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Taketomi Takaharu
Dental and Oral Medical Center
Associate Professor
Career
■ Career
■ Member History
- Apr. 2022 - Present
Kurume University, School of Medicine Dental and Oral Medical Center, Associate professor - Apr. 2017 - Mar. 2022
Kurume University, School of Medicine Dental and Oral Medical Center, Lecturer - Apr. 2013 - Mar. 2017
Kurume University, School of Medicine Dental and Oral Medical Center, Assistant Professor - Apr. 2009 - Mar. 2013
Kyushu University, Faculty of Dental Science, Assistant Professor - Apr. 2004 - Mar. 2009
Japan Society for the Promotion of Science, JSPS Research Fellowship for Young Scientists
■ Member History
Research activity information
■ Award
■ 共同研究希望
■ 共同研究実績
- 2012
日本口腔外科学会, 優秀ポスター発表賞
Zoledronate の TLR4 シグナルを介した自然免疫への関与
村津大地, 吉賀大午, 武富孝治, 鬼村朋宏, 中村誠司 - 2010
International Cleft Lip and Palate Foundation, Best Paper Award
Sprouty2 deficient mice exhibit cleft palate.
Kaori Matsumura;Takaharu Taketomi;Masaaki Sasaguri;Takeshi Mitsuyasu;Daigo Yoshiga;Shinsaku Arai;Takashi Maehara;Terukazu Sanui;Seiji Nakamura - 2010
日本口腔科学会, 学会賞
Sprouty2はマウス口蓋癒合に関与する
松村香織;武富孝治;笹栗正明;光安岳志;吉賀大午;新井伸作;前原 隆;讃井彰一;中村誠司 - Mar. 2005
井上科学振興財団, 第22回 井上研究奨励賞
MAPK経路抑制因子Sprouty2が腸壁内神経叢に与える影響に関する研究
武富 孝治
- Preoperative endovascular arterial embolization to avoid maxillary artery injury in maxillary gingival cancer surgery.
Takaharu Taketomi; Terukazu Sanui; Takao Fukuda; Go Takeshita; Junichi Nojiri
Radiology case reports, Aug. 2024 - An 84-Year-Old Man with a History of Myeloma and Biphosphonate-Related Osteonecrosis of the Jaw Treated with Preoperative Vascular Embolization Before Partial Maxillectomy.
Takaharu Taketomi; Takao Fukuda; Junichi Nojiri; Terukazu Sanui
The American journal of case reports, 20 Jul. 2024 - A Case of a Dentigerous Cyst in the Maxillary Sinus Treated Preoperatively With Vascular Embolization to Avoid Intraoperative Abnormal Bleeding.
Takaharu Taketomi; Takao Fukuda; Go Takeshita; Terukazu Sanui
Cureus, Dec. 2023 - An Isolated Laminar Osteoma Arising in the Maxillary Sinus.
Takaharu Taketomi; Kouhei Imayama; Ken Nakamura; Jingo Kusukawa
The American journal of case reports, 27 Mar. 2023 - Basal cell adenoma of the minor salivary glands in the buccal mucosa: A case report and literature review: Basal cell adenoma of the minor salivary glands
Takaharu Taketomi; Ken Nakamura; Terukazu Sanui; Takao Fukuda; Yukiko Tominaga; Yukari Takase; Jingo Kusukawa
Oral and Maxillofacial Surgery Cases, Sep. 2022 - Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression.
Yukari Watanabe; Takao Fukuda; Chikako Hayashi; Yuki Nakao; Masaaki Toyoda; Kentaro Kawakami; Takanori Shinjo; Misaki Iwashita; Hiroaki Yamato; Karen Yotsumoto; Takaharu Taketomi; Takeshi Uchiumi; Terukazu Sanui; Fusanori Nishimura
Scientific reports, 03 Aug. 2022 - miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.
Chikako Hayashi; Takao Fukuda; Kentaro Kawakami; Masaaki Toyoda; Yuki Nakao; Yukari Watanabe; Takanori Shinjo; Tomomi Sano; Misaki Iwashita; Karen Yotsumoto; Miyu Shida; Takaharu Taketomi; Terukazu Sanui; Takeshi Uchiumi; Takashi Kanematsu; Fusanori Nishimura
Frontiers in cell and developmental biology, 2022 - Combined application of geranylgeranylacetone and amelogenin promotes angiogenesis and wound healing in human periodontal ligament cells.
