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Nishi Akinori
Department of Pharmacology
Professor
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久留米大学医学部薬理学講座では、モノアミンを中心とした中枢神経伝達、神経精神疾患に関する研究を行っています。中枢神経伝達に関する生化学的研究では、DARPP-32リン酸化を介するドーパミンシグナル解析を中心に行い、ドーパミンによる神経精神機能調節メカニズムの解明を目指しています。
Career
■ Career
- Apr. 2024 - Present
Kurume University, 医学部医療検査学科, 学科長 - 2015 - Present
Kurume University, Kurume University, 校長 - 2006 - Present
Kurume University, School of Medicine, 教授 - 1997 - 2020
ロックフェラー大学, 客員研究員 - 2004 - 2006
Kurume University, School of Medicine, 助教授 - 1998 - 2004
Kurume University, School of Medicine, 講師 - 1985 - 1998
Kurume University, School of Medicine, 助手 - 1995 - 1997
ロックフェラー大学, ポスドク
Research activity information
■ Paper
■ 研究者からの一言アピール
- 炎症性腸疾患に伴う抑うつ・不安 ～炎症抑制によるアプローチ～
西 昭徳
Depression Strategy, 2024, [Invited]
Lead - Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments
Ryusuke Sin; Naoki Sotogaku; Yoshinori N. Ohnishi; Takahide Shuto; Mahomi Kuroiwa; Yukie Kawahara; Keita Sugiyama; Yuki Murakami; Masaaki Kanai; Hiroshi Funakoshi; Ayanabha Chakraborti; James A Bibb; Akinori Nishi
Brain, Behavior, and Immunity, Aug. 2023 - DARPP-32/protein phosphatase 1 regulates Rasgrp2 as a novel component of dopamine D1 receptor signaling in striatum.
Mahomi Kuroiwa; Takahide Shuto; Taku Nagai; Mutsuki Amano; Kozo Kaibuchi; Angus C Nairn; Akinori Nishi
Neurochemistry international, Jan. 2023 - Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice.
Hideo Hagihara; Hirotaka Shoji; Mahomi Kuroiwa; Isabella A Graef; Gerald R Crabtree; Akinori Nishi; Tsuyoshi Miyakawa
Molecular brain, 22 Nov. 2022 - SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex.
Minoru Hatayama; Kei-Ichi Katayama; Yukie Kawahara; Hayato Matsunaga; Noriko Takashima; Yoshimi Iwayama; Yoshifumi Matsumoto; Akinori Nishi; Takeo Yoshikawa; Jun Aruga
Communications biology, 09 Sep. 2022 - Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity
Yuki Kishikawa; Yukie Kawahara; Yoshinori N. Ohnishi; Naoki Sotogaku; Tomoko Koeda; Hiroshi Kawahara; Akinori Nishi
Frontiers in Pharmacology, 08 Sep. 2022 - Noradrenaline activation of hippocampal dopamine D1 receptors promotes antidepressant effects.
Katsunori Kobayashi; Kisako Shikano; Mahomi Kuroiwa; Mio Horikawa; Wakana Ito; Akinori Nishi; Eri Segi-Nishida; Hidenori Suzuki
Proceedings of the National Academy of Sciences of the United States of America, 16 Aug. 2022 - Distinct role of dopamine in the PFC and NAc during exposure to cocaine-associated cues.
Yukie Kawahara; Yoshinori N Ohnishi; Yoko H Ohnishi; Hiroshi Kawahara; Akinori Nishi
The international journal of neuropsychopharmacology, 09 Oct. 2021 - The herbal medicines Inchinkoto and Saireito improved hepatic fibrosis via aquaporin 9 in the liver of a rat bile duct ligation model.
Naoki Hashizume; Ryusuke Shin; Jun Akiba; Naoki Sotogaku; Kimio Asagiri; Shigeki Hikida; Suguru Fukahori; Shinji Ishii; Nobuyuki Saikusa; Yoshinori Koga; Hideaki Egami; Yoshiaki Tanaka; Akinori Nishi; Minoru Yagi
Pediatric surgery international, Aug. 2021, [Reviewed] - Dopamine D1 receptor-expressing neurons activity is essential for locomotor and sensitizing effects of a single injection of cocaine.
Yukari Nakamura; Sophie Longueville; Akinori Nishi; Denis Hervé; Jean-Antoine Girault; Yuki Nakamura
The European journal of neuroscience, Aug. 2021, [Reviewed] - Subregion-Specific Regulation of Dopamine D1 Receptor Signaling in the Striatum: Implication for L-DOPA-Induced Dyskinesia.
Keita Sugiyama; Mahomi Kuroiwa; Takahide Shuto; Yoshinori N Ohnishi; Yukie Kawahara; Yuta Miyamoto; Takaichi Fukuda; Akinori Nishi
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28 Jul. 2021, [Reviewed] - Erratum: Voluntary exercise is motivated by ghrelin, possibly related to the central reward circuit (Journal of Endocrinology (2021) DOI: 10.1530/JOE-19-0213)
Hiroharu Mifune; Yuji Tajiri; Yusuke Sakai; Yukie Kawahara; Kento Hara; Takahiro Sato; Yoshihiro Nishi; Akinori Nishi; Ryouichi Mitsuzono; Tatsuyuki Kakuma; Masayasu Kojima
Journal of Endocrinology, 01 Apr. 2021 - Distinct role of dopamine in the PFC and NAc in retrieval of cocaine reward memory
Yukie Kawahara; Yoshinori Ohnishi; Yoko Ohnishi; Hiroshi Kawahara; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021 - Obligatory roles of dopamine D1 receptors in the dentate gyrus in antidepressant actions of a selective serotonin reuptake inhibitor, fluoxetine.
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yong-Seok Oh; Jin-Hyeok Jang; Chang-Hoon Shin; Yoshinori N Ohnishi; Yuuki Hanada; Tsuyoshi Miyakawa; Yong Kim; Paul Greengard; Akinori Nishi
Molecular psychiatry, Jun. 2020, [Reviewed] - Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice.
Takatoshi Hikida; Makiko Morita; Mahomi Kuroiwa; Tom Macpherson; Takahide Shuto; Naoki Sotogaku; Minae Niwa; Akira Sawa; Akinori Nishi
Neuroscience research, Feb. 2020, [Reviewed] - Differential regulation of dopamine D1 receptor signaling in subregions of the striatum
Sugiyama Keita; Kuroiwa Mahomi; Shuto Takahide; Fukuda Takaichi; Nishi Akinori
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Can alcohol administration to female mice change their preference and attitude to unattractive male mouse?
Yoshinori Ohnishi; Yukie Kawahara; Yoko Ohnishi; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Cocaine-induced conditioned place preference and locomotor response are distinctively regulated by glutamate and dopamine receptor signaling in the prefrontal cortex
Yukie Kawahara; Yoshinori Ohnishi; Yoko Ohnishi; Hiroshi Kawahara; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2020 - Sex Differences in Dendritic Spine Formation in the Hippocampus and Animal Behaviors in a Mouse Model of Hyperthyroidism.
Tetsushi Niiyama; Mahomi Kuroiwa; Yusaku Yoshioka; Yosuke Kitahara; Takahide Shuto; Tatsuyuki Kakuma; Keisuke Ohta; Kei-Ichiro Nakamura; Akinori Nishi; Mami Noda
Frontiers in cellular neuroscience, 2020, [Reviewed] - Voluntary exercise is motivated by ghrelin, possibly related to the central reward circuit.
Hiroharu Mifune; Yuji Tajiri; Yusuke Sakai; Yukie Kawahara; Kento Hara; Takahiro Sato; Yoshihiro Nishi; Akinori Nishi; Ryouichi Mitsuzono; Tatsuyuki Kakuma; Masayasu Kojima
The Journal of endocrinology, 01 Jan. 2020, [Reviewed] - Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology.
Masayuki Ide; Tetsuo Ohnishi; Manabu Toyoshima; Shabeesh Balan; Motoko Maekawa; Chie Shimamoto-Mitsuyama; Yoshimi Iwayama; Hisako Ohba; Akiko Watanabe; Takashi Ishii; Norihiro Shibuya; Yuka Kimura; Yasuko Hisano; Yui Murata; Tomonori Hara; Momo Morikawa; Kenji Hashimoto; Yayoi Nozaki; Tomoko Toyota; Yuina Wada; Yosuke Tanaka; Tadafumi Kato; Akinori Nishi; Shigeyoshi Fujisawa; Hideyuki Okano; Masanari Itokawa; Nobutaka Hirokawa; Yasuto Kunii; Akiyoshi Kakita; Hirooki Yabe; Kazuya Iwamoto; Kohji Meno; Takuya Katagiri; Brian Dean; Kazuhiko Uchida; Hideo Kimura; Takeo Yoshikawa
EMBO molecular medicine, Dec. 2019, [Reviewed] - Three divisions of the mouse caudal striatum differ in the proportions of dopamine D1 and D2 receptor-expressing cells, distribution of dopaminergic axons, and composition of cholinergic and GABAergic interneurons.
