve: A quantitative simulation.
Ishihara K; Sarai N; Asakura K; Noma A; Matsuoka S
J Mol Cell Cardiol, 2009, [Reviewed] - Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.
Ishihara K; Yan D-H
J Physiol, 2007, [Reviewed] - Different intracellular polyamine concentrations underlie the difference in the inward rectifier K+ currents in atria and ventricles of the guinea-pig heart.
Yan D-H; Nishimura K; Yoshida K; Nakahira K; Ehara T; Igarashi K; Ishihara K
J Physiol, 2005, [Reviewed] - Two Kir2.1 channel populations with different sensitivities to Mg2+ and polyamine block: a model for the cardiac strong inward rectifier K+ channel.
Yan D-H; Ishihara K
J Physiol, 2005, [Reviewed] - Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line.
Ishihara K; Ehara T
J Physiol, 2004, [Reviewed] - Inward rectifier K+ current under physiological cytoplasmic conditions in guinea-pig cardiac ventricular cells
K Ishihara; DH Yan; S Yamamoto; T Ehara
JOURNAL OF PHYSIOLOGY-LONDON, May 2002, [Reviewed] - Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes.
Kaibara M; Ishihara K; Doi Y; Hayashi H; Ehara T; Taniyama K
FEBS Lett, 2002, [Reviewed] - A repolarization-induced transient increase in the outward current of the inward rectifier K+ channel in guinea-pig cardiac myocytes.
Ishihara K; Ehara T
J Physiol, 1998, [Reviewed] - Time-dependent outward currents through the inward rectifier potassium channel IRK1 - The role of weak blocking molecules
K Ishihara
JOURNAL OF GENERAL PHYSIOLOGY, Feb. 1997, [Reviewed] - The tetravalent organic cation spermine causes the gating of the IRK1 channel expressed in murine fibroblast cells.
Ishihara K; Hiraoka M; Ochi R
J Physiol, 1996, [Reviewed] - Gating mechanism of the cloned inward rectifier potassium channel from mouse heart.
Ishihara K; Hiraoka M
J Membr Biol, 1994, [Reviewed] - The alfa1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy.
Knowlton KU; Michel MC; Itani M; Shubeita HE; Ishihara K; Brown JH; Chien KR
J Biol Chem, 1993, [Reviewed] - Anion channels activated by adrenaline in cardiac myocytes.
Ehara T; Ishihara K
Nature, 1990, [Reviewed] - The Mg2+ block and intrinsic gating underlying inward rectification of the K+ current in guinea-pig cardiac myocytes.
Ishihara K; Mitsuiye T; Noma A; Takano M
J Physiol, 1989, [Reviewed]
- Molecular mechanisms of cardiac inward rectifier K+ current, IK1
柳(石原) 圭子
Polyamine, Mar. 2022, [Reviewed], [Invited]
Lead - Molecular Mechanisms Underlying the Extracellular K+ Dependences of IK1
Keiko Yanagi (Ishihara)
Japanese Journal of Electrocardiology, Aug. 2020, [Reviewed], [Invited]
Lead - カリウムイオンの濃度により心電図の再分極が起こるのはなぜか?(質疑応答・臨床一般)
柳(石原) 圭子
日本医事新報, Jul. 2017, [Invited]
- Molecular mechanisms underlying the cardiac strong inward rectifier K+ current, IK1
柳(石原)圭子
日本ポリアミン学会 第11回年会, 24 Jan. 2020, [Invited] - IK1(Kir2.1)チャネルの細胞外K+依存性の分子機構 （心電学フロンティア2019 K+チャネルのしくみ）
柳(石原) 圭子
