TIGIT expression on neoplastic cells is a poor prognostic factor for adult T-cell leukaemia/lymphoma.
Yuichi Yamada; Hiroaki Miyoshi; Mai Takeuchi; Kazutaka Nakashima; Kyohei Yamada; Takeharu Kato; Ken Tanaka; Kei Kohno; Yoshitaka Imaizumi; Yasushi Miyazaki; Koichi Ohshima
Pathology, Dec. 2024

Modeling NK-cell lymphoma in mice reveals its cell-of-origin and microenvironmental changes and identifies therapeutic targets.
Junji Koya; Tomohiko Tanigawa; Kota Mizuno; Haryoon Kim; Yuta Ito; Mitsuhiro Yuasa; Kentaro Yamaguchi; Yasunori Kogure; Yuki Saito; Sumito Shingaki; Mariko Tabata; Koichi Murakami; Kenichi Chiba; Ai Okada; Yuichi Shiraishi; Amira Marouf; Raphaël Liévin; Sammara Chaubard; Arnaud Jaccard; Olivier Hermine; Laurence de Leval; Olivier Tournilhac; Gandhi Damaj; Philippe Gaulard; Lucile Couronné; Teruhito Yasui; Kazutaka Nakashima; Hiroaki Miyoshi; Koichi Ohshima; Keisuke Kataoka
Nature communications, 22 Oct. 2024

Rejuvenated iPSC-derived GD2-directed CART Cells Harbor Robust Cytotoxicity Against Small Cell Lung Cancer.
Shintaro Kinoshita; Midori Ishii; Jun Ando; Takaharu Kimura; Tomoyuki Yamaguchi; Sakiko Harada; Fumiyuki Takahashi; Kazutaka Nakashima; Yozo Nakazawa; Satoshi Yamazaki; Koichi Ohshima; Kazuhisa Takahashi; Hiromitsu Nakauchi; Miki Ando
Cancer research communications, 11 Mar. 2024

Clinicopathological features of adult T-cell leukemia/lymphoma with T-follicular helper phenotype.
Reiji Muto; Hiroaki Miyoshi; Kazutaka Nakashima; Mai Takeuchi; Makoto Hamasaki; Koichi Ohshima
Cancer medicine, Mar. 2024

Clinicopathological analysis of CD47 and signal regulatory protein alpha expression in myeloid sarcoma patients: CD47 expression is a favourable prognostic factor.
Ken Tanaka; Hiroaki Miyoshi; Keisuke Kawamoto; Yasumasa Shimasaki; Kazutaka Nakashima; Teppei Imamoto; Kyohei Yamada; Mai Takeuchi; Mayuko Moritsubo; Takuya Furuta; Kei Kohno; Shinobu Tamura; Takashi Sonoki; Koichi Ohshima
Pathology, Feb. 2024

Clinicopathological comparison between PTCL-TBX21 and PTCL-GATA3 in Japanese patients.
Yasumasa Shimasaki; Hiroaki Miyoshi; Keisuke Kawamoto; Noriaki Yoshida; Tatsuzo Mishina; Kazutaka Nakashima; Teppei Imamoto; Takeshi Sugio; Eriko Yanagida; Takeharu Kato; Kyohei Yamada; Mai Takeuchi; Takaharu Suzuki; Mayuko Moritsubo; Takuya Furuta; Yoshitaka Imaizumi; Jun Takizawa; Koji Kato; Junji Suzumiya; Ritsuro Suzuki; Koichi Ohshima
Cancer medicine, Feb. 2024

Co-expression of regulatory B-cell markers, transforming growth factor β and interleukin-10 as a prognostic factor in diffuse large B-cell lymphoma.
Tatsuzo Mishina; Hiroaki Miyoshi; Mai Takeuchi; Kohta Miyawaki; Kazutaka Nakashima; Kyohei Yamada; Mayuko Moritsubo; Kanako Inoue-Mitsuyama; Yasumasa Shimasaki; Teppei Imamoto; Keisuke Kawamoto; Takuya Furuta; Kei Kohno; Koji Kato; Koichi Akashi; Koichi Ohshima
Pathology, research and practice, Feb. 2024