Yuta Miyamoto; Issei Nagayoshi; Akinori Nishi; Takaichi Fukuda
Brain structure & function, Nov. 2019, [Reviewed] - Region-specific regulation of dopamine signaling in the striatum
Sugiyama Keita; Kuroiwa Mahomi; Syuto Takahide; Fukuda Takaichi; Nishi Akinori
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019 - Cytomatrix proteins CAST and ELKS regulate retinal photoreceptor development and maintenance.
Akari Hagiwara; Yosuke Kitahara; Chad Paul Grabner; Christian Vogl; Manabu Abe; Ryo Kitta; Keisuke Ohta; Keiichiro Nakamura; Kenji Sakimura; Tobias Moser; Akinori Nishi; Toshihisa Ohtsuka
The Journal of cell biology, 05 Nov. 2018, [Reviewed] - Striosome-based map of the mouse striatum that is conformable to both cortical afferent topography and uneven distributions of dopamine D1 and D2 receptor-expressing cells.
Miyamoto Y; Katayama S; Shigematsu N; Nishi A; Fukuda T
Brain structure & function, Sep. 2018, [Reviewed] - p11 in Cholinergic Interneurons of the Nucleus Accumbens Is Essential for Dopamine Responses to Rewarding Stimuli.
Hanada Y; Kawahara Y; Ohnishi YN; Shuto T; Kuroiwa M; Sotogaku N; Greengard P; Sagi Y; Nishi A
eNeuro, Sep. 2018, [Reviewed] - Gap Junctions Interconnect Different Subtypes of Parvalbumin-Positive Interneurons in Barrels and Septa with Connectivity Unique to Each Subtype.
Shigematsu N; Nishi A; Fukuda T
Cerebral cortex (New York, N.Y. : 1991), Feb. 2018, [Reviewed] - Dopamine D1 receptor activation in the dentate gyrus enhances antidepressant effects of SSRI
Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Yukie Kawahara; Yoshinori Ohnishi; Yuuki Hanada; Akinori Nishi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018 - Link between endoplasmic reticulum stress and autophagy in neurodegenerative diseases.
Hosoi T; Nomura J; Tanaka K; Ozawa K; Nishi A; Nomura Y
Endoplasmic Reticulum Stress in Diseases, 16 Nov. 2017, [Reviewed], [Invited] - Potential for targeting dopamine/DARPP-32 signaling in neuropsychiatric and neurodegenerative disorders
Akinori Nishi; Takahide Shuto
EXPERT OPINION ON THERAPEUTIC TARGETS, Mar. 2017, [Reviewed] - Glutamate Counteracts Dopamine/PKA Signaling via Dephosphorylation of DARPP-32 Ser-97 and Alteration of Its Cytonuclear Distribution
Akinori Nishi; Miriam Matamales; Veronica Musante; Emmanuel Valjent; Mahomi Kuroiwa; Yosuke Kitahara; Heike Rebholz; Paul Greengard; Jean-Antoine Girault; Angus C. Nairn
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2017, [Reviewed] - Neuroprotective effects of 4-phenylbutyric acid and its derivatives: Possible therapeutics for neurodegenerative diseases.
Mimori S; Hosoi T; Kaneko M; Ozawa K; Kanazaki T; Nishi A; Nomura Y
Journal of Health Science, 2017, [Reviewed] - Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders
Katsuya Yamada; Susumu Takahashi; Fuyuki Karube; Fumino Fujiyama; Kazuto Kobayashi; Akinori Nishi; Toshihiko Momiyama
JOURNAL OF PHYSIOLOGICAL SCIENCES, Nov. 2016, [Reviewed] - Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications
Pim R. A. Heckman; Marlies A. van Duinen; Eva P. P. Bollen; Akinori Nishi; Lawrence P. Wennogle; Arjan Blokland; Jos Prickaerts
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Oct. 2016, [Reviewed] - Long-Term Citalopram Treatment Alters the Stress Responses of the Cortical Dopamine and Noradrenaline Systems: the Role of Cortical 5-HT1A Receptors
Fumi Kaneko; Yukie Kawahara; Yuki Kishikawa; Yuuki Hanada; Makiko Yamada; Tatsuyuki Kakuma; Hiroshi Kawahara; Akinori Nishi
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Aug. 2016, [Reviewed] - Neuroprotection by Endoplasmic Reticulum Stress-Induced HRD1 and Chaperones: Possible Therapeutic Targets for Alzheimer's and Parkinson's Disease.
Nomura J; Hosoi T; Kaneko M; Ozawa K; Nishi A; Nomura Y
Medical sciences (Basel, Switzerland), Aug. 2016, [Reviewed] - リハ研究の進め方・まとめかた これから始める人と今さら聞けない人のために(II章) 倫理と利益相反 倫理委員会への書類提出と研究承認まで 研究の倫理的裏付けを得よう 倫理審査
村上 郁磨; 西 昭徳
Journal of Clinical Rehabilitation, May 2016 - Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo
Taku Nagai; Shinichi Nakamuta; Keisuke Kuroda; Sakura Nakauchi; Tomoki Nishioka; Tetsuya Takano; Xinjian Zhang; Daisuke Tsuboi; Yasuhiro Funahashi; Takashi Nakano; Junichiro Yoshimoto; Kenta Kobayashi; Motokazu Uchigashima; Masahiko Watanabe; Masami Miura; Akinori Nishi; Kazuto Kobayashi; Kiyofumi Yamada; Mutsuki Amano; Kozo Kaibuchi
NEURON, Feb. 2016, [Reviewed] - 研究の倫理的裏付けを得よう‐倫理審査
村上 郁磨; 西 昭徳
Journal of Clinical Rehabilitation, 2016 - Chronic Fluoxetine Induces the Enlargement of Perforant Path-Granule Cell Synapses in the Mouse Dentate Gyrus
Yosuke Kitahara; Keisuke Ohta; Hiroshi Hasuo; Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Akinobu Togo; Kei-ichiro Nakamura; Akinori Nishi
PLOS ONE, Jan. 2016, [Reviewed] - Antidepressant-induced changes in synaptic morphology in the mouse dentate gyrus.
Kitahara Y; Nishi A
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2016, [Reviewed] - The role of ventral striatal cAMP signaling in stress-induced behaviors
Florian Plattner; Kanehiro Hayashi; Adan Hernandez; David R. Benavides; Tara C. Tassin; Chunfeng Tan; Jonathan Day; Maggy W. Fina; Eunice Y. Yuen; Zhen Yan; Matthew S. Goldberg; Angus C. Nairn; Paul Greengard; Eric J. Nestler; Ronald Taussig; Akinori Nishi; Miles D. Houslay; James A. Bibb
NATURE NEUROSCIENCE, Aug. 2015, [Reviewed] - Regulation of ERK Kinase by MEK1 Kinase Inhibition in the Brain
Tara C. Tassin; David R. Benavides; Florian Plattner; Akinori Nishi; James A. Bibb
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2015, [Reviewed] - PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens
Yoko H. Ohnishi; Yoshinori N. Ohnishi; Takanori Nakamura; Mizuki Ohno; Pamela J. Kennedy; Ohkawa Yasuyuki; Akinori Nishi; Rachael Neve; Teruhisa Tsuzuki; Eric J. Nestler
PLOS ONE, May 2015, [Reviewed] - Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function
Ken Uematsu; Myriam Heiman; Marina Zelenina; Julio Padovan; Brian T. Chait; Anita Aperia; Akinori Nishi; Paul Greengard
JOURNAL OF NEUROCHEMISTRY, Mar. 2015, [Reviewed] - PKA-Dependent Phosphorylation of Ribosomal Protein S6 Does Not Correlate with Translation Efficiency in Striatonigral and Striatopallidal Medium-Sized Spiny Neurons
Anne Biever; Emma Puighermanal; Akinori Nishi; Alexandre David; Claire Panciatici; Sophie Longueville; Dimitris Xirodimas; Giuseppe Gangarossa; Oded Meyuhas; Denis Herve; Jean-Antoine Girault; Emmanuel Valjent
JOURNAL OF NEUROSCIENCE, Mar. 2015, [Reviewed] - FUNCTIONAL ROLE OF THE N-TERMINAL DOMAIN OF Delta FOSB IN RESPONSE TO STRESS AND DRUGS OF ABUSE
Y. N. Ohnishi; Y. H. Ohnishi; V. Vialou; E. Mouzon; Q. Laplant; A. Nishi; E. J. Nestler
NEUROSCIENCE, Jan. 2015, [Reviewed] - Possible involvement of endoplasmic reticulum stress in the pathogenesis of Alzheimer's disease.