Hiroaki Yamato; Terukazu Sanui; Karen Yotsumoto; Yuki Nakao; Yukari Watanabe; Chikako Hayashi; Ryosuke Aihara; Misaki Iwashita; Urara Tanaka; Takaharu Taketomi; Takao Fukuda; Fusanori Nishimura
Journal of cellular biochemistry, Jul. 2021 - Exosomes from TNF-α-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss.
Yuki Nakao; Takao Fukuda; Qunzhou Zhang; Terukazu Sanui; Takanori Shinjo; Xiaoxing Kou; Chider Chen; Dawei Liu; Yukari Watanabe; Chikako Hayashi; Hiroaki Yamato; Karen Yotsumoto; Urara Tanaka; Takaharu Taketomi; Takeshi Uchiumi; Anh D Le; Songtao Shi; Fusanori Nishimura
Acta biomaterialia, 01 Mar. 2021 - Solitary Neurofibroma of the Hard Palate: A Case Report and Literature Review.
Takaharu Taketomi; Ken Nakamura; Yui Teratani; Katsuhisa Matsuo; Jingo Kusukawa
The American journal of case reports, 22 Feb. 2021 - Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages.
Karen Yotsumoto; Terukazu Sanui; Urara Tanaka; Hiroaki Yamato; Rehab Alshargabi; Takanori Shinjo; Yuki Nakao; Yukari Watanabe; Chikako Hayashi; Takaharu Taketomi; Takao Fukuda; Fusanori Nishimura
Frontiers in immunology, 2020 - Sprouty2 is involved in the control of osteoblast proliferation and differentiation through the FGF and BMP signaling pathways.
Takaharu Taketomi; Tomohiro Onimura; Daigo Yoshiga; Daichi Muratsu; Terukazu Sanui; Takao Fukuda; Jingo Kusukawa; Seiji Nakamura
Cell biology international, Sep. 2018 - Amelogenin induces M2 macrophage polarisation via PGE2/cAMP signalling pathway.
Kensuke Yamamichi; Takao Fukuda; Terukazu Sanui; Kyosuke Toyoda; Urara Tanaka; Yuki Nakao; Karen Yotsumoto; Hiroaki Yamato; Takaharu Taketomi; Takeshi Uchiumi; Fusanori Nishimura
Archives of oral biology, Nov. 2017 - A case of the pleomorphic adenoma of minor salivary gland that resulted in maxillary metastasis 20 years after primary tumor resection
Takaharu Taketomi; Keita Todoroki; Kinuko Ogata; Yushi Abe; Makoto Koga; Jingo Kusukawa
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 01 Mar. 2017 - A case of basal cell adenocarcinoma of soft palate
武富孝治; 武富孝治; 轟圭太; 中村守厳; 安陪由思; 古場朗洋; 古場朗洋; 楠川仁悟
日本口腔腫瘍学会誌, 2017 - Inhibition of Sprouty2 polarizes macrophages toward an M2 phenotype by stimulation with interferon γ and Porphyromonas gingivalis lipopolysaccharide.
Ryo Atomura; Terukazu Sanui; Takao Fukuda; Urara Tanaka; Kyosuke Toyoda; Takaharu Taketomi; Kensuke Yamamichi; Hajime Akiyama; Fusanori Nishimura
Immunity, inflammation and disease, Mar. 2016 - Grp78 Is Critical for Amelogenin-Induced Cell Migration in a Multipotent Clonal Human Periodontal Ligament Cell Line.
Kyosuke Toyoda; Takao Fukuda; Terukazu Sanui; Urara Tanaka; Kensuke Yamamichi; Ryo Atomura; Hidefumi Maeda; Atsushi Tomokiyo; Takaharu Taketomi; Takeshi Uchiumi; Fusanori Nishimura
Journal of cellular physiology, Feb. 2016 - Sprouty2 inhibition promotes proliferation and migration of periodontal ligament cells
U. Tanaka; T. Sanui; T. Fukuda; K. Toyoda; T. Taketomi; R. Atomura; K. Yamamichi; H. Maeda; F. Nishimura
Oral Diseases, Nov. 2015 - Mutation of Spry2 induces proliferation and differentiation of osteoblasts but inhibits proliferation of gingival epithelial cells.