Co-stimulatory and immune checkpoint molecules are important in the tumor microenvironment of Hodgkin-like adult T-cell leukemia/lymphoma.
Mai Takeuchi; Hiroaki Miyoshi; Yuichiro Semba; Kyohei Yamada; Kazutaka Nakashima; Kensaku Sato; Takuya Furuta; Mayuko Moritsubo; Yusuke Ogura; Ken Tanaka; Teppei Imamoto; Fumiko Arakawa; Kei Kohno; Koichi Ohshima
Haematologica, 01 Dec. 2023

HTLV-1 bZIP Factor-Induced Reprogramming of Lactate Metabolism and Epigenetic Status Promote Leukemic Cell Expansion.
Kosuke Toyoda; Jun-Ichirou Yasunaga; Takafumi Shichijo; Yuichiro Arima; Kenichi Tsujita; Azusa Tanaka; Tarig Salah; Wenyi Zhang; Osama Hussein; Miyu Sonoda; Miho Watanabe; Daisuke Kurita; Kazutaka Nakashima; Kyohei Yamada; Hiroaki Miyoshi; Koichi Ohshima; Masao Matsuoka
Blood cancer discovery, 01 Sep. 2023

Digital spatial profiling of CD4+ T cells in classic Hodgkin lymphoma.
Mai Takeuchi; Hiroaki Miyoshi; Yuichiro Semba; Kyohei Yamada; Kazutaka Nakashima; Kensaku Sato; Takuya Furuta; Mayuko Moritsubo; Yusuke Ogura; Ken Tanaka; Teppei Imamoto; Fumiko Arakawa; Kei Kohno; Koichi Ohshima
Virchows Archiv : an international journal of pathology, Aug. 2023

Clinicopathological analysis of immunohistochemical expression of immune checkpoint molecules in follicular lymphoma.
Eriko Yanagida; Hiroaki Miyoshi; Mai Takeuchi; Joji Shimono; Kazutaka Nakashima; Kyohei Yamada; Keisuke Kawamoto; Mayuko Moritsubo; Yasumasa Shimasaki; Kanako Inoue; Teppei Imamoto; Takuya Furuta; Kei Kohno; Koichi Ohshima
Hematological oncology, Oct. 2022

CD37 expression in follicular lymphoma.
Takuro Yoshimura; Hiroaki Miyoshi; Joji Shimono; Kazutaka Nakashima; Mai Takeuchi; Eriko Yanagida; Kyohei Yamada; Yasumasa Shimasaki; Mayuko Moritsubo; Takuya Furuta; Kei Kohno; Koichi Ohshima
Annals of hematology, May 2022

Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma.
Sakiko Harada; Miki Ando; Jun Ando; Midori Ishii; Tomoyuki Yamaguchi; Satoshi Yamazaki; Tokuko Toyota; Kazuo Ohara; Manami Ohtaka; Mahito Nakanishi; Chansu Shin; Yasunori Ota; Kazutaka Nakashima; Koichi Ohshima; Chihaya Imai; Yozo Nakazawa; Hiromitsu Nakauchi; Norio Komatsu
Molecular therapy : the journal of the American Society of Gene Therapy, 02 Feb. 2022

The first case of methotrexate-associated lymphoproliferative disorder presenting as follicular T-cell lymphoma.
Reiji Muto; Toshiro Kawakita; Hiroaki Miyoshi; Fumiko Arakawa; Kazutaka Nakashima; Koichi Ohshima; Toshihiko Murayama
Pathology international, Nov. 2021

iPSC-Derived Neoantigen-Specific CTL Therapy for Ewing Sarcoma.
Midori Ishii; Jun Ando; Satoshi Yamazaki; Tokuko Toyota; Kazuo Ohara; Yoshiki Furukawa; Yoshiyuki Suehara; Mahito Nakanishi; Kazutaka Nakashima; Koichi Ohshima; Hiromitsu Nakauchi; Miki Ando
Cancer immunology research, Oct. 2021

Expression of telomerase reverse transcriptase in peripheral T-cell lymphoma.
Fumiko Arakawa; Hiroaki Miyoshi; Noriaki Yoshida; Kazutaka Nakashima; Yosaku Watatani; Takuya Furuta; Kyohei Yamada; Mayuko Moritsubo; Mai Takeuchi; Eriko Yanagida; Yasumasa Shimasaki; Kei Kohno; Keisuke Kataoka; Koichi Ohshima
Cancer medicine, Oct. 2021