Hosoi T; Nomura J; Ozawa K; Nishi A; Nomura Y
Endoplasmic Reticulum Stress in Diseases, 2015, [Reviewed] - The spontaneously hypertensive rat/Izm (SHR/Izm) shows attention deficit/hyperactivity disorder-like behaviors but without impulsive behavior: Therapeutic implications of low-dose methylphenidate
Yuki Kishikawa; Yukie Kawahara; Makiko Yamada; Furni Kaneko; Hiroshi Kawahara; Akinori Nishi
BEHAVIOURAL BRAIN RESEARCH, Nov. 2014, [Reviewed] - Memory Enhancement by Targeting Cdk5 Regulation of NR2B
Florian Plattner; Adan Hernandez; Tara M. Kistler; Karine Pozo; Ping Zhong; Eunice Y. Yuen; Chunfeng Tan; Ammar H. Hawasli; Sam F. Cooke; Akinori Nishi; Ailan Guo; Thorsten Wiederhold; Zhen Yan; James A. Bibb
NEURON, Mar. 2014, [Reviewed] - Upregulation of the dorsal raphe nucleus-prefrontal cortex serotonin system by chronic treatment with escitalopram in hyposerotonergic Wistar-Kyoto rats.
Makiko Yamada; Yukie Kawahara; Fumi Kaneko; Yuki Kishikawa; Naoki Sotogaku; Wilfred J Poppinga; Joost H A Folgering; Eliyahu Dremencov; Hiroshi Kawahara; Akinori Nishi
Neuropharmacology, Sep. 2013, [Reviewed] - Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia
Keizo Takao; Katsunori Kobayashi; Hideo Hagihara; Koji Ohira; Hirotaka Shoji; Satoko Hattori; Hisatsugu Koshimizu; Juzoh Umemori; Keiko Toyama; Hironori K. Nakamura; Mahomi Kuroiwa; Jun Maeda; Kimie Atsuzawa; Kayoko Esaki; Shun Yamaguchi; Shigeki Furuya; Tsuyoshi Takagi; Noah M. Walton; Nobuhiro Hayashi; Hidenori Suzuki; Makoto Higuchi; Nobuteru Usuda; Tetsuya Suhara; Akinori Nishi; Mitsuyuki Matsumoto; Shunsuke Ishii; Tsuyoshi Miyakawa
Neuropsychopharmacology, Jul. 2013, [Reviewed] - Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum
Takahide Shuto; Mahomi Kuroiwa; Yuki Koga; Yukie Kawahara; Naoki Sotogaku; Koji Toyomasu; Akinori Nishi
NEUROSCIENCE LETTERS, May 2013, [Reviewed] - Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system
Yukie Kawahara; Fumi Kaneko; Makiko Yamada; Yuki Kishikawa; Hiroshi Kawahara; Akinori Nishi
NEUROPHARMACOLOGY, Apr. 2013, [Reviewed] - 薬物依存とドーパミンシグナル情報伝達系
西昭徳
THE LUNG perspectives, 2013 - Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons
Mahomi Kuroiwa; Miho Hamada; Eriko Hieda; Takahide Shuto; Naoki Sotogaku; Marc Flajolet; Gretchen L. Snyder; Joseph P. Hendrick; Allen Fienberg; Akinori Nishi
NEUROPHARMACOLOGY, Dec. 2012, [Reviewed] - Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning
Huxing Cui; Brittany L. Mason; Charlotte Lee; Akinori Nishi; Joel K. Elmquist; Michael Lutter
PHYSIOLOGY & BEHAVIOR, May 2012, [Reviewed] - Dorsal raphe nucleus serotonin neurons in WKY rats demonstrate subresponsivity to an acute application of escitalopram: Effect of repeated escitalopram treatment
Makiko Yamada; Yukie Kawahara; Fumi Kaneko; Yuki Furushima; Eliyahu Dremencov; Hiroshi Kawahara; Akinori Nishi
Japanese Journal of Neuropsychopharmacology, Apr. 2012, [Reviewed] - Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex
Mahomi Kuroiwa; Gretchen L. Snyder; Takahide Shuto; Atsuo Fukuda; Yuchio Yanagawa; David R. Benavides; Angus C. Nairn; James A. Bibb; Paul Greengard; Akinori Nishi
PSYCHOPHARMACOLOGY, Feb. 2012, [Reviewed] - Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake
Tomoyuki Mitsumori; Tomoyuki Furuyashiki; Toshihiko Momiyama; Akinori Nishi; Takahide Shuto; Takashi Hayakawa; Fumitaka Ushikubi; Shiho Kitaoka; Tomohiro Aoki; Haruhisa Inoue; Toshiyuki Matsuoka; Shuh Narumiya
EUROPEAN JOURNAL OF NEUROSCIENCE, Aug. 2011, [Reviewed] - Mechanisms for the modulation of dopamine D-1 receptor signaling in striatal neurons
Akinori Nishi; Mahomi Kuroiwa; Takahide Shuto
FRONTIERS IN NEUROANATOMY, Jul. 2011, [Reviewed] - Treatment of the Psychostimulant-Sensitized Animal Model of Schizophrenia
Takahide Shuto; Akinori Nishi
CNS NEUROSCIENCE & THERAPEUTICS, 2011, [Reviewed] - Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission
Akinori Nishi; Gretchen L. Snyder
JOURNAL OF PHARMACOLOGICAL SCIENCES, Sep. 2010, [Reviewed] - Role of adrenoceptors in the regulation of dopamine/DARPP-32 signaling in neostriatal neurons
Masato Hara; Ryuichi Fukui; Eriko Hieda; Mahomi Kuroiwa; Helen S. Bateup; Tatsuhiko Kano; Paul Greengard; Akinori Nishi
JOURNAL OF NEUROCHEMISTRY, May 2010, [Reviewed] - Role of phosphodiesterases in dopamine signal transduction
NISHI Akinori; KUROIWA Mahomi; SHUTO Takahide
Folia Pharmacologica Japonica, Jan. 2010 - CK2 negatively regulates G alpha(s) signaling
Heike Rebholz; Akinori Nishi; Sabine Liebscher; Angus C. Nairn; Marc Flajolet; Paul Greengard
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2009, [Reviewed] - PERIPHERALLY ADMINISTERED GHRELIN INDUCES BIMODAL EFFECTS ON THE MESOLIMBIC DOPAMINE SYSTEM DEPENDING ON FOOD-CONSUMPTIVE STATES
Y. Kawahara; H. Kawahara; F. Kaneko; M. Yamada; Y. Nishi; E. Tanaka; A. Nishi
NEUROSCIENCE, Jul. 2009 - Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice
Koichi Tanda; Akinori Nishi; Naoki Matsuo; Kazuo Nakanishi; Nobuyuki Yamasaki; Tohru Sugimoto; Keiko Toyama; Keizo Takao; Tsuyoshi Miyakawa
MOLECULAR BRAIN, 2009, [Reviewed] - Regulation of DARPP-32 phosphorylation by three distinct dopamine D(1)-like receptor signaling pathways in the neostriatum
Mahomi Kuroiwa; Helen S. Bateup; Takahide Shuto; Hideho Higashi; Masatoshi Tanaka; Akinori Nishi
JOURNAL OF NEUROCHEMISTRY, Nov. 2008, [Reviewed] - Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum
Akinori Nishi; Mahomi Kuroiwa; Diane B. Miller; James P. O'Callaghan; Helen S. Bateup; Takahide Shuto; Naoki Sotogaku; Takaichi Fukuda; Nathaniel Heintz; Paul Greengard; Gretchen L. Snyder
JOURNAL OF NEUROSCIENCE, Oct. 2008, [Reviewed] - Cell type-specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
Helen S. Bateup; Per Svenningsson; Mahomi Kuroiwa; Shiaoching Gong; Akinori Nishi; Nathaniel Heintz; Paul Greengard
NATURE NEUROSCIENCE, Aug. 2008, [Reviewed] - A phosphatase cascade by which rewarding stimuli control nucleosomal response
Alexandre Stipanovich; Emmanuel Valjent; Miriam Matamales; Akinori Nishi; Jung-Hyuck Ahn; Matthieu Maroteaux; Jesus Bertran-Gonzalez; Karen Brami-Cherrier; Herve Enslen; Anne-Gaelle Corbille; Odile Filhol; Angus C. Nairn; Paul Greengard; Denis Herve; Jean-Antoine Girault
NATURE, Jun. 2008, [Reviewed] - Repeated administration of a dopamine D1 receptor agonist reverses the increased proportions of striatal dopamine D1(High) and D2(High) receptors in methamphetamine-sensitized rats