第66回日本不整脈心電学会学術大会, 25 Jul. 2019, [Invited] - New insights into K+ dependences of the strong inward rectifier potassium channel Kir2.1 (Symposium44 (International Scientific Program Committee Symposium) / Cutting-edge approaches to long-lasting questions and novel aspects of inward rectifier K+ channel
ISHIHARA Keiko
FAOPS2019/the 96th Annual Meeting of the Physiological Society of Japan, Mar. 2019 - New insights into basic properties of the strong inward rectifier K+ channel
Ishihara Keiko
The 49th NIPS International Symposium "Ion channels: looking back, seeing ahead", Dec. 2018, [Invited] - Mechanisms for external K+ dependence of K+ permeation and gating of Kir2.1 inward rectifier K+ channel (Symposium 12: Simulation studies of structures, dynamics, and functions of ion channels and transporters ) K+ permeation and gating of Kir2.1 inward r
Ishihara Keiko; Satoshi Matsuoka; Makoto Takano
第94回 日本生理学会, Mar. 2017 - Revisiting K+ dependence of conductance and gating of strong inward rectifier K+ channels (symposium 33:Structure based approaches to the functioning mechanisms of ion channels and the search for their novel inhibitors）
Ishihara Keiko; Itoh Masayuki; Igata Sachiyo; Takano Makoto
第93回 日本生理学会, Mar. 2016 - マグネシウムと不整脈
柳(石原) 圭子
第33回日本マグネシウム学会学術集会, Sep. 2013, [Invited] - Mgの電気生理学（心電学フロンティア2012）
柳(石原) 圭子
第29回日本心電学会学術集会, Sep. 2012, [Invited] - Low-affinity polyamine block of IK1 facilitating the cardiac repolarization. (Special Symposium ‘Ion channels, Arrhythmogenesis and Channelopathy')
Ishihara K
The 4th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2011)/第26回日本不整脈学会/第28回日本心電学会, Sep. 2011, [Invited] - Subunits of inward rectifier K+ channel subfamilies Kir2 and Kir3 form heteromultimers in heterologous expression systems
Ishihara Keiko; Yamamoto Tomomi; Kubo Yoshihiro
日本生理学会, May 2010 - Low-affinity spermine block mediating the outward currents of Kir2 channels: implications for the cardiac strong inward rectifier K+ current IK1
Ishihara K
The IUPS 2009 Satellite Symposium "Ion channels and membrane transport systems: function, structure, and physiology", Aug. 2009, [Invited] - 再分極予備能としての内向き整流Kチャネル電流IK1トランジェント成分（特別企画 臨床医のための心臓生理・心臓薬理学）
石原 圭子
第24回日本不整脈学会学術大会・第26回日本心電学会学術集会合同学術集会, Jun. 2009, [Invited] - Inward rectifier potassium current IK1 during the cardiac myocellular repolarization: an in silico study
Ishihara K
4th International Symposium of Cell/Biodynamics Simulation Project, Kyoto University "Medical Systems Biology of the Heart", Nov. 2007, [Invited]
■ 共同研究実績
- カテコラミン誘発多形性心室頻拍(CPVT)とKCNJ2変異の関連(滋賀大学医学部循環器内科学)
- カリウムイオンの流れに依存するチャネルブロックの分子機構(福井大学医学部)
- 結晶構造解析に基づくGタンパク制御型カリウムチャネル薬理作用の解析(大阪大学医学部薬理学)
- 心不全モデル動物における不整脈と細胞内ポリアミンの関わり(アミンファーマ研究所)
- カリウムチャネルに対する麻酔薬の作用(佐賀大学医学部麻酔蘇生学)
- 脊髄組織におけるKir2.x局在の解析(佐賀大学医学部組織神経解剖学)
- 包括的心筋細胞モデルを用いた再分極予備能の研究(京都大学医学部生理学)
- Kirチャネルファミリーのヘテロ形成能(生理学研究所神経機能素子部門)
- 心筋組織における細胞内遊離ポリアミン濃度の推定(千葉大学薬学部)
- ヒトKir2.2チャネル遺伝子のクローニング(長崎大学医学部薬理学)