Terukazu Sanui; Urara Tanaka; Takao Fukuda; Kyosuke Toyoda; Takaharu Taketomi; Ryo Atomura; Kensuke Yamamichi; Fusanori Nishimura
Journal of cellular biochemistry, Apr. 2015 - Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through controlled expression of SOCS1 in macrophages.
Daichi Muratsu; Daigo Yoshiga; Takaharu Taketomi; Tomohiro Onimura; Yoshihiro Seki; Akinobu Matsumoto; Seiji Nakamura
PloS one, 2013 - Identification of novel amelogenin-binding proteins by proteomics analysis.
Takao Fukuda; Terukazu Sanui; Kyosuke Toyoda; Urara Tanaka; Takaharu Taketomi; Takeshi Uchiumi; Fusanori Nishimura
PloS one, 2013 - Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling.
Kaori Matsumura; Takaharu Taketomi; Keigo Yoshizaki; Shinsaku Arai; Terukazu Sanui; Daigo Yoshiga; Akihiko Yoshimura; Seiji Nakamura
Biochemical and biophysical research communications, 28 Jan. 2011 - The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1.
Atsushi Nonami; Takaharu Taketomi; Akiko Kimura; Kazuko Saeki; Hiromi Takaki; Takahito Sanada; Koji Taniguchi; Mine Harada; Reiko Kato; Akihiko Yoshimura
Genes to cells : devoted to molecular & cellular mechanisms, Sep. 2005 - Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia.
Takaharu Taketomi; Daigo Yoshiga; Koji Taniguchi; Takashi Kobayashi; Atsushi Nonami; Reiko Kato; Mika Sasaki; Atsuo Sasaki; Hitoshi Ishibashi; Maiko Moriyama; Kei-ichiro Nakamura; Junji Nishimura; Akihiko Yoshimura
Nature neuroscience, Jul. 2005 - Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells.
Atsushi Nonami; Reiko Kato; Koji Taniguchi; Daigo Yoshiga; Takaharu Taketomi; Satoru Fukuyama; Mine Harada; Atsuo Sasaki; Akihiko Yoshimura
The Journal of biological chemistry, 10 Dec. 2004 - Model analysis of difference between EGF pathway and FGF pathway.
Satoshi Yamada; Takaharu Taketomi; Akihiko Yoshimura
Biochemical and biophysical research communications, 20 Feb. 2004 - Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Atsuo Sasaki; Takaharu Taketomi; Reiko Kato; Kazuko Saeki; Atsushi Nonami; Mika Sasaki; Masamitsu Kuriyama; Naoaki Saito; Masabumi Shibuya; Akihiko Yoshimura
Nature cell biology, May 2003 - Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
Reiko Kato; Atsushi Nonami; Takaharu Taketomi; Toru Wakioka; Asato Kuroiwa; Yoichi Matsuda; Akihiko Yoshimura
Biochemical and biophysical research communications, 21 Mar. 2003 - Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.
Atsuo Sasaki; Takaharu Taketomi; Reiko Kato; Kazuko Saeki; Atsushi Nonami; Mika Sasaki; Masamitsu Kuriyama; Naoaki Saito; Masafumi Shibuya; Akihiko Yoshimura
Cell cycle (Georgetown, Tex.), 2003 - Marsupialization for odontogenic keratocysts: long-term follow-up analysis of the effects and changes in growth characteristics.