Takahide Shuto; Philip Seeman; Mahomi Kuroiwa; Akinori Nishi
EUROPEAN JOURNAL OF NEUROSCIENCE, May 2008, [Reviewed] - Expression of D1 but not D2 dopamine receptors in striatal neurons producing neurokinin B in rats
Takahiro Sonomura; Kouichi Nakamura; Takahiro Furuta; Hiroyuki Hioki; Akinori Nishi; Atsushi Yamanaka; Masanori Uemura; Takeshi Kaneko
EUROPEAN JOURNAL OF NEUROSCIENCE, Dec. 2007, [Reviewed] - Differential regulation of the Cdk5-dependent phosphorylation sites of inhibitor-1 and DARPP-32 by depolarization
Chan Nguyen; Tomohisa Hosokawa; Mahomi Kuroiwa; Nancy Y. Ip; Akinori Nishi; Shin-ichi Hisanaga; James A. Bibb
JOURNAL OF NEUROCHEMISTRY, Nov. 2007, [Reviewed] - Prostaglandin E-2 acts on EP1 receptor and amplifies both dopamine D-1 and D-2 receptor signaling in the striatum
Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Masayuki Miyasaka; Paul Greengard; Shuh Narumiya
JOURNAL OF NEUROSCIENCE, Nov. 2007, [Reviewed] - Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons
Naoki Sotogaku; Sarah E. Tully; Cristal I. Gama; Hideho Higashi; Masatoshi Tanaka; Linda C. Hsieh-Wilson; Akinori Nishi
JOURNAL OF NEUROCHEMISTRY, Oct. 2007, [Reviewed] - Regulation of dopaminergic signaling in neostriatal neurons
西 昭徳
The journal of the Kurume Medical Association, Jul. 2007 - Regulation of protein phosphatase inhibitor-1 by cyclin-dependent kinase 5
Chan Nguyen; Akinori Nishi; Janice W. Kansy; Joseph Fernandez; Kanehiro Hayashi; Frank Gillardon; Hugh C. Hemmings; Angus C. Nairn; James A. Bibb
JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2007, [Reviewed] - The B ''/PR72 subunit mediates Ca2+-dependent dephosphorylation of DARPP-32 by protein phosphatase 2A
Jung-Hyuck Ahn; Jee Young Sung; Thomas McAvoy; Akinori Nishi; Veerle Janssens; Jozef Goris; Paul Greengard; Angus C. Nairn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2007, [Reviewed] - Role of DARPP-32 in dopaminergic signaling in neostriatal neurons
西 昭徳
The journal of the Kurume Medical Association, Feb. 2007 - Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56 delta subunit
Jung-Hyuck Ahn; Thomas McAvoy; Sergey V. Rakhilin; Akinori Nishi; Paul Greengard; Angus C. Nairn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2007, [Reviewed] - Sulfation patterns of glycosaminoglycans encode molecular recognition and activity
Cristal I. Gama; Sarah E. Tully; Naoki Sotogaku; Peter M. Clark; Manish Rawat; Nagarajan Vaidehi; William A. Goddard; Akinori Nishi; Linda C. Hsieh-Wilson
NATURE CHEMICAL BIOLOGY, Sep. 2006, [Reviewed] - Effects of nicorandil preconditioning on membrane dystrophin
Takahiro Shojima; Nobuhiko Hayashida; Akinori Nishi; Kazuyoshi Takagi; Hidetugu Hori; Kazuhiro Yoshikawa; Shigeaki Aoyagi
European Journal of Cardio-thoracic Surgery, Sep. 2006, [Reviewed] - Reversal of methamphetamine-induced behavioral sensitization by repeated administration of a dopamine D-1 receptor agonist
Takahide Shuto; Mahomi Kuroiwa; Mitsuko Hamamura; Kenichi Yabuuchi; Takao Shimazoe; Shigenori Watanabe; Akinori Nishi; Tsuneyuki Yamamoto
NEUROPHARMACOLOGY, Jun. 2006, [Reviewed] - In vivo recellularization of plain decellularized xenografts with specific cell characterization in the systemic circulation: Histological and immunohistochemical study
Kazuyoshi Takagi; Shuji Fukunaga; Akinori Nishi; Takahiro Shojima; Kazuhiro Yoshikawa; Hidetsugu Hori; Hidetoshi Akashi; Shigeaki Aoyagi
Artificial Organs, Apr. 2006, [Reviewed] - Role of adenosine A(1), receptors in the modulation of dopamine D-1, and adenosine A(2a) receptor signaling in the neostriatum
K. Yabuuchi; M. Kuroiwa; T. Shuto; N. Sotogaku; G. L. Snyder; H. Higashi; M. Tanaka; P. Greengard; A. Nishi
NEUROSCIENCE, 2006, [Reviewed] - Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways
K Uematsu; M Futter; LC Hsieh-Wilson; H Higashi; H Maeda; AC Nairn; P Greengard; A Nishi
JOURNAL OF NEUROCHEMISTRY, Dec. 2005, [Reviewed] - Nicotine regulates DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of 32 kDa) phosphorylation at multiple sites in neostriatal neurons
M Hamada; JP Hendrick; GR Ryan; M Kuroiwa; H Higashi; M Tanaka; AC Nairn; P Greengard; A Nishi
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 2005, [Reviewed] - Impairment of hippocampal long-term depression and defective spatial learning and memory in p35(-/-) mice
T Ohshima; H Ogura; K Tomizawa; K Hayashi; H Suzuki; T Saito; H Kamei; A Nishi; JA Bibb; S Hisanaga; H Matsui; K Mikoshiba
JOURNAL OF NEUROCHEMISTRY, Aug. 2005, [Reviewed] - Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5)
M Futter; K Uematsu; SA Bullock; Y Kim; HC Hemmings; A Nishi; P Greengard; AC Nairn
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2005, [Reviewed] - Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades.
Akinori Nishi; Yasuo Watanabe; Hideho Higashi; Masatoshi Tanaka; Angus C Nairn; Paul Greengard
Proceedings of the National Academy of Sciences of the United States of America, 25 Jan. 2005, [Reviewed] - タンパク質リン酸化・脱リン酸化の行動への影響
西 昭徳
実験医学, 2005, [Invited] - Mechanical unloading improves intracellular Ca 2+ regulation in rats with doxorubicin-induced cardiomyopathy
Tohru Takaseya; Masaru Ishimatsu; Eiki Tayama; Akinori Nishi; Takashi Akasu; Shigeaki Aoyagi
Journal of the American College of Cardiology, 07 Dec. 2004, [Reviewed] - Identification of tyrosine hydroxylase as a physiological substrate for Cdk5
JW Kansy; SC Daubner; A Nishi; N Sotogaku; MD Lloyd; C Nguyen; L Lu; JW Haycock; BT Hope; PF Fitzpatrick; JA Bibb
JOURNAL OF NEUROCHEMISTRY, Oct. 2004, [Reviewed] - A network of control mediated by regulator of calcium/calmodulin-dependent signaling
SV Rakhilin; PA Olson; A Nishi; NN Starkova; AA Fienberg; AC Nairn; DJ Surmeier; P Greengard
SCIENCE, Oct. 2004, [Reviewed] - Differential regulation of dopamine D1 and D2 signaling by nicotine in neostriatal neurons
M Hamada; H Higashi; AC Nairn; P Greengard; A Nishi
JOURNAL OF NEUROCHEMISTRY, Sep. 2004, [Reviewed] - DARPP-32: An integrator of neurotransmission
P Svenningsson; A Nishi; G Fisone; JA Girault; AC Nairn; P Greengard
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, [Reviewed] - The role of DARPP-32 in the actions of drugs of abuse
AC Nairn; P Svenningsson; A Nishi; G Fisone; JA Girault; P Greengard
NEUROPHARMACOLOGY, 2004, [Reviewed] - Effect of methylphenidate on dopamine/DARPP signalling in adult, but not young, mice
R Fukui; P Svenningsson; T Matsuishi; H Higashi; AC Nairn; P Greengard; A Nishi
