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Division of Endocrinology and Metabolism Department of Internal Medicine
Associate Professor
Research activity information
■ Paper
- Desmosome Assembly Regulates Apical‐Basal Polarization and Nuclear Shape in Simple Epithelial Cells
Tobuhiro Nita; Junya Hayase; Akira Kohda; Akira Shiose; Hideki Sumimoto; Sachiko Kamakura
Genes to Cells, 19 Jan. 2026, [Reviewed]
Last, Corresponding - The Protein Kinase aPKC as Well as the Small GTPases RhoA and Cdc42 Regulates Neutrophil Chemotaxis Partly by Recruiting the ROCK Kinase to the Leading Edge.
Atsushi Naito; Sachiko Kamakura; Junya Hayase; Akira Kohda; Hiroaki Niiro; Koichi Akashi; Hideki Sumimoto
Genes to cells : devoted to molecular & cellular mechanisms, Mar. 2025, [Reviewed]
Corresponding - The scaffold protein IQGAP1 promotes reorientation of epithelial cell polarity at the two-cell stage for cystogenesis.
Michihiro Horikawa; Junya Hayase; Sachiko Kamakura; Akira Kohda; Masafumi Nakamura; Hideki Sumimoto
Genes to cells : devoted to molecular & cellular mechanisms, Dec. 2024, [Reviewed] - The NADPH oxidases DUOX1 and DUOX2 are sorted to the apical plasma membrane in epithelial cells via their respective maturation factors DUOXA1 and DUOXA2.
Akira Kohda; Sachiko Kamakura; Junya Hayase; Hideki Sumimoto
Genes to cells : devoted to molecular & cellular mechanisms, Oct. 2024, [Reviewed] - Hypoxia stabilizes the H2 O2 -producing oxidase Nox4 in cardiomyocytes via suppressing autophagy-related lysosomal degradation.
Shogo Matsunaga; Akira Kohda; Sachiko Kamakura; Junya Hayase; Kei Miyano; Akira Shiose; Hideki Sumimoto
Genes to cells : devoted to molecular & cellular mechanisms, Jan. 2024, [Reviewed] - TMEM25 is a Par3-binding protein that attenuates claudin assembly during tight junction development.
Sachiko Kamakura; Junya Hayase; Akira Kohda; Yuko Iwakiri; Kanako Chishiki; Tomoko Izaki; Hideki Sumimoto
EMBO reports, Jan. 2024, [Reviewed]
Lead - GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity.
Tsubasa Sakurai; Sachiko Kamakura; Junya Hayase; Akira Kohda; Masafumi Nakamura; Hideki Sumimoto
The Journal of biological chemistry, Oct. 2022 - Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl.
Vlad Tocan; Junya Hayase; Sachiko Kamakura; Akira Kohda; Shouichi Ohga; Motoyuki Kohjima; Hideki Sumimoto
The Journal of biological chemistry, Dec. 2021 - Intramolecular interaction in LGN, an adaptor protein that regulates mitotic spindle orientation.
Hiroki Takayanagi; Junya Hayase; Sachiko Kamakura; Kei Miyano; Kanako Chishiki; Satoru Yuzawa; Hideki Sumimoto
The Journal of biological chemistry, 20 Dec. 2019 - Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1.
Takuya Kiyohara; Kei Miyano; Sachiko Kamakura; Junya Hayase; Kanako Chishiki; Akira Kohda; Hideki Sumimoto
Genes to cells : devoted to molecular & cellular mechanisms, Jun. 2018 - Tropomyosin-related kinase B mediated signaling contributes to the induction of malignant phenotype of gallbladder cancer.
Makoto Kawamoto; Hideya Onishi; Keigo Ozono; Akio Yamasaki; Akira Imaizumi; Sachiko Kamakura; Kenji Nakano; Yoshinao Oda; Hideki Sumimoto; Masafumi Nakamura
Oncotarget, 30 May 2017 - Ric-8A, an activator protein of Gαi, controls mammalian epithelial cell polarity for tight junction assembly and cystogenesis.
Kanako Chishiki; Sachiko Kamakura; Junya Hayase; Hideki Sumimoto
Genes to cells : devoted to molecular & cellular mechanisms, Mar. 2017 - Ric-8A-mediated stabilization of the trimeric G protein subunit Gαi is inhibited by pertussis toxin-catalyzed ADP-ribosylation.
Kanako Chishiki; Sachiko Kamakura; Junya Hayase; Satoru Yuzawa; Hideki Sumimoto
Biochemical and biophysical research communications, 12 Feb. 2017 - c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation.
Riki Ishibashi; Satoshi Kozuki; Sachiko Kamakura; Hideki Sumimoto; Fumiko Toyoshima
The Journal of biological chemistry, 12 Feb. 2016 - Structural basis of cofactor-mediated stabilization and substrate recognition of the α-tubulin acetyltransferase αTAT1.
Satoru Yuzawa; Sachiko Kamakura; Junya Hayase; Hideki Sumimoto
The Biochemical journal, 01 Apr. 2015 - The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway.
Sachiko Kamakura; Masatoshi Nomura; Junya Hayase; Yuko Iwakiri; Akihiko Nishikimi; Ryoichi Takayanagi; Yoshinori Fukui; Hideki Sumimoto
Developmental cell, 12 Aug. 2013 - Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A.