Composite Epstein-Barr Virus-associated T-lymphoblastic and Peripheral T-cell Lymphomas: A Clonal Study.
Hiroki Hosoi; Toshiki Mushino; Kazutaka Nakashima; Kodai Kuriyama; Shinobu Tamura; Shogo Murata; Ken-Ichi Imadome; Koichi Ohshima; Takashi Sonoki
Internal medicine (Tokyo, Japan), 01 Jul. 2021

Human T-cell lymphotropic virus HBZ and tax mRNA expression are associated with specific clinicopathological features in adult T-cell leukemia/lymphoma.
Kyohei Yamada; Hiroaki Miyoshi; Noriaki Yoshida; Joji Shimono; Kensaku Sato; Kazutaka Nakashima; Mai Takeuchi; Fumiko Arakawa; Naoko Asano; Eriko Yanagida; Masao Seto; Koichi Ohshima
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Feb. 2021

Clinicopathological analysis of immunohistochemical expression of CD47 and SIRPα in adult T-cell leukemia/lymphoma.
Eriko Yanagida; Hiroaki Miyoshi; Mai Takeuchi; Noriaki Yoshida; Kazutaka Nakashima; Kyohei Yamada; Takeshi Umeno; Yasumasa Shimasaki; Takuya Furuta; Masao Seto; Koichi Ohshima
Hematological oncology, Dec. 2020

TACC3 expression as a prognostic factor in aggressive types of adult T-cell leukemia/lymphoma patients.
Mayuko Moritsubo; Hiroaki Miyoshi; Kotaro Matsuda; Noriaki Yoshida; Kazutaka Nakashima; Eriko Yanagida; Kyohei Yamada; Mai Takeuchi; Takaharu Suzuki; Hiroko Muta; Takeshi Umeno; Takuya Furuta; Masao Seto; Koichi Ohshima
International journal of laboratory hematology, Dec. 2020

Cytokine-related genes play critical roles in extrafollicular growth of follicular lymphoma cells.
Noriaki Yoshida; Hiroaki Miyoshi; Fumiko Arakawa; Kazutaka Nakashima; Keisuke Kawamoto; Masao Seto; Koichi Ohshima
Hematological oncology, Dec. 2020

Differences in the immunosurveillance pattern associated with DNA mismatch repair status between right-sided and left-sided colorectal cancer.
Hiroki Kanno; Hiroaki Miyoshi; Naohiro Yoshida; Tomoya Sudo; Kazutaka Nakashima; Mai Takeuchi; Yoriko Nomura; Masao Seto; Toru Hisaka; Hiroyuki Tanaka; Koji Okuda; Yoshito Akagi; Koichi Ohshima
Cancer science, Aug. 2020

Combination of CD47 and signal-regulatory protein-α constituting the "don't eat me signal" is a prognostic factor in diffuse large B-cell lymphoma.
Ryo Kazama; Hiroaki Miyoshi; Mai Takeuchi; Kohta Miyawaki; Kazutaka Nakashima; Noriaki Yoshida; Keisuke Kawamoto; Eriko Yanagida; Kyohei Yamada; Takeshi Umeno; Takaharu Suzuki; Koji Kato; Jun Takizawa; Masao Seto; Koichi Akashi; Koichi Ohshima
Cancer science, Jul. 2020

HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling.
Yusuke Higuchi; Jun-Ichirou Yasunaga; Yu Mitagami; Hirotake Tsukamoto; Kazutaka Nakashima; Koichi Ohshima; Masao Matsuoka
Proceedings of the National Academy of Sciences of the United States of America, 16 Jun. 2020

Expression of the ghrelin/growth hormone secretagogue receptor axis and its functional role in promoting tumor growth in primary central nervous system lymphomas.
Hiroko Muta; Yasuo Sugita; Takuya Furuta; Yuki Shiimura; Koichi Ohshima; Kazutaka Nakashima; Kensaku Sato; Motohiro Morioka; Hideyuki Abe; Takanori Nozawa; Yukihiko Fujii; Akiyoshi Kakita
Neuropathology : official journal of the Japanese Society of Neuropathology, Jun. 2020