JOURNAL OF NEUROCHEMISTRY, Dec. 2003, [Reviewed] - Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling
S Matsuyama; R Fukui; H Higashi; A Nishi
EUROPEAN JOURNAL OF NEUROSCIENCE, Sep. 2003, [Reviewed] - Metabotropic mGlu5 receptors regulate adenosine A(2A) receptor signaling
A Nishi; F Liu; S Matsuyama; M Hamada; H Higashi; AC Nairn; P Greengard
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2003, [Reviewed] - Regulation of psychomotor functions by dopamine: Integration of various approaches
Masashi Sasa; Akinori Nishi; Kazuto Kobayashi; Hiromi Sano; Toshihiko Momiyama; Kazuhide Uramura; Toshihiko Yada; Norio Mori; Katsuaki Suzuki; Yoshio Minabe
Folia Pharmacologica Japonica, 2003 - Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A
A Nishi; JA Bibb; S Matsuyama; M Hamada; H Higashi; AC Nairn; P Greengard
JOURNAL OF NEUROCHEMISTRY, May 2002, [Reviewed] - Neurotensin regulates DARPP-32 Thr34 phosphorylation in neostriatal neurons by activation of dopamine D1-type receptors
S Matsuyama; H Higashi; H Maeda; P Greengard; A Nishi
JOURNAL OF NEUROCHEMISTRY, Apr. 2002, [Reviewed] - Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors
F Liu; XH Ma; J Ule; JA Bibb; A Nishi; AJ DeMaggio; Z Yan; AC Nairn; P Greengard
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2001, [Reviewed] - Phosphorylation of protein phosphatase inhibitor-1 by Cdk5
JA Bibbb; A Nishi; JP O'Callaghan; J Ule; M Lan; GL Snyder; A Horiuchi; T Saito; S Hisanaga; AJ Czernik; AC Nairn; P Greengard
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2001, [Reviewed] - Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
JA Bibb; JS Chen; Taylor, JR; P Svenningsson; A Nishi; GL Snyder; Z Yan; ZK Sagawa; CC Ouimet; AC Nairn; EJ Nestler; P Greengard
NATURE, Mar. 2001, [Reviewed] - Phosphorylation of protein phosphatase-1 inhibitors, inhibitor-1 and DARPP-32, in renal medulla
E Higuchi; A Nishi; H Higashi; Y Ito; H Kato
EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2000, [Reviewed] - Amplification of dopaminergic signaling by a positive feedback loop
A Nishi; JA Bibb; GL Snyder; H Higashi; AC Nairn; P Greengard
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2000, [Reviewed] - Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
JA Bibb; GL Snyder; A Nishi; Z Yan; L Meijer; AA Fienberg; LH Tsai; YT Kwon; JA Girault; AJ Czernik; RL Huganir; HC Hemmings; AC Nairn; P Greengard
NATURE, Dec. 1999, [Reviewed] - Regulation of Na+,K+-ATPase isoforms in rat neostriatum by dopamine and protein kinase C
A Nishi; G Fisone; GL Snyder; Dulubova, I; A Aperia; AC Nairn; P Greengard
JOURNAL OF NEUROCHEMISTRY, Oct. 1999, [Reviewed] - Requirement for DARPP-32 in mediating effect of dopamine D2 receptor activation
A Nishi; GL Snyder; AA Fienberg; G Fisone; A Aperia; AC Naim; P Greengard
EUROPEAN JOURNAL OF NEUROSCIENCE, Jul. 1999, [Reviewed] - Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons
A Nishi; GL Snyder; AC Nairn; P Greengard
JOURNAL OF NEUROCHEMISTRY, May 1999, [Reviewed] - DARPP-32: Regulator of the Efficacy of Dopaminergic Neurotransmission
A A Fienberg; N Hiroi; P G Mermelstein; W Song,G L; Snyder; A Nishi,A Cheramy; J; P O'Callaghan; D B Miller; D G Cole; R Corbett; C N Haile; D C Cooper; S P Onn; A A Grace; C C Ouimet; F J White; S E Hyman; D J Surmeier; J Girault,E J Nestler; P Greengard
Science, 07 Aug. 1998 - The DARPP-32 protein phosphatase-1 cascade: a model for signal integration
P Greengard; AC Nairn; JA Girault; CC Ouimet; GL Snyder; G Fisone; PB Allen; A Fienberg; A Nishi
BRAIN RESEARCH REVIEWS, May 1998, [Reviewed] - Bidirectional regulation of DARPP-32 phosphorylation by dopamine
A Nishi; GL Snyder; P Greengard
JOURNAL OF NEUROSCIENCE, Nov. 1997, [Reviewed] - TTKG
西 昭徳; 伊藤雄平
腎と透析, 1997, [Invited] - Clinical quiz-MRI findings in hypertensive encephalopathy
Nishi A; Ito Y; Kato H
Pediatr Nephrol, 1997, [Reviewed] - Recurrent exercise-induced acute renal failure in renal hypouricemia
M Ninomiya; Y Ito; A Nishi; T Matsumoto; A Koga; Y Hori; H Nishida; G Nomura; H Kato
ACTA PAEDIATRICA, Aug. 1996, [Reviewed] - 血管炎とANCA
西 昭徳; 伊藤雄平
小児内科, 1996, [Invited] - LONGITUDINAL CHANGES IN PERITONEAL EQUILIBRATION TEST WITH OR WITHOUT PERITONITIS IN CHILDREN
A NISHI; Y ITO; Y AMAMOTO; K AIDA; H KATO
PEDIATRIC NEPHROLOGY, Oct. 1995, [Reviewed] - Changes in peritoneal equilibration test following peritonitis in children receiving continuous peritoneal dialysis
Nishi Akinori; Aida Katsumaro; Amamoto Yusuke; Ito Yuhei
Nihon Shoni Jinzobyo Gakkai Zasshi, 1995, [Reviewed] - Anti‐neutrophil cytoplasmic antibody for proteinase 3 in a child with polyarteritis nodosa
YUHEI ITO; AKINORI NISHI; MINAKO SAKAGUCHI; YOSHIHARU SUZUKI; KAZUNARI KANEKO; CHIKAI YASUOKA; SABUROU TOMITA; HIROHISA KATO
Pediatrics International, 1995, [Reviewed] - 水電解質の異常 腎尿路の救急医療 -小児における腎尿路の救急-
伊藤雄平; 西 昭徳
腎と透析, 1994, [Invited] - RENAL NA+, K+-ATPASE IN DAHL SALT-SENSITIVE RATS - K+ DEPENDENCE, EFFECT OF CELL ENVIRONMENT AND PROTEIN-KINASES
A NISHI; AM BERTORELLO; A APERIA
ACTA PHYSIOLOGICA SCANDINAVICA, Nov. 1993, [Reviewed] - DOPAMINE REGULATION OF RENAL NA+,K+-ATPASE ACTIVITY IS LACKING IN DAHL SALT-SENSITIVE RATS
A NISHI; AC EKLOF; AM BERTORELLO; A APERIA
HYPERTENSION, Jun. 1993, [Reviewed] - HIGH-SALT DIET UP-REGULATES ACTIVITY AND MESSENGER-RNA OF RENAL NA+-K+-ATPASE IN DAHL SALT-SENSITIVE RATS
A NISHI; G CELSI; A APERIA
AMERICAN JOURNAL OF PHYSIOLOGY, Mar. 1993, [Reviewed] - Dahl salt-sensitive ratの近位尿細管Na+,K+-ATPase活性はなぜドーパミン不応性か
西 昭徳; 伊藤雄平; Aperia A
発達腎研究会誌, 1993 - ADRENOCORTICOID REGULATION OF NA+,K+-ATPASE IN ADULT-RAT KIDNEY - EFFECTS ON POSTTRANSLATIONAL PROCESSING AND MESSENGER-RNA ABUNDANCE
G CELSI; J STAHL; ZM WANG; A NISHI
ACTA PHYSIOLOGICA SCANDINAVICA, Jun. 1992, [Reviewed] - HIGH SALT DIET DOWN-REGULATES PROXIMAL TUBULE NA+, K+-ATPASE ACTIVITY IN DAHL SALT-RESISTANT BUT NOT IN DAHL SALT-SENSITIVE RATS - EVIDENCE OF DEFECTIVE DOPAMINE REGULATION
A NISHI; AM BERTORELLO; A APERIA
ACTA PHYSIOLOGICA SCANDINAVICA, Mar. 1992, [Reviewed] - ABUNDANCE OF NA+-K+-ATPASE MESSENGER-RNA IS REGULATED BY GLUCOCORTICOID HORMONES IN INFANT RAT KIDNEYS
G CELSI; A NISHI; G AKUSJARVI; A APERIA
AMERICAN JOURNAL OF PHYSIOLOGY, Feb. 1991, [Reviewed]
- レット症候群モデルマウスにおける睡眠・覚醒病態とオレキシンシグナル伝達の異常
弓削康太郎; 高橋知之; 弓削康太郎; 高橋知之; 河原幸江; 坂井勇介; 佐藤貴弘; 児島将康; 西昭徳; 松石豊次郎; 松石豊次郎; 山下裕史朗; 山下裕史朗
日本脳科学会プログラム・講演抄録集, 2022 - What methods are physiologically or pharmacologically effective for attracting female mice?