Norifumi Nakamura; Takeshi Mitsuyasu; Yoshiko Mitsuyasu; Takaharu Taketomi; Yoshinori Higuchi; Masamichi Ohishi
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, Nov. 2002 - Identification of a Dominant Negative Mutant of Sprouty that Potentiates Fibroblast Growth Factor-but Not Epidermal Growth Factor-induced ERK Activation
Atsuo Sasaki; Takaharu Taketomi; Toru Wakioka; Reiko Kato; Akihiko Yoshimura
Journal of Biological Chemistry, 28 Sep. 2001
- 免疫学のニューワールド粘膜免疫 基礎研究から予防・治療戦略へ
武富 孝治; 清野 宏
国際歯科学士会日本部会雑誌, Sep. 2007 - 免疫学の新世界 粘膜免疫 基礎から最先端予防医療への展開
武富 孝治; 清野 宏
東京都歯科医師会雑誌, Aug. 2007
- 【サイトカインの多彩な機能と臨床応用 免疫・造血・代謝・発生・神経の調節機構と疾患治療への最新アプローチ】サイトカインの制御因子 Sprouty/Spredファミリーによる増殖因子,サイトカインのシグナル制御
加藤 玲子; 武富 孝治; 野波 篤; 谷口 浩二; 吉村 昭彦
(株)羊土社, Dec. 2005 - 形態形成制御におけるシグナル伝達 MAPキナーゼ制御分子Sprouty/Spredファミリーの作用機構
吉村 昭彦; 加藤 玲子; 佐々木 敦朗; 武富 孝治
(公社)日本生化学会, Aug. 2002
- 軟口蓋部に発生したsialolipomaの1例
中村 守厳; 武井 雄介; 久篠 奈苗; 古場 朗洋; 武富 孝治; 楠川 仁悟
日本口腔科学会雑誌, Jul. 2017, (NPO)日本口腔科学会 - 脱灰象牙質を用いた骨再生研究 FIB/SEMトモグラフィー法による移植脱灰象牙質-周囲新生骨界面の3次元的微細構造解析
田上 隆一郎; 宮園 佳宏; 武富 孝治; 岩本 修; 楠川 仁悟
日本口腔科学会雑誌, Jul. 2017, (NPO)日本口腔科学会 - 上顎洞に生じた骨腫の1例
徳永 秀信; 武富 孝治; 吉武 稔浩; 緒方 絹子; 岩本 修; 楠川 仁悟
日本口腔科学会雑誌, Mar. 2016, (NPO)日本口腔科学会 - 腕頭静脈に及ぶ内頸静脈血栓塞栓を伴った舌癌頸部リンパ節転移の1例
武富 孝治; 安陪 由思; 緒方 絹子; 原田 真知子; 古場 朗洋; 岩本 修; 楠川 仁悟
日本口腔科学会雑誌, Sep. 2015, (NPO)日本口腔科学会 - 外科的治療を行ったBMA関連顎骨壊死症例の臨床的検討
原田 真知子; 田上 隆一郎; 緒方 絹子; 高野 雅代; 武富 孝治; 楠川 仁悟
日本口腔科学会雑誌, Jul. 2015, (NPO)日本口腔科学会 - Y-box結合タンパク質の骨芽細胞における動態解析
福田 隆男; 田中 麗; 讃井 彰一; 豊田 敬介; 後村 亮; 武富 孝治; 濱地 貴文; 前田 勝正
日本歯科医師会雑誌, Aug. 2012, (公社)日本歯科医師会 - ZoledoronateがTLR4シグナルを介した炎症反応へ与える影響
村津 大地; 吉賀 大午; 武富 孝治; 鬼村 朋宏; 中村 誠司
日本骨代謝学会学術集会プログラム抄録集, Jul. 2012, (一社)日本骨代謝学会 - FGFシグナル抑制因子Sprouty2による骨芽細胞増殖制御機構の解析
鬼村 朋宏; 武富 孝治; 吉賀 大午; 村津 大地; 中村 誠司
日本骨代謝学会学術集会プログラム抄録集, Jul. 2012, (一社)日本骨代謝学会 - 口腔癌術後に緊急手術を要した症例に関する検討 気管切開術の適応について
八坂 美沙; 武富 孝治; 川野 真太郎; 豊嶋 健史; 見立 英治; 新井 伸作; 篠崎 昌一; 平野 充広; 田中 秀明; 杉浦 剛; 森 悦秀; 中村 誠司
日本口腔科学会雑誌, Jan. 2012, (NPO)日本口腔科学会 - 口腔悪性腫瘍術後早期におけるSIRS評価の有用性についての検討
新井 伸作; 笹栗 正明; 武富 孝治; 豊嶋 健史; 田中 秀明; 久保 慶朗; 川野 真太郎; 大部 一成; 中村 誠司
日本口腔科学会雑誌, Jan. 2012, (NPO)日本口腔科学会 - ヒトY-box結合蛋白(YB-1)の骨芽細胞における細胞動態解析
福田 隆男; 田中 麗; 讃井 彰一; 豊田 敬介; 久保田 祥平; 武富 孝治; 濱地 貴文; 前田 勝正
日本歯周病学会会誌, Sep. 2011, (NPO)日本歯周病学会 - マウス口蓋癒合におけるSprouty2の役割
松村 香織; 武富 孝治; 吉崎 恵悟; 笹栗 正明; 光安 岳志; 吉賀 大午; 新井 伸作; 前原 隆; 讃井 彰一; 中村 誠司
日本口腔科学会雑誌, Jan. 2011, (NPO)日本口腔科学会 - Sprouty2遺伝子欠損マウスにおける口蓋裂の発症について
松村 香織; 武富 孝治; 笹栗 正明; 光安 岳志; 辻口 友美; 新井 伸作; 吉賀 大午; 中村 誠司
日本口腔外科学会雑誌, Sep. 2010, (公社)日本口腔外科学会 - マウス口蓋形成におけるSprouty2の役割
松村 香織; 武富 孝治; 笹栗 正明; 光安 岳志; 辻口 友美; 吉賀 大午; 新井 伸作; 吉崎 恵悟; 中村 誠司
日本口蓋裂学会雑誌, Apr. 2010, (一社)日本口蓋裂学会 - 歯周組織細胞群における新規アメロジェニン結合タンパク質の検索
福田 隆男; 讃井 彰一; 武富 孝治; 後藤 英文; 濱地 貴文; 前田 勝正