Comprehensive immunohistochemical analysis of immune checkpoint molecules in adult T cell leukemia/lymphoma.
Mai Takeuchi; Hiroaki Miyoshi; Kazutaka Nakashima; Keisuke Kawamoto; Kyohei Yamada; Eriko Yanagida; Hiroko Muta; Mayuko Moritsubo; Takeshi Umeno; Takaharu Suzuki; Masao Seto; Koichi Ohshima
Annals of hematology, May 2020

成人T細胞白血病・リンパ腫における免疫チェックポイント分子の網羅的検索　　　　　　　　　　　　　　　
竹内 真衣; 三好 寛明; 中嶋 一貴; 山田 恭平; 柳田 恵理子; 牟田 紘子; 森坪 麻友子; 梅野 毅史; 瀬戸 加大; 大島 孝一
日本病理学会会誌, Mar. 2020

Clinical Features, Pathological Features, and Treatment Outcomes of 22 Patients with Aggressive Adult T-cell Leukemia-lymphoma Treated with a Humanized CCR4 Antibody (Mogamulizumab) at a Single Institution during a 6-year Period (2012-2018).
Noriaki Kawano; Noriaki Yoshida; Sayaka Kawano; Fumiko Arakawa; Hiroaki Miyoshi; Kyohei Yamada; Kazutaka Nakashima; Shuro Yoshida; Takuro Kuriyama; Taro Tochigi; Takashi Nakaike; Tomonori Shimokawa; Kiyoshi Yamashita; Kousuke Marutsuka; Koichi Mashiba; Ikuo Kikuchi; Koichi Ohshima
Internal medicine (Tokyo, Japan), 01 Aug. 2019

Clinicopathological analysis of immunohistochemical expression of retinoic acid-related orphan receptor-γt in peripheral T-cell lymphoma, not otherwise specified.
Eriko Yanagida; Hiroaki Miyoshi; Keisuke Kawamoto; Kazutaka Nakashima; Kotaro Matsuda; Kyohei Yamada; Reiji Muto; Koji Nagafuji; Masao Seto; Koichi Ohshima
Human pathology, Sep. 2018

Elevated Expression of Transforming Acidic Coiled-Coil Containing Protein 3 (TACC3) Is Associated With a Poor Prognosis in Osteosarcoma.
Kotaro Matsuda; Hiroaki Miyoshi; Koji Hiraoka; Tetsuya Hamada; Kazutaka Nakashima; Naoto Shiba; Koichi Ohshima
Clinical orthopaedics and related research, Sep. 2018

Analysis of the BRAFV600E mutation in 19 cases of Langerhans cell histiocytosis in Japan.
Yuya Sasaki; Ying Guo; Fumiko Arakawa; Hiroaki Miyoshi; Noriaki Yoshida; Yuhki Koga; Kazutaka Nakashima; Daisuke Kurita; Daisuke Niino; Masao Seto; Koichi Ohshima
Hematological oncology, Sep. 2017

Prognostic impact of GATA binding protein-3 expression in primary lung adenocarcinoma.
Toshihiro Hashiguchi; Hiroaki Miyoshi; Kazutaka Nakashima; Shintaro Yokoyama; Ryoichi Matsumoto; Daigo Murakami; Masahiro Mitsuoka; Shinzo Takamori; Yoshito Akagi; Koichi Ohshima
Human pathology, May 2017

Prognostic Value of Programmed Death Ligand 1 and Programmed Death 1 Expression in Thymic Carcinoma.
Shintaro Yokoyama; Hiroaki Miyoshi; Kazutaka Nakashima; Joji Shimono; Toshihiro Hashiguchi; Masahiro Mitsuoka; Shinzo Takamori; Yoshito Akagi; Koichi Ohshima
Clinical cancer research : an official journal of the American Association for Cancer Research, 15 Sep. 2016

HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and Proliferation.
Kenji Sugata; Jun-Ichirou Yasunaga; Haruka Kinosada; Yuichi Mitobe; Rie Furuta; Mohamed Mahgoub; Chiho Onishi; Kazutaka Nakashima; Koichi Ohshima; Masao Matsuoka
Cancer research, 01 Sep. 2016