OHNISHI Yoshinori; KAWAHARA Yukie; KISHI Yuki; OHNISHI Yoko; NISHI Akinori
日本薬理学会年会要旨集(Web), 2022 - Differential role of dopamine in the PFC and NAc in cocaine-associated reward memory and behavior
河原幸江; 大西克典; 大西陽子; 河原博; 西昭徳
日本薬理学雑誌, 2021 - 線条体におけるドパミンD1受容体シグナルの領域特異的な制御:L-ドパ誘発性ジスキネジアとの関連性
杉山慶太; 黒岩真帆美; 首藤隆秀; 大西克典; 河原幸江; 宮本雄太; 福田孝一; 西昭徳
日本脳科学会プログラム・講演抄録集, 2021 - 炎症性腸疾患に合併するうつ病・不安障害の病態解明とトリプトファン代謝酵素阻害薬680C91の治療効果の解析
沈 龍佑; 外角 直樹; 河原 幸江; 西 昭徳
臨床薬理, Oct. 2020 - 健康寿命延伸に向けて、薬局薬剤師による行動科学を用いた骨粗鬆症重症化予防への取り組み
金子 富美; 杉岡 勇樹; 山口 信也; 深町 潤; 川畑 信浩; 大塚 幸三; 覚前 美希; 谷 佳成恵; 西 昭徳; 津田 彰
日本骨粗鬆症学会雑誌, Sep. 2020 - 総胆管結紮モデルによる茵ちん蒿湯と柴苓湯の肝線維化抑制効果の検討
橋詰 直樹; 八木 実; 沈 龍佑; 秋葉 純; 外角 直樹; 西 昭徳; 田中 芳明; 恵紙 英昭
日本小児外科学会雑誌, Feb. 2020 - 閉塞性黄疸モデルを用いたアスタキサンチンの抗酸化作用と肝繊維化抑制の新たな解析
橋詰 直樹; 沈 龍佑; 秋葉 純; 外角 直樹; 西 昭徳; 松井 孝憲; 山岸 昌一; 田中 芳明; 八木 実
学会誌JSPEN, Sep. 2019 - 甲状腺機能異常症におけるグリアと神経細胞の形態変化およびその性差
吉岡 優作; 片渕 俊彦; 北原 陽介; 首藤 隆秀; 西 昭徳; Semtner Marcus; Kettenmann Helmut; 野田 百美
日本生理学雑誌, May 2018 - 多理論統合モデル(TTM)にもとづく骨粗鬆症治療アドヒアランス向上のための薬剤師の介入マニュアル
金子 富美; 杉岡 勇樹; 山口 信也; 深町 潤; 川畑 信浩; 下田 健一; 平田 律子; 谷 佳成恵; 冨田 彩乃; 西 昭徳; 津田 彰
久留米大学心理学研究, Mar. 2018 - ドパミン神経回路と神経精神疾患 ドパミン神経伝達研究の貢献
西 昭徳
日本法医学雑誌, Dec. 2017 - 行動科学に基づく薬剤師の介入が骨粗鬆症重症化予防に及ぼす影響 Pharma Act Project
杉岡 勇樹; 山口 信也; 深町 潤; 立山 勝規; 二ノ宮 由季; 角 咲貴子; 平位 浩一; 谷 佳成恵; 金子 富美; 西 昭徳; 津田 彰
日本薬剤師会学術大会講演要旨集, Oct. 2017 - コカイン誘発性の行動感作と場所嗜好における前頭前野ドーパミン放出とD1受容体の役割(Involvement of conical dopamine release and D1 receptors in cocaine-induced sensitization and place preference)
河原 幸江; 大西 克典; 石橋 正敏; 河原 博; 西 昭徳
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2017 - 行動科学に基づいた保険薬剤師の介入による骨粗鬆症治療薬のアドヒアランス向上プログラムの検討 TTMに即した介入で服薬指導を行う薬剤師への調査報告(1)
金子 富美; 杉岡 勇樹; 山口 信也; 深町 潤; 谷 佳成恵; 西 昭徳; 津田 彰
日本心理学会大会発表論文集, Aug. 2017 - 生薬alkanninとshikoninのAβとタウタンパク凝集阻害と神経細胞死阻害活性 抗アルツハイマー病薬創製に向けて
細井 徹; 俵 明里; 今田 理裕; 東田 千尋; 金子 雅幸; 藤田 有紀; 奥田 充顕; 杉本 八郎; 小澤 光一郎; 西 昭徳; 野村 靖幸
日本薬学会年会要旨集, Mar. 2017 - Long-term antioxidant foods suppress cocaine addiction after social defeat stress
Yoshinori Ohnishi; Yukie Kawahara; Yoko Ohnishi; Rachael Neve; Nestler Eric; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017 - 大脳皮質-大脳基底核回路におけるドーパミン系の新たな働きと精神疾患との関わり ドーパミンシグナルを制御するDARPP-32 神経タイプ特異的な機能と制御
西 昭徳; 首藤 隆秀
日本神経精神薬理学会年会プログラム・抄録集, Jul. 2016 - 社会的敗北ストレスは報酬刺激および侵害刺激に対する側坐核ドーパミン応答性を変化させる(Social defeat stress affects the dopamine responses in the nucleus accumbens to rewarding and aversive events)
河原 幸江; 大西 克典; 河原 博; 西 昭徳
日本神経精神薬理学会年会プログラム・抄録集, Jul. 2016 - Nrf exacerbates cocaine addiction after social defeat stress
Yoshinori Ohnishi; Yukie Kawahara; Yoko Ohnishi; Rachael Neve; Erie Nestler; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016 - Social defeat stress enhances the dopamine responses in the nucleus accumbens to both rewarding and aversive events
Yukie Kawahara; Yoshinori Ohnishi; Hiroshi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016 - Social Isolated DISC1 Mutant Mice Displayed High Sensitivity to Chronic Cocaine Exposure and Rolipram Treatment
Takatoshi Hikida; Makiko Morita; Mahomi Kuroiwa; Tom Macpherson; Taichi Itou; Takahide Shuto; Naoki Sotogaku; Minae Niwa; Akira Sawa; Akinori Nishi
NEUROPSYCHOPHARMACOLOGY, Dec. 2015 - 抗うつ薬による歯状回-貫通線維シナプスの形態変化 FIB-SEMを用いた構造解析
北原 陽介; 太田 啓介; 首藤 隆秀; 黒岩 真帆美; 外角 直樹; 蓮尾 博; 都合 亜記暢; 中村 桂一郎; 西 昭徳
日本脳科学会プログラム・抄録集, Nov. 2015 - DISC1マウスの隔離飼育に対するドパミンシグナル応答 ホスホジエステラーゼの役割(Role of PDEs in alteration of dopamine signaling after isolation stress in DISC1 mutant mice)
黒岩 真帆美; 首藤 隆秀; 外角 直樹; 森田 真規子; 澤 明; 疋田 貴俊; 西 昭徳
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2015 - 社会的ストレス下においてDISC1変異マウスのコカイン感受性はPDE4により制御される(Cocaine-induced behavioral sensitization is regulated by PDE4 in social stressed DISC1 mutant mice)
疋田 貴俊; 森田 真規子; マクファーソン・トム; 伊藤 大一; 丹羽 美苗; 黒岩 真帆美; 澤 明; 西 昭徳
日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2015 - Glucocorticoid-Mediated Dopaminergic Changes and Epigenetic modifications: A Critical Period of Vulnerability to Stress During Adolescence
Minae Niwa; Richard Lee; Shin-ichi Kano; Makiko Morita; Akinori Nishi; Takatoshi Hikida; Akira Sawa
NEUROPSYCHOPHARMACOLOGY, Dec. 2014 - Role of PDE-mediated signaling and its crosstalk in brain function
A. Nishi; M. Kuroiwa; T. Shuto; S. Gretchen
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2014 - Effects of low-dose methylphenidate on attention-deficit hyperactivity disorder (ADHD)-like behaviors in the spontaneously hypertensive rat, an animal model of ADHD
Yuki Kishikawa; Yukie Kawahara; Makiko Yamada; Hiroshi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014 - Effect of chronic fluoxetine on spine morphology of granule cells in the dentate gyrus: 3-dimensional reconstruction study using FIB/SEM
Yosuke Kitahara; Keisuke Ohta; Takahide Shuto; Mahomi Kuroiwa; Naoki Sotogaku; Hiroshi Hasuo; Akinobu Togo; Kei-ichiro Nakamura; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014 - コカインにより活性化される線条体ドーパミン神経伝達に対するレスベラトロールの急性作用
首藤 隆秀; 黒岩 真帆美; 古賀 夕貴; 西 昭徳
日本薬理学雑誌, Mar. 2013 - Functional role of the N-terminal domain of Delta FosB in response to stress and drugs of abuse
Yoshinori Ohnishi; Yoko Ohnishi; Ezekiell Mouzon; Vincent Vialou; Quincey Laplant; Akinori Nishi; Eric Nestler
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - Muscarinic receptors acting at pre- and post-synaptic sites differentially regulate dopamine/DARPP-32 signaling in striatonigral and striatopallidal neurons
Mahomi Kuroiwa; Miho Hamada; Eriko Hieda; Takahide Shuto; Naoki Sotogaku; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - Food reward-sensitive interaction of ghrelin and opioid receptor pathways in mesolimbic dopamine system
Yukie Kawahara; Fumi Kaneko; Makiko Yamada; Yuki Kishikawa; Hiroshi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013 - 抗うつ薬による海馬歯状回顆粒細胞の形態変化:FIB/SEMを用いた樹状突起の3D電顕解析
北原陽介; 首藤隆秀; 黒岩真帆美; 外角直樹; 蓮尾博; 都合亜記暢; 太田啓介; 中村桂一郎; 西昭徳
日本薬理学会西南部会プログラム/抄録集, 2013 - Effects of resveratrol on cocaine-induced dopamine D1 receptor signaling in the striatum
Takahide Shuto; Mahomi Kuroiwa; Yuki Koga; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012 - Peripherally administered ghrelin modulates the mesolimbic dopamine system via distinct opioid pathways associated with reward value of food
Yukie Kawahara; Fumi Kaneko; Makiko Yamada; Yuki Furushima; Hiroshi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012 - Comparison of the dorsal raphe serotonergic circuitry in WKY and Wistar rat strains