日本歯周病学会会誌, Apr. 2009, (NPO)日本歯周病学会 - 歯原性角化嚢胞の免疫組織学的検討 開窓前後のKi67,Bcl-2の発現について
森山 佳子; 中村 典史; 光安 岳志; 武富 孝治; 樋口 勝規; 大石 正道
日本口腔科学会雑誌, Nov. 2000, (NPO)日本口腔科学会 - 頸部郭清術後のリンパ液貯留についての検討
本田 康生; 大部 一成; 吉川 博政; 武富 孝治; 大石 正道
日本口腔外科学会雑誌, Apr. 2000, (公社)日本口腔外科学会
- Spatial transcriptome analysis of GMSC-derived exoxme mediated peridontal tissue regneration
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2024 - 31 Mar. 2028 - Challenge to periodontal tissue regeneration and refractory immune diseases based on amelogenin-CRP78 complex
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2023 - 31 Mar. 2027 - New therapeutic strategy for periodontal disease targeting exosomal miRNA derived from GMSCs.
Grant-in-Aid for Scientific Research (B)
Kyushu University
01 Apr. 2020 - 31 Mar. 2024 - The development of periodontal and endodontal tissue regenetation targeted amelogenin/GRP78 complex
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2020 - 31 Mar. 2024 - A study of the regulatory mechanism of lymph node metastasis in oral cancer by Sprouty, tyrosine kinase inhibitor molecule.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2017 - 31 Mar. 2022 - Development of a novel periodontal tissue regenarative therapy that induces resolution of inflammation and tissue remodeling
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2017 - 31 Mar. 2020 - Development of new periodontal treatment targeting using GMSC-derived exosomes
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2017 - 31 Mar. 2020 - A study of the involvement of Sprouty/Spred, suppressor of FGF signal, in the control of ameloblastoma proliferation.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2014 - 31 Mar. 2018 - The effects of Spry2 on the differentiation of Pg LPS-stimulated macrophages.
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2014 - 31 Mar. 2017 - Molecular basis of amelogenin-induced periodontal tissue regeneration
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2014 - 31 Mar. 2017 - MAPK 経路制御因子 Sprouty2 によるエナメル上皮腫増殖抑制機構の解明
Apr. 2014 - Mar. 2015 - ビスフォスフォネート系薬剤関連顎骨壊死発症におけるTLRシグナル伝達経路の役割
Apr. 2012 - Mar. 2013 - A study of the suppression mechanism of tongue cancer growth/ metastasis by Sprouty, the regulating factor of MAP kinase cascade.
Grant-in-Aid for Young Scientists (B)
2011 - 2013 - 塩基性線維芽細胞成長因子(bFGF)シグナルのアンタゴニストを標的とした歯周組織再生療法の開発
医学系研究助成
2010 - 2012 - Elucidation of inhibition mechanism of ameloblastoma growth・ differentiation by Sprouty regulating MAPK cascade.
Grant-in-Aid for Research Activity Start-up
Kyushu University
2009 - 2010
■ 共同研究希望
■ 共同研究実績