Microarray analysis of gene expression by microdissected epidermis and dermis in mycosis fungoides and adult T-cell leukemia/lymphoma.
Keiko Hashikawa; Shinichiro Yasumoto; Kazutaka Nakashima; Fumiko Arakawa; Junichi Kiyasu; Yoshizo Kimura; Hiroshi Saruta; Takekuni Nakama; Kaori Yasuda; Kosuke Tashiro; Satoru Kuhara; Takashi Hashimoto; Koichi Ohshima
International journal of oncology, Sep. 2014

FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor.
Koichi Azuma; Akihiko Kawahara; Kahori Sonoda; Kazutaka Nakashima; Kousuke Tashiro; Kosuke Watari; Hiroto Izumi; Masayoshi Kage; Michihiko Kuwano; Mayumi Ono; Tomoaki Hoshino
Oncotarget, 15 Aug. 2014

Association of the expression of mutant epidermal growth factor receptor protein as determined with mutation-specific antibodies in non-small cell lung cancer with progression-free survival after gefitinib treatment.
Koichi Azuma; Isamu Okamoto; Akihiko Kawahara; Tomoki Taira; Kazutaka Nakashima; Satoshi Hattori; Takashi Kinoshita; Masayuki Takeda; Kazuhiko Nakagawa; Shinzo Takamori; Michihiko Kuwano; Mayumi Ono; Masayoshi Kage
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Jan. 2012

Identification of non-small-cell lung cancer with activating EGFR mutations in malignant effusion and cerebrospinal fluid: rapid and sensitive detection of exon 19 deletion E746-A750 and exon 21 L858R mutation by immunocytochemistry.
Akihiko Kawahara; Koichi Azuma; Akiko Sumi; Tomoki Taira; Kazutaka Nakashima; Emiko Aikawa; Hideyuki Abe; Tomohiko Yamaguchi; Shinzo Takamori; Jun Akiba; Masayoshi Kage
Lung cancer (Amsterdam, Netherlands), Oct. 2011

Nuclear β-catenin expression in basal cell adenomas of salivary gland.
Akihiko Kawahara; Hiroshi Harada; Hideyuki Abe; Tomohiko Yamaguchi; Tomoki Taira; Kazutaka Nakashima; Hiroyuki Mihashi; Jun Akiba; Masayoshi Kage
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Jul. 2011

Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer.
Akihiko Kawahara; Satoshi Hattori; Jun Akiba; Kazutaka Nakashima; Tomoki Taira; Kosuke Watari; Fumihito Hosoi; Manami Uba; Yuji Basaki; Kikuo Koufuji; Kazuo Shirouzu; Shin-Ichi Akiyama; Michihiko Kuwano; Masayoshi Kage; Mayumi Ono
Oncology reports, Aug. 2010

The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancer.
Akihiko Kawahara; Koichi Azuma; Satoshi Hattori; Kazutaka Nakashima; Yuji Basaki; Jun Akiba; Sinzo Takamori; Hisamichi Aizawa; Takashi Yanagawa; Hiroto Izumi; Kimitoshi Kohno; Suminori Kono; Masayoshi Kage; Michihiko Kuwano; Mayumi Ono
Human pathology, Jul. 2010

Molecular diagnosis of activating EGFR mutations in non-small cell lung cancer using mutation-specific antibodies for immunohistochemical analysis.
Akihiko Kawahara; Chizuko Yamamoto; Kazutaka Nakashima; Koichi Azuma; Satoshi Hattori; Masaki Kashihara; Hisamichi Aizawa; Yuji Basaki; Michihiko Kuwano; Masayoshi Kage; Tetsuya Mitsudomi; Mayumi Ono
Clinical cancer research : an official journal of the American Association for Cancer Research, 15 Jun. 2010

Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers.
Teruhiko Fujii; Akihiko Kawahara; Yuji Basaki; Satoshi Hattori; Kazutaka Nakashima; Kenji Nakano; Kazuo Shirouzu; Kimitoshi Kohno; Takashi Yanagawa; Hideaki Yamana; Kazuto Nishio; Mayumi Ono; Michihiko Kuwano; Masayoshi Kage
Cancer research, 01 Mar. 2008