Kanako Chishiki; Sachiko Kamakura; Satoru Yuzawa; Junya Hayase; Hideki Sumimoto
Biochemical and biophysical research communications, 07 Jun. 2013 - Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment.
Yuko Iwakiri; Sachiko Kamakura; Junya Hayase; Hideki Sumimoto
The Biochemical journal, 15 Apr. 2013 - The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.
Junya Hayase; Sachiko Kamakura; Yuko Iwakiri; Yoshihiro Yamaguchi; Tomoko Izaki; Takashi Ito; Hideki Sumimoto
The Journal of cell biology, 04 Mar. 2013 - Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).
Satoru Yuzawa; Sachiko Kamakura; Yuko Iwakiri; Junya Hayase; Hideki Sumimoto
Proceedings of the National Academy of Sciences of the United States of America, 29 Nov. 2011 - Membrane phospholipid metabolism during phagocytosis in human neutrophils.
Reiko Minakami; Yuichi Maehara; Sachiko Kamakura; Osamu Kumano; Kei Miyano; Hideki Sumimoto
Genes to cells : devoted to molecular & cellular mechanisms, May 2010 - A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase.
Masahiko Taura; Kei Miyano; Reiko Minakami; Sachiko Kamakura; Ryu Takeya; Hideki Sumimoto
The Biochemical journal, 15 Apr. 2009 - Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants.
Hideki Sumimoto; Sachiko Kamakura; Takashi Ito
Science's STKE : signal transduction knowledge environment, 28 Aug. 2007 - Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3.
Tomoko Izaki; Sachiko Kamakura; Motoyuki Kohjima; Hideki Sumimoto
Biochemical and biophysical research communications, 24 Mar. 2006 - Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein.
Tomoko Izaki; Sachiko Kamakura; Motoyuki Kohjima; Hideki Sumimoto
Biochemical and biophysical research communications, 01 Apr. 2005
- 肝細胞の極性決定及び管腔apical膜の形成はPar3,Cdc42,及びaPKCがLglと協調して制御する
トカン ヴラッド; トカン ヴラッド; 早瀬純也; 鎌倉幸子; 神田朗; 大賀正一; 国府島庸之; 住本英樹
日本生化学会大会(Web), 2023 - マウスES細胞の分化過程において,c-RelがInscuteable遺伝子の発現を制御する。
石橋理基; 上月智司; 上月智司; 鎌倉幸子; 住本英樹; 豊島文子; 豊島文子
日本分子生物学会年会プログラム・要旨集(Web), 2016 - Morg1はPar6-aPKC複合体のCrumbs3とCdc42への結合を促進し上皮細胞のapical膜identityを確立する
早瀬純也; 鎌倉幸子; 住本英樹
日本分子生物学会年会プログラム・要旨集(Web), 2013 - 細胞極性制御因子mInscは好中球のケモタキシスを制御する
鎌倉幸子; 野村政壽; 早瀬純也; 岩切優子; 錦見昭彦; 高柳涼一; 福井宣規; 住本英樹
日本分子生物学会年会プログラム・要旨集(Web), 2013 - Slp2-aはシグナル伝達分子podocalyxinをapical面に輸送し,claudin-2の発現調節を行う
安田貴雄; 三枝智香; 鎌倉幸子; 住本英樹; 福田光則
日本分子生物学会年会プログラム・要旨集(Web), 2012 - 新規Par6結合タンパク質による上皮細胞極性の制御機構
早瀬純也; 鎌倉幸子; 岩切優子; 山口佳洋; 山口佳洋; 伊崎智子; 伊藤隆司; 住本英樹
日本分子生物学会年会プログラム・要旨集(Web), 2011 - 食細胞NADPHオキシダーゼ細胞質因子p40phoxの膜移行の制御機構
水上令子; 水上令子; 本坊和也; 湯澤聡; 武谷立; 鈴木展生; 鎌倉幸子; 稲垣冬彦; 住本英樹
日本生体防御学会学術総会講演抄録集, 2007 - p40phoxのPXドメインとPtdIns(3)Pとの結合はp40phoxのPB1ドメインによって負に制御されている
水上令子; 水上令子; 本坊和也; 湯澤聡; 武谷立; 鈴木展生; 鎌倉幸子; 稲垣冬彦; 住本英樹
生化学, 2007 - Analysis of the Regulatory Region of the Human Dopamine D4 Receptor Gene.
鎌倉幸子; 岩城明子; 松本光之; 服巻保幸
日本分子生物学会年会プログラム・講演要旨集, 1997
- Regulation of tight junction formation by cell polarity proteins
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2018 - 31 Mar. 2021 - Regulation of directional movement during leukocyte chemotaxis by cell polarity proteins
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2015 - 31 Mar. 2018 - Regulation of directional movement during leukocyte chemotaxis by cell polarity proteins
Grant-in-Aid for Scientific Research (C)
Kyushu University
01 Apr. 2012 - 31 Mar. 2015 - Regulation of directionality of chemotaxing leukocyte by the polarity protein complex
Grant-in-Aid for Young Scientists (B)
Kyushu University
2010 - 2011 - Regulation of cell polarity by a novel Par3-binding protein
Grant-in-Aid for Young Scientists (B)
Kyushu University
2008 - 2009 - Regulatory Mechanism for the reactive oxygen-producing enzyme family Nox
Grant-in-Aid for Scientific Research (B)
Kyushu University
2006 - 2007