Makiko Yamada; Yukie Kawahara; Fumi Kaneko; Yuki Furushima; Dremencov Eliyahu; Hirosi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012 - Effect of antidepressants on the function of dentate gyrus: possible roles for dopamine D1 receptors
Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012 - 抗うつ薬により誘導された脱成熟歯状回におけるドーパミンD1受容体機能
西 昭徳; 黒岩 真帆美; 首藤 隆秀
日本脳科学会プログラム・抄録集, Oct. 2011 - フルオキセチン慢性投与による海馬歯状回ドーパミンD1受容体シグナルの増強(Effect of chronic fluoxetine treatment on dopamine D1 receptor signaling in the hippocampal dentate gyrus)
黒岩 真帆美; 外角 直樹; 首藤 隆秀; 宮川 剛; 西 昭徳
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Oct. 2011 - Comparison of the Depression-Like Behavior and Serotonergic System between Wistar and Wistar-Kyoto Rat Strains
YAMADA Makiko; KAWAHARA Yukie; KANEKO Fumi; FURUSHIMA Yuki; DREMENCOV Eliyahu; KAWAHARA Hiroshi; NISHI Akinori
日本神経精神薬理学雑誌 = Japanese journal of psychopharmacology, 25 Apr. 2011 - ドーパミン細胞質・核内DARPP-32シグナルのグルタミン酸による制御
西 昭徳; 黒岩 真帆美
日本薬理学雑誌, Mar. 2011 - Differential effect of methylphenidate on extracellular catecholamine levels in the ADHD model rat
Yuki Furushima; Yukie Kawahara; Makiko Yamada; Masaru Ishimatsu; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - Comparison of the serotonergic system and behavior between Wistar and Wistar-Kyoto rats
Makiko Yamada; Yukie Kawahara; Fumi Kaneko; Yuki Furushima; Dremencov Eliyahu; Hirosi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - Shingosine-1-phosphate regulates PKA/DARPP-32 signaling in striatal medium spiny neurons via GPR6-independent mechanisms
Ken Uematsu; Naohisa Uchimura; Toyojiro Matsuishi; Akinori Nishi
NEUROSCIENCE RESEARCH, 2011 - Regulation of dopamine signaling by muscarinic receptors in the striatum
Mahomi Kuroiwa; Eriko Hieda; Miho Hamada; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - Effect of a sirtuin activator, resveratrol, on behavioral sensitization to cocaine
Yuki Koga; Takahide Shuto; Mahomi Kuroiwa; Kouji Toyomasu; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011 - 大脳皮質ドーパミンD1シグナルを制御するホスホジエステラーゼ4に関する研究(Role of phosphodiesterase 4 in dopamine D1 receptor/cAMP/PKA signaling in the frontal cortex)
黒岩 真帆美; 首藤 隆秀; 西 昭徳
日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2010 - ホスホジエステラーゼ阻害薬による中枢ドーパミンシグナル調節
黒岩 真帆美; 首藤 隆秀; 西 昭徳
日本薬理学雑誌, Mar. 2010 - Methylphenidate(MPH)投与による注意欠陥多動性障害(ADHD)モデルラットの前頭前野のカテコールアミン量
古島由紀; 古島由紀; 石松秀; 山田麻記子; 河原幸江; 西昭徳; 赤須崇
日本生理学雑誌, 2010 - Regulation of D1 receptor/DARPP-32 signaling by muscarinic receptors via the release of dopamine in the striatum
Eriko Hieda; Miho Hamada; Mahomi Kuroiwa; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Methylphenidate decreases extracellular noradrenaline level of prefrontal cortex in the ADHD model rat
Yuki Furushima; Masaru Ishimatsu; Makiko Yamada; Yukie Kawahara; Akinori Nishi; Takashi Akasu
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010 - Comparison of the depression-like behavior and serotonergic system between Wistar and Wistar Kyoto strains of rats
M. Yamada; Y. Kawahara; F. Kaneko; Y. Furushima; E. Dremencov; H. Kawahara; A. Nishi
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2010 - Role of phosphodiesterase 4 and 10A in dopaminergic signaling
Mahomi Kuroiwa; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - Comparison of serotonergic system in WKY and wistar
Makiko Yamada; Yukie Kawahara; Fumi Kaneko; Hirosi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010 - INTRACELLULAR CA2+SIGNALING OF METABOTROPIC GLUTAMATE RECEPTOR 5 IS REGULATED BY THE RECEPTOR PHOSPHORYLATION
M. Zelenina; A. Nishi; K. Uematsu; M. Heiman; P. Greengard; A. Aperia
GLIA, Oct. 2009 - ROLES OF PHOSPHODIESTERASES IN THE REGULATION OF DOPAMINERGIC SIGNALING
KUROIWA M.; NISHI A.
Journal of brain science, 12 Jun. 2009 - Peripherally administered ghrelin induces bimodal effects on mesolimbic dopamine system depending on food-consumptive states
Yukie Kawahara; Hiroshi Kawhara; Fumi Kaneko; Makiko Yamada; Yoshihiro Nishi; Eiichiro Tanaka; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Distinct roles of PDE4 and. PDE10A in the regulation of dopamine signaling in the striatum
Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Three distinct dopamine D-1-like receptor signaling pathways
Mahorni Kuroiwa; Helen S. Bateup; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Regulation of DARRP-32 phosphorylation by muscarinic receptors via presynaptic and postsynaptic mechanisms in the striatum
Eriko Hieda; Miho Hamada; Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Are Wistar Kyoto rats a genetic animal model of depression? - Behavioral and pharmacological evaluation
Makiko Yamada; Yukie Kawahara; Fumi Kaneko; Hirosi Kawahara; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009 - Phosphodiesteraseによる線条体リン酸化シグナルの制御:ドーパミン神経終末とmedium spiny neuronの比較
西 昭徳; 黒岩 真帆美
日本薬理学雑誌, Mar. 2008 - Prostaglandin E-2 acts on EP1 receptor and amplifies both dopamine D1 and D2 receptor signaling in the striatum
Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Masayuki Miyasaka; Paul Greengard; Shuh Narumiya
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Neuronal type specific regulation of DARPP-32 phosphorylation in the striatum of D1R/D2R-DARPP-32 mice
Mahomi Kuroiwa; Helen S. Bateup; Paul Greengard; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Long-term administration of citalopram abolished the stress responses of monoamines in prefrontal cortex and amygdala of rat
Fumi Kaneko; Yukie Kawahara; Hiroshi Kawahara; Masatoshi Tanaka; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008 - Roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
Akinori Nishi; Mahomi Kuroiwa; Gretchen L. Snyder
NEUROSCIENCE RESEARCH, 2008 - DARPP-32-dependent regulation of spinophilin Ser94 phosphorylation in neostriatal neurons of direct and indirect pathways
Ken Uematsu; Hisao Maeda; Akinori Nishi
NEUROSCIENCE RESEARCH, 2007 - Dopamine D-1-Iike receptors coupled to adenylyl cyclase, phospholipase C and adenosine A2A receptor signaling regulate DARPP-32 phosphorylation.
Mahomi Kuroiwa; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Effect of acute and chronic administration of methamphetamine on locomotor activity in mGluR5 knockout mice
Takahide Shuto; Akinori Nishi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - Prostaglandin e receptor subtype EP1 regulates dopamine receptor signaling in the striatum.
Shiho Kitaoka; Tomoyuki Furuyashiki; Akinori Nishi; Takahide Shuto; Sho Koyasu; Toshiyuki Matsuoka; Shuh Narumiya
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007 - 線条体ドーパミン情報伝達におけるDARPP-32とRCSの機能的役割
西 昭徳; 黒岩 真帆美; 田中 正敏
日本薬理学雑誌, Feb. 2006 - SKF83959 regulates DARPP-32 phosphorylation by activating PLC-dependent and independent cascades
M Kuroiwa; A Nishi; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Prostaglandin E2 potentiates dopamine D1 receptor signaling via EP1
Shiho Kitaoka; Sho Koyasu; Akinori Nishi; Tomoyuki Furuyashiki; Toshiyuki Matsuoka; Shuh Narumiya
NEUROSCIENCE RESEARCH, 2006 - Chondroitin sulfate E promotes the neurite outgrowth of dopaminergic neurons through phospholipase C-mediated signaling
N Sotogaku; A Nishi; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - SKF83959 regulates DARPP-32 phosphorylation by activating PLC-dependent and independent cascades
Mahomi Kuroiwa; Akinori Nishi
NEUROSCIENCE RESEARCH, 2006 - Role of DARPP-32 Thr34 phosphorylation in methamphetamine-induced behavioral sensitization
T Shuto; A Nishi; T Yamamoto; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Prostaglandin E-2 potentiates D1R signaling via EP1
S Kitaoka; S Koyasu; Y Tanaka; A Nishi; T Furuyashiki; T Matsuoka; M Miyasaka; S Narumiya
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006 - Prostaglandin E-2 modulates midbrain dopaminergic system via its receptor EP1
Y Tanaka; T Furuyashiki; T Matsuoka; S Kitaoka; T Nagai; K Yamada; A Mizoguchi; A Nishi; T Nabeshima; S Narumiya
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - Regulation of dopamine/DARPP-32 signaling by glutamate in neostriatal neurons
A Nishi; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - Adaptation of pre- and postsynaptic dopaminergic signaling in methamphetamine-sensitized rats
M Kuroiwa; T Shuto; A Nishi; M Tanaka
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005 - Glutamatergic modulation of dopamine/DARPP-32 signaling in neostriatal neurons.
A Nishi; H Higashi; P Greengard
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003 - Interaction of dopamine/DARPP-32 signaling with glutamate in neostriatal neurons
A Nishi; P Greengard
NEUROPHARMACOLOGY, Aug. 2002 - Regulation of DARPP-32 phosphorylation by NMDA and AMPA receptors in neostriatal neurons
A Nishi; M Hamada; H Higashi
JAPANESE JOURNAL OF PHARMACOLOGY, 2002 - REGULATION OF RENAL TUBULAR NA+,K+-ATPASE ACTIVITY IS DIFFERENT IN DAHL SALT-SENSITIVE AND SALT-RESISTANT RATS
A NISHI; A BERTORELLO; A APERIA
JOURNAL OF GENERAL PHYSIOLOGY, Dec. 1990 - THE ABUNDANCE OF NA,K-ATPASE MESSENGER-RNA IS REGULATED BY GLUCOCORTICOID HORMONES IN THE INFANT RAT-KIDNEY
G CELSI; A NISHI; G AKUSJARVI; A APERIA
JOURNAL OF GENERAL PHYSIOLOGY, Dec. 1990
- 薬の基本とはたらきがわかる薬理学
西 昭徳, Joint work, 末梢神経に作用する薬（末梢神経系とは／交感神経作用薬／副交感神経作用薬）・中枢神経系に作用する薬（抗うつ薬と気分安定薬／抗精神病薬／パーキンソン病治療薬／認知症治療薬／全身麻酔薬）
羊土社, 2023 - エース薬理学
西 昭徳, Contributor, パーキンソン病治療薬
南山堂, 2020 - ベッドサイドの薬理学
西昭徳, Contributor, 抗てんかん薬、パーキンソン病治療薬、重症筋無力症治療薬、抗精神病薬、気分障害治療薬・精神治療薬、認知症治療薬、小児の薬物治療
丸善出版, 2018, Not reviewed - リハ研究の進め方・まとめ方
村上 郁磨; 西 昭徳, Contributor, 研究の倫理的裏付けを得よう‐倫理審査
医歯薬出版, 2017, Not reviewed - The role of phosphodiesterases in disorders of motivated behavior, in Cyclic-nucleotide phosphodiesterases in the central nervous system from biology to drug discovery
Snyder GL; Hendrick JP; Nishi A, Contributor, 303-351
Wiley & Sons, Inc., 2014, Not reviewed
- JAPAN BRAIN SCIENCE SOCIETY
- THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
- JAPAN PEDIATRIC SOCIETY
- THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
- THE JAPANESE PHARMACOLOGICAL SOCIETY
- Development of treatments for post traumatic stress disorder related to surgery and intensive care.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2023 - 31 Mar. 2026 - Elucidating the mechanisms by which female mice identify attractive male mice.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2022 - 31 Mar. 2025 - Development of novel therapeutics for neuropsychiatric disorders targeting dopamine signaling
Grant-in-Aid for Scientific Research (B)
Kurume University
01 Apr. 2022 - 31 Mar. 2025 - Involvement of dopamine and noradrenaline signaling mechanisms in depression and schizophrenia.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2019 - 31 Mar. 2022 - Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system
Grant-in-Aid for Scientific Research (B)
Kurume University
Apr. 2019 - Mar. 2022 - Investigation of the interaction between dopamine and noradrenaline signaling in the hippocampus to develop novel treatment of depression
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2018 - 31 Mar. 2021 - Novel approaches for treatment of addiction after social defeat stress
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2018 - 31 Mar. 2021 - Development of therapeutic method to suppress drug abuse by suppressing dopamine D1 signal
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2016 - 31 Mar. 2020 - Development of novel therapeutic approaches focused on phosphodiesterases for psychiatric disorders
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2016 - 31 Mar. 2019 - Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders
Grant-in-Aid for Scientific Research (B)
Kurume University
Apr. 2016 - Mar. 2019 - Does oxdative stress reaction in nucleus accumbes exacerbate cocaine addiction after social defeat stress?
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2015 - 31 Mar. 2018 - 治療抵抗性統合失調症の診断法及び治療法の開発
2016 - 2018 - Role of chondroitin sulfate-E in the modulation of neuronal morphology
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2014 - 31 Mar. 2017 - ドパミン神経系を標的とした精神神経疾患治療薬の創薬基盤研究
Oct. 2016 - Mar. 2017 - Functional role of the N-terminal domain of DFosB in response to stress and drugs of abuse.
Grant-in-Aid for Scientific Research (C)
Kurume University
01 Apr. 2012 - 31 Mar. 2015 - ptimization of FIB/SEM techniques ? the novel ultrastructureeanalysis by combination of serial thin ablation and block surface material contrastobservation - for biomedical mesoscale three dimentional structural analysis.
Grant-in-Aid for Challenging Exploratory Research
Kurume University
2012 - 2012 - 精神疾患モデルマウスの脳のシグナル伝達の生化学的解析
2007 - 2012 - 遺伝子発現を制御するドーパミンシグナル：DARPP-32を介する調節機構
2010 - 2011 - ドーパミンシグナルの多様性を探る：神経サブタイプ個別解析
Apr. 2009 - Mar. 2010 - 神経再生療法開発のための基礎的研究
Apr. 2008 - Mar. 2009 - 線条体領域ドーパミン情報伝達マップ：病態モデルへの展開
2006 - 2007 - Elucidating the structure and function of chondrotin sulfate proteoglycan in differentitation, development and regeneration of dopaminergic neurons
Grant-in-Aid for Scientific Research (C)
Kurume University
2004 - 2005 - 線条体領域ドーパミン情報伝達マップ
2004 - 2005 - Role of GABA_B receptors in dopamine/DARPP-32 signaling
Grant-in-Aid for Scientific Research (C)
Kurume University
2003 - 2004 - 神経発達を促進する分子機構の研究
2002 - 2004 - Neurochemical studies on pathophysiology and treatment of attention deficit hyperactivity disorder
Grant-in-Aid for Scientific Research (C)
Department of Pediatrics and Child Health, Kurume University School of Medicine
2001 - 2004 - 線条体ドーパミン情報伝達機構の生後発達：注意欠陥・多動性障害病態解明へのアプローチ
Apr. 2002 - Mar. 2003 - 線条体神経におけるドーパミン抑制性入力とグルタミン酸興奮性入力の統合
2002 - 2003 - ドーパミン情報伝達とシグナル統合細胞間分子回路
2001 - 2002 - ドーパミン情報伝達系、特にドーパミンD1シグナル増幅系分子機構の解析
2000 - 2001 - 線条体神経細胞におけるドーパミン情報伝達系、特にDARPP-32リン酸化を介する分子機構の解析
Apr. 1999 - Mar. 2000 - 線条体神経細胞でのドーパミン情報伝達系、特にD1/D2レセプター相互作用の解析
1999 - 2000 - 線条体神経細胞でのレセプター刺激／蛋白リン酸化を介する細胞内シグナリングの解析
1998 - 1999
- 特願2018-121098, IL-1ß阻害薬
外角 直樹; 沈 龍佑; 西 昭徳 - 特許5828345, 特願2013-543442, うつ病治療のための併用剤
西 昭徳; 小林 克則; 宮川 剛 - 特願2015-124397, ドーパミンシグナル伝達の抑制剤
上松 謙; 西 昭徳
■ 研究者からの一言アピール